Research Topics
| Howard AizensteinSummaryAffiliation: University of Pittsburgh Country: USA Publications
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Detail Information
Publications
fMRI correlates of white matter hyperintensities in late-life depressionHoward J Aizenstein
Department of Psychiatry, University of Pittsburgh, USA
Am J Psychiatry 168:1075-82. 2011..This study used an emotional faces paradigm that has been shown to engage the affective limbic brain regions...
The relation of White Matter Hyperintensities to implicit learning in healthy older adultsH J Aizenstein
Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
Int J Geriatr Psychiatry 17:664-9. 2002....
Altered functioning of the executive control circuit in late-life depression: episodic and persistent phenomenaHoward J Aizenstein
Department of Psychiatry, University of Pittsburgh, and Western Psychiatric Institute and Clinic, 3811 O Hara Street, Pittsburgh, PA 15213, USA
Am J Geriatr Psychiatry 17:30-42. 2009..To characterize the functional neuroanatomy of late-life depression (LLD) by probing for both episodic and persistent alterations in the executive-control circuit of elderly adults...- Three-dimensional surface mapping of the caudate nucleus in late-life depressionMeryl A Butters
Department of Psychiatry, University of Pittsburgh, and Western Psychiatric Institute and Clinic, 3811 O Hara St, Pittsburgh, PA 15213, USA
Am J Geriatr Psychiatry 17:4-12. 2009.... - Psychomotor speed and functional brain MRI 2 years after completing a physical activity treatmentCaterina Rosano
Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, 130 North Bellefield Street, Room 512, Pittsburgh, PA 15213, USA
J Gerontol A Biol Sci Med Sci 65:639-47. 2010..It is not known whether these associations are also significant for longer-term adherence to moderate-intensity activities... - Default-mode network connectivity and white matter burden in late-life depressionMinjie Wu
Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA
Psychiatry Res 194:39-46. 2011..The correlation between white-matter hyperintensities burden and default-mode network connectivity emphasizes the role of vascular changes in late-life depression etiopathogenesis... - Event-related functional magnetic resonance imaging investigation of executive control in very old individuals with mild cognitive impairmentCaterina Rosano
School of Public Health, Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
Biol Psychiatry 57:761-7. 2005..76, p = .02) but not with changes in accuracy rates. CONCLUSIONS: PPC and dlPFC may show early functional changes associated with MCI... - Altered cerebral blood flow patterns associated with pathologic worry in the elderlyCarmen Andreescu
Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, 3811 O Hara Street, Pittsburgh, PA, USA
Depress Anxiety 28:202-9. 2011..The aim of this study was to examine the neural correlates of emotion regulation in late-life GAD... - Conflict-related activity in the caudal anterior cingulate cortex in the absence of awarenessStefan Ursu
Department of Psychiatry, University of California, Davis, Sacramento, CA 95817, USA
Biol Psychol 80:279-86. 2009..These results suggest that the performance monitoring function of the cACC extends beyond detection of errors made with or without awareness, and involves detection of multiple responses even when they are outside of awareness... - Gray matter changes in late life depression--a structural MRI analysisCarmen Andreescu
The Advanced Center for Interventions and Services Research for Late life Mood Disorders, Department of Psychiatry, University of Pittsburgh School of Medicine and the John A Hartford Center of Excellence in Geriatric Psychiatry, Pittsburgh, PA 15213, USA
Neuropsychopharmacology 33:2566-72. 2008..However, it remains likely that both processes as well as other factors contribute to the heterogeneity of volumetric brain changes in LLD... - Special article: gait measures indicate underlying focal gray matter atrophy in the brain of older adultsCaterina Rosano
Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA, USA
J Gerontol A Biol Sci Med Sci 63:1380-8. 2008..Our objective was to identify the spatial distribution of focal atrophy within mobility-related brain regions in relationship with quantitative gait characteristics... - A regions-of-interest volumetric analysis of mobility limitations in community-dwelling older adultsCaterina Rosano
School of Public Health, Department of Epidemiology, University of Pittsburgh, Pennsylvania, USA
J Gerontol A Biol Sci Med Sci 62:1048-55. 2007..This study examined the association between gray matter volumes of regions related to motor control, gait, and balance and whether this association is independent of burden of white matter hyperintensities... - Regional brain activation during concurrent implicit and explicit sequence learningHoward J Aizenstein
University of Pittsburgh Medical School, Department of Psychiatry, 3811 O Hara Street, Pittsburgh, PA 15213, USA
Cereb Cortex 14:199-208. 2004..Our results suggest a relative dissociation of the brain regions engaged during ESL and ISL, whereby ESL and ISL can be viewed as partially distinct but overlapping parallel processes... - Focal atrophy and cerebrovascular disease increase dementia risk among cognitively normal older adultsCaterina Rosano
School of Public Health, Department of Epidemiology, University of Pittsburgh, Pennysylvania, USA
J Neuroimaging 17:148-55. 2007.... - The BOLD hemodynamic response in healthy agingHoward J Aizenstein
University of Pittsburgh School of Medicine, PA, USA
J Cogn Neurosci 16:786-93. 2004..g., inclusion of low-significance and/or negative voxels) underscores the importance of ROI selection criteria in the interpretation of fMRI studies using elderly populations... - Delays in auditory-cued step initiation are related to increased volume of white matter hyperintensities in older adultsPatrick J Sparto
Department of Physical Therapy, University of Pittsburgh, 6035 Forbes Tower, Pittsburgh, PA 15260, USA
Exp Brain Res 188:633-40. 2008.... - Prefrontal and striatal activation in elderly subjects during concurrent implicit and explicit sequence learningHoward J Aizenstein
Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Department of Psychiatry, 3811 O Hara Street, Pittsburgh, PA 15213, USA
Neurobiol Aging 27:741-51. 2006..Moreover, these changes are observed during an implicit task, and thus do not seem to be mediated by awareness... - Striatal outcome processing in healthy agingKarin M Cox
Department of Psychology, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
Cogn Affect Behav Neurosci 8:304-17. 2008..In sum, our data suggest that the signaling of outcome valence remains relatively stable into late adulthood, although more research is needed to understand some subtle changes that might occur across the life span... - Prefrontal and striatal activation during sequence learning in geriatric depressionHoward J Aizenstein
Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
Biol Psychiatry 58:290-6. 2005..The aim of the present study was to test this hypothesis with the use of functional magnetic resonance imaging (fMRI) tasks that are known to engage the prefrontal and neostriatal cognitive circuits... - Amygdalae morphometry in late-life depressionRobert J Tamburo
Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA
Int J Geriatr Psychiatry 24:837-46. 2009.... - Caudate asymmetry: a neurobiological marker of moderate prenatal alcohol exposure in young adultsJennifer Willford
Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
Neurotoxicol Teratol 32:589-94. 2010..The average magnitude of caudate asymmetry for the 1T group was intermediate between the 0T and 3T groups. Subtle anatomical changes in the caudate are detected at the moderate end of the spectrum of prenatal alcohol exposure... - Acute 5-HT reuptake blockade potentiates human amygdala reactivityKristin L Bigos
Department of Pharmaceutical Sciences, University of Pittsburgh, PA, USA
Neuropsychopharmacology 33:3221-5. 2008.... - Altered striatal response to reward in bulimia nervosa after recoveryAngela Wagner
Department of Psychiatry, School of Medicine, University of Pittsburgh, Western Psychiatric Institute and Clinic, Pittsburgh, Pennsylvania, USA
Int J Eat Disord 43:289-94. 2010..It is possible that disturbances of systems modulating reward may contribute to a vulnerability to develop an eating disorder... - Alterations in the hemodynamic response function in cognitively impaired HIV/AIDS subjectsShannon B Juengst
Department of Psychiatry, University of Pittsburgh School of Medicine, United States
J Neurosci Methods 163:208-12. 2007..The HRF of MNCD/HAD subjects did not return to baseline after 16s, suggesting subtle alterations in neuronal function, which may affect event-related fMRI studies... - Patterns of mild cognitive impairment after treatment of depression in the elderlyRishi K Bhalla
Department of Psychiatry, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
Am J Geriatr Psychiatry 17:308-16. 2009.... - Optimum template selection for atlas-based segmentationMinjie Wu
Department of Electrical and Computer Engineering, University of Pittsburgh, Pittsburgh, PA 15213, USA
Neuroimage 34:1612-8. 2007..Moreover, the improved accuracy of atlas-based segmentation using optimum templates approaches the accuracy of manual tracing, and thus is valid for automated brain imaging analyses... - fMRI activation in late-life anxious depression: a potential biomarkerCarmen Andreescu
Department of Psychiatry, The Advanced Center in Interventions and Services Research for Late Life Mood Disorders, University of Pittsburgh School of Medicine and the John A Hartford Center of Excellence in Geriatric Psychiatry, Pittsburgh, PA, USA
Int J Geriatr Psychiatry 24:820-8. 2009..Subjects were trained on the Preparing to Overcome Prepotency (POP) task, which is an executive control task that reliably activates the lateral prefrontal cortex-anterior cingulate cortex (ACC) cognitive control circuit... - Trajectories of treatment response in late-life depression: psychosocial and clinical correlatesAriel G Gildengers
Intervention Research Center for Late Life Mood Disorders, Department of Psychiatry, University of Pittsburgh School of Medicine, 3811 O Hara Street, Pittsburgh, PA 15213, USA
J Clin Psychopharmacol 25:S8-13. 2005..Further study focusing on risk factors associated with slower response may help optimize treatment in elderly patients who do not respond quickly to first-line therapies... - MRI studies in late-life mood disordersCarmen Andreescu
Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA
Curr Top Behav Neurosci 11:269-87. 2012..In this chapter, we will review the contribution of MRI studies to late-life mood and anxiety disorders: major depression, bipolar disorder and anxiety disorders in late-life... - Executive control function, brain activation and white matter hyperintensities in older adultsVijay K Venkatraman
Department of Bioengineering, School of Engineering, University of Pittsburgh, Pittsburgh, PA 15261, USA
Neuroimage 49:3436-42. 2010..It is not clear whether greater fMRI activation indicates a strategy to compensate for underlying brain structural abnormalities while maintaining higher performance... - Cognitive impairment in acquired brain injury: a predictor of rehabilitation outcomes and an opportunity for novel interventionsEllen Whyte
Department of Psychiatry, School of Medicine, WPIC BT 764, 3811 O Hara St, Pittsburgh PA 15213, USA
PM R 3:S45-51. 2011..Furthermore, we examine nascent promising research that suggests that interventions that target cognitive impairments can lead to better rehabilitation outcomes... - Differences in brain structure and function in older adults with self-reported disabling and nondisabling chronic low back painNeilly Buckalew
Clinical Scientist Training Program, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
Pain Med 11:1183-97. 2010..The primary aim of this pilot study was to identify structural and functional brain differences in older adults with self-reported disabling chronic low back pain (CLBP) compared with those who reported nondisabling CLBP... - Brain activity during bladder filling is related to white matter structural changes in older women with urinary incontinenceStasa D Tadic
Division of Geriatric Medicine and Institute on Aging, University of Pittsburgh, Pittsburgh, PA, USA
Neuroimage 51:1294-302. 2010.... - Gain in adiposity across 15 years is associated with reduced gray matter volume in healthy womenIsabella Soreca
Department of Psychiatry, University of Pittsburgh, 3811 O Hara Street, Pittsburgh, PA 15213, USA
Psychosom Med 71:485-90. 2009..Cross-sectional results indicate that reduced GMV may be associated with excess body weight... - Prevalence of cognitive disorders differs as a function of age in HIV virus infectionJames T Becker
Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
AIDS 18:S11-8. 2004..However, HIV viral load at study entry was significantly higher among those participants who had developed cognitive impairment one year later. CONCLUSION: Age is a significant risk modifier for prevalent neuropsychological disorder... - Amyloid deposition begins in the striatum of presenilin-1 mutation carriers from two unrelated pedigreesWilliam E Klunk
Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
J Neurosci 27:6174-84. 2007..The early, focal striatal amyloid deposition observed in these PS1 mutation carriers is often is not associated with clinical symptoms... - Quantitative comparison of AIR, SPM, and the fully deformable model for atlas-based segmentation of functional and structural MR imagesMinjie Wu
Department of Electrical and Computer Engineering, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
Hum Brain Mapp 27:747-54. 2006.... - A fully automated method for quantifying and localizing white matter hyperintensities on MR imagesMinjie Wu
Department of Electrical and Computer Engineering, University of Pittsburgh, USA
Psychiatry Res 148:133-42. 2006..Given the emergence of large NeuroImage databases, techniques, such as that described here, will allow for a better understanding of the relationship between WMHs and neuropsychiatric disorders... - Amyloid imaging in mild cognitive impairment subtypesDavid A Wolk
Alzheimer s Disease Research Center, University of Pittsburgh, Pittsburgh, PA 19104, USA
Ann Neurol 65:557-68. 2009.... - Pathways linking late-life depression to persistent cognitive impairment and dementiaMeryl A Butters
Department of Psychiatry, School of Medicine, University of Pittsburgh, Pennsylvania, USA
Dialogues Clin Neurosci 10:345-57. 2008.... - 3D mapping of ventricular and corpus callosum abnormalities in HIV/AIDSPaul M Thompson
Laboratory of Neuro Imaging, Dept of Neurology, UCLA School of Medicine, 635 Charles E Young Drive South, Suite 225E, Los Angeles, CA 90095 7332, USA
Neuroimage 31:12-23. 2006..We (1) identified regions with greatest differences between AIDS patients and healthy controls and (2) correlated specific 3D patterns of structural differences with measures of immune system deterioration and cognitive decline... - Alzheimer disease with psychosis: excess cognitive impairment is restricted to the misidentification subtypeGina Perez-Madriñan
Dept of Psychiatry, Univ of Pittsburgh, PA, USA
Am J Geriatr Psychiatry 12:449-56. 2004..We hypothesized that these two groups differed in their patterns of cognitive impairment, compared with AD subjects without psychosis... - Automated ROI-based brain parcellation analysis of frontal and temporal brain volumes in schizophreniaPilar Lopez-Garcia
Department of Psychiatry, School of Medicine, University of California, Davis, United States
Psychiatry Res 147:153-61. 2006..The automated ROI-based method can be used as a valid and efficient tool for quantification of regional gray matter volume in schizophrenia in multiple ROIs across the brains of large numbers of subjects... - Tracking Alzheimer's diseasePaul M Thompson
Department of Neurology, Laboratory of Neuro Imaging, UCLA School of Medicine, 635 Charles E Young Drive South, Suite 225E, Los Angeles, CA 90095 7332, USA
Ann N Y Acad Sci 1097:183-214. 2007..Strengths and weaknesses of these different imaging measures for basic neuroscience and drug trials are discussed... - 3D pattern of brain atrophy in HIV/AIDS visualized using tensor-based morphometryMing Chang Chiang
Laboratory of Neuro Imaging, Department of Neurology, UCLA School of Medicine, 635 Charles E Young Drive South, Suite 225E, Los Angeles, CA 90095 7332, USA
Neuroimage 34:44-60. 2007..To perform TBM, we developed a new MRI-based analysis technique that uses fluid image warping, and a new alpha-entropy-based information-theoretic measure of image correspondence, called the Jensen-Rényi divergence (JRD)... - Ventricular volume and dementia progression in the Cardiovascular Health StudyOwen T Carmichael
Neurology Department, University of California, Davis, CA 95616, USA
Neurobiol Aging 28:389-97. 2007..Larger ventricles in healthy subjects may indicate susceptibility to, or progression of, dementia-related pathology... - Cerebral ventricular changes associated with transitions between normal cognitive function, mild cognitive impairment, and dementiaOwen T Carmichael
Neurology and Computer Science Departments, Center for Neuroscience, University of California Davis, 1544 Newton Court, Davis, CA 95616, USA
Alzheimer Dis Assoc Disord 21:14-24. 2007..Patients with diabetes had faster VBR change. Ventricular expansion may accelerate late in the progression from normal cognitive function to dementia, and may be modulated by diabetes... - Thinning of the cerebral cortex visualized in HIV/AIDS reflects CD4+ T lymphocyte declinePaul M Thompson
Laboratory of Neuro Imaging, Department of Neurology, University of California School of Medicine, Los Angeles, CA 90095 1769, USA
Proc Natl Acad Sci U S A 102:15647-52. 2005..They provide an approach to gauge the impact of AIDS on the living brain and show that the brain is still vulnerable to infection even when patients are receiving antiretroviral therapy...
Research Grants
- Predictors of Treatment Response in Late-Life DepressionHoward Aizenstein; Fiscal Year: 2006..This award will support the applicant in obtaining the training necessary to undertake this direction of research and to develop as an independent scientist. ..
- Altered Functioning of Cognitive and Affective Circuits in Late-Life DepressionHoward Aizenstein; Fiscal Year: 2007..These treatment response subgroups can then serve as targets for future prevention and treatment studies. ..
- Altered Functioning of Cognitive and Affective Circuits in Late-Life DepressionHoward Aizenstein; Fiscal Year: 2009..These treatment response subgroups can then serve as targets for future prevention and treatment studies. ..
- Altered Functioning of Cognitive and Affective Circuits in Late-Life DepressionHoward J Aizenstein; Fiscal Year: 2010..These treatment response subgroups can then serve as targets for future prevention and treatment studies. ..
- Altered Functioning of Cognitive and Affective Circuits in Late-Life DepressionHoward Aizenstein; Fiscal Year: 2009..These treatment response subgroups can then serve as targets for future prevention and treatment studies. ..