Khalil Ahmed

Summary

Affiliation: University of Minnesota
Country: USA

Publications

  1. ncbi request reprint Joining the cell survival squad: an emerging role for protein kinase CK2
    Khalil Ahmed
    Cellular and Molecular Biochemistry Research Laboratory 151, Minneapolis Veterans Affairs Medical Center, Dept Laboratory Medicine and Pathology, MN 55417, USA
    Trends Cell Biol 12:226-30. 2002
  2. doi request reprint Special issue on protein kinase CK2 in health and disease. Preface
    Khalil Ahmed
    University of Minnesota, Minneapolis, USA
    Mol Cell Biochem 316:1-3. 2008
  3. ncbi request reprint Protein kinase CK2 modulates apoptosis induced by resveratrol and epigallocatechin-3-gallate in prostate cancer cells
    Kashif A Ahmad
    Cellular and Molecular Biochemistry Research Laboratory 151, Veterans Affairs Medical Center, One Veterans Drive, Minneapolis, MN 55417, USA
    Mol Cancer Ther 6:1006-12. 2007
  4. ncbi request reprint Targeting CK2 for cancer therapy
    Kashif A Ahmad
    Cellular and Molecular Biochemistry Research Laboratory, Minneapolis Veterans Affairs Medical Center, Chaska, Minnesota 55417, USA
    Anticancer Drugs 16:1037-43. 2005
  5. ncbi request reprint Downregulation of CK2 induces apoptosis in cancer cells--a potential approach to cancer therapy
    Guixia Wang
    Cellular and Molecular Biochemistry Research Laboratory 151, Minneapolis Veterans Affairs Medical Center, Minneapolis, MN 55417, USA
    Mol Cell Biochem 274:77-84. 2005
  6. ncbi request reprint CK2 signaling in androgen-dependent and -independent prostate cancer
    Guixia Wang
    Cellular and Molecular Biochemistry Research Laboratory 151, Minneapolis Veterans Affairs Medical Center, Minneapolis, Minnesota 55417, USA
    J Cell Biochem 99:382-91. 2006
  7. doi request reprint Systemic administration of antisense oligonucleotides simultaneously targeting CK2α and α' subunits reduces orthotopic xenograft prostate tumors in mice
    Janeen H Trembley
    Research Service, Minneapolis VA Health Care System, University of Minnesota, Minneapolis, MN 55417, USA
    Mol Cell Biochem 356:21-35. 2011
  8. doi request reprint Impact of protein kinase CK2 on inhibitor of apoptosis proteins in prostate cancer cells
    Guixia Wang
    Cellular and Molecular Biochemistry Research Laboratory 151, Minneapolis Veterans Affairs Medical Center, University of Minnesota, One Veterans Drive, Minneapolis, MN 55417, USA
    Mol Cell Biochem 316:91-7. 2008
  9. ncbi request reprint Role of protein kinase CK2 in the regulation of tumor necrosis factor-related apoptosis inducing ligand-induced apoptosis in prostate cancer cells
    Guixia Wang
    Cellular and Molecular Biochemistry Research Laboratory, Minneapolis Veterans Affairs Medical Center, Minneapolis, Minnesota 55417, USA
    Cancer Res 66:2242-9. 2006
  10. ncbi request reprint Intracellular hydrogen peroxide production is an upstream event in apoptosis induced by down-regulation of casein kinase 2 in prostate cancer cells
    Kashif A Ahmad
    Cellular and Molecular Biochemistry Research Laboratory, Minneapolis Veterans Affairs Medical Center, Department of Laboratory Medicine and Pathology, and the Cancer Center, University of Minnesota, Minneapolis, MN 55417, USA
    Mol Cancer Res 4:331-8. 2006

Research Grants

  1. STUDIES OF NORMAL AND NEOPLASTIC PROSTATE
    Khalil Ahmed; Fiscal Year: 2007
  2. NORMAL AND NEOPLASTIC PROSTATE
    Khalil Ahmed; Fiscal Year: 2002
  3. STUDIES OF NORMAL AND NEOPLASTIC PROSTATE
    Khalil Ahmed; Fiscal Year: 1980

Collaborators

Detail Information

Publications21

  1. ncbi request reprint Joining the cell survival squad: an emerging role for protein kinase CK2
    Khalil Ahmed
    Cellular and Molecular Biochemistry Research Laboratory 151, Minneapolis Veterans Affairs Medical Center, Dept Laboratory Medicine and Pathology, MN 55417, USA
    Trends Cell Biol 12:226-30. 2002
    ..Here, we summarize our emerging knowledge about how CK2 might participate in the transduction of survival signals...
  2. doi request reprint Special issue on protein kinase CK2 in health and disease. Preface
    Khalil Ahmed
    University of Minnesota, Minneapolis, USA
    Mol Cell Biochem 316:1-3. 2008
  3. ncbi request reprint Protein kinase CK2 modulates apoptosis induced by resveratrol and epigallocatechin-3-gallate in prostate cancer cells
    Kashif A Ahmad
    Cellular and Molecular Biochemistry Research Laboratory 151, Veterans Affairs Medical Center, One Veterans Drive, Minneapolis, MN 55417, USA
    Mol Cancer Ther 6:1006-12. 2007
    ..Further, the data hint at the potential of using these polyphenols alongside CK2 inhibitors in combination chemotherapy...
  4. ncbi request reprint Targeting CK2 for cancer therapy
    Kashif A Ahmad
    Cellular and Molecular Biochemistry Research Laboratory, Minneapolis Veterans Affairs Medical Center, Chaska, Minnesota 55417, USA
    Anticancer Drugs 16:1037-43. 2005
    ..Our studies minimize generally held concerns regarding suitability of CK2 as a target for cancer therapy and provide the first encouraging results for potential future application of this approach for cancer therapy...
  5. ncbi request reprint Downregulation of CK2 induces apoptosis in cancer cells--a potential approach to cancer therapy
    Guixia Wang
    Cellular and Molecular Biochemistry Research Laboratory 151, Minneapolis Veterans Affairs Medical Center, Minneapolis, MN 55417, USA
    Mol Cell Biochem 274:77-84. 2005
    ..The results provide the first preliminary evidence that such an approach may be feasible for targeting CK2 in cancer cells. Together, our results suggest that CK2 is potentially a highly plausible target for cancer therapy...
  6. ncbi request reprint CK2 signaling in androgen-dependent and -independent prostate cancer
    Guixia Wang
    Cellular and Molecular Biochemistry Research Laboratory 151, Minneapolis Veterans Affairs Medical Center, Minneapolis, Minnesota 55417, USA
    J Cell Biochem 99:382-91. 2006
    ..We present a brief overview of these developments in the context of prostate biology. An important outcome of these studies is the emerging concept that CK2 can be effectively targeted for cancer therapy...
  7. doi request reprint Systemic administration of antisense oligonucleotides simultaneously targeting CK2α and α' subunits reduces orthotopic xenograft prostate tumors in mice
    Janeen H Trembley
    Research Service, Minneapolis VA Health Care System, University of Minnesota, Minneapolis, MN 55417, USA
    Mol Cell Biochem 356:21-35. 2011
    ..We propose that the molecular downregulation of CK2 through bispecific targeting of the two catalytic subunits may be uniquely useful for therapeutic elimination of tumors...
  8. doi request reprint Impact of protein kinase CK2 on inhibitor of apoptosis proteins in prostate cancer cells
    Guixia Wang
    Cellular and Molecular Biochemistry Research Laboratory 151, Minneapolis Veterans Affairs Medical Center, University of Minnesota, One Veterans Drive, Minneapolis, MN 55417, USA
    Mol Cell Biochem 316:91-7. 2008
    ..Together, our results suggest that one of the modes of CK2-mediated modulation of apoptotic activity is via its impact on cellular IAPs...
  9. ncbi request reprint Role of protein kinase CK2 in the regulation of tumor necrosis factor-related apoptosis inducing ligand-induced apoptosis in prostate cancer cells
    Guixia Wang
    Cellular and Molecular Biochemistry Research Laboratory, Minneapolis Veterans Affairs Medical Center, Minneapolis, Minnesota 55417, USA
    Cancer Res 66:2242-9. 2006
    ..Our data support the potential usefulness of anticancer strategies that may involve the combination of TRAIL and down-regulation of CK2...
  10. ncbi request reprint Intracellular hydrogen peroxide production is an upstream event in apoptosis induced by down-regulation of casein kinase 2 in prostate cancer cells
    Kashif A Ahmad
    Cellular and Molecular Biochemistry Research Laboratory, Minneapolis Veterans Affairs Medical Center, Department of Laboratory Medicine and Pathology, and the Cancer Center, University of Minnesota, Minneapolis, MN 55417, USA
    Mol Cancer Res 4:331-8. 2006
    ....
  11. pmc Protein B23/nucleophosmin/numatrin nuclear dynamics in relation to protein kinase CK2 and apoptotic activity in prostate cells
    Guixia Wang
    Cellular and Molecular Biochemistry Research Laboratory 151, Minneapolis Veterans Affairs Medical Center, and Department of Laboratory Medicine and Pathology and Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota 55417, USA
    Biochemistry 49:3842-52. 2010
    ....
  12. ncbi request reprint Induction of apoptosis by antisense CK2 in human prostate cancer xenograft model
    Joel W Slaton
    Minneapolis Veterans Affairs Medical Center, Minneapolis, Minnesota, USA
    Mol Cancer Res 2:712-21. 2004
    ....
  13. ncbi request reprint Modulation of death receptor-mediated apoptosis by CK2
    Guixia Wang
    Cellular and Molecular Biochemistry Research Laboratory 151, Minneapolis Veterans Affairs Medical Center, MN 55417, USA
    Mol Cell Biochem 274:201-5. 2005
    ....
  14. ncbi request reprint Cell cycle dependent regulation of protein kinase CK2 signaling to the nuclear matrix
    Huamin Wang
    Cellular and Molecular Biochemistry Research Laboratory 151, Minneapolis Veterans Affairs Medical Center and Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota 55417, USA
    J Cell Biochem 88:812-22. 2003
    ..Considering that nuclear matrix is central to several nuclear functions, this pattern of intracellular distribution of CK2 may have implications for its role in the oncogenic process. Published 2003 Wiley-Liss, Inc...
  15. pmc Emergence of protein kinase CK2 as a key target in cancer therapy
    Janeen H Trembley
    Cellular and Molecular Biochemistry Research Laboratory, Research Service, Minneapolis V A Medical Center, and Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55417, USA
    Biofactors 36:187-95. 2010
    ..Thus, appropriate strategies to target CK2 especially by molecular approaches may lead to a highly feasible and effective approach to eradication of a given cancer...
  16. pmc Nanoencapsulated anti-CK2 small molecule drug or siRNA specifically targets malignant cancer but not benign cells
    Janeen H Trembley
    Research Service, Minneapolis VA Health Care System, MN, USA
    Cancer Lett 315:48-58. 2012
    ..By direct comparison of two CK2-directed cargos, our data provide proof that the TBG encapsulation design for delivery of drugs specifically to cancer cells has strong potential for small molecule- and nucleic acid-based cancer therapy...
  17. pmc Phosphorylation of murine caspase-9 by the protein kinase casein kinase 2 regulates its cleavage by caspase-8
    Maureen A McDonnell
    Department of Laboratory Medicine and Pathology University of Minnesota, Minneapolis, MN 55455, USA
    J Biol Chem 283:20149-58. 2008
    ..Thus, our data suggest that modification of procaspase-9 to protect it from inappropriate cleavage and activation is yet another mechanism by which the oncogenic kinase CK2 promotes survival...
  18. ncbi request reprint Heat shock mediated modulation of protein kinase CK2 in the nuclear matrix
    Alan T Davis
    Minneapolis Veterans Affairs Medical Center, Department of Laboratory Medicine and Pathology and University of Minnesota Cancer Center, University of Minnesota, Minneapolis, Minnesota 55417, USA
    J Cell Biochem 85:583-91. 2002
    ..The results support the notion that CK2 association with the nuclear matrix in response to heat shock may serve a protective role in the cell response to stress...
  19. ncbi request reprint NF-Kappa-B downregulation strategies in head and neck cancer treatment
    Alpen Patel
    Department of Otolaryngology, University of Minnesota, Minneapolis, Minnesota, USA
    Otolaryngol Head Neck Surg 131:288-95. 2004
    ..Multiple biochemical and genetic strategies were used to downregulate early response gene NF-KappaB, whose activation controls squamous cell cancer-associated pathways...
  20. ncbi request reprint CK2 phosphorylation of SAG at Thr10 regulates SAG stability, but not its E3 ligase activity
    Hongbin He
    Division of Cancer Biology, Department of Radiation Oncology, University of Michigan Comprehensive Cancer Center, 4304 CCGC, 1500 East Medical Center Drive, Ann Arbor, MI 48109 0936, USA
    Mol Cell Biochem 295:179-88. 2007
    ..These studies suggested that CK2 might regulate SAG-SCF E3 ligase activity through modulating SAG's stability, rather than its enzymatic activity directly...
  21. pmc Expression of protein kinase CK2 in astroglial cells of normal and neovascularized retina
    Andrei A Kramerov
    Ophthalmology Research Laboratories, Cedars Sinai Medical Center, University of California at Los Angeles School of Medicine, 90048, USA
    Am J Pathol 168:1722-36. 2006
    ..Based on its retinal localization, CK2 may be considered a new immunohistochemical astrocytic marker, and combination of CK2 inhibitors and octreotide may be a promising future treatment for proliferative retinopathies...

Research Grants18

  1. STUDIES OF NORMAL AND NEOPLASTIC PROSTATE
    Khalil Ahmed; Fiscal Year: 2007
    ..The relevance of these studies is underscored by the fact that prostate cancer is a leading cause of cancer-related deaths in men in the U.S.A. ..
  2. NORMAL AND NEOPLASTIC PROSTATE
    Khalil Ahmed; Fiscal Year: 2002
    ..In summary, these studies will provide fundamentally important new information on the mechanisms of CK2 functional activity as well as its implications in prostate tumor biology and a potential therapeutic target. ..
  3. STUDIES OF NORMAL AND NEOPLASTIC PROSTATE
    Khalil Ahmed; Fiscal Year: 1980
    ..Nuclear membrane has been shown to contain distinct protein kinase and phosphatase activities. Work is being undertaken to characterize these activities in the prostatic nuclear membrane. ..