Hector C Aguilar

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc A novel receptor-induced activation site in the Nipah virus attachment glycoprotein (G) involved in triggering the fusion glycoprotein (F)
    Hector C Aguilar
    Department of Microbiology, Immunology, and Molecular Genetics, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
    J Biol Chem 284:1628-35. 2009
  2. pmc A quantitative and kinetic fusion protein-triggering assay can discern distinct steps in the nipah virus membrane fusion cascade
    Hector C Aguilar
    Department of Microbiology, Immunology and Molecular Genetics, David Geffen School of Medicine, UCLA, Los Angeles, California 90095, USA
    J Virol 84:8033-41. 2010
  3. pmc Endothelial galectin-1 binds to specific glycans on nipah virus fusion protein and inhibits maturation, mobility, and function to block syncytia formation
    Omai B Garner
    Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California, United States of America
    PLoS Pathog 6:e1000993. 2010
  4. pmc Polybasic KKR motif in the cytoplasmic tail of Nipah virus fusion protein modulates membrane fusion by inside-out signaling
    Hector C Aguilar
    Department of Microbiology, Immunology, and Molecular Genetics, David Geffen School of Medicine, University of California at Los Angeles, 609 Charles E Young Drive East, Los Angeles, CA 90095, USA
    J Virol 81:4520-32. 2007
  5. pmc N-glycans on Nipah virus fusion protein protect against neutralization but reduce membrane fusion and viral entry
    Hector C Aguilar
    Department of MIMG, David Geffen Schoo of Medicine at UCLA, Los Angeles, CA 90095, USA
    J Virol 80:4878-89. 2006
  6. pmc Two key residues in ephrinB3 are critical for its use as an alternative receptor for Nipah virus
    Oscar A Negrete
    Department of Microbiology, Immunology and Molecular Genetics, David Geffen School of Medicine, University of California Los Angeles, California, USA
    PLoS Pathog 2:e7. 2006
  7. pmc Single amino acid changes in the Nipah and Hendra virus attachment glycoproteins distinguish ephrinB2 from ephrinB3 usage
    Oscar A Negrete
    Department of Microbiology, Immunology and Molecular Genetics, UCLA AIDS Institute, 609 Charles Young Dr, 3825 Molecular Science Building, Los Angeles, CA 90095, USA
    J Virol 81:10804-14. 2007
  8. ncbi request reprint EphrinB2 is the entry receptor for Nipah virus, an emergent deadly paramyxovirus
    Oscar A Negrete
    Department of Microbiology, Immunology and Molecular Genetics, UCLA, Los Angeles, California 90095, USA
    Nature 436:401-5. 2005
  9. pmc A broad-spectrum antiviral targeting entry of enveloped viruses
    Mike C Wolf
    Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, CA 90025, USA
    Proc Natl Acad Sci U S A 107:3157-62. 2010
  10. pmc Emerging paramyxoviruses: molecular mechanisms and antiviral strategies
    Hector C Aguilar
    Department of Microbiology, Immunology and Molecular Genetics, University of California Los Angeles, CA 90095, USA
    Expert Rev Mol Med 13:e6. 2011

Collaborators

Detail Information

Publications13

  1. pmc A novel receptor-induced activation site in the Nipah virus attachment glycoprotein (G) involved in triggering the fusion glycoprotein (F)
    Hector C Aguilar
    Department of Microbiology, Immunology, and Molecular Genetics, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
    J Biol Chem 284:1628-35. 2009
    ..In sum, we implicate the coordinated interaction between the base of NiV-G globular head domain and the stalk domain in mediating receptor-induced F triggering during viral entry...
  2. pmc A quantitative and kinetic fusion protein-triggering assay can discern distinct steps in the nipah virus membrane fusion cascade
    Hector C Aguilar
    Department of Microbiology, Immunology and Molecular Genetics, David Geffen School of Medicine, UCLA, Los Angeles, California 90095, USA
    J Virol 84:8033-41. 2010
    ..Thus, our results reveal multiple critical parameters that govern the paramyxovirus fusion cascade, and our assays should help efforts to elucidate other class I membrane fusion processes...
  3. pmc Endothelial galectin-1 binds to specific glycans on nipah virus fusion protein and inhibits maturation, mobility, and function to block syncytia formation
    Omai B Garner
    Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California, United States of America
    PLoS Pathog 6:e1000993. 2010
    ..These studies identify a unique set of mechanisms for regulating pathophysiology of NiV infection at the level of the target cell...
  4. pmc Polybasic KKR motif in the cytoplasmic tail of Nipah virus fusion protein modulates membrane fusion by inside-out signaling
    Hector C Aguilar
    Department of Microbiology, Immunology, and Molecular Genetics, David Geffen School of Medicine, University of California at Los Angeles, 609 Charles E Young Drive East, Los Angeles, CA 90095, USA
    J Virol 81:4520-32. 2007
    ..007, r(2) = 0.82). In toto, our data suggest that inside-out signaling by specific residues in the cytoplasmic tail of NiV-F can modulate its fusogenicity by multiple distinct mechanisms...
  5. pmc N-glycans on Nipah virus fusion protein protect against neutralization but reduce membrane fusion and viral entry
    Hector C Aguilar
    Department of MIMG, David Geffen Schoo of Medicine at UCLA, Los Angeles, CA 90095, USA
    J Virol 80:4878-89. 2006
    ..These features underscore the varied roles that N-glycans on NiV-F play in the pathobiology of NiV entry but also shed light on the general mechanisms of paramyxovirus fusion with host cells...
  6. pmc Two key residues in ephrinB3 are critical for its use as an alternative receptor for Nipah virus
    Oscar A Negrete
    Department of Microbiology, Immunology and Molecular Genetics, David Geffen School of Medicine, University of California Los Angeles, California, USA
    PLoS Pathog 2:e7. 2006
    ..Thus, ephrinB3 is a bona fide alternate receptor for NiV entry, and two residues in the G-H loop of the ephrin B-class ligands are critical determinants of NiV receptor activity...
  7. pmc Single amino acid changes in the Nipah and Hendra virus attachment glycoproteins distinguish ephrinB2 from ephrinB3 usage
    Oscar A Negrete
    Department of Microbiology, Immunology and Molecular Genetics, UCLA AIDS Institute, 609 Charles Young Dr, 3825 Molecular Science Building, Los Angeles, CA 90095, USA
    J Virol 81:10804-14. 2007
    ..Characterizing the determinants of ephrinB2 versus -B3 usage will further our understanding of henipavirus pathogenesis...
  8. ncbi request reprint EphrinB2 is the entry receptor for Nipah virus, an emergent deadly paramyxovirus
    Oscar A Negrete
    Department of Microbiology, Immunology and Molecular Genetics, UCLA, Los Angeles, California 90095, USA
    Nature 436:401-5. 2005
    ..Cumulatively, our data show that ephrinB2 is a functional receptor for NiV...
  9. pmc A broad-spectrum antiviral targeting entry of enveloped viruses
    Mike C Wolf
    Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, CA 90025, USA
    Proc Natl Acad Sci U S A 107:3157-62. 2010
    ..In sum, our data reveal a class of broad-spectrum antivirals effective against enveloped viruses that target the viral lipid membrane and compromises its ability to mediate virus-cell fusion...
  10. pmc Emerging paramyxoviruses: molecular mechanisms and antiviral strategies
    Hector C Aguilar
    Department of Microbiology, Immunology and Molecular Genetics, University of California Los Angeles, CA 90095, USA
    Expert Rev Mol Med 13:e6. 2011
    ..This review focuses on the molecular mechanisms discovered and the antiviral strategies pursued in recent years for emerging paramyxoviruses, with particular emphasis on viral entry and exit mechanisms...
  11. pmc A mechanistic paradigm for broad-spectrum antivirals that target virus-cell fusion
    Frederic Vigant
    Department of Microbiology, Immunology and Molecular Genetics, University of California Los Angeles, Los Angeles, California, United States of America
    PLoS Pathog 9:e1003297. 2013
    ..01) delayed the time to death in a murine lethal challenge model of Rift Valley Fever Virus (RVFV). The viral membrane may be a viable target for broad-spectrum antivirals that target virus-cell fusion...
  12. pmc A catalytically and genetically optimized beta-lactamase-matrix based assay for sensitive, specific, and higher throughput analysis of native henipavirus entry characteristics
    Mike C Wolf
    Department of Microbiology, Immunology, and Molecular Genetics, UCLA, Los Angeles, CA, USA 90095
    Virol J 6:119. 2009
    ..In toto, these methods will provide a more biologically relevant assay for studying henipavirus entry at less than BSL-4 conditions...
  13. ncbi request reprint Novel innate immune functions for galectin-1: galectin-1 inhibits cell fusion by Nipah virus envelope glycoproteins and augments dendritic cell secretion of proinflammatory cytokines
    Ernest L Levroney
    Department of Microbiology, Immunology, and Molecular Genetics, David Geffen School of Medicine at University of California, Los Angeles, CA 90095, USA
    J Immunol 175:413-20. 2005
    ..Thus, gal-1 may have direct antiviral effects and may also augment the innate immune response against this emerging pathogen...