Habibul Ahsan

Summary

Affiliation: University of Chicago
Country: USA

Publications

  1. pmc Dietary intake of methionine, cysteine, and protein and urinary arsenic excretion in Bangladesh
    Julia E Heck
    Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York, USA
    Environ Health Perspect 117:99-104. 2009
  2. pmc Nonmalignant respiratory effects of chronic arsenic exposure from drinking water among never-smokers in Bangladesh
    Faruque Parvez
    Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY, USA
    Environ Health Perspect 116:190-5. 2008
  3. pmc Reduction in urinary arsenic levels in response to arsenic mitigation efforts in Araihazar, Bangladesh
    Yu Chen
    Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York, USA
    Environ Health Perspect 115:917-23. 2007
  4. pmc Genome-wide association study identifies chromosome 10q24.32 variants associated with arsenic metabolism and toxicity phenotypes in Bangladesh
    Brandon L Pierce
    Department of Health Studies, The University of Chicago, Chicago, Illinois, United States of America
    PLoS Genet 8:e1002522. 2012
  5. pmc Urinary and dietary analysis of 18,470 bangladeshis reveal a correlation of rice consumption with arsenic exposure and toxicity
    Stephanie Melkonian
    Department of Health Studies, The University of Chicago, Chicago, Illinois, United States of America
    PLoS ONE 8:e80691. 2013
  6. pmc Arsenic exposure from drinking water and QT-interval prolongation: results from the Health Effects of Arsenic Longitudinal Study
    Yu Chen
    Department of Population Health, New York University School of Medicine, New York University, New York, New York 10016 USA
    Environ Health Perspect 121:427-32, 432e1-7. 2013
  7. pmc A cross-sectional study of the impact of blood selenium on blood and urinary arsenic concentrations in Bangladesh
    Christine Marie George
    Department of International Health, Program in Global Disease Epidemiology and Control, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD E5535, USA
    Environ Health 12:52. 2013
  8. pmc Invited commentary: use of arsenical skin lesions to predict risk of internal cancer: implications for prevention and future research
    Habibul Ahsan
    Center for Cancer Epidemiology and Prevention, University of Chicago Medical Center, Chicago, IL 60615, USA
    Am J Epidemiol 177:213-6. 2013
  9. ncbi request reprint Arsenic metabolism, genetic susceptibility, and risk of premalignant skin lesions in Bangladesh
    Habibul Ahsan
    Departments of Epidemiology, Columbia University, USA
    Cancer Epidemiol Biomarkers Prev 16:1270-8. 2007
  10. pmc Arsenic exposure from drinking water, arsenic methylation capacity, and carotid intima-media thickness in Bangladesh
    Yu Chen
    Departments of Population Health and Environmental Medicine, School of Medicine, New York University, 650 First Avenue, Room 510, New York, NY 10016, USA
    Am J Epidemiol 178:372-81. 2013

Research Grants

Detail Information

Publications120 found, 100 shown here

  1. pmc Dietary intake of methionine, cysteine, and protein and urinary arsenic excretion in Bangladesh
    Julia E Heck
    Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York, USA
    Environ Health Perspect 117:99-104. 2009
    ..Once ingested, arsenic is metabolized via methylation and excreted in urine. Knowledge about nutritional factors affecting individual variation in methylation is limited...
  2. pmc Nonmalignant respiratory effects of chronic arsenic exposure from drinking water among never-smokers in Bangladesh
    Faruque Parvez
    Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY, USA
    Environ Health Perspect 116:190-5. 2008
    ..The association with nonmalignant respiratory illnesses has not been well established because the assessments of respiratory symptoms may be influenced by recall bias or interviewer bias because participants had visible skin lesions...
  3. pmc Reduction in urinary arsenic levels in response to arsenic mitigation efforts in Araihazar, Bangladesh
    Yu Chen
    Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York, USA
    Environ Health Perspect 115:917-23. 2007
    ..There is a need to identify and evaluate an effective mitigation program for arsenic exposure from drinking water in Bangladesh...
  4. pmc Genome-wide association study identifies chromosome 10q24.32 variants associated with arsenic metabolism and toxicity phenotypes in Bangladesh
    Brandon L Pierce
    Department of Health Studies, The University of Chicago, Chicago, Illinois, United States of America
    PLoS Genet 8:e1002522. 2012
    ..These results have potential translational implications for the prevention and treatment of arsenic-associated toxicities worldwide...
  5. pmc Urinary and dietary analysis of 18,470 bangladeshis reveal a correlation of rice consumption with arsenic exposure and toxicity
    Stephanie Melkonian
    Department of Health Studies, The University of Chicago, Chicago, Illinois, United States of America
    PLoS ONE 8:e80691. 2013
    ....
  6. pmc Arsenic exposure from drinking water and QT-interval prolongation: results from the Health Effects of Arsenic Longitudinal Study
    Yu Chen
    Department of Population Health, New York University School of Medicine, New York University, New York, New York 10016 USA
    Environ Health Perspect 121:427-32, 432e1-7. 2013
    ..Arsenic exposure from drinking water has been associated with heart disease; however, underlying mechanisms are uncertain...
  7. pmc A cross-sectional study of the impact of blood selenium on blood and urinary arsenic concentrations in Bangladesh
    Christine Marie George
    Department of International Health, Program in Global Disease Epidemiology and Control, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD E5535, USA
    Environ Health 12:52. 2013
    ..Recent evidence suggests that selenium may play a role in arsenic elimination by forming a selenium-arsenic conjugate in the liver before excretion into the bile...
  8. pmc Invited commentary: use of arsenical skin lesions to predict risk of internal cancer: implications for prevention and future research
    Habibul Ahsan
    Center for Cancer Epidemiology and Prevention, University of Chicago Medical Center, Chicago, IL 60615, USA
    Am J Epidemiol 177:213-6. 2013
    ....
  9. ncbi request reprint Arsenic metabolism, genetic susceptibility, and risk of premalignant skin lesions in Bangladesh
    Habibul Ahsan
    Departments of Epidemiology, Columbia University, USA
    Cancer Epidemiol Biomarkers Prev 16:1270-8. 2007
    ....
  10. pmc Arsenic exposure from drinking water, arsenic methylation capacity, and carotid intima-media thickness in Bangladesh
    Yu Chen
    Departments of Population Health and Environmental Medicine, School of Medicine, New York University, 650 First Avenue, Room 510, New York, NY 10016, USA
    Am J Epidemiol 178:372-81. 2013
    ..Future prospective studies are needed to confirm the association between arsenic methylation capacity and atherosclerosis-related outcomes. ..
  11. pmc Association between arsenic exposure from drinking water and proteinuria: results from the Health Effects of Arsenic Longitudinal Study
    Yu Chen
    Department of Environmental Medicine, New York University School of Medicine, New York, NY, USA
    Int J Epidemiol 40:828-35. 2011
    ..Proteinuria has been recognized as a marker for an increased risk of chronic renal disease. It is unclear whether arsenic (As) exposure from drinking water is associated with proteinuria...
  12. ncbi request reprint Consumption of folate-related nutrients and metabolism of arsenic in Bangladesh
    Julia E Heck
    Department of Epidemiology, Mailman School of Public Health and Institute for Social and Economic Research and Policy, Columbia University, New York, NY, USA
    Am J Clin Nutr 85:1367-74. 2007
    ..Previous studies suggest that persons with more complete methylation, characterized as greater proportions of DMA and lesser proportions of MMA and InAs in urine, have a lower risk of adverse arsenic-related health outcomes...
  13. ncbi request reprint Silencing of glutathione S-transferase P1 by promoter hypermethylation and its relationship to environmental chemical carcinogens in hepatocellular carcinoma
    Yu Jing Zhang
    Department of Environmental Health Sciences, Mailman School of Public Health of Columbia University, 701 West 168th Street, New York, NY 10032, USA
    Cancer Lett 221:135-43. 2005
    ..The mechanism by which environmental exposures induce epigenetic changes in HCC needs further analysis...
  14. pmc Folate, homocysteine, and arsenic metabolism in arsenic-exposed individuals in Bangladesh
    Mary V Gamble
    Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY 10032, USA
    Environ Health Perspect 113:1683-8. 2005
    ..This may be particularly relevant in Bangladesh, where the prevalence of hyperhomocysteinemia is extremely high...
  15. pmc Arsenic and manganese exposure and children's intellectual function
    Gail A Wasserman
    Department of Psychiatry, College of Physicians and Surgeons, Columbia University, 1051 Riverside Drive, New York City, NY 10032, USA
    Neurotoxicology 32:450-7. 2011
    ..25). Findings are consistent with other reports documenting adverse impact of both As and Mn exposure on child developmental outcomes, although associations appear muted at these relatively low exposure levels...
  16. pmc Arsenic exposure, dietary patterns, and skin lesion risk in bangladesh: a prospective study
    Brandon L Pierce
    Department of Health Studies, University of Chicago, Illinois, USA
    Am J Epidemiol 173:345-54. 2011
    ..Eating a diet rich in gourds and root vegetables and increasing dietary diversity may reduce arsenical skin lesion risk in Bangladesh...
  17. pmc Water arsenic exposure and intellectual function in 6-year-old children in Araihazar, Bangladesh
    Gail A Wasserman
    Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    Environ Health Perspect 115:285-9. 2007
    ..We recently reported results of a cross-sectional investigation of intellectual function in 10-year-olds in Bangladesh, who had been exposed to arsenic from drinking water in their home wells...
  18. pmc Folate and arsenic metabolism: a double-blind, placebo-controlled folic acid-supplementation trial in Bangladesh
    Mary V Gamble
    Departments of Environmental Health Sciences, Columbia University, New York, NY, USA
    Am J Clin Nutr 84:1093-101. 2006
    ..Consequently, folate nutritional status may influence arsenic methylation and toxicity...
  19. ncbi request reprint Genomic methylation of peripheral blood leukocyte DNA: influences of arsenic and folate in Bangladeshi adults
    J Richard Pilsner
    Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, 60 Haven Avenue, B1, New York, NY 10032, USA
    Am J Clin Nutr 86:1179-86. 2007
    ..It is not known whether arsenic exposure influences genomic DNA methylation in human populations chronically exposed to arsenic-contaminated drinking water...
  20. pmc Folic acid supplementation lowers blood arsenic
    Mary V Gamble
    Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY 10032, USA
    Am J Clin Nutr 86:1202-9. 2007
    ..Methylation of ingested inorganic arsenic (InAs) to monomethylarsonic (MMAs) and dimethylarsinic (DMAs) acids relies on folate-dependent one-carbon metabolism and facilitates urinary arsenic elimination...
  21. pmc Arsenic exposure at low-to-moderate levels and skin lesions, arsenic metabolism, neurological functions, and biomarkers for respiratory and cardiovascular diseases: review of recent findings from the Health Effects of Arsenic Longitudinal Study (HEALS) in
    Yu Chen
    Departments of Environmental Medicine and Medicine and New York University Cancer Institute, New York University School of Medicine, New York, NY, USA
    Toxicol Appl Pharmacol 239:184-92. 2009
    ....
  22. pmc Influence of cobalamin on arsenic metabolism in Bangladesh
    Megan N Hall
    Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York 10032, USA
    Environ Health Perspect 117:1724-9. 2009
    ..Although DMA(V) is the least toxic metabolite, increasing evidence suggests that MMA(III) may be the most cytotoxic and genotoxic As intermediary metabolite...
  23. pmc Urinary 15-F2t-isoprostane, aflatoxin B1 exposure and hepatitis B virus infection and hepatocellular carcinoma in Taiwan
    Hui Chen Wu
    Department of Environmental Health Sciences, Mailman School of Public Health of Columbia University, New York, NY 10032, USA
    Carcinogenesis 29:971-6. 2008
    ..These results suggest that elevated levels of urinary 15-F(2t)-IsoP may be related to increasing level of aflatoxin exposure and are associated with an increased risk of HCC...
  24. pmc Aflatoxin B1 exposure, hepatitis B virus infection, and hepatocellular carcinoma in Taiwan
    Hui Chen Wu
    Department of Environmental Health Sciences, Mailman School of Public Health of Columbia University, 630 West 168th Street, RM19 418, New York, NY 10032, USA
    Cancer Epidemiol Biomarkers Prev 18:846-53. 2009
    ..However, in this larger study, the effect of combined AFB1 exposure and HBV infection is more consistent with an additive than a multiplicative model...
  25. pmc Interpretation of genome-wide infinium methylation data from ligated DNA in formalin-fixed, paraffin-embedded paired tumor and normal tissue
    Farzana Jasmine
    Department of Health Studies, The University of Chicago, Chicago, IL 60637, USA
    BMC Res Notes 5:117. 2012
    ..We report locus-specific correlation and concordance of tumor-specific differentially methylated loci (DML), both of which were not previously assessed...
  26. pmc A prospective study of the synergistic effects of arsenic exposure and smoking, sun exposure, fertilizer use, and pesticide use on risk of premalignant skin lesions in Bangladeshi men
    Stephanie Melkonian
    Department of Health Studies, University of Chicago, Illinois, USA
    Am J Epidemiol 173:183-91. 2011
    ..Understanding differential arsenic susceptibility allows researchers to develop interventions to prevent the health consequences of this massive problem in the Bangladeshi population and beyond...
  27. pmc Changes in gene expression profiles in response to selenium supplementation among individuals with arsenic-induced pre-malignant skin lesions
    Muhammad G Kibriya
    Department of Epidemiology, Mailman School of Public Health, Columbia University, USA
    Toxicol Lett 169:162-76. 2007
    ..Additionally, this study suggests that long-term selenium supplementation may revert some of the gene expression changes presumably induced by chronic As exposure in individuals with pre-malignant skin lesions...
  28. pmc Betel quid chewing in rural Bangladesh: prevalence, predictors and relationship to blood pressure
    Julia E Heck
    Department of Epidemiology, University of California, Los Angeles, CA, USA
    Int J Epidemiol 41:462-71. 2012
    ..The purpose of our study was to examine the prevalence and predictors of betel quid chewing in a rural area of Bangladesh, and determine its effects on body mass index (BMI) and blood pressure...
  29. ncbi request reprint Predicting hepatocellular carcinoma by detection of aberrant promoter methylation in serum DNA
    Yu Jing Zhang
    Department of Environmental Health Sciences, Mailman School of Public Health of Columbia University, New York, New York 10032, USA
    Clin Cancer Res 13:2378-84. 2007
    ..We explored the possible diagnostic value of aberrant promoter hypermethylation of three tumor suppressor genes in serum DNA for early detection of HCC...
  30. pmc A prospective study of arsenic exposure, arsenic methylation capacity, and risk of cardiovascular disease in Bangladesh
    Yu Chen
    Department of Population Health, New York University School of Medicine, New York, New York 10016, USA
    Environ Health Perspect 121:832-8. 2013
    ..Few prospective studies have evaluated the influence of arsenic methylation capacity on cardiovascular disease (CVD) risk...
  31. pmc Association between arsenic exposure from drinking water and hematuria: results from the Health Effects of Arsenic Longitudinal Study
    Tyler R McClintock
    Department of Population Health, New York University School of Medicine, New York, NY, USA Department of Environmental Medicine, New York University School of Medicine, New York, NY, USA Department of Urology, New York University School of Medicine, New York, NY, USA
    Toxicol Appl Pharmacol 276:21-7. 2014
    ..17 μg/l, respectively. These data indicate a positive association of As exposure with both prevalence and incidence of dipstick hematuria. This exposure effect appears modifiable by relatively short-term changes in drinking water As...
  32. pmc Associations of plasma selenium with arsenic and genomic methylation of leukocyte DNA in Bangladesh
    J Richard Pilsner
    Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, New York 10032, USA
    Environ Health Perspect 119:113-8. 2011
    ..In addition, antagonism between As and Se, whereby each reduces toxicity of the other, has been well documented in animal models. Se status may therefore modify the health effects of As in As-exposed populations...
  33. ncbi request reprint Arsenic exposure from drinking water and risk of premalignant skin lesions in Bangladesh: baseline results from the Health Effects of Arsenic Longitudinal Study
    Habibul Ahsan
    Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY 10032, USA
    Am J Epidemiol 163:1138-48. 2006
    ..53, 5.44), and 5.39 (95% CI: 3.69, 7.86), respectively. The effect seemed to be influenced by gender, age, and body mass index. These findings provide information that should be considered in future research and policy decisions...
  34. ncbi request reprint Urinary 8-oxodeoxyguanosine, aflatoxin B1 exposure and hepatitis B virus infection and hepatocellular carcinoma in Taiwan
    Hui Chen Wu
    Departments of Environmental Health Sciences, Mailman School of Public Health of Columbia University, New York, NY 10032, USA
    Carcinogenesis 28:995-9. 2007
    ..These results suggest that elevated levels of urinary 8-oxodG may be related to increasing level of aflatoxin exposure but may also indicate enhanced repair of oxidative DNA damage and therefore lower risk of HCC...
  35. pmc Folate deficiency, hyperhomocysteinemia, low urinary creatinine, and hypomethylation of leukocyte DNA are risk factors for arsenic-induced skin lesions
    J Richard Pilsner
    Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, 60 Haven Ave, B1, New York, NY 10032 USA
    Environ Health Perspect 117:254-60. 2009
    ..Clinical manifestations of As toxicity vary considerably among individuals and populations, and poor methylation capacity is thought to confer greater susceptibility...
  36. pmc Arsenic exposure from drinking water and mortality from cardiovascular disease in Bangladesh: prospective cohort study
    Yu Chen
    Department of Environmental Medicine, New York University School of Medicine, New York, NY 10016, USA
    BMJ 342:d2431. 2011
    ..To evaluate the association between arsenic exposure and mortality from cardiovascular disease and to assess whether cigarette smoking influences the association...
  37. pmc Association between arsenic exposure from drinking water and plasma levels of cardiovascular markers
    Fen Wu
    Department of Environmental Medicine, New York University School of Medicine, New York, USA
    Am J Epidemiol 175:1252-61. 2012
    ....
  38. pmc Polycyclic aromatic hydrocarbon- and aflatoxin-albumin adducts, hepatitis B virus infection and hepatocellular carcinoma in Taiwan
    Hui Chen Wu
    Department of Environmental Health Sciences, Mailman School of Public Health of Columbia University, New York, NY, USA
    Cancer Lett 252:104-14. 2007
    ..Environmental PAH exposure seems to enhance the hepatocarcinogenicity of chronic HBV infection...
  39. ncbi request reprint Arsenic exposure from drinking water, dietary intakes of B vitamins and folate, and risk of high blood pressure in Bangladesh: a population-based, cross-sectional study
    Yu Chen
    Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA
    Am J Epidemiol 165:541-52. 2007
    ..Future research is needed to evaluate the effect of low-level arsenic exposure on specific cardiovascular outcomes...
  40. ncbi request reprint Effect of selenium and vitamin e supplementation on plasma protein carbonyl levels in patients with arsenic-related skin lesions
    Julie Mahata
    Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY, USA
    Nutr Cancer 60:55-60. 2008
    ....
  41. ncbi request reprint Modification of risk of arsenic-induced skin lesions by sunlight exposure, smoking, and occupational exposures in Bangladesh
    Yu Chen
    Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York 10032, USA
    Epidemiology 17:459-67. 2006
    ..The risk of skin lesions associated with arsenic exposure from drinking water in Bangladesh is considerably greater in men than in women...
  42. pmc A prospective study of tobacco smoking and mortality in Bangladesh
    Fen Wu
    Department of Population Health, New York University School of Medicine, New York, New York, United States of America
    PLoS ONE 8:e58516. 2013
    ..Limited data are available on smoking-related mortality in low-income countries, where both chronic disease burden and prevalence of smoking are increasing...
  43. ncbi request reprint DNA repair gene XPD and susceptibility to arsenic-induced hyperkeratosis
    Habibul Ahsan
    Department of Epidemiology, Mailman School of Public Health, Columbia University, Room 18 129, 622 West 168th Street, New York, NY 10032, USA
    Toxicol Lett 143:123-31. 2003
    ..Future larger studies are needed to confirm this novel finding and investigate how combinations of different candidate genes and/or other host and environmental factors may influence the risk of arsenic induced skin and other cancers...
  44. pmc Association between arsenic exposure from drinking water and plasma levels of soluble cell adhesion molecules
    Yu Chen
    Departments of Environmental Medicine and Medicine, and New York University Cancer Institute, New York University School of Medicine, New York, New York 10016, USA
    Environ Health Perspect 115:1415-20. 2007
    ..Epidemiologic studies of cardiovascular disease risk factors and appropriate biomarkers in populations exposed to a wide range of arsenic levels are a public health research priority...
  45. pmc A genome-wide study of cytogenetic changes in colorectal cancer using SNP microarrays: opportunities for future personalized treatment
    Farzana Jasmine
    Department of Health Studies, The University of Chicago, Chicago, Illinois, United States of America
    PLoS ONE 7:e31968. 2012
    ..Our study shows the application of high density SNP arrays for cytogenetic study in CRC and its potential utility for personalized treatment...
  46. ncbi request reprint A CYP19 (aromatase) polymorphism is associated with increased premenopausal breast cancer risk
    Kathryn E Talbott
    Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, 10032, USA
    Breast Cancer Res Treat 111:481-7. 2008
    ..The finding supports the potential role of variation in estrogen biosynthesis genes in premenopausal breast cancer risk...
  47. ncbi request reprint Aflatoxin B1 and polycyclic aromatic hydrocarbon adducts, p53 mutations and p16 methylation in liver tissue and plasma of hepatocellular carcinoma patients
    Yu Jing Zhang
    Department of Environmental Health Science, Mailman School of Public Health of Columbia University, New York, NY 10032, USA
    Int J Cancer 119:985-91. 2006
    ..These data suggest that genetic, epigenetic and environmental exposure biomarkers in plasma may help in estimating the risk for the development of HCC...
  48. pmc Arsenic exposure from drinking water, and all-cause and chronic-disease mortalities in Bangladesh (HEALS): a prospective cohort study
    Maria Argos
    Department of Health Studies, University of Chicago, Chicago, IL 60637, USA
    Lancet 376:252-8. 2010
    ..We therefore prospectively assessed whether chronic and recent changes in arsenic exposure are associated with all-cause and chronic-disease mortalities in a Bangladeshi population...
  49. pmc Dietary B vitamin intakes and urinary total arsenic concentration in the Health Effects of Arsenic Longitudinal Study (HEALS) cohort, Bangladesh
    Maria Argos
    Department of Health Studies, The University of Chicago, 5841 S Maryland Avenue, MC2007, Chicago, IL 60637, USA
    Eur J Nutr 49:473-81. 2010
    ..Dietary factors influencing the metabolism of ingested arsenic may potentially be important modifiers of the health effects of arsenic in this population...
  50. pmc Protective effects of B vitamins and antioxidants on the risk of arsenic-related skin lesions in Bangladesh
    Lydia B Zablotska
    Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York, USA
    Environ Health Perspect 116:1056-62. 2008
    ..The mitigating effects of diet on arsenic-related premalignant skin lesions are largely unknown...
  51. pmc Water manganese exposure and children's intellectual function in Araihazar, Bangladesh
    Gail A Wasserman
    Department of Psychiatry, College of Physicians and Surgeons, Columbia University, and New York State Psychiatric Institute, New York, New York 10032, USA
    Environ Health Perspect 114:124-9. 2006
    ..S. Environmental Protection Agency lifetime health advisory level. We conclude that in both Bangladesh and the United States, some children are at risk for Mn-induced neurotoxicity...
  52. ncbi request reprint A prospective study of variability in systolic blood pressure and mortality in a rural Bangladeshi population cohort
    Lital Yinon
    Departments of Population Health and Environmental Medicine, New York University School of Medicine, New York, NY, USA
    Prev Med 57:807-12. 2013
    ..However, most of these were in populations with pre-existing cardiovascular diseases (CVD) and studies in general population are lacking...
  53. ncbi request reprint Blood arsenic as a biomarker of arsenic exposure: results from a prospective study
    Marni Hall
    Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University Medical Center, 60 Haven Avenue B1, New York, NY 10032, USA
    Toxicology 225:225-33. 2006
    ..This prospective study confirms the increased risk of skin lesions in relation to As concentrations in blood, urine and water and also establishes that BAs is a useful biomarker of As exposure in this study population...
  54. pmc Arsenic exposure and impaired lung function. Findings from a large population-based prospective cohort study
    Faruque Parvez
    1 Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, New York
    Am J Respir Crit Care Med 188:813-9. 2013
    ..Limited evidence for the deleterious effects on lung function exists among individuals exposed to a high dose of arsenic...
  55. pmc A prospective study of blood selenium levels and the risk of arsenic-related premalignant skin lesions
    Yu Chen
    Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA
    Cancer Epidemiol Biomarkers Prev 16:207-13. 2007
    ..The findings support the hypothesis that dietary selenium intake may reduce the incidence of arsenic-related premalignant skin lesions among populations exposed to arsenic exposure from drinking water...
  56. pmc Interaction between arsenic exposure from drinking water and genetic susceptibility in carotid intima-media thickness in Bangladesh
    Fen Wu
    Department of Population Health, New York University School of Medicine, New York, NY, USA Department of Environmental Medicine, New York University School of Medicine, New York, NY, USA
    Toxicol Appl Pharmacol 276:195-203. 2014
    ..Future replication studies in diverse populations are needed to confirm the findings. ..
  57. pmc Do placental genes affect maternal breast cancer? Association between offspring's CGB5 and CSH1 gene variants and maternal breast cancer risk
    Yu Chen
    Department of Environmental Medicine, New York University Cancer Institute, New York University School of Medicine, New York, NY, USA
    Cancer Res 68:9729-34. 2008
    ..90; 95% CI, 0.53-1.51; P for interaction=0.04). The findings suggest that placental CGB5 genotype may be predictive of maternal post-pregnancy breast cancer risk among women who give birth early in life...
  58. pmc Arsenic exposure and motor function among children in Bangladesh
    Faruque Parvez
    Department of Environmental Health Sciences, Columbia University Mailman School of Public Health, New York, New York, USA
    Environ Health Perspect 119:1665-70. 2011
    ..Very little is known, however, about possible associations with other neurologic outcomes such as motor function...
  59. pmc Prospective investigation of major dietary patterns and risk of cardiovascular mortality in Bangladesh
    Yu Chen
    Department of Environmental Medicine, New York University School of Medicine, New York, NY, USA
    Int J Cardiol 167:1495-501. 2013
    ..However, no studies have applied this technique to a population outside of the developed world...
  60. ncbi request reprint Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation and its relationship to aflatoxin B1-DNA adducts and p53 mutation in hepatocellular carcinoma
    Yu Jing Zhang
    Departments of Environmental Health Sciences and Epidemiology, Mailman School of Public Health, Columbia University, 700 West 168th Street, New York, NY 10032, USA
    Int J Cancer 103:440-4. 2003
    ..The role of chemical carcinogens in hypermethylation needs further investigation...
  61. ncbi request reprint Susceptibility to arsenic-induced hyperkeratosis and oxidative stress genes myeloperoxidase and catalase
    Habibul Ahsan
    Department of Epidemiology, Mailman School of Public Health, Columfbia University, Room 720G, 722 West 168th Street, New York, NY 10032, USA
    Cancer Lett 201:57-65. 2003
    ..Our findings, although based on small numbers, suggest that the oxidative stress genes MPO and CAT may influence the risk of arsenic-induced premalignant hyperkeratotic skin lesions...
  62. pmc Prevalence of arsenic exposure from drinking water and awareness of its health risks in a Bangladeshi population: results from a large population-based study
    Faruque Parvez
    Mailman School of Public Health, Columbia University, New York, New York 10032, USA
    Environ Health Perspect 114:355-9. 2006
    ..Increasing knowledge of the health consequences of As may be an important element in facilitating remediation...
  63. pmc Intakes of several nutrients are associated with incidence of arsenic-related keratotic skin lesions in Bangladesh
    Stephanie Melkonian
    Department of Health Studies, The University of Chicago, Chicago, IL, USA
    J Nutr 142:2128-34. 2012
    ..Understanding differential susceptibility to skin lesion incidence based on nutrient intake will help researchers develop targeted interventions to prevent health consequences of arsenic poisoning in Bangladesh and beyond...
  64. pmc A prospective study of arsenic exposure from drinking water and incidence of skin lesions in Bangladesh
    Maria Argos
    Department of Health Studies, The University of Chicago, Illinois 60637, USA
    Am J Epidemiol 174:185-94. 2011
    ..Chronic arsenic exposure from drinking water was associated with increased incidence of skin lesions, even at low levels of arsenic exposure (<100 μg/L)...
  65. ncbi request reprint Arsenic exposure and anemia in Bangladesh: a population-based study
    Julia E Heck
    Department of Epidemiology, Mailman School of Public Health, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    J Occup Environ Med 50:80-7. 2008
    ..The purpose of this study was to examine the association between arsenic exposure and anemia, based on blood hemoglobin concentration...
  66. pmc Socioeconomic status and risk for arsenic-related skin lesions in Bangladesh
    Maria Argos
    Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA
    Am J Public Health 97:825-31. 2007
    ..In this study, we explored the association between socioeconomic status and arsenic toxicity...
  67. ncbi request reprint Protein and amino acid intakes in a rural area of Bangladesh
    Julia E Heck
    Department of Epidemiology, Columbia University, New York, USA
    Food Nutr Bull 31:206-13. 2010
    ..Few studies have described protein and amino acid intakes in rural Bangladesh, a country with considerable undernutrition...
  68. pmc Variants in estrogen-biosynthesis genes CYP17 and CYP19 and breast cancer risk: a family-based genetic association study
    Habibul Ahsan
    Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York, USA
    Breast Cancer Res 7:R71-81. 2005
    ....
  69. ncbi request reprint Nutritional influence on risk of high blood pressure in Bangladesh: a population-based cross-sectional study
    Yu Chen
    Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA
    Am J Clin Nutr 84:1224-32. 2006
    ..The nutritional determinants of hypertension in Bangladesh and other low-income countries are largely unknown...
  70. ncbi request reprint Combined genetic assessment of transforming growth factor-beta signaling pathway variants may predict breast cancer risk
    Virginia G Kaklamani
    Cancer Genetics Program, Division of Hematology Oncology, Department of Medicine, Feinberg School of Medicine and Robert H Lurie Comprehensive Cancer Center, Northwestern University, 676 North St Clair Street, Chicago, IL 60611, USA
    Cancer Res 65:3454-61. 2005
    ..25-3.87). This is the first study assessing the TGF-beta signaling pathway through two common and functionally relevant TGFBR1 and TGFB1 variants. This approach may predict breast cancer risk in a large subset of the population...
  71. ncbi request reprint A pilot genome-wide association study of early-onset breast cancer
    Muhammad G Kibriya
    Department of Health Studies, The University of Chicago, 5841 S Maryland Avenue, MC 2007, Chicago, IL 60637, USA
    Breast Cancer Res Treat 114:463-77. 2009
    ..Nevertheless, without systematic replication, findings from this pilot study, especially the associations of breast cancer in relation to specific SNPs, should be interpreted with great caution...
  72. pmc Variants of the adiponectin (ADIPOQ) and adiponectin receptor 1 (ADIPOR1) genes and colorectal cancer risk
    Virginia G Kaklamani
    Cancer Genetics Program, Division of Hematology and Oncology, Department of Medicine and Robert H Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA
    JAMA 300:1523-31. 2008
    ..While there is evidence of an association between circulating adiponectin levels and colorectal cancer risk, no association between genes of the adiponectin pathway and colorectal cancer have been reported to date...
  73. ncbi request reprint Variants in estrogen metabolism and biosynthesis genes and urinary estrogen metabolites in women with a family history of breast cancer
    Heather Greenlee
    Department of Epidemiology, Mailman School of Public Health, Columbia University, 722 West 168th Street, 7th Floor, New York, NY 10032, USA
    Breast Cancer Res Treat 102:111-7. 2007
    ....
  74. pmc A prospective study of respiratory symptoms associated with chronic arsenic exposure in Bangladesh: findings from the Health Effects of Arsenic Longitudinal Study (HEALS)
    Faruque Parvez
    Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, New York, USA
    Thorax 65:528-33. 2010
    ..A total of 7.31, 9.95 and 2.03% of the 11 746 participants completing 4 years of active follow-up reported having a chronic cough, breathing problem or blood in their sputum, respectively, as assessed by trained physicians...
  75. pmc Arsenic exposure from drinking water and dyspnoea risk in Araihazar, Bangladesh: a population-based study
    Gene R Pesola
    Division of Pulmonary and Critical Care Medicine, Dept of Medicine, Harlem Hospital, Columbia University, New York, NY 10037, USA
    Eur Respir J 39:1076-83. 2012
    ..This study suggests that mandated well water testing for arsenic with reduction in exposure may significantly reduce diseases that manifest as dyspnoea, usually cardiac or pulmonary...
  76. pmc Whole-genome amplification enables accurate genotyping for microarray-based high-density single nucleotide polymorphism array
    Farzana Jasmine
    Department of Health Studies, The University of Chicago, 5841 South Maryland Avenue, MC 2007, Chicago, IL 60637, USA
    Cancer Epidemiol Biomarkers Prev 17:3499-508. 2008
    ..29%. In conclusion, our study confirms that high-density oligonucleotide array-based genotyping can yield reproducible data and MDA-WGA DNA products can be effectively used for genome-wide SNP genotyping analysis...
  77. ncbi request reprint Arsenic exposure from drinking-water and carotid artery intima-medial thickness in healthy young adults in Bangladesh
    Yu Chen
    Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, 10032, USA
    J Health Popul Nutr 24:253-7. 2006
    ....
  78. pmc Variants of the adiponectin and adiponectin receptor 1 genes and breast cancer risk
    Virginia G Kaklamani
    Division of Hematology Oncology, Department of Medicine, Robert H Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    Cancer Res 68:3178-84. 2008
    ..89; P(trend) = 0.001). This is the first report of an association between functionally relevant variants of the adiponectin pathway and breast cancer risk. The results warrant further studies of the adiponectin pathway in breast cancer...
  79. ncbi request reprint A randomized, double-blind placebo-controlled trial evaluating the effects of vitamin E and selenium on arsenic-induced skin lesions in Bangladesh
    Wendy J Verret
    Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York 10032, USA
    J Occup Environ Med 47:1026-35. 2005
    ..We sought to determine whether supplementation of vitamin E (alpha-tocopherol), selenium (L-selenomethionine), or their combination improves arsenical skin lesions...
  80. ncbi request reprint Association between arsenic exposure and a measure of subclinical sensory neuropathy in Bangladesh
    Danella M Hafeman
    Mailman School of Public Health, Columbia University, New York, NY 10032, USA
    J Occup Environ Med 47:778-84. 2005
    ..We examined the association between arsenic exposure and peripheral neuropathy in Bangladesh, where the population has been chronically exposed to arsenic in drinking water...
  81. pmc Association between manganese exposure through drinking water and infant mortality in Bangladesh
    Danella Hafeman
    Mailman School of Public Health, Columbia University, New York, New York 10032, USA
    Environ Health Perspect 115:1107-12. 2007
    ..In this cross-sectional study we assessed the association between water manganese and all-cause infant mortality in the offspring of female participants in the Health Effects of Arsenic Longitudinal Study Cohort...
  82. ncbi request reprint Health Effects of Arsenic Longitudinal Study (HEALS): description of a multidisciplinary epidemiologic investigation
    Habibul Ahsan
    Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY 10032, USA
    J Expo Sci Environ Epidemiol 16:191-205. 2006
    ..HEALS is a valuable resource for examining novel research questions on the health effects of As exposure...
  83. doi request reprint Tremor severity and age: a cross-sectional, population-based study of 2,524 young and midlife normal adults
    Elan D Louis
    GH Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, New York, USA
    Mov Disord 26:1515-20. 2011
    ..These data suggest that age-dependent increase in tremor amplitude is not restricted to older people but occurs in all adult age groups...
  84. ncbi request reprint TGFBR1*6A may contribute to hereditary colorectal cancer
    Yansong Bian
    Cancer Genetics Program, Division of Hematology Oncology, Department of Medicine, Robert H Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, 676 N St Clair St, Suite 880, Chicago, IL 60611, USA
    J Clin Oncol 23:3074-8. 2005
    ..To test this hypothesis, we determined whether TGFBR16A contributes to a proportion of mismatch repair (MMR) gene mutation-negative hereditary nonpolyposis colorectal cancer (HNPCC) patients...
  85. pmc A prospective study of body mass index and mortality in Bangladesh
    Brandon L Pierce
    Department of Health Studies, The University of Chicago, Chicago, IL 60637, USA
    Int J Epidemiol 39:1037-45. 2010
    ..However, this relationship is not well characterized in Bangladesh, where the BMI distribution is shifted towards lower values...
  86. pmc Genomewide scan for loss of heterozygosity and chromosomal amplification in breast carcinoma using single-nucleotide polymorphism arrays
    Maria Argos
    Department of Health Studies, University of Chicago, 5841 S Maryland Avenue, MC 2007, Chicago, IL 60637, USA
    Cancer Genet Cytogenet 182:69-74. 2008
    ..The present study demonstrates a feasible methodological approach for the assessment of LOH and copy number changes...
  87. pmc Folate and cobalamin deficiencies and hyperhomocysteinemia in Bangladesh
    Mary V Gamble
    Department of Environmental Health Sciences, School of Public Health, Columbia University, New York, NY 10032, USA
    Am J Clin Nutr 81:1372-7. 2005
    ..This has been largely attributed to dietary deficiencies in cobalamin associated with vegetarianism among these Indian Asians...
  88. pmc Analyses and interpretation of whole-genome gene expression from formalin-fixed paraffin-embedded tissue: an illustration with breast cancer tissues
    Muhammad G Kibriya
    Department of Health Studies, The University of Chicago, 5841 S, Maryland Avenue, MC 2007, Chicago, IL 60637, USA
    BMC Genomics 11:622. 2010
    ..We used a whole genome DASL assay (addressing 18,391 genes) on a total of 72 samples from paired breast tumor and surrounding healthy tissues from both FF and FFPE samples...
  89. pmc A genome-wide DNA methylation study in colorectal carcinoma
    Muhammad G Kibriya
    Department of Health Studies, The University of Chicago, Chicago, IL 60637, USA
    BMC Med Genomics 4:50. 2011
    ..We performed a genome-wide scan of 27,578 CpG loci covering 14,475 genes to identify differentially methylated loci (DML) in colorectal carcinoma (CRC)...
  90. pmc Water arsenic exposure and children's intellectual function in Araihazar, Bangladesh
    Gail A Wasserman
    Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, New York, USA
    Environ Health Perspect 112:1329-33. 2004
    ..5 microg/L. The association was generally stronger for well-water As than for urinary As...
  91. ncbi request reprint A family-based genetic association study of variants in estrogen-metabolism genes COMT and CYP1B1 and breast cancer risk
    Habibul Ahsan
    Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY 10032, USA
    Breast Cancer Res Treat 85:121-31. 2004
    ....
  92. pmc Baseline comorbidities in a skin cancer prevention trial in Bangladesh
    Maria Argos
    Department of Health Studies, The University of Chicago, Chicago, IL 60637, USA
    Eur J Clin Invest 43:579-88. 2013
    ..This study reports on the design, methods and baseline analyses from the Bangladesh Vitamin E and Selenium Trial (BEST), a population-based chemoprevention study conducted among adults in Bangladesh with visible arsenic toxicity...
  93. doi request reprint Unidentified genetic variants influence pancreatic cancer risk: an analysis of polygenic susceptibility in the PanScan study
    Brandon L Pierce
    Department of Health Studies, University of Chicago, Chicago, Illinois 60637, USA
    Genet Epidemiol 36:517-24. 2012
    ..Our results suggest that focusing association studies on genic regions and conducting larger GWA studies can reveal additional PanCa susceptibility loci...
  94. pmc Genetic susceptibility to type 2 diabetes is associated with reduced prostate cancer risk
    Brandon L Pierce
    Department of Health Studies, The University of Chicago, Chicago, IL 60637, USA
    Hum Hered 69:193-201. 2010
    ..To examine the collective effects of type 1 (T1D) and type 2 diabetes (T2D) risk alleles on prostate cancer (PCa) risk...
  95. pmc Power and instrument strength requirements for Mendelian randomization studies using multiple genetic variants
    Brandon L Pierce
    Department of Health Studies, University of Chicago, Chicago, IL, USA
    Int J Epidemiol 40:740-52. 2011
    ..e. instrumental variables (IVs)] of the exposure. Power and IV strength requirements for MR studies using multiple genetic variants have not been explored...
  96. ncbi request reprint Design options for molecular epidemiology research within cohort studies
    Andrew G Rundle
    Department of Epidemiology, Mailman School of Public Health and Herbert Irving Comprehensive Cancer Center, Columbia University, 722 West 168th, Room 730, New York, NY 10032, USA
    Cancer Epidemiol Biomarkers Prev 14:1899-907. 2005
    ..However, in total, of the two designs, the nested case-control study is better suited for studying biomarkers that can be influenced by analytic batch, long-term storage, and freeze-thaw cycles...
  97. doi request reprint Environmental mutagens induced transversions but not transitions in regulatory region of mitochondrial DNA
    Michael A Partridge
    Center for Radiological Research, Columbia University, New York, NY 10032, USA
    J Toxicol Environ Health A 72:301-4. 2009
    ..Data suggest that only a change in the number of rare transversions would be indicative of an increase in point mutations in mtDNA after exposure to mutagens...
  98. ncbi request reprint Validity of a food-frequency questionnaire for a large prospective cohort study in Bangladesh
    Yu Chen
    Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, USA
    Br J Nutr 92:851-9. 2004
    ..To our knowledge, the present study is the first to document the validity of a FFQ with the use of 7 d FD in a Bangladeshi population...
  99. pmc Cancer burden from arsenic in drinking water in Bangladesh
    Yu Chen
    Department of Epidemiology, Mailman School of Public Health, Columbia University, 722 W 168th Street, New York, NY 10032, USA
    Am J Public Health 94:741-4. 2004
    ..Results indicated at least a doubling of lifetime mortality risk from liver, bladder, and lung cancers (229.6 vs 103.5 per 100 000 population) in Bangladesh owing to arsenic in drinking water...
  100. pmc Genome-wide "pleiotropy scan" identifies HNF1A region as a novel pancreatic cancer susceptibility locus
    Brandon L Pierce
    Department of Health Studies and Comprehensive Cancer Center, University of Chicago, Chicago, Illinois 60637, USA
    Cancer Res 71:4352-8. 2011
    ..This novel "pleiotropy scan" method may be useful for identifying susceptibility loci for other cancer phenotypes...
  101. doi request reprint Association study of type 2 diabetes genetic susceptibility variants and risk of pancreatic cancer: an analysis of PanScan-I data
    Brandon L Pierce
    Department of Health Studies and Comprehensive Cancer Center, The University of Chicago, IL, 60637, USA
    Cancer Causes Control 22:877-83. 2011
    ..To examine associations between recently identified common type 2 diabetes (T2D) susceptibility genetic variants and pancreatic cancer risk...

Research Grants13

  1. Genetic Susceptibility to Arsenic-induced Skin Cancer
    Habibul Ahsan; Fiscal Year: 2004
    ..Data generated will have implications not only for the massive public health issue relevant for millions of people in an underdeveloped country but also for arsenic exposed populations in other countries, including the US. ..
  2. Chemoprevention of arsenic-induced skin cancer
    Habibul Ahsan; Fiscal Year: 2009
    ..The results of this randomized clinical trial will provide data on potential low-cost interventions for reducing the cancer risk among millions of arsenic exposed population in Bangladesh and probably other parts of the world. ..
  3. Chemoprevention of arsenic-induced skin cancer
    Habibul Ahsan; Fiscal Year: 2008
    ..The results of this randomized clinical trial will provide data on potential low-cost interventions for reducing the cancer risk among millions of arsenic exposed population in Bangladesh and probably other parts of the world. ..
  4. Genetic Susceptibility to Arsenic-induced Skin Cancer
    Habibul Ahsan; Fiscal Year: 2007
    ..abstract_text> ..
  5. Genomewide association in early-onset breast cancer
    Habibul Ahsan; Fiscal Year: 2007
    ..In conclusion, this research aims to identify new genes for early-onset breast cancer, which is a major source of morbidity, mortality and loss of life expectancy throughout the world. ..
  6. Genomewide association in early-onset breast cancer
    Habibul Ahsan; Fiscal Year: 2008
    ..In conclusion, this research aims to identify new genes for early-onset breast cancer, which is a major source of morbidity, mortality and loss of life expectancy throughout the world. ..
  7. Chemoprevention of arsenic-induced skin cancer
    Habibul Ahsan; Fiscal Year: 2007
    ..The results of this randomized clinical trial will provide data on potential low-cost interventions for reducing the cancer risk among millions of arsenic exposed population in Bangladesh and probably other parts of the world. ..
  8. Genetic Susceptibility to Arsenic-induced Skin Cancer
    Habibul Ahsan; Fiscal Year: 2008
    ..abstract_text> ..
  9. Chemoprevention of arsenic-induced skin cancer
    Habibul Ahsan; Fiscal Year: 2006
    ..The results of this randomized clinical trial will provide data on potential low-cost interventions for reducing the cancer risk among millions of arsenic exposed population in Bangladesh and probably other parts of the world. ..
  10. Genetic Susceptibility to Arsenic-induced Skin Cancer
    Habibul Ahsan; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  11. Chemoprevention of arsenic-induced skin cancer
    Habibul Ahsan; Fiscal Year: 2005
    ..The results of this randomized clinical trial will provide data on potential low-cost interventions for reducing the cancer risk among millions of arsenic exposed population in Bangladesh and probably other parts of the world. ..
  12. Genetic Susceptibility to Arsenic-induced Skin Cancer
    Habibul Ahsan; Fiscal Year: 2005
    ..Data generated will have implications not only for the massive public health issue relevant for millions of people in an underdeveloped country but also for arsenic exposed populations in other countries, including the US. ..
  13. Chemoprevention of arsenic-induced skin cancer
    Habibul Ahsan; Fiscal Year: 2010
    ..In addition to the original aims on skin cancer and mortality this current proposal also includes a new aim about the treatment effects on diabetes mellitus. ..