Research Topics
Genomes and GenesSpecies | Nassima Ait-DaoudSummaryAffiliation: University of Texas Health Science Center Country: USA Publications
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Publications
Combining ondansetron and naltrexone reduces craving among biologically predisposed alcoholics: preliminary clinical evidenceN Ait-Daoud
Treatment Research Center, Department of Psychiatry, University of Texas, Health Science Center at San Antonio, 78229 3900, USA
Psychopharmacology (Berl) 154:23-7. 2001..We now hypothesize further that an important mechanism by which the combination diminishes alcohol consumption is through a reduction in craving...- Combining ondansetron and naltrexone treats biological alcoholics: corroboration of self-reported drinking by serum carbohydrate deficient transferrin, a biomarkerN Ait-Daoud
Department of Psychiatry and the Southwest Texas Addiction Research and Technology START Center, University of Texas Health Science Center at San Antonio, San Antonio 78229 3900, Texas, USA
Alcohol Clin Exp Res 25:847-9. 2001.... - Effects of isradipine on methamphetamine-induced changes in attentional and perceptual-motor skills of cognitionBankole A Johnson
Department of Psychiatry, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229 3900, USA
Psychopharmacology (Berl) 178:296-302. 2005..Yet, isradipine's effects on cognitive performance in methamphetamine-dependent individuals are not known... - Oral topiramate for treatment of alcohol dependence: a randomised controlled trialBankole A Johnson
Department of Psychiatry, University of Texas Health Science Center at San Antonio, TX 78229 3900, USA
Lancet 361:1677-85. 2003..We aimed to see whether topiramate was more effective than placebo as a treatment for alcohol dependence... - Effects of isradipine on cocaine-induced subjective moodBankole A Johnson
Department of Psychiatry, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229 3900, USA
J Clin Psychopharmacol 24:180-91. 2004..Also, isradipine-mediated inhibition of mesolimbic DA release may be an ineffective treatment of cocaine dependence... - Oral topiramate reduces the consequences of drinking and improves the quality of life of alcohol-dependent individuals: a randomized controlled trialBankole A Johnson
Department of Psychiatry, The University of Texas Health Science Center at San Antonio, 78229 3900, USA
Arch Gen Psychiatry 61:905-12. 2004..Topiramate, a fructopyranose derivative, was superior to placebo at improving the drinking outcomes of alcohol-dependent individuals... - Ondansetron reduces the craving of biologically predisposed alcoholicsBankole A Johnson
Department of Psychiatry, University of Texas, Health Science Center at San Antonio, 7703 Floyd Curl Drive, Mail Stop 7792, San Antonio, TX 78229 3900, USA
Psychopharmacology (Berl) 160:408-13. 2002..Proximate motivational drives such as craving could have determined drinking behavior. We therefore investigated whether ondansetron treatment would reduce alcohol craving significantly among EOA... - Kinetic and cardiovascular comparison of immediate-release isradipine and sustained-release isradipine among non-treatment-seeking, cocaine-dependent individualsBankole A Johnson
South Texas Addiction Research and Technology Center, Department of Psychiatry, The University of Texas Health Science Center at San Antonio, 3939 Medical Drive, Suite 100, San Antonio, TX 78229 3900, USA
Prog Neuropsychopharmacol Biol Psychiatry 29:15-20. 2005..The more favorable cardiovascular profile of SR isradipine would, however, make it more appropriate as an investigational medication for the treatment of stimulant dependence and related neurovascular disorders... - Effects of isradipine, a dihydropyridine-class calcium-channel antagonist, on d-methamphetamine's subjective and reinforcing effectsBankole A Johnson
Department of Psychiatry, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
Int J Neuropsychopharmacol 8:203-13. 2005..Depending upon conditioning status, isradipine can reduce some methamphetamine-induced positive subjective and reinforcing effects associated with its abuse liability in methamphetamine addicts... 
Drinking histories in alcohol-use-disordered youth: preliminary findings on relationships to platelet serotonin transporter expression with genotypes of the serotonin transporterMichael A Dawes
Department of Psychiatry, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229 3900, USA
J Stud Alcohol Drugs 70:899-907. 2009..Specifically, we wanted to examine the relationships between the following: platelet 5-HTT and 5-HTT genotype; platelet 5-HTT parameters and age at onset, as well as duration of drinking; and 5-HTT genotype and impulse control...- A prospective, open-label trial of ondansetron in adolescents with alcohol dependenceMichael A Dawes
START Center, Division of Alcohol and Drug Addiction, Department of Psychiatry, The University of Texas Health Science Center at San Antonio UTHSCSA, 3939 Medical Drive, Suite 100, San Antonio, TX 78229 3900, USA
Addict Behav 30:1077-85. 2005..Findings of decreased drinking underscore the need for future double-blind, placebo-controlled studies in this adolescent population... - Ondansetron reduces mood disturbance among biologically predisposed, alcohol-dependent individualsBankole A Johnson
Department of Psychiatry, The University of Texas Health Science Center at San Antonio, 78229 3900, USA
Alcohol Clin Exp Res 27:1773-9. 2003.... - Development of novel pharmacotherapies for the treatment of alcohol dependence: focus on antiepilepticsBankole A Johnson
Department of Psychiatry, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229 3900, USA
Alcohol Clin Exp Res 28:295-301. 2004..DiClemente; (5) Synopsis of promising medications to treat alcoholism, by Robert M. Swift; and (6) New knowledge on the development of antiepileptic medications for the treatment of alcoholism, by Robert J. Malcolm, Jr... - A pilot evaluation of the safety and tolerability of repeat dose administration of long-acting injectable naltrexone (Vivitrex) in patients with alcohol dependenceBankole A Johnson
University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229 3900, USA
Alcohol Clin Exp Res 28:1356-61. 2004..A long-acting injectable naltrexone formulation (Vivitrex) was designed to facilitate patient adherence by providing an extended duration of therapeutic naltrexone over 1 month, thereby eliminating the need for daily dosing... - Prediction of serotonergic treatment efficacy using age of onset and Type A/B typologies of alcoholismJohn D Roache
Department of Psychiatry, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, Mailstop 7792, San Antonio, Texas 78229, USA
Alcohol Clin Exp Res 32:1502-12. 2008..Randomized participants underwent 11 weeks of treatment with ondansetron (1, 4, or 16 microg/kg twice daily; n = 67, 77, and 71, respectively) or identical placebo (n = 56), plus weekly standardized group cognitive behavioral therapy... - Reductions in and relations between "craving" and drinking in a prospective, open-label trial of ondansetron in adolescents with alcohol dependenceMichael A Dawes
START Center, Division of Alcohol and Drug Addiction, Department of Psychiatry, The University of Texas Health Science Center at San Antonio, The South Texas Addiction Research and Technology Center, San Antonio, TX 78229 3900, USA
Addict Behav 30:1630-7. 2005..These preliminary results suggest that the A-OCDS can be useful as an outcome measure in clinical studies of adolescents with alcohol dependence... - Platelet serotonin uptake and paroxetine binding among allelic genotypes of the serotonin transporter in alcoholicsMartin A Javors
South Texas Addiction Research and Technology START Center, and Department of Psychiatry, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
Prog Neuropsychopharmacol Biol Psychiatry 29:7-13. 2005..Our findings in currently drinking alcoholics support the hypothesis that those with the LL genotype of the 5'-HTTLPR region of the 5-HTT gene have reduced 5-HTT function... - Effects of repeated-dose isradipine on the abuse liability of cocaineJohn D Roache
Department of Psychiatry, The University of Texas Health Science Center at San Antonio, San Antonio, 78229, USA
Exp Clin Psychopharmacol 13:319-26. 2005..Isradipine enhanced, rather than antagonized, subjective effects, indicating that isradipine does not antagonize cocaine's abuse liability in dependent research volunteers... - Topiramate reduces the harm of excessive drinking: implications for public health and primary careJennie Z Ma
Department of Psychiatry, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA
Addiction 101:1561-8. 2006..Topiramate's potential to decrease the public health consequences of hazardous drinking needs to be established in future long-term studies... - Topiramate for treating alcohol dependence: a randomized controlled trialBankole A Johnson
Department of Psychiatry and Neurobehavioral Sciences, University of Virginia, Charlottesville, VA 22908, USA
JAMA 298:1641-51. 2007.... - Kinetic and cardiovascular effects of acute topiramate dosing among non-treatment-seeking, methamphetamine-dependent individualsBankole A Johnson
Department of Psychiatry and Neurobehavioral Sciences, University of Virginia, P O Box 800623, Charlottesville, VA 22908 0623, USA
Prog Neuropsychopharmacol Biol Psychiatry 31:455-61. 2007..Larger laboratory studies with chronic dosing regimens are needed to establish whether or not there is a kinetic interaction between topiramate and methamphetamine... - Treating smoking dependence in depressed alcoholicsNassima Ait-Daoud
Department of Psychiatry and Neurobehavioral Sciences, University of Virginia, Charlottesville, Virginia, USA
Alcohol Res Health 29:213-20. 2006..Additional treatment strategies targeting dually dependent individuals with comorbid psychiatric disorders, including special populations such as women and adolescents, await further investigation... - A preliminary randomized, double-blind, placebo-controlled study of the safety and efficacy of ondansetron in the treatment of methamphetamine dependenceBankole A Johnson
Department of Psychiatry and Neurobehavioral Sciences, University of Virginia, Charlottesville, VA 22908 0623, USA
Int J Neuropsychopharmacol 11:1-14. 2008..These findings should be viewed in light of the possibility that a less intensive cognitive behavioural therapy regimen might have yielded more positive results in this initial phase II trial exploring for the efficacy of ondansetron... 
Improvement of physical health and quality of life of alcohol-dependent individuals with topiramate treatment: US multisite randomized controlled trialBankole A Johnson
Department of Psychiatry and Neurobehavioral Sciences, University of Virginia, Charlottesville, VA 22908 0623, USA
Arch Intern Med 168:1188-99. 2008..We sought to determine whether topiramate's antidrinking effects are bolstered by improvements in physical and psychosocial well-being...- Can serotonin transporter genotype predict serotonergic function, chronicity, and severity of drinking?Bankole A Johnson
Department of Psychiatry and Neurobehavioral Sciences, University of Virginia, Charlottesville, VA 22908 0623, USA
Prog Neuropsychopharmacol Biol Psychiatry 32:209-16. 2008..Thus, 5-HTT expression varies with current and lifetime drinking in L-carriers alone... - Evaluating readiness and treatment seeking effects in a pharmacotherapy trial for alcohol dependenceJ Kim Penberthy
Center for Addiction Research and Education, Department of Psychiatry and Neurobehavioral Sciences, University of Virginia Health System, Charlottesville, Virginia 22908 0623, USA
Alcohol Clin Exp Res 31:1538-44. 2007..Our goal was to evaluate drinking behavior before initiating a randomized, double-blind pharmacotherapy clinical trial for alcohol dependence... - Effects of topiramate on methamphetamine-induced changes in attentional and perceptual-motor skills of cognition in recently abstinent methamphetamine-dependent individualsBankole A Johnson
Department of Psychiatric Medicine, University of Virginia, P O Box 800623, Charlottesville, VA 22908 0623, USA
Prog Neuropsychopharmacol Biol Psychiatry 31:123-30. 2007..Topiramate's complicated cognitive effects among methamphetamine addicts need more comprehensive examination... - A preliminary randomized, double-blind, placebo-controlled study of the safety and efficacy of ondansetron in the treatment of cocaine dependenceBankole A Johnson
Department of Psychiatric Medicine, University of Virginia, P O Box 800623, Charlottesville, VA 22908 0623, USA
Drug Alcohol Depend 84:256-63. 2006..04). These results suggest the possibility of a non-linear dose-response function, with evidence supporting efficacy for the 4.0 mg group... - Understanding and treating alcohol dependenceBankole A Johnson
Department of Psychiatric Medicine, University of Virginia, Charlottesville, Virginia 22908 0623, USA
Alcohol Clin Exp Res 30:567-84. 2006..Johnson, DSc, MD, PhD; and (5) Differential Effects of Pharmacological Agents on Craving, by Nassima Ait-Daoud, MD... - Effects of isradipine on cocaine-induced changes in cognitive performance in recently abstinent cocaine-dependent individualsBankole A Johnson
Department of Psychiatric Medicine, University of Virginia, Charlottesville, VA 22908 0623, USA
Int J Neuropsychopharmacol 8:549-56. 2005..Hence, cocaine-taking by cocaine-dependent individuals produces little improvement in cognitive performance and attention in either the presence or absence of isradipine... - Relative bioavailability of an extemporaneous ondansetron 4-mg capsule formulation versus solutionY W Francis Lam
Department of Pharmacology, University of Texas Health Science Center, San Antonio, Texas 78229-3900, USA
Pharmacotherapy 24:477-81. 2004..The commercially available solution would be a useful alternative formulation for administration of low-dose ondansetron in research and clinical settings... - Isradipine decreases the hemodynamic response of cocaine and methamphetamine results from two human laboratory studies: results from two human laboratory studiesBankole A Johnson
Department of Psychiatric Medicine, University of Virginia, Charlottesville, Virginia 22908 0623, USA
Am J Hypertens 18:813-22. 2005..We therefore examined, in two separate experiments of similar design conducted contemporaneously, the hemodynamic effects of cocaine or methamphetamine in the presence and absence of isradipine... - World Health Organization/International Society for Biomedical Research on Alcoholism study on state and trait markers of alcohol use and dependence: back to the futureFriedrich M Wurst
Psychiatric University Hospital Basel, Switzerland
Alcohol Clin Exp Res 29:1268-75. 2005 - Effects of acute topiramate dosing on methamphetamine-induced subjective moodBankole A Johnson
Department of Psychiatric Medicine, University of Virginia, Charlottesville, VA 22908 0623, USA
Int J Neuropsychopharmacol 10:85-98. 2007..Thus, testing chronically administered or higher doses, or both, of topiramate would be necessary to determine conclusively whether or not it can attenuate the positive subjective and reinforcing effects of methamphetamine... - An overview of medications for the treatment of alcohol withdrawal and alcohol dependence with an emphasis on the use of older and newer anticonvulsantsNassima Ait-Daoud
Department of Psychiatric Medicine, University of Virginia, P O Box 800623, Charlottesville, VA 22908 0623, USA
Addict Behav 31:1628-49. 2006..Furthermore, as a class of medication, there appears to be a growing interest in investigating the utility of novel anticonvulsants such as topiramate for the treatment of alcohol dependence... - Use of oral topiramate to promote smoking abstinence among alcohol-dependent smokers: a randomized controlled trialBankole A Johnson
Department of Psychiatric Medicine, University of Virginia, Charlottesville 22908 0623, USA
Arch Intern Med 165:1600-5. 2005..Herein, we extend that proof-of-concept study by determining whether cigarette-smoking, alcohol-dependent individuals from the earlier study also experienced improved smoking outcomes... - Comorbid alcohol and nicotine dependence: from the biomolecular basis to clinical consequencesNassima Ait-Daoud
Department of Psychiatric Medicine, University of Virginia, Charlottesville 22908 0623, USA
Alcohol Clin Exp Res 29:1541-9. 2005..Lesch, MD, PhD; and (5) Pharmacotherapy for Promotion of Abstinence from Nicotine Among Alcohol-Dependent Individuals, by Bankole A. Johnson, DSc, MD, PhD... - Emerging biomarkers: new directions and clinical applicationsFriedrich M Wurst
Psychiatric University Hospital, Wilhelm Klein Strasse 27, CH 4025 Basel, Switzerland
Alcohol Clin Exp Res 29:465-73. 2005.... - Acute intravenous low- and high-dose cocaine reduces quantitative global and regional cerebral blood flow in recently abstinent subjects with cocaine use disorderBankole A Johnson
Department of Psychiatric Medicine, University of Virginia, Charlottesville, Virginia 22908 0623, USA
J Cereb Blood Flow Metab 25:928-36. 2005..Increasingly larger doses of cocaine may be associated with greater risk for ischemic stroke...