Howard Aizenstein

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. pmc fMRI correlates of white matter hyperintensities in late-life depression
    Howard J Aizenstein
    Department of Psychiatry, University of Pittsburgh, USA
    Am J Psychiatry 168:1075-82. 2011
  2. ncbi request reprint The relation of White Matter Hyperintensities to implicit learning in healthy older adults
    H J Aizenstein
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Int J Geriatr Psychiatry 17:664-9. 2002
  3. pmc Altered functioning of the executive control circuit in late-life depression: episodic and persistent phenomena
    Howard J Aizenstein
    Department of Psychiatry, University of Pittsburgh, and Western Psychiatric Institute and Clinic, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Am J Geriatr Psychiatry 17:30-42. 2009
  4. pmc Psychomotor speed and functional brain MRI 2 years after completing a physical activity treatment
    Caterina Rosano
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, 130 North Bellefield Street, Room 512, Pittsburgh, PA 15213, USA
    J Gerontol A Biol Sci Med Sci 65:639-47. 2010
  5. pmc Three-dimensional surface mapping of the caudate nucleus in late-life depression
    Meryl A Butters
    Department of Psychiatry, University of Pittsburgh, and Western Psychiatric Institute and Clinic, 3811 O Hara St, Pittsburgh, PA 15213, USA
    Am J Geriatr Psychiatry 17:4-12. 2009
  6. pmc Default-mode network connectivity and white matter burden in late-life depression
    Minjie Wu
    Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA
    Psychiatry Res 194:39-46. 2011
  7. pmc Event-related functional magnetic resonance imaging investigation of executive control in very old individuals with mild cognitive impairment
    Caterina Rosano
    School of Public Health, Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Biol Psychiatry 57:761-7. 2005
  8. pmc Altered cerebral blood flow patterns associated with pathologic worry in the elderly
    Carmen Andreescu
    Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, 3811 O Hara Street, Pittsburgh, PA, USA
    Depress Anxiety 28:202-9. 2011
  9. pmc Conflict-related activity in the caudal anterior cingulate cortex in the absence of awareness
    Stefan Ursu
    Department of Psychiatry, University of California, Davis, Sacramento, CA 95817, USA
    Biol Psychol 80:279-86. 2009
  10. doi request reprint White matter hyperintensity burden and disability in older adults: is chronic pain a contributor?
    Neilly Buckalew
    Department of Geriatric Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    PM R 5:471-80; quiz 480. 2013

Collaborators

Detail Information

Publications49

  1. pmc fMRI correlates of white matter hyperintensities in late-life depression
    Howard J Aizenstein
    Department of Psychiatry, University of Pittsburgh, USA
    Am J Psychiatry 168:1075-82. 2011
    ..This study used an emotional faces paradigm that has been shown to engage the affective limbic brain regions...
  2. ncbi request reprint The relation of White Matter Hyperintensities to implicit learning in healthy older adults
    H J Aizenstein
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Int J Geriatr Psychiatry 17:664-9. 2002
    ....
  3. pmc Altered functioning of the executive control circuit in late-life depression: episodic and persistent phenomena
    Howard J Aizenstein
    Department of Psychiatry, University of Pittsburgh, and Western Psychiatric Institute and Clinic, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Am J Geriatr Psychiatry 17:30-42. 2009
    ..To characterize the functional neuroanatomy of late-life depression (LLD) by probing for both episodic and persistent alterations in the executive-control circuit of elderly adults...
  4. pmc Psychomotor speed and functional brain MRI 2 years after completing a physical activity treatment
    Caterina Rosano
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, 130 North Bellefield Street, Room 512, Pittsburgh, PA 15213, USA
    J Gerontol A Biol Sci Med Sci 65:639-47. 2010
    ..It is not known whether these associations are also significant for longer-term adherence to moderate-intensity activities...
  5. pmc Three-dimensional surface mapping of the caudate nucleus in late-life depression
    Meryl A Butters
    Department of Psychiatry, University of Pittsburgh, and Western Psychiatric Institute and Clinic, 3811 O Hara St, Pittsburgh, PA 15213, USA
    Am J Geriatr Psychiatry 17:4-12. 2009
    ....
  6. pmc Default-mode network connectivity and white matter burden in late-life depression
    Minjie Wu
    Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA
    Psychiatry Res 194:39-46. 2011
    ..The correlation between white-matter hyperintensities burden and default-mode network connectivity emphasizes the role of vascular changes in late-life depression etiopathogenesis...
  7. pmc Event-related functional magnetic resonance imaging investigation of executive control in very old individuals with mild cognitive impairment
    Caterina Rosano
    School of Public Health, Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Biol Psychiatry 57:761-7. 2005
    ....
  8. pmc Altered cerebral blood flow patterns associated with pathologic worry in the elderly
    Carmen Andreescu
    Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, 3811 O Hara Street, Pittsburgh, PA, USA
    Depress Anxiety 28:202-9. 2011
    ..The aim of this study was to examine the neural correlates of emotion regulation in late-life GAD...
  9. pmc Conflict-related activity in the caudal anterior cingulate cortex in the absence of awareness
    Stefan Ursu
    Department of Psychiatry, University of California, Davis, Sacramento, CA 95817, USA
    Biol Psychol 80:279-86. 2009
    ..These results suggest that the performance monitoring function of the cACC extends beyond detection of errors made with or without awareness, and involves detection of multiple responses even when they are outside of awareness...
  10. doi request reprint White matter hyperintensity burden and disability in older adults: is chronic pain a contributor?
    Neilly Buckalew
    Department of Geriatric Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    PM R 5:471-80; quiz 480. 2013
    ..To secondarily compare WMH of the participants with CLBP with the pain-free controls...
  11. pmc Gray matter changes in late life depression--a structural MRI analysis
    Carmen Andreescu
    The Advanced Center for Interventions and Services Research for Late life Mood Disorders, Department of Psychiatry, University of Pittsburgh School of Medicine and the John A Hartford Center of Excellence in Geriatric Psychiatry, Pittsburgh, PA 15213, USA
    Neuropsychopharmacology 33:2566-72. 2008
    ..However, it remains likely that both processes as well as other factors contribute to the heterogeneity of volumetric brain changes in LLD...
  12. pmc Special article: gait measures indicate underlying focal gray matter atrophy in the brain of older adults
    Caterina Rosano
    Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA, USA
    J Gerontol A Biol Sci Med Sci 63:1380-8. 2008
    ..Our objective was to identify the spatial distribution of focal atrophy within mobility-related brain regions in relationship with quantitative gait characteristics...
  13. pmc Amygdalae morphometry in late-life depression
    Robert J Tamburo
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA
    Int J Geriatr Psychiatry 24:837-46. 2009
    ....
  14. ncbi request reprint Regional brain activation during concurrent implicit and explicit sequence learning
    Howard J Aizenstein
    University of Pittsburgh Medical School, Department of Psychiatry, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Cereb Cortex 14:199-208. 2004
    ..Our results suggest a relative dissociation of the brain regions engaged during ESL and ISL, whereby ESL and ISL can be viewed as partially distinct but overlapping parallel processes...
  15. ncbi request reprint Focal atrophy and cerebrovascular disease increase dementia risk among cognitively normal older adults
    Caterina Rosano
    School of Public Health, Department of Epidemiology, University of Pittsburgh, Pennysylvania, USA
    J Neuroimaging 17:148-55. 2007
    ....
  16. ncbi request reprint The BOLD hemodynamic response in healthy aging
    Howard J Aizenstein
    University of Pittsburgh School of Medicine, PA, USA
    J Cogn Neurosci 16:786-93. 2004
    ..g., inclusion of low-significance and/or negative voxels) underscores the importance of ROI selection criteria in the interpretation of fMRI studies using elderly populations...
  17. ncbi request reprint A regions-of-interest volumetric analysis of mobility limitations in community-dwelling older adults
    Caterina Rosano
    School of Public Health, Department of Epidemiology, University of Pittsburgh, Pennsylvania, USA
    J Gerontol A Biol Sci Med Sci 62:1048-55. 2007
    ..This study examined the association between gray matter volumes of regions related to motor control, gait, and balance and whether this association is independent of burden of white matter hyperintensities...
  18. pmc Delays in auditory-cued step initiation are related to increased volume of white matter hyperintensities in older adults
    Patrick J Sparto
    Department of Physical Therapy, University of Pittsburgh, 6035 Forbes Tower, Pittsburgh, PA 15260, USA
    Exp Brain Res 188:633-40. 2008
    ....
  19. ncbi request reprint Prefrontal and striatal activation in elderly subjects during concurrent implicit and explicit sequence learning
    Howard J Aizenstein
    Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Department of Psychiatry, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Neurobiol Aging 27:741-51. 2006
    ..Moreover, these changes are observed during an implicit task, and thus do not seem to be mediated by awareness...
  20. pmc Striatal outcome processing in healthy aging
    Karin M Cox
    Department of Psychology, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
    Cogn Affect Behav Neurosci 8:304-17. 2008
    ..In sum, our data suggest that the signaling of outcome valence remains relatively stable into late adulthood, although more research is needed to understand some subtle changes that might occur across the life span...
  21. ncbi request reprint Prefrontal and striatal activation during sequence learning in geriatric depression
    Howard J Aizenstein
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Biol Psychiatry 58:290-6. 2005
    ..The aim of the present study was to test this hypothesis with the use of functional magnetic resonance imaging (fMRI) tasks that are known to engage the prefrontal and neostriatal cognitive circuits...
  22. pmc Caudate asymmetry: a neurobiological marker of moderate prenatal alcohol exposure in young adults
    Jennifer Willford
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Neurotoxicol Teratol 32:589-94. 2010
    ..The average magnitude of caudate asymmetry for the 1T group was intermediate between the 0T and 3T groups. Subtle anatomical changes in the caudate are detected at the moderate end of the spectrum of prenatal alcohol exposure...
  23. pmc Acute 5-HT reuptake blockade potentiates human amygdala reactivity
    Kristin L Bigos
    Department of Pharmaceutical Sciences, University of Pittsburgh, PA, USA
    Neuropsychopharmacology 33:3221-5. 2008
    ....
  24. doi request reprint Altered striatal response to reward in bulimia nervosa after recovery
    Angela Wagner
    Department of Psychiatry, School of Medicine, University of Pittsburgh, Western Psychiatric Institute and Clinic, Pittsburgh, Pennsylvania, USA
    Int J Eat Disord 43:289-94. 2010
    ..It is possible that disturbances of systems modulating reward may contribute to a vulnerability to develop an eating disorder...
  25. pmc Patterns of mild cognitive impairment after treatment of depression in the elderly
    Rishi K Bhalla
    Department of Psychiatry, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Am J Geriatr Psychiatry 17:308-16. 2009
    ....
  26. pmc fMRI activation in late-life anxious depression: a potential biomarker
    Carmen Andreescu
    Department of Psychiatry, The Advanced Center in Interventions and Services Research for Late Life Mood Disorders, University of Pittsburgh School of Medicine and the John A Hartford Center of Excellence in Geriatric Psychiatry, Pittsburgh, PA, USA
    Int J Geriatr Psychiatry 24:820-8. 2009
    ..Subjects were trained on the Preparing to Overcome Prepotency (POP) task, which is an executive control task that reliably activates the lateral prefrontal cortex-anterior cingulate cortex (ACC) cognitive control circuit...
  27. ncbi request reprint Trajectories of treatment response in late-life depression: psychosocial and clinical correlates
    Ariel G Gildengers
    Intervention Research Center for Late Life Mood Disorders, Department of Psychiatry, University of Pittsburgh School of Medicine, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    J Clin Psychopharmacol 25:S8-13. 2005
    ..Further study focusing on risk factors associated with slower response may help optimize treatment in elderly patients who do not respond quickly to first-line therapies...
  28. ncbi request reprint Optimum template selection for atlas-based segmentation
    Minjie Wu
    Department of Electrical and Computer Engineering, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Neuroimage 34:1612-8. 2007
    ..Moreover, the improved accuracy of atlas-based segmentation using optimum templates approaches the accuracy of manual tracing, and thus is valid for automated brain imaging analyses...
  29. ncbi request reprint Alterations in the hemodynamic response function in cognitively impaired HIV/AIDS subjects
    Shannon B Juengst
    Department of Psychiatry, University of Pittsburgh School of Medicine, United States
    J Neurosci Methods 163:208-12. 2007
    ..The HRF of MNCD/HAD subjects did not return to baseline after 16s, suggesting subtle alterations in neuronal function, which may affect event-related fMRI studies...
  30. pmc MRI studies in late-life mood disorders
    Carmen Andreescu
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA
    Curr Top Behav Neurosci 11:269-87. 2012
    ..In this chapter, we will review the contribution of MRI studies to late-life mood and anxiety disorders: major depression, bipolar disorder and anxiety disorders in late-life...
  31. doi request reprint Cognitive impairment in acquired brain injury: a predictor of rehabilitation outcomes and an opportunity for novel interventions
    Ellen Whyte
    Department of Psychiatry, School of Medicine, WPIC BT 764, 3811 O Hara St, Pittsburgh PA 15213, USA
    PM R 3:S45-51. 2011
    ..Furthermore, we examine nascent promising research that suggests that interventions that target cognitive impairments can lead to better rehabilitation outcomes...
  32. pmc Differences in brain structure and function in older adults with self-reported disabling and nondisabling chronic low back pain
    Neilly Buckalew
    Clinical Scientist Training Program, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Pain Med 11:1183-97. 2010
    ..The primary aim of this pilot study was to identify structural and functional brain differences in older adults with self-reported disabling chronic low back pain (CLBP) compared with those who reported nondisabling CLBP...
  33. pmc Executive control function, brain activation and white matter hyperintensities in older adults
    Vijay K Venkatraman
    Department of Bioengineering, School of Engineering, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Neuroimage 49:3436-42. 2010
    ..It is not clear whether greater fMRI activation indicates a strategy to compensate for underlying brain structural abnormalities while maintaining higher performance...
  34. ncbi request reprint Prevalence of cognitive disorders differs as a function of age in HIV virus infection
    James T Becker
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    AIDS 18:S11-8. 2004
    ..The purpose of this report is to describe the prevalence and incidence of cognitive impairment in HIV-infected individuals enrolled in a community-based study...
  35. pmc Brain activity during bladder filling is related to white matter structural changes in older women with urinary incontinence
    Stasa D Tadic
    Division of Geriatric Medicine and Institute on Aging, University of Pittsburgh, Pittsburgh, PA, USA
    Neuroimage 51:1294-302. 2010
    ....
  36. pmc Amyloid deposition begins in the striatum of presenilin-1 mutation carriers from two unrelated pedigrees
    William E Klunk
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    J Neurosci 27:6174-84. 2007
    ..The early, focal striatal amyloid deposition observed in these PS1 mutation carriers is often is not associated with clinical symptoms...
  37. pmc Gain in adiposity across 15 years is associated with reduced gray matter volume in healthy women
    Isabella Soreca
    Department of Psychiatry, University of Pittsburgh, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Psychosom Med 71:485-90. 2009
    ..Cross-sectional results indicate that reduced GMV may be associated with excess body weight...
  38. pmc Amyloid imaging in mild cognitive impairment subtypes
    David A Wolk
    Alzheimer s Disease Research Center, University of Pittsburgh, Pittsburgh, PA 19104, USA
    Ann Neurol 65:557-68. 2009
    ....
  39. pmc Quantitative comparison of AIR, SPM, and the fully deformable model for atlas-based segmentation of functional and structural MR images
    Minjie Wu
    Department of Electrical and Computer Engineering, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Hum Brain Mapp 27:747-54. 2006
    ....
  40. pmc A fully automated method for quantifying and localizing white matter hyperintensities on MR images
    Minjie Wu
    Department of Electrical and Computer Engineering, University of Pittsburgh, USA
    Psychiatry Res 148:133-42. 2006
    ..Given the emergence of large NeuroImage databases, techniques, such as that described here, will allow for a better understanding of the relationship between WMHs and neuropsychiatric disorders...
  41. pmc Pathways linking late-life depression to persistent cognitive impairment and dementia
    Meryl A Butters
    Department of Psychiatry, School of Medicine, University of Pittsburgh, Pennsylvania, USA
    Dialogues Clin Neurosci 10:345-57. 2008
    ....
  42. ncbi request reprint Alzheimer disease with psychosis: excess cognitive impairment is restricted to the misidentification subtype
    Gina Perez-Madriñan
    Dept of Psychiatry, Univ of Pittsburgh, PA, USA
    Am J Geriatr Psychiatry 12:449-56. 2004
    ..We hypothesized that these two groups differed in their patterns of cognitive impairment, compared with AD subjects without psychosis...
  43. ncbi request reprint 3D mapping of ventricular and corpus callosum abnormalities in HIV/AIDS
    Paul M Thompson
    Laboratory of Neuro Imaging, Dept of Neurology, UCLA School of Medicine, 635 Charles E Young Drive South, Suite 225E, Los Angeles, CA 90095 7332, USA
    Neuroimage 31:12-23. 2006
    ..We (1) identified regions with greatest differences between AIDS patients and healthy controls and (2) correlated specific 3D patterns of structural differences with measures of immune system deterioration and cognitive decline...
  44. pmc Tracking Alzheimer's disease
    Paul M Thompson
    Department of Neurology, Laboratory of Neuro Imaging, UCLA School of Medicine, 635 Charles E Young Drive South, Suite 225E, Los Angeles, CA 90095 7332, USA
    Ann N Y Acad Sci 1097:183-214. 2007
    ..Strengths and weaknesses of these different imaging measures for basic neuroscience and drug trials are discussed...
  45. pmc 3D pattern of brain atrophy in HIV/AIDS visualized using tensor-based morphometry
    Ming Chang Chiang
    Laboratory of Neuro Imaging, Department of Neurology, UCLA School of Medicine, 635 Charles E Young Drive South, Suite 225E, Los Angeles, CA 90095 7332, USA
    Neuroimage 34:44-60. 2007
    ..To perform TBM, we developed a new MRI-based analysis technique that uses fluid image warping, and a new alpha-entropy-based information-theoretic measure of image correspondence, called the Jensen-Rényi divergence (JRD)...
  46. pmc Thinning of the cerebral cortex visualized in HIV/AIDS reflects CD4+ T lymphocyte decline
    Paul M Thompson
    Laboratory of Neuro Imaging, Department of Neurology, University of California School of Medicine, Los Angeles, CA 90095 1769, USA
    Proc Natl Acad Sci U S A 102:15647-52. 2005
    ..They provide an approach to gauge the impact of AIDS on the living brain and show that the brain is still vulnerable to infection even when patients are receiving antiretroviral therapy...
  47. pmc Ventricular volume and dementia progression in the Cardiovascular Health Study
    Owen T Carmichael
    Neurology Department, University of California, Davis, CA 95616, USA
    Neurobiol Aging 28:389-97. 2007
    ..Larger ventricles in healthy subjects may indicate susceptibility to, or progression of, dementia-related pathology...
  48. pmc Cerebral ventricular changes associated with transitions between normal cognitive function, mild cognitive impairment, and dementia
    Owen T Carmichael
    Neurology and Computer Science Departments, Center for Neuroscience, University of California Davis, 1544 Newton Court, Davis, CA 95616, USA
    Alzheimer Dis Assoc Disord 21:14-24. 2007
    ..Patients with diabetes had faster VBR change. Ventricular expansion may accelerate late in the progression from normal cognitive function to dementia, and may be modulated by diabetes...
  49. ncbi request reprint Automated ROI-based brain parcellation analysis of frontal and temporal brain volumes in schizophrenia
    Pilar Lopez-Garcia
    Department of Psychiatry, School of Medicine, University of California, Davis, United States
    Psychiatry Res 147:153-61. 2006
    ..The automated ROI-based method can be used as a valid and efficient tool for quantification of regional gray matter volume in schizophrenia in multiple ROIs across the brains of large numbers of subjects...

Research Grants7

  1. Predictors of Treatment Response in Late-Life Depression
    Howard Aizenstein; Fiscal Year: 2006
    ..This award will support the applicant in obtaining the training necessary to undertake this direction of research and to develop as an independent scientist. ..
  2. Altered Functioning of Cognitive and Affective Circuits in Late-Life Depression
    Howard Aizenstein; Fiscal Year: 2007
    ..These treatment response subgroups can then serve as targets for future prevention and treatment studies. ..
  3. Altered Functioning of Cognitive and Affective Circuits in Late-Life Depression
    Howard Aizenstein; Fiscal Year: 2009
    ..These treatment response subgroups can then serve as targets for future prevention and treatment studies. ..
  4. Altered Functioning of Cognitive and Affective Circuits in Late-Life Depression
    Howard J Aizenstein; Fiscal Year: 2010
    ..These treatment response subgroups can then serve as targets for future prevention and treatment studies. ..
  5. Altered Functioning of Cognitive and Affective Circuits in Late-Life Depression
    Howard Aizenstein; Fiscal Year: 2009
    ..These treatment response subgroups can then serve as targets for future prevention and treatment studies. ..