S A Ahrendt

Summary

Affiliation: University of Rochester
Country: USA

Publications

  1. ncbi request reprint Surgical therapy of iatrogenic lesions of biliary tract
    S A Ahrendt
    Department of Surgery, The Medical College of Wisconsin, Milwaukee 53226, USA
    World J Surg 25:1360-5. 2001
  2. ncbi request reprint p53 mutations and survival in stage I non-small-cell lung cancer: results of a prospective study
    Steven A Ahrendt
    Department of Surgery, University of Rochester, Rochester, NY 14642, USA
    J Natl Cancer Inst 95:961-70. 2003
  3. ncbi request reprint Molecular assessment of lymph nodes in patients with resected stage I non-small cell lung cancer: preliminary results of a prospective study
    Steven A Ahrendt
    Department of Surgery, University of Rochester, 601 Elmwood Avenue, Rochester, NY 14642, USA
    J Thorac Cardiovasc Surg 123:466-73; discussion 473-4. 2002
  4. ncbi request reprint Cigarette smoking is strongly associated with mutation of the K-ras gene in patients with primary adenocarcinoma of the lung
    S A Ahrendt
    Department of Surgery, University of Rochester, Rochester, New York 14642, USA
    Cancer 92:1525-30. 2001
  5. ncbi request reprint O(6)-Methylguanine-DNA methyltransferase promoter hypermethylation shifts the p53 mutational spectrum in non-small cell lung cancer
    P Wolf
    Department of Surgery, Medical College of Wisconsin, 601 Elmwood Avenue, Milwaukee, WI 53226, USA
    Cancer Res 61:8113-7. 2001
  6. ncbi request reprint Vascular endothelial growth factor and DPC4 predict adjuvant therapy outcomes in resected pancreatic cancer
    Alok A Khorana
    James P Wilmot Cancer Center and the Department of Medicine, University of Rochester, Rochester, NY 14642, and the National Human Genomics Research Institute, National Institutes of Health, Bethesda, MD, USA
    J Gastrointest Surg 9:903-11. 2005
  7. ncbi request reprint The p53 codon 72 proline allele is associated with p53 gene mutations in non-small cell lung cancer
    Yingchuan Hu
    Department of Surgery, University of Rochester Medical School, Rochester, New York 14642, USA
    Clin Cancer Res 11:2502-9. 2005
  8. ncbi request reprint hOGG1 Ser326Cys polymorphism and G:C-to-T:A mutations: no evidence for a role in tobacco-related non small cell lung cancer
    Ying Chuan Hu
    Department of Surgery, University of Rochester Medical School, Rochester, NY 14642, USA
    Int J Cancer 114:387-93. 2005
  9. ncbi request reprint Thymidylate synthase expression predicts the response to 5-fluorouracil-based adjuvant therapy in pancreatic cancer
    Ying Chuan Hu
    Department of Surgery, University of Rochester, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Clin Cancer Res 9:4165-71. 2003
  10. ncbi request reprint Translational research in lung cancer
    Yuhchyau Chen
    Department of Radiation Oncology, University of Rochester Medical Center, Rochester, New York 14642, USA
    Semin Surg Oncol 21:205-19. 2003

Research Grants

  1. MOLECULAR STAGING AND SCREENING OF LUNG CANCER
    Steven Ahrendt; Fiscal Year: 2002

Collaborators

Detail Information

Publications17

  1. ncbi request reprint Surgical therapy of iatrogenic lesions of biliary tract
    S A Ahrendt
    Department of Surgery, The Medical College of Wisconsin, Milwaukee 53226, USA
    World J Surg 25:1360-5. 2001
    ..Success rates over 90% have been reported from several centers to date with intermediate follow-up...
  2. ncbi request reprint p53 mutations and survival in stage I non-small-cell lung cancer: results of a prospective study
    Steven A Ahrendt
    Department of Surgery, University of Rochester, Rochester, NY 14642, USA
    J Natl Cancer Inst 95:961-70. 2003
    ..Therefore, we initiated a prospective study to determine the association of p53 gene mutations with survival in patients with stage I NSCLC...
  3. ncbi request reprint Molecular assessment of lymph nodes in patients with resected stage I non-small cell lung cancer: preliminary results of a prospective study
    Steven A Ahrendt
    Department of Surgery, University of Rochester, 601 Elmwood Avenue, Rochester, NY 14642, USA
    J Thorac Cardiovasc Surg 123:466-73; discussion 473-4. 2002
    ....
  4. ncbi request reprint Cigarette smoking is strongly associated with mutation of the K-ras gene in patients with primary adenocarcinoma of the lung
    S A Ahrendt
    Department of Surgery, University of Rochester, Rochester, New York 14642, USA
    Cancer 92:1525-30. 2001
    ..The majority of lung carcinoma cases occur in current or former smokers. K-ras gene mutations are common in lung adenocarcinoma and have been associated with cigarette smoking, asbestos exposure, and female gender...
  5. ncbi request reprint O(6)-Methylguanine-DNA methyltransferase promoter hypermethylation shifts the p53 mutational spectrum in non-small cell lung cancer
    P Wolf
    Department of Surgery, Medical College of Wisconsin, 601 Elmwood Avenue, Milwaukee, WI 53226, USA
    Cancer Res 61:8113-7. 2001
    ..006). MGMT promoter hypermethylation was also strongly associated with G to A transitions at CpG sites. Inactivation of the MGMT gene by promoter hypermethylation alters the pattern of p53 mutation in NSCLC...
  6. ncbi request reprint Vascular endothelial growth factor and DPC4 predict adjuvant therapy outcomes in resected pancreatic cancer
    Alok A Khorana
    James P Wilmot Cancer Center and the Department of Medicine, University of Rochester, Rochester, NY 14642, and the National Human Genomics Research Institute, National Institutes of Health, Bethesda, MD, USA
    J Gastrointest Surg 9:903-11. 2005
    ..Adjuvant therapy may have both antiangiogenic and cytotoxic effects. Addition of anti-VEGF agents to adjuvant regimens may further improve outcomes...
  7. ncbi request reprint The p53 codon 72 proline allele is associated with p53 gene mutations in non-small cell lung cancer
    Yingchuan Hu
    Department of Surgery, University of Rochester Medical School, Rochester, New York 14642, USA
    Clin Cancer Res 11:2502-9. 2005
    ..The codon 72 polymorphism did not influence patient survival in either the entire patient group or among patients with p53 mutant tumors. In summary, the p53 Pro allele is associated with an increased frequency of p53 mutations in NSCLC...
  8. ncbi request reprint hOGG1 Ser326Cys polymorphism and G:C-to-T:A mutations: no evidence for a role in tobacco-related non small cell lung cancer
    Ying Chuan Hu
    Department of Surgery, University of Rochester Medical School, Rochester, NY 14642, USA
    Int J Cancer 114:387-93. 2005
    ..This decrease in p53 mutations in vivo is not consistent with a decrease in the repair of 8-hydroxyguanine among carriers of the hOGG1 codon 326 Cys allele in vitro...
  9. ncbi request reprint Thymidylate synthase expression predicts the response to 5-fluorouracil-based adjuvant therapy in pancreatic cancer
    Ying Chuan Hu
    Department of Surgery, University of Rochester, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Clin Cancer Res 9:4165-71. 2003
    ..5-FU is also widely used in the adjuvant therapy of pancreatic cancer. Therefore, we explored the hypothesis that TS expression was associated with patient prognosis and the response to adjuvant therapy in pancreatic cancer...
  10. ncbi request reprint Translational research in lung cancer
    Yuhchyau Chen
    Department of Radiation Oncology, University of Rochester Medical Center, Rochester, New York 14642, USA
    Semin Surg Oncol 21:205-19. 2003
    ..We believe that knowledge of lung cancer biology will continue to provide the foundation for future improvements in lung cancer treatment...
  11. ncbi request reprint Screening of homologous recombination gene polymorphisms in lung cancer patients reveals an association of the NBS1-185Gln variant and p53 gene mutations
    Pedro P Medina
    Molecular Pathology Program, Spanish National Cancer Center CNIO, 28029 Madrid, Spain
    Cancer Epidemiol Biomarkers Prev 12:699-704. 2003
    ..42 for heterozygous and odds ratio = 38.3 for NBS1-185Gln homozygous). Germ-line variants in the NBS1 gene may play a role in the lung carcinogenesis in cigarette smokers...
  12. ncbi request reprint The XRCC1 codon 399 Gln allele is associated with adenine to guanine p53 mutations in non-small cell lung cancer
    Celine Casse
    Department of Surgery, Box SURG, University of Rochester, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Mutat Res 528:19-27. 2003
    ..4%). In summary, the XRCC1 Gln allele is associated with AT to GC mutations in p53 in NSCLC. The XRCC1 gene may play a role in the repair of cigarette smoking-induced DNA damage...
  13. ncbi request reprint Surgical management of pancreatic cancer
    Steven A Ahrendt
    Department of Surgery, University of Rochester, New York, USA
    Oncology (Williston Park) 16:725-34; discussion 734, 736-8, 740, 743. 2002
    ..Despite advances in nonoperative palliation, surgery continues to play an important role in the management of patients with locally advanced, unresectable pancreatic cancer...
  14. ncbi request reprint Cystic pancreatic neuroendocrine tumors: is preoperative diagnosis possible?
    Steven A Ahrendt
    Department of Surgery, Medical College of Wisconsin, Milwaukee, WI, USA
    J Gastrointest Surg 6:66-74. 2002
    ..Their high resectability rate further supports the role of surgical exploration and resection in the treatment of pancreatic cystic neoplasms...
  15. ncbi request reprint Tissue factor expression, angiogenesis, and thrombosis in pancreatic cancer
    Alok A Khorana
    James P Wilmot Cancer Center, Department of Medicine, University of Rochester, Rochester, New York 14642, USA
    Clin Cancer Res 13:2870-5. 2007
    ..We correlated TF expression with vascular endothelial growth factor (VEGF) expression, microvessel density, and venous thromboembolism in resected pancreatic cancer...
  16. ncbi request reprint Gene promoter hypermethylation in tumors and lymph nodes of stage I lung cancer patients
    Susan V Harden
    Department of Otolaryngology Head and Neck Surgery, Division of Head and Neck Cancer Research, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21206 2198, USA
    Clin Cancer Res 9:1370-5. 2003
    ..Although this study showed important trends, a larger prospective study is required to better understand the value of methylation analysis in detecting occult metastasis...
  17. ncbi request reprint Molecular detection approaches for smoking associated tumors
    Ying Chuan Hu
    Department of Surgery, University of Rochester, 601 Elmwood Avenue, Rochester, New York, NY 14642, USA
    Oncogene 21:7289-97. 2002
    ....

Research Grants1

  1. MOLECULAR STAGING AND SCREENING OF LUNG CANCER
    Steven Ahrendt; Fiscal Year: 2002
    ..Completion of the proposed mentored training period will provide the candidate with an excellent foundation for pursuing his long-term goals in academic surgical oncology. ..