Rexford Ahima

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. ncbi request reprint Central actions of adipocyte hormones
    Rexford S Ahima
    University of Pennsylvania School of Medicine, Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, Philadelphia, PA 19104, USA
    Trends Endocrinol Metab 16:307-13. 2005
  2. pmc Adipokines and the peripheral and neural control of energy balance
    Rexford S Ahima
    Department of Medicine, University of Pennsylvania School of Medicine, Division of Endocrinology, Diabetes and Metabolism, Philadelphia, Pennsylvania 19104, USA
    Mol Endocrinol 22:1023-31. 2008
  3. ncbi request reprint Adipokines that link obesity and diabetes to the hypothalamus
    Rexford S Ahima
    Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Prog Brain Res 153:155-74. 2006
  4. ncbi request reprint Adipose tissue as an endocrine organ
    Rexford S Ahima
    University of Pennsylvania School of Medicine, Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, Philadelphia, PA 19104, USA
    Obesity (Silver Spring) 14:242S-249S. 2006
  5. ncbi request reprint Obesity: much silence makes a mighty noise
    Rexford S Ahima
    University of Pennsylvania School of Medicine, Department of Medicine, Division of Endocrinology, Philadelphia, Pennsylvania 19104, USA
    Gastroenterology 132:2085-6. 2007
  6. pmc Brain regulation of appetite and satiety
    Rexford S Ahima
    Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, University of Pennsylvania School of Medicine, 415 Curie Boulevard, Philadelphia, PA 19104, USA
    Endocrinol Metab Clin North Am 37:811-23. 2008
  7. ncbi request reprint Leptin signaling
    Rexford S Ahima
    Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, University of Pennsylvania School of Medicine, 415 Curie Boulevard, 764 Clinical Research Building, Philadelphia, PA 19104, USA
    Physiol Behav 81:223-41. 2004
  8. pmc Revisiting leptin's role in obesity and weight loss
    Rexford S Ahima
    Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Clin Invest 118:2380-3. 2008
  9. pmc Linking adiponectin to proteinuria
    Rexford S Ahima
    Department of Medicine, Division of Endocrinology, Diabetes, and Metabolism, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Clin Invest 118:1619-22. 2008
  10. pmc No Kiss1ng by leptin during puberty?
    Rexford S Ahima
    Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, and Institute for Diabetes, Obesity and Metabolism, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Clin Invest 121:34-6. 2011

Research Grants

  1. CNS Action of Appetite Suppressant Aminosterol
    Rexford Ahima; Fiscal Year: 2009
  2. CNS Action of Appetite Suppressant Aminosterol
    Rexford Ahima; Fiscal Year: 2004
  3. CNS Action of Appetite Suppressant Aminosterol
    Rexford S Ahima; Fiscal Year: 2010

Collaborators

Detail Information

Publications62

  1. ncbi request reprint Central actions of adipocyte hormones
    Rexford S Ahima
    University of Pennsylvania School of Medicine, Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, Philadelphia, PA 19104, USA
    Trends Endocrinol Metab 16:307-13. 2005
    ..Moreover, data pertaining to the potential central effects of adiponectin, cytokines and resistin on energy homeostasis, glucose and lipid metabolism are discussed...
  2. pmc Adipokines and the peripheral and neural control of energy balance
    Rexford S Ahima
    Department of Medicine, University of Pennsylvania School of Medicine, Division of Endocrinology, Diabetes and Metabolism, Philadelphia, Pennsylvania 19104, USA
    Mol Endocrinol 22:1023-31. 2008
    ..Understanding adipokine signaling in the brain and other organs will provide insights into the pathogenesis and treatment of obesity, diabetes and various metabolic disorders...
  3. ncbi request reprint Adipokines that link obesity and diabetes to the hypothalamus
    Rexford S Ahima
    Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Prog Brain Res 153:155-74. 2006
    ..Understanding the signal transduction of adipocyte hormones will provide novel insights on the pathogenesis and treatment of obesity, diabetes, and various metabolic disorders...
  4. ncbi request reprint Adipose tissue as an endocrine organ
    Rexford S Ahima
    University of Pennsylvania School of Medicine, Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, Philadelphia, PA 19104, USA
    Obesity (Silver Spring) 14:242S-249S. 2006
    ..As with leptin, adiponectin requires the central melanocortin pathway. Furthermore, adiponectin stimulates fatty acid oxidation and reduces glucose and lipids, at least in part, by activating AMPK in muscle and liver...
  5. ncbi request reprint Obesity: much silence makes a mighty noise
    Rexford S Ahima
    University of Pennsylvania School of Medicine, Department of Medicine, Division of Endocrinology, Philadelphia, Pennsylvania 19104, USA
    Gastroenterology 132:2085-6. 2007
  6. pmc Brain regulation of appetite and satiety
    Rexford S Ahima
    Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, University of Pennsylvania School of Medicine, 415 Curie Boulevard, Philadelphia, PA 19104, USA
    Endocrinol Metab Clin North Am 37:811-23. 2008
    ..The pathogenesis and treatment of obesity and abnormalities of glucose and lipid metabolism are discussed...
  7. ncbi request reprint Leptin signaling
    Rexford S Ahima
    Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, University of Pennsylvania School of Medicine, 415 Curie Boulevard, 764 Clinical Research Building, Philadelphia, PA 19104, USA
    Physiol Behav 81:223-41. 2004
    ..This review will focus on the signaling pathways which mediate these diverse effects of leptin in the brain and other physiologic systems...
  8. pmc Revisiting leptin's role in obesity and weight loss
    Rexford S Ahima
    Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Clin Invest 118:2380-3. 2008
    ..Thus, leptin is a critical factor linking reduced energy stores to eating behavior. Potentially, leptin therapy could sustain weight loss by overriding the tendency toward energy conservation...
  9. pmc Linking adiponectin to proteinuria
    Rexford S Ahima
    Department of Medicine, Division of Endocrinology, Diabetes, and Metabolism, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Clin Invest 118:1619-22. 2008
    ..The benefits of adiponectin were observed in diabetic and nondiabetic mice. These findings suggest that adiponectin is a biomarker for kidney disease and may be targeted for prevention and treatment...
  10. pmc No Kiss1ng by leptin during puberty?
    Rexford S Ahima
    Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, and Institute for Diabetes, Obesity and Metabolism, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Clin Invest 121:34-6. 2011
    ..In contrast, deletion of LepR from the ventral premammillary nucleus, a region of the brain involved in sexual behavior, prevented puberty and fertility. These findings highlight the complex biology of leptin in reproduction...
  11. pmc Estrogen sulfotransferase is expressed in subcutaneous adipose tissue of obese humans in association with TNF-alpha and SOCS3
    Rexford S Ahima
    Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 96:E1153-8. 2011
    ..Animal studies suggest that EST modulates glucose and lipid metabolism in adipose tissue, but it is unknown whether EST is expressed in human adipose tissue and, if so, how its expression relates to features of the metabolic syndrome...
  12. ncbi request reprint Appetite suppression and weight reduction by a centrally active aminosterol
    Rexford S Ahima
    Division of Endocrinology, Diabetes and Metabolism, University of Pennsylvania School of Medicine, 764 Clinical Research Building, 415 Curie Boulevard, Philadelphia, PA 19104, USA
    Diabetes 51:2099-104. 2002
    ..These findings indicate that MSI-1436 acts in the brain to regulate food intake and energy expenditure, likely through suppression of orexigenic hypothalamic pathways...
  13. ncbi request reprint Antagonism of ghrelin for glycemic control in type 2 diabetes mellitus?
    Rexford S Ahima
    University of Pennsylvania School of Medicine, Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, Philadelphia, PA 19104, USA
    Endocrinology 148:5173-4. 2007
  14. ncbi request reprint Metabolic actions of adipocyte hormones: focus on adiponectin
    Rexford S Ahima
    Division of Endocrinology, Diabetes and Metabolism, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Obesity (Silver Spring) 14:9S-15S. 2006
    ..A causal role of adiponectin in diabetes, dyslipidemia, and atherosclerosis has been established in knockout mice. Therefore, adiponectin seems to be a marker of obesity-related diseases and a potential therapeutic target...
  15. ncbi request reprint Leptin regulation of neuroendocrine systems
    R S Ahima
    Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, 19104, USA
    Front Neuroendocrinol 21:263-307. 2000
    ..g., paraventricular, lateral, and perifornical areas, as well as other sites in the brainstem, spinal cord, and cortical and subcortical regions...
  16. ncbi request reprint Adipose tissue as an endocrine organ
    R S Ahima
    Division of Endocrinology, Diabetes and Metabolism, University of Pennsylvania School of Medicine, 764 CRB, 415 Curie Blvd, Philadelphia, PA 19104, USA
    Trends Endocrinol Metab 11:327-32. 2000
    ..Other adipose products, for example, proinflammatory cytokines, complement factors and components of the coagulation/fibrinolytic cascade, may mediate the metabolic and cardiovascular complications associated with obesity...
  17. ncbi request reprint Postnatal regulation of hypothalamic neuropeptide expression by leptin: implications for energy balance and body weight regulation
    R S Ahima
    Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, University of Pennsylvania School of Medicine, 764 Clinical Research Building, 415 Curie Blvd, 19104, Philadelphia, PA, USA
    Regul Pept 92:1-7. 2000
    ....
  18. pmc Digging deeper into obesity
    Rexford S Ahima
    Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, and The Institute for Diabetes, Obesity and Metabolism, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Clin Invest 121:2076-9. 2011
    ..This issue of the JCI highlights important concepts in our understanding of the pathogenesis of obesity and its complications...
  19. ncbi request reprint Brain adipocytokine action and metabolic regulation
    Rexford S Ahima
    University of Pennsylvania School of Medicine, Division of Endocrinology, Diabetes and Metabolism, 764 Clinical Research Building, 415 Curie Blvd, Philadelphia, PA 19104, USA
    Diabetes 55:S145-54. 2006
    ..Understanding the actions of these "adipocytokines" will provide insight into the pathogenesis and treatment of obesity and related diseases...
  20. ncbi request reprint Molecular regulation of eating behavior: new insights and prospects for therapeutic strategies
    R S Ahima
    Division of Endocrinology, Diabetes and Metabolism, University of Pennsylvania, School of Medicine, 764 CRB, 415 Curie Blvd, Philadelphia, PA 19104, USA
    Trends Mol Med 7:205-13. 2001
    ..Major efforts are underway to determine whether the peripheral and central pathways involved in the regulation of feeding behavior and energy balance could be targeted for the treatment of obesity...
  21. doi request reprint Adipokines in obesity
    Rexford S Ahima
    Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Front Horm Res 36:182-97. 2008
    ....
  22. ncbi request reprint Divergent effects of leptin in mice susceptible or resistant to obesity
    N Takahashi
    University of Pennsylvania School of Medicine, Division of Endocrinology, Diabetes and Metabolism, Philadelphia, Pennsylvania 19104, USA
    Horm Metab Res 34:691-7. 2002
    ..These results indicate that differences in leptin responsiveness between strains might occur centrally or peripherally, leading to alteration in the patterns of food intake, thermogenesis and energy storage...
  23. ncbi request reprint The hormone resistin links obesity to diabetes
    C M Steppan
    Department of Medicine, The Penn Diabetes Center, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    Nature 409:307-12. 2001
    ..Insulin-stimulated glucose uptake by adipocytes is enhanced by neutralization of resistin and is reduced by resistin treatment. Resistin is thus a hormone that potentially links obesity to diabetes...
  24. pmc Postnatal leptin surge and regulation of circadian rhythm of leptin by feeding. Implications for energy homeostasis and neuroendocrine function
    R S Ahima
    Department of Medicine, Division of Endocrinology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    J Clin Invest 101:1020-7. 1998
    ..The temporal relationship between leptin and other hormones in neonatal and adult mice suggests that leptin is involved in the maturation and function of the neuroendocrine axis...
  25. pmc CRTC2 (TORC2) contributes to the transcriptional response to fasting in the liver but is not required for the maintenance of glucose homeostasis
    John Le Lay
    Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Cell Metab 10:55-62. 2009
    ..Collectively, these results provide genetic evidence supporting a role for CRTC2 in the transcriptional response to fasting, but indicate only a limited contribution of this cofactor to the maintenance of glucose homeostasis...
  26. pmc Leptin accelerates the onset of puberty in normal female mice
    R S Ahima
    Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    J Clin Invest 99:391-5. 1997
    ..We propose that leptin is the signal that informs the brain that energy stores are sufficient to support the high energy demands of reproduction, and may be a major determinant of the timing of puberty...
  27. ncbi request reprint Regulation of neuronal and glial proteins by leptin: implications for brain development
    R S Ahima
    Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    Endocrinology 140:2755-62. 1999
    ..These findings suggest that leptin, a peripheral signal of energy stores in adult animals, is required for normal neuronal and glial maturation in the mouse nervous system...
  28. ncbi request reprint Hormonal and metabolic defects in a prader-willi syndrome mouse model with neonatal failure to thrive
    M Stefan
    Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia 19104 6140, USA
    Endocrinology 146:4377-85. 2005
    ..Together, the data reveal defects in endocrine pancreatic function as well as glucose and hepatic energy metabolism that may underlie the neonatal phenotype of PWS...
  29. pmc Adipose differentiation-related protein regulates lipids and insulin in pancreatic islets
    D M Faleck
    Department of Medicine, Division of Endocrinology, Diabetes, and Metabolism, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Am J Physiol Endocrinol Metab 299:E249-57. 2010
    ..Moreover, the reduction of ADFP impaired the ability of palmitate to increase insulin secretion. These findings demonstrate that ADFP is important in regulation of lipid metabolism and insulin secretion in beta-cells...
  30. pmc The effects of a soluble activin type IIB receptor on obesity and insulin sensitivity
    I Akpan
    University of Pennsylvania School of Medicine, Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, Philadelphia, PA 19104, USA
    Int J Obes (Lond) 33:1265-73. 2009
    ..We treated mice on chow and high-fat diets with a soluble activin receptor type IIB (ActRIIB, RAP-031), which is a putative endogenous signaling receptor for myostatin and other ligands of the TGF-beta superfamily...
  31. pmc Critical role for thyroid hormone receptor beta2 in the regulation of paraventricular thyrotropin-releasing hormone neurons
    E D Abel
    Division of Endocrinology, Metabolism and Diabetes, University of Utah School of Medicine 15 North 2030 East, Building 533, Room 3410B, Salt Lake City, UT 84112, USA
    J Clin Invest 107:1017-23. 2001
    ..Thus TR-beta2 is the key TR isoform responsible for T(3)-mediated negative-feedback regulation by hypophysiotropic TRH neurons...
  32. ncbi request reprint Overcoming insulin resistance with CNTF
    Rexford S Ahima
    Nat Med 12:511-2. 2006
  33. ncbi request reprint Mouse and human resistins impair glucose transport in primary mouse cardiomyocytes, and oligomerization is required for this biological action
    Christophe Graveleau
    Division of Endocrinology, Metabolism, and Diabetes, University of Utah, Salt Lake City, Utah 84112, USA
    J Biol Chem 280:31679-85. 2005
    ..Thus, in cardiomyocytes, both mouse and human resistins directly impair glucose transport; and in contrast to effects on the liver, these actions of resistin require oligomerization...
  34. pmc Divergent metabolic adaptations to intestinal parasitic nematode infection in mice susceptible or resistant to obesity
    Tracie Wong
    Division of Gastroenterology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Gastroenterology 133:1979-88. 2007
    ..An environmental factor that may have shaped our energy homeostasis throughout evolution is parasitic nematode infection...
  35. ncbi request reprint Gut peptides and other regulators in obesity
    Matthew T Scharf
    University of Pennsylvania School of Medicine, Division of Endocrinology, Diabetes and Metabolism, 415 Curie Blvd, Philadelphia, PA 19104, USA
    Semin Liver Dis 24:335-47. 2004
    ..Efforts are underway to determine how these peripheral and central pathways may be targeted for treatment of obesity and related diseases...
  36. ncbi request reprint Body fat, leptin, and hypothalamic amenorrhea
    Rexford S Ahima
    Division of Endocrinology, Diabetes, and Metabolism, University of Pennsylvania School of Medicine, Philadelphia, USA
    N Engl J Med 351:959-62. 2004
  37. ncbi request reprint A novel aminosterol reverses diabetes and fatty liver disease in obese mice
    Nobuhiko Takahashi
    Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Hepatol 41:391-8. 2004
    ..Since NAFLD is associated with insulin resistance and diabetes, we hypothesized that improvement of these factors would reverse obesity-related NAFLD...
  38. pmc Loss of resistin ameliorates hyperlipidemia and hepatic steatosis in leptin-deficient mice
    Neel S Singhal
    Division of Endocrinology, Diabetes and Metabolism, University of Pennsylvania School of Medicine, 415 Curie Blvd, Philadelphia, PA 19104, USA
    Am J Physiol Endocrinol Metab 295:E331-8. 2008
    ..Together, these results demonstrate a crucial role of resistin in promoting hepatic steatosis and hyperlipidemia in obese mice...
  39. ncbi request reprint Regulation of resistin expression and circulating levels in obesity, diabetes, and fasting
    Michael W Rajala
    Department of Cell Biology and Diabetes Research and Training Center, Albert Einstein College of Medicine, Bronx, New York, USA
    Diabetes 53:1671-9. 2004
    ..Taken together, these findings suggest that the nutritional regulation of resistin and changes in resistin gene expression and circulating levels in obesity are mediated, at least in part, through insulin and glucose...
  40. pmc Inhibition of ADRP prevents diet-induced insulin resistance
    Gladys M Varela
    Department of Medicine, Institute for Diabetes, Obesity, and Metabolism, University of Pennsylvania School of Medicine, 415 Curie Blvd, 712A Clinical Research Bldg, Philadelphia, PA 19104, USA
    Am J Physiol Gastrointest Liver Physiol 295:G621-8. 2008
    ..These results demonstrate an important role for ADRP in the pathogenesis of diet-induced insulin resistance...
  41. ncbi request reprint Adiponectin acts in the brain to decrease body weight
    Yong Qi
    Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, and The Penn Diabetes Center, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Nat Med 10:524-9. 2004
    ..Agouti (A(y)/a) mice did not respond to ADP or leptin, indicating the melanocortin pathway may be a common target. These results show that ADP has unique central effects on energy homeostasis...
  42. ncbi request reprint Regulation of fasted blood glucose by resistin
    Ronadip R Banerjee
    Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, and The Penn Diabetes Center, 611 CRB, 415 Curie Boulevard, Universityof Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Science 303:1195-8. 2004
    ..Remarkably, lack of resistin diminishes the increase in post-fast blood glucose normally associated with increased weight, suggesting a role for resistin in mediating hyperglycemia associated with obesity...
  43. ncbi request reprint Role of endogenous glucagon-like peptide-1 in islet regeneration after partial pancreatectomy
    Diva D De Leon
    Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    Diabetes 52:365-71. 2003
    ..These studies point to a role for endogenous GLP-1 in beta-cell regeneration after Ppx in mice...
  44. ncbi request reprint Central resistin induces hepatic insulin resistance via neuropeptide Y
    Neel S Singhal
    Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Neurosci 27:12924-32. 2007
    ..Together, these results suggest that resistin action on NPY neurons is an important regulator of hepatic insulin sensitivity...
  45. ncbi request reprint Insulin secretion is increased in pancreatic islets of neuropeptide Y-deficient mice
    Yumi Imai
    Department of Medicine, Division of Endocrinology, Diabetes, and Metabolism, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Endocrinology 148:5716-23. 2007
    ....
  46. ncbi request reprint Loss of resistin improves glucose homeostasis in leptin deficiency
    Yong Qi
    University of Pennsylvania School of Medicine, Division of Endocrinology, DiabetesMetabolism, 764 Clinical Research Building, 415 Curie Blvd, Philadelphia, PA 19104, USA
    Diabetes 55:3083-90. 2006
    ..Together, these results provide strong support for an important role of resistin in insulin resistance and diabetes associated with genetic or diet-induced obesity...
  47. ncbi request reprint Area postrema neurons are modulated by the adipocyte hormone adiponectin
    Mark Fry
    Department of Physiology, Queen s University, Kingston, Ontario, Canada, K7L 3N6
    J Neurosci 26:9695-702. 2006
    ....
  48. ncbi request reprint Neuropeptide Y deficiency attenuates responses to fasting and high-fat diet in obesity-prone mice
    Hiralben R Patel
    University of Pennsylvania School of Medicine, Division of Endocrinology, Diabetes and Metabolism, 764 Clinical Research Building, 415 Curie Blvd, Philadelphia, PA 19104, USA
    Diabetes 55:3091-8. 2006
    ..Insulin, leptin, and triglyceride levels increase with adiposity in both wild-type and NPYko mice...
  49. ncbi request reprint Ghrelin--a new player in glucose homeostasis?
    Rexford S Ahima
    Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Cell Metab 3:301-2. 2006
    ..These effects were not related to changes in food intake or weight, suggesting ghrelin has unique actions on key components of glucose homeostasis...
  50. ncbi request reprint Neuroendocrine and metabolic effects of adipocyte-derived hormones
    Malaka B Jackson
    Division of Endocrinology, University of Pennsylvania School of Medicine, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Clin Sci (Lond) 110:143-52. 2006
    ..Understanding the actions of adipocyte hormones will provide novel insights into the pathophysiology and treatment of obesity...
  51. ncbi request reprint Innate immunity modulates adipokines in humans
    Paul D Anderson
    Cardiovascular Institute, University of Pennsylvania Medical Center, Philadelphia, PA 19104 6160, USA
    J Clin Endocrinol Metab 92:2272-9. 2007
    ..Chronic inflammation converges in type 2 diabetes and atherosclerosis. Modulation of adipokine signaling by innate immunity in humans is of considerable interest given the role of adipokines in insulin resistance and atherosclerosis...
  52. ncbi request reprint Reduction of hepatosteatosis and lipid levels by an adipose differentiation-related protein antisense oligonucleotide
    Yumi Imai
    Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19010, USA
    Gastroenterology 132:1947-54. 2007
    ..We postulated that a reduction in ADRP would ameliorate hepatic steatosis and improve insulin action...
  53. ncbi request reprint Neuroendocrine profiles associated with energy intake, sleep, and stress in the night eating syndrome
    Kelly C Allison
    University of Pennsylvania School of Medicine, Department of Psychiatry, Weight and Eating Disorders Program, 3535 Market Street, Suite 3021, Philadelphia, Pennsylvania 19104, USA
    J Clin Endocrinol Metab 90:6214-7. 2005
    ..Night eating syndrome (NES) is characterized by evening hyperphagia and frequent awakenings with ingestion of food. It is associated with obesity and depressed mood. Greater understanding of hormonal influences on NES is desirable...
  54. ncbi request reprint Functional improvement of dystrophic muscle by myostatin blockade
    Sasha Bogdanovich
    Department of Physiology and Pennsylvania Muscle Institute, University of Pennsylvania School of Medicine, 3700 Hamilton Walk, Richards A 601, Philadelphia, Pennsylvania 19104 6085, USA
    Nature 420:418-21. 2002
    ....
  55. ncbi request reprint Dominant inhibition of thyroid hormone action selectively in the pituitary of thyroid hormone receptor-beta null mice abolishes the regulation of thyrotropin by thyroid hormone
    E Dale Abel
    Division of Endocrinology, University of Utah School of Medicine, 15 North 2030 East, Building 533, Room 3410B, Salt Lake City, Utah 84112, USA
    Mol Endocrinol 17:1767-76. 2003
    ....
  56. ncbi request reprint Ciliary neurotrophic factor and leptin induce distinct patterns of immediate early gene expression in the brain
    Joseph F Kelly
    Department of Medicine and Division of Endocrinology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02115, USA
    Diabetes 53:911-20. 2004
    ..Our findings support the hypothesis that CNTF and leptin engage distinct CNS sites and CNTF possesses inflammatory properties distinct from leptin...
  57. pmc Glomerular and tubular epithelial defects in kd/kd mice lead to progressive renal failure
    Michael P Madaio
    Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, 19104, USA
    Am J Nephrol 25:604-10. 2005
    ..Recent identification of the mutant gene and the observation that podocytes are affected, led to the hypothesis that there are primary renal epithelial cell defects in this strain...
  58. ncbi request reprint Obesity epidemic in need of answers
    Rexford S Ahima
    Gastroenterology 131:991. 2006
  59. ncbi request reprint Foxa2 integrates the transcriptional response of the hepatocyte to fasting
    Liping Zhang
    Department of Genetics, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Cell Metab 2:141-8. 2005
    ..We conclude that Foxa2 is required for execution of the hepatic gluconeogenic program by integrating the transcriptional response of the hepatocyte to hormonal stimulation...
  60. ncbi request reprint Insulin resistance: cause or consequence of nonalcoholic steatohepatitis?
    Rexford S Ahima
    Gastroenterology 132:444-6. 2007
  61. pmc Effects of TNF-alpha neutralization on adipocytokines and skeletal muscle adiposity in the metabolic syndrome
    Janet Lo
    Program in Nutritional Metabolism, Massachusetts General Hospital, 55 Fruit St, LON207, Boston, MA 02114, USA
    Am J Physiol Endocrinol Metab 293:E102-9. 2007
    ..These findings may help to explain the lack of effect on insulin sensitivity and extend our knowledge of the biological effects of TNF-alpha neutralization in obesity...
  62. pmc Adiponectin selectively inhibits oxytocin neurons of the paraventricular nucleus of the hypothalamus
    Ted D Hoyda
    Department of Physiology, Faculty of Life Sciences, Queen s University, 18 Stuart Street, Kingston, Ontario, Canada
    J Physiol 585:805-16. 2007
    ....

Research Grants11

  1. CNS Action of Appetite Suppressant Aminosterol
    Rexford Ahima; Fiscal Year: 2009
    ..Understanding of the central neuronal actions MSI-1436 may elucidate novel targets for the treatment of obesity and related diseases. ..
  2. CNS Action of Appetite Suppressant Aminosterol
    Rexford Ahima; Fiscal Year: 2004
    ..New pathways affected by MSI-1436 may elucidate novel cellular targets for the treatment of obesity. ..
  3. CNS Action of Appetite Suppressant Aminosterol
    Rexford S Ahima; Fiscal Year: 2010
    ..Understanding of the central neuronal actions MSI-1436 may elucidate novel targets for the treatment of obesity and related diseases. ..