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Species | Hector C AguilarSummaryAffiliation: University of California Country: USA Publications
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Publications
A novel receptor-induced activation site in the Nipah virus attachment glycoprotein (G) involved in triggering the fusion glycoprotein (F)Hector C Aguilar
Department of Microbiology, Immunology, and Molecular Genetics, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
J Biol Chem 284:1628-35. 2009..In sum, we implicate the coordinated interaction between the base of NiV-G globular head domain and the stalk domain in mediating receptor-induced F triggering during viral entry...- A quantitative and kinetic fusion protein-triggering assay can discern distinct steps in the nipah virus membrane fusion cascadeHector C Aguilar
Department of Microbiology, Immunology and Molecular Genetics, David Geffen School of Medicine, UCLA, Los Angeles, California 90095, USA
J Virol 84:8033-41. 2010..Thus, our results reveal multiple critical parameters that govern the paramyxovirus fusion cascade, and our assays should help efforts to elucidate other class I membrane fusion processes... - Endothelial galectin-1 binds to specific glycans on nipah virus fusion protein and inhibits maturation, mobility, and function to block syncytia formationOmai B Garner
Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California, United States of America
PLoS Pathog 6:e1000993. 2010..These studies identify a unique set of mechanisms for regulating pathophysiology of NiV infection at the level of the target cell... - Polybasic KKR motif in the cytoplasmic tail of Nipah virus fusion protein modulates membrane fusion by inside-out signalingHector C Aguilar
Department of Microbiology, Immunology, and Molecular Genetics, David Geffen School of Medicine, University of California at Los Angeles, 609 Charles E Young Drive East, Los Angeles, CA 90095, USA
J Virol 81:4520-32. 2007..007, r(2) = 0.82). In toto, our data suggest that inside-out signaling by specific residues in the cytoplasmic tail of NiV-F can modulate its fusogenicity by multiple distinct mechanisms... - N-glycans on Nipah virus fusion protein protect against neutralization but reduce membrane fusion and viral entryHector C Aguilar
Department of MIMG, David Geffen Schoo of Medicine at UCLA, Los Angeles, CA 90095, USA
J Virol 80:4878-89. 2006..These features underscore the varied roles that N-glycans on NiV-F play in the pathobiology of NiV entry but also shed light on the general mechanisms of paramyxovirus fusion with host cells... - Two key residues in ephrinB3 are critical for its use as an alternative receptor for Nipah virusOscar A Negrete
Department of Microbiology, Immunology and Molecular Genetics, David Geffen School of Medicine, University of California Los Angeles, California, USA
PLoS Pathog 2:e7. 2006..Thus, ephrinB3 is a bona fide alternate receptor for NiV entry, and two residues in the G-H loop of the ephrin B-class ligands are critical determinants of NiV receptor activity... - Single amino acid changes in the Nipah and Hendra virus attachment glycoproteins distinguish ephrinB2 from ephrinB3 usageOscar A Negrete
Department of Microbiology, Immunology and Molecular Genetics, UCLA AIDS Institute, 609 Charles Young Dr, 3825 Molecular Science Building, Los Angeles, CA 90095, USA
J Virol 81:10804-14. 2007..Characterizing the determinants of ephrinB2 versus -B3 usage will further our understanding of henipavirus pathogenesis... 
EphrinB2 is the entry receptor for Nipah virus, an emergent deadly paramyxovirusOscar A Negrete
Department of Microbiology, Immunology and Molecular Genetics, UCLA, Los Angeles, California 90095, USA
Nature 436:401-5. 2005..Cumulatively, our data show that ephrinB2 is a functional receptor for NiV...- A broad-spectrum antiviral targeting entry of enveloped virusesMike C Wolf
Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, CA 90025, USA
Proc Natl Acad Sci U S A 107:3157-62. 2010..In sum, our data reveal a class of broad-spectrum antivirals effective against enveloped viruses that target the viral lipid membrane and compromises its ability to mediate virus-cell fusion... - Emerging paramyxoviruses: molecular mechanisms and antiviral strategiesHector C Aguilar
Department of Microbiology, Immunology and Molecular Genetics, University of California Los Angeles, CA 90095, USA
Expert Rev Mol Med 13:e6. 2011..This review focuses on the molecular mechanisms discovered and the antiviral strategies pursued in recent years for emerging paramyxoviruses, with particular emphasis on viral entry and exit mechanisms... - A catalytically and genetically optimized beta-lactamase-matrix based assay for sensitive, specific, and higher throughput analysis of native henipavirus entry characteristicsMike C Wolf
Department of Microbiology, Immunology, and Molecular Genetics, UCLA, Los Angeles, CA, USA 90095
Virol J 6:119. 2009..In toto, these methods will provide a more biologically relevant assay for studying henipavirus entry at less than BSL-4 conditions... - Novel innate immune functions for galectin-1: galectin-1 inhibits cell fusion by Nipah virus envelope glycoproteins and augments dendritic cell secretion of proinflammatory cytokinesErnest L Levroney
Department of Microbiology, Immunology, and Molecular Genetics, David Geffen School of Medicine at University of California, Los Angeles, CA 90095, USA
J Immunol 175:413-20. 2005..Thus, gal-1 may have direct antiviral effects and may also augment the innate immune response against this emerging pathogen...