Elias Aizenman

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. pmc Mediation of neuronal apoptosis by Kv2.1-encoded potassium channels
    Sumon Pal
    Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    J Neurosci 23:4798-802. 2003
  2. ncbi request reprint Alterations of N-methyl-D-aspartate receptor properties after chemical ischemia
    E Aizenman
    Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    J Pharmacol Exp Ther 295:572-7. 2000
  3. pmc Microglia induce neurotoxicity via intraneuronal Zn(2+) release and a K(+) current surge
    Megan E Knoch
    Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    Glia 56:89-96. 2008
  4. pmc Protein kinase C regulation of neuronal zinc signaling mediates survival during preconditioning
    Mandar A Aras
    Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    J Neurochem 110:106-17. 2009
  5. pmc ERK signaling leads to mitochondrial dysfunction in extracellular zinc-induced neurotoxicity
    Kai He
    Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    J Neurochem 114:452-61. 2010
  6. pmc Regulation of neuronal proapoptotic potassium currents by the hepatitis C virus nonstructural protein 5A
    Callie A Norris
    Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    J Neurosci 32:8865-70. 2012
  7. pmc Selective inhibition of mitogen-activated protein kinase phosphatases by zinc accounts for extracellular signal-regulated kinase 1/2-dependent oxidative neuronal cell death
    Yeung Ho
    Department of Neuroscience, University of Pittsburgh School of Medicine, 7041 BST 3, 3501 Fifth Ave, Pittsburgh, PA 15261, USA
    Mol Pharmacol 74:1141-51. 2008
  8. pmc Regulation of apoptotic potassium currents by coordinated zinc-dependent signalling
    Patrick T Redman
    Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    J Physiol 587:4393-404. 2009
  9. pmc Apoptotic surge of potassium currents is mediated by p38 phosphorylation of Kv2.1
    Patrick T Redman
    Department of Neurobiology and Pharmacology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Proc Natl Acad Sci U S A 104:3568-73. 2007
  10. ncbi request reprint Reversible modulation of GABA(A) receptor-mediated currents by light is dependent on the redox state of the receptor
    Daniel N Leszkiewicz
    Department of Neurobiology, University of Pittsburgh School of Medicine Pittsburgh, PA 15261, USA
    Eur J Neurosci 17:2077-83. 2003

Collaborators

Detail Information

Publications34

  1. pmc Mediation of neuronal apoptosis by Kv2.1-encoded potassium channels
    Sumon Pal
    Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    J Neurosci 23:4798-802. 2003
    ..1. These results suggest that Kv2.1-encoded K+ channels are necessary for the apoptotic signaling cascade in mammalian cortical neurons in culture and are sufficient for increasing the susceptibility to apoptogens in a nonexcitable cell...
  2. ncbi request reprint Alterations of N-methyl-D-aspartate receptor properties after chemical ischemia
    E Aizenman
    Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    J Pharmacol Exp Ther 295:572-7. 2000
    ..These results suggest that the alterations in NMDA receptor properties after KCN exposure may contribute to the molecular mechanisms that are activated in neurons to withstand lethal ischemic events in the brain after preconditioning...
  3. pmc Microglia induce neurotoxicity via intraneuronal Zn(2+) release and a K(+) current surge
    Megan E Knoch
    Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    Glia 56:89-96. 2008
    ..These results establish a direct link between microglial-generated oxygen and nitrogen reactive products and neuronal cell death mediated by intracellular Zn(2+) release and a surge in K(+) currents...
  4. pmc Protein kinase C regulation of neuronal zinc signaling mediates survival during preconditioning
    Mandar A Aras
    Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    J Neurochem 110:106-17. 2009
    ..These results indicate that neuronal Zn(2+) serves as an important, highly regulated signaling component responsible for the initiation of a neuroprotective pathway...
  5. pmc ERK signaling leads to mitochondrial dysfunction in extracellular zinc-induced neurotoxicity
    Kai He
    Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    J Neurochem 114:452-61. 2010
    ..These results provide new insight on the mechanism of extracellular zinc-induced toxicity in which the regulation of mitochondrial function by the Ras/MEK/ERK pathway is closely associated with neuronal viability...
  6. pmc Regulation of neuronal proapoptotic potassium currents by the hepatitis C virus nonstructural protein 5A
    Callie A Norris
    Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    J Neurosci 32:8865-70. 2012
    ..1. Our results indicate that NS5A1b limits K+ currents following injury, leading to increased neuronal viability. NS5A1b may thus serve as a model for a new generation of neuroprotective agents...
  7. pmc Selective inhibition of mitogen-activated protein kinase phosphatases by zinc accounts for extracellular signal-regulated kinase 1/2-dependent oxidative neuronal cell death
    Yeung Ho
    Department of Neuroscience, University of Pittsburgh School of Medicine, 7041 BST 3, 3501 Fifth Ave, Pittsburgh, PA 15261, USA
    Mol Pharmacol 74:1141-51. 2008
    ..Thus, the elevation of intracellular zinc within neurons subjected to oxidative stress can trigger a robust positive feedback loop operating through activated ERK1/2 that rapidly sets into motion a zinc-dependent pathway of cell death...
  8. pmc Regulation of apoptotic potassium currents by coordinated zinc-dependent signalling
    Patrick T Redman
    Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    J Physiol 587:4393-404. 2009
    ..Kv2.1-encoded channels thus regulate neuronal survival by providing a converging input for two Zn(2+)-dependent signal transduction cascades...
  9. pmc Apoptotic surge of potassium currents is mediated by p38 phosphorylation of Kv2.1
    Patrick T Redman
    Department of Neurobiology and Pharmacology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Proc Natl Acad Sci U S A 104:3568-73. 2007
    ..Consequently, phosphorylation of Kv2.1 residue S800 by p38 leads to trafficking and membrane insertion during apoptosis, and remarkably, the absence of S800 phosphorylation is sufficient to prevent completion of the cell death program...
  10. ncbi request reprint Reversible modulation of GABA(A) receptor-mediated currents by light is dependent on the redox state of the receptor
    Daniel N Leszkiewicz
    Department of Neurobiology, University of Pittsburgh School of Medicine Pittsburgh, PA 15261, USA
    Eur J Neurosci 17:2077-83. 2003
    ..These results suggest that GABAA receptors can be reversibly modified by a brief pulse of light via an allosteric mechanism that is intimately linked to redox modulation...
  11. ncbi request reprint Protein kinases and light: unlikely partners in a receptor localization puzzle
    Daniel N Leszkiewicz
    Department of Neurobiology, University of Pittsburgh School of Medicine, E1456 BST, 15261, Pittsburgh, PA, USA
    Physiol Behav 77:533-6. 2002
    ..These observations support a critical role for protein kinases in the rapid redistribution of neurotransmitter receptors, with profound physiological significance...
  12. pmc Zn2+ regulates Kv2.1 voltage-dependent gating and localization following ischemia
    Mandar A Aras
    Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Eur J Neurosci 30:2250-7. 2009
    ..1 channel activity and localization following ischemia. The identification of Zn(2+) in mediating ischemic modulation of Kv2.1 may lead to a better understanding of cellular adaptive responses to injury...
  13. pmc Convergent Ca2+ and Zn2+ signaling regulates apoptotic Kv2.1 K+ currents
    Meghan C McCord
    Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Proc Natl Acad Sci U S A 110:13988-93. 2013
    ....
  14. ncbi request reprint Methylisothiazolinone, a neurotoxic biocide, disrupts the association of SRC family tyrosine kinases with focal adhesion kinase in developing cortical neurons
    Kai He
    Department of Neurobiology, University of Pittsburgh School of Medicine E1456 BST, Pittsburgh, PA 15261, USA
    J Pharmacol Exp Ther 317:1320-9. 2006
    ..Prolonged exposure to low levels of MIT and related compounds may have damaging consequences to the developing nervous system...
  15. pmc A molecular technique for detecting the liberation of intracellular zinc in cultured neurons
    Hirokazu Hara
    Department of Neurobiology, University of Pittsburgh School of Medicine, E1456 BST, Pittsburgh, PA 15261, USA
    J Neurosci Methods 137:175-80. 2004
    ..Our results indicate that Cd(2+) can effectively induce transactivation of MRE in neurons by liberating Zn(2+) from its intracellular binding sites...
  16. pmc Caspase 3 activation is essential for neuroprotection in preconditioning
    BethAnn McLaughlin
    Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Proc Natl Acad Sci U S A 100:715-20. 2003
    ..We outline a neuroprotective pathway where events normally associated with apoptotic cell death are critical for cell survival...
  17. pmc Cyclin e1 regulates Kv2.1 channel phosphorylation and localization in neuronal ischemia
    Niyathi H Shah
    Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261
    J Neurosci 34:4326-31. 2014
    ..These results support a novel role for neuronal cyclin E1 in regulating the phosphorylation status and localization of Kv2.1 channels, a likely component of signaling cascades leading to ischemic preconditioning. ..
  18. pmc Targeted single-neuron infection with rabies virus for transneuronal multisynaptic tracing
    Tuan D Nguyen
    Department of Otolaryngology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    J Neurosci Methods 209:367-70. 2012
    ..Here we report on a method that can initially infect a single neuron-of-choice, allowing for greater precision and specificity of labeled circuits...
  19. pmc KCC2 expression in immature rat cortical neurons is sufficient to switch the polarity of GABA responses
    Hanmi Lee
    Department Neurobiology, University of Pittsburgh School of Medicine, W1447 Biomedical Science Tower, 3500 Terrace Street, Pittsburgh, PA 15261, USA
    Eur J Neurosci 21:2593-9. 2005
    ..We conclude that KCC2 expression is not only necessary but is also sufficient for ending the depolarizing period of GABA in developing cortical neurons...
  20. pmc Obligatory role of ASK1 in the apoptotic surge of K+ currents
    Mandar A Aras
    Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Neurosci Lett 387:136-40. 2005
    ..Finally, over-expression of thioredoxin, an inhibitory binding partner of ASK1, is sufficient to halt the apoptotic current surge in neurons. Thus, ASK1 is an obligatory component of the pro-apoptotic modulation of K+ channels...
  21. doi request reprint Assessment of cell viability in primary neuronal cultures
    Mandar A Aras
    Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Curr Protoc Neurosci . 2008
    ..Finally, the fifth assay details the measurement of luciferase expression as an indication of neuronal viability within a relatively small population of transfected neurons...
  22. pmc Redox regulation of intracellular zinc: molecular signaling in the life and death of neurons
    Mandar A Aras
    Department of Neurobiology, University of Pittsburgh School of Medicine, 3500 Terrace St, Pittsburgh, PA 15261, USA
    Antioxid Redox Signal 15:2249-63. 2011
    ..Thus, redox-sensitive proteins, like metallothioneins, may play a critical role in determining neuronal cell fate by regulating the localization and concentration of intracellular free Zn(2+)...
  23. ncbi request reprint Amino terminal domain regulation of NMDA receptor function
    Greta Ann Herin
    Department of Neurobiology, University of Pittsburgh School of Medicine, E1456 BST, Pittsburgh, PA 15261, USA
    Eur J Pharmacol 500:101-11. 2004
    ..Modulation of the NMDA receptor by the ATD is considered within a framework of functional modularity of multisubunit ion channels. We also consider the potential importance of the ATD in assembly of the receptor...
  24. pmc Nitrosative stress and potassium channel-mediated neuronal apoptosis: is zinc the link?
    Sumon Pal
    Department of Neurobiology, University of Pittsburgh School of Medicine, E1456 BST, Pittsburgh, PA 15261, USA
    Pflugers Arch 448:296-303. 2004
    ..Emerging evidence suggests that the liberation of intracellular zinc as well as over-activation of potassium channels may be two important components of nitrosative stress-induced neuronal death...
  25. pmc Novel neuroprotective K+ channel inhibitor identified by high-throughput screening in yeast
    Elena Zaks-Makhina
    Department of Pharmacology, University of Pittsburgh School of Medicine, Pittsburgh PA 15261, USA
    Mol Pharmacol 65:214-9. 2004
    ..1 channels. Therefore, yeast-based screening has identified a novel uncharged neuroprotective mammalian K+ channel inhibitor...
  26. pmc Synaptic Zn2+ inhibits neurotransmitter release by promoting endocannabinoid synthesis
    Tamara Perez-Rosello
    Department of Otolaryngology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    J Neurosci 33:9259-72. 2013
    ..We reveal a previously unknown action of synaptic Zn(2+): synaptic Zn(2+) inhibits glutamate release by promoting 2-AG synthesis...
  27. pmc A role for the redox site in the modulation of the NMDA receptor by light
    Daniel Leszkiewicz
    Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    J Physiol 545:435-40. 2002
    ..Hence, light and redox modulation of the NMDA receptor may share a common intramolecular pathway for altering the function of this ion channel...
  28. pmc Zinc accumulation after target loss: an early event in retrograde degeneration of thalamic neurons
    Peter W Land
    Department of Neurobiology and Center for Neuroscience, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Eur J Neurosci 21:647-57. 2005
    ..Moreover, zinc accumulation in vivo can occur in the absence of presynaptic zinc release. Together these findings suggest that accumulation of intracellular zinc is a ubiquitous component of the cell death cascade in neurons...
  29. ncbi request reprint In vitro neurotoxicity of methylisothiazolinone, a commonly used industrial and household biocide, proceeds via a zinc and extracellular signal-regulated kinase mitogen-activated protein kinase-dependent pathway
    Shen Du
    Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    J Neurosci 22:7408-16. 2002
    ..Because of their widespread use, the neurotoxic consequences of both acute and chronic human exposure to these toxins need to be evaluated...
  30. ncbi request reprint Channels gone bad. Reflections from a Tapas bar
    Elias Aizenman
    Department of Neurobiology, University of Pittsburgh School of Medicine, Pennsylvania 15261, USA
    Neuron 34:679-83. 2002
  31. pmc Peroxynitrite-induced neuronal apoptosis is mediated by intracellular zinc release and 12-lipoxygenase activation
    Yumin Zhang
    Department of Neurology and Program in Neuroscience, Children s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 24:10616-27. 2004
    ....
  32. ncbi request reprint Elevation of intracellular cAMP evokes activity-dependent release of adenosine in cultured rat forebrain neurons
    Yin Lu
    Department of Neurology and Program in Neuroscience, Children s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Eur J Neurosci 19:2669-81. 2004
    ..These data suggest the existence of a homeostatic negative feedback loop in which increases in neuronal activity are damped by release of adenosine following activation of glutamate receptors...
  33. pmc Intracellular zinc release, 12-lipoxygenase activation and MAPK dependent neuronal and oligodendroglial death
    Yumin Zhang
    Department of Anatomy, Physiology and Genetics and Program in Neuroscience, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA
    Mol Med 13:350-5. 2007
    ..In this review, we describe how the activation of 12-lipoxygenase and mitogen-activated protein kinase (MAPK) contribute to the toxicity of liberated zinc to neurons and oligodendrocytes...
  34. ncbi request reprint The selective p38 inhibitor SB-239063 protects primary neurons from mild to moderate excitotoxic injury
    Jeffrey J Legos
    High Throughput Biology, Discovery Research, GlaxoSmithKline, PO Box 1539, Mail Code UW 2523, 709 Swedeland Road, 19406, King of Prussia, PA, USA
    Eur J Pharmacol 447:37-42. 2002
    ....