A E Ahmed

Summary

Affiliation: University of Texas Medical Branch
Country: USA

Publications

  1. ncbi request reprint Chloroacetonitrile (CAN) induces glutathione depletion and 8-hydroxylation of guanine bases in rat gastric mucosa
    A E Ahmed
    Department of Pathology, University of Texas Medical Branch, Galveston 77555 0605, USA
    J Biochem Mol Toxicol 13:119-26. 1999
  2. ncbi request reprint Induction of oxidative stress and TNF-alpha secretion by dichloroacetonitrile, a water disinfectant by-product, as possible mediators of apoptosis or necrosis in a murine macrophage cell line (RAW)
    A E Ahmed
    Molecular Toxicology Laboratory, Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555, USA
    Toxicol In Vitro 14:199-210. 2000
  3. ncbi request reprint Neurological impairment in fetal mouse brain by drinking water disinfectant byproducts
    Ahmed E Ahmed
    Molecular Toxicology Laboratory of the Department of Pathology, 06 09, University of Texas Medical Branch, Galveston, TX 77555 0609, USA
    Neurotoxicology 26:633-40. 2005
  4. ncbi request reprint Fetal origin of adverse pregnancy outcome: the water disinfectant by-product chloroacetonitrile induces oxidative stress and apoptosis in mouse fetal brain
    Ahmed E Ahmed
    Molecular Toxicology Laboratory, University of Texas Medical Branch, Galveston, TX 77550, USA
    Brain Res Dev Brain Res 159:1-11. 2005
  5. doi request reprint Dibromoacetonitrile-induced protein oxidation and inhibition of proteasomal activity in rat glioma cells
    Ahmed E Ahmed
    Molecular Toxicology Laboratory, Department of Pathology, University of Texas Medical Branch, Galveston, TX, USA
    Toxicol Lett 179:29-33. 2008
  6. ncbi request reprint Whole-body autoradiographic disposition, elimination and placental transport of [14C]tri-o-cresyl phosphate in mice
    A E Ahmed
    Department of Pathology, University of Texas Medical Branch, Galveston 77555 0605
    J Appl Toxicol 13:259-67. 1993
  7. ncbi request reprint Studies on the mechanism of urotoxic effects of N,N'-dimethylaminopropionitrile in rats and mice. 1. Biochemical and morphologic characterization of the injury and its relationship to metabolism
    M M Mumtaz
    Department of Pathology, University of Texas Medical Branch, Galveston 77550
    J Toxicol Environ Health 33:1-17. 1991
  8. doi request reprint Chloroacetonitrile induces intrauterine growth restriction and musculoskeletal toxicity in fetal mouse
    A E Ahmed
    Molecular Toxicology Laboratory, Department of Pathology, University of Texas Medical Branch, Galveston, TX, USA
    Toxicol Ind Health 24:511-8. 2008
  9. ncbi request reprint Species difference in the disposition of acrylonitrile: quantitative whole-body autoradiographic study in rats and mice
    Sam Jacob
    Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555 0605, USA
    Toxicol Ind Health 20:9-19. 2004
  10. ncbi request reprint Effect of route of administration on the disposition of acrylonitrile: quantitative whole-body autoradiographic study in rats
    Sam Jacob
    Department of Pathology, Route 0609, University of Texas Medical Branch, Galveston, TX 77555 0609, USA
    Pharmacol Res 48:479-88. 2003

Collaborators

Detail Information

Publications10

  1. ncbi request reprint Chloroacetonitrile (CAN) induces glutathione depletion and 8-hydroxylation of guanine bases in rat gastric mucosa
    A E Ahmed
    Department of Pathology, University of Texas Medical Branch, Galveston 77555 0605, USA
    J Biochem Mol Toxicol 13:119-26. 1999
    ....
  2. ncbi request reprint Induction of oxidative stress and TNF-alpha secretion by dichloroacetonitrile, a water disinfectant by-product, as possible mediators of apoptosis or necrosis in a murine macrophage cell line (RAW)
    A E Ahmed
    Molecular Toxicology Laboratory, Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555, USA
    Toxicol In Vitro 14:199-210. 2000
    ..These studies indicate that DCAN induces dose-dependent apoptosis or necrosis in RAW cells that could be due to the disturbance in intracellular redox status and initiation of ROI-mediated oxidative mechanisms of cellular damage...
  3. ncbi request reprint Neurological impairment in fetal mouse brain by drinking water disinfectant byproducts
    Ahmed E Ahmed
    Molecular Toxicology Laboratory of the Department of Pathology, 06 09, University of Texas Medical Branch, Galveston, TX 77555 0609, USA
    Neurotoxicology 26:633-40. 2005
    ..Future studies will examine the molecular mechanisms of these events and its impact on neural development of offspring...
  4. ncbi request reprint Fetal origin of adverse pregnancy outcome: the water disinfectant by-product chloroacetonitrile induces oxidative stress and apoptosis in mouse fetal brain
    Ahmed E Ahmed
    Molecular Toxicology Laboratory, University of Texas Medical Branch, Galveston, TX 77550, USA
    Brain Res Dev Brain Res 159:1-11. 2005
    ..These events could predispose the fetus to altered brain development leading to APO as well as behavioral and learning and memory deficits...
  5. doi request reprint Dibromoacetonitrile-induced protein oxidation and inhibition of proteasomal activity in rat glioma cells
    Ahmed E Ahmed
    Molecular Toxicology Laboratory, Department of Pathology, University of Texas Medical Branch, Galveston, TX, USA
    Toxicol Lett 179:29-33. 2008
    ..In conclusion, the present study indicates that exposure of C6 cells to DBAN results in generation of ROS, lipid peroxidation, accumulation of oxidized proteins and inhibition of proteasomal activity...
  6. ncbi request reprint Whole-body autoradiographic disposition, elimination and placental transport of [14C]tri-o-cresyl phosphate in mice
    A E Ahmed
    Department of Pathology, University of Texas Medical Branch, Galveston 77555 0605
    J Appl Toxicol 13:259-67. 1993
    ..Brain and spinal cord had the least amount of [14C]TOCP. This finding may support reports that explain the insensitivity of the mice towards organophosphate-induced delayed neurotoxicity (OPIDN) of TOCP...
  7. ncbi request reprint Studies on the mechanism of urotoxic effects of N,N'-dimethylaminopropionitrile in rats and mice. 1. Biochemical and morphologic characterization of the injury and its relationship to metabolism
    M M Mumtaz
    Department of Pathology, University of Texas Medical Branch, Galveston 77550
    J Toxicol Environ Health 33:1-17. 1991
    ..These studies indicate that there are species differences in DMAPN toxicity. The differences may be due to differences in the formation of reactive metabolic intermediates of DMAPN...
  8. doi request reprint Chloroacetonitrile induces intrauterine growth restriction and musculoskeletal toxicity in fetal mouse
    A E Ahmed
    Molecular Toxicology Laboratory, Department of Pathology, University of Texas Medical Branch, Galveston, TX, USA
    Toxicol Ind Health 24:511-8. 2008
    ..In conclusion, intrauterine exposure to low levels of CAN decreases fetal body weight and induces malformations in the musculoskeletal system in mice...
  9. ncbi request reprint Species difference in the disposition of acrylonitrile: quantitative whole-body autoradiographic study in rats and mice
    Sam Jacob
    Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555 0605, USA
    Toxicol Ind Health 20:9-19. 2004
    ..The study also demonstrated that administration of VCN in rats resulted in covalent interactions and retention of 2-[14C]-VCN/metabolites in the tissues thus exerting more chronic toxicity to rats than to mice...
  10. ncbi request reprint Effect of route of administration on the disposition of acrylonitrile: quantitative whole-body autoradiographic study in rats
    Sam Jacob
    Department of Pathology, Route 0609, University of Texas Medical Branch, Galveston, TX 77555 0609, USA
    Pharmacol Res 48:479-88. 2003
    ..v. route of administration. The study also demonstrates that the systemic administration of VCN enhances its covalent interaction and retention in the tissues thus cause more toxicity in these organs...