Research Topics
| R AdolphsSummaryAffiliation: University of Iowa Country: USA Publications
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Publications
Intact recognition of facial emotion in Parkinson's diseaseR Adolphs
Department of Neurology, University of Iowa College of Medicine, Iowa City 52242, USA
Neuropsychology 12:253-8. 1998..The findings do not support the notion that the sectors of basal ganglia that are dysfunctional in Parkinson's disease are essential for recognizing emotion in facial expressions...- Hemispheric perception of emotional valence from facial expressionsR Adolphs
Department of Neurology, University of Iowa College of Medicine, USA
Neuropsychology 15:516-24. 2001..The authors suggest that perception of negative valence relies preferentially on the right hemisphere, whereas perception of positive valence relies on both left and right hemispheres... - Neural systems for recognizing emotionRalph Adolphs
Division of Cognitive Neuroscience, Department of Neurology, 200 Hawkins Drive, University of Iowa College of Medicine, 52242, USA
Curr Opin Neurobiol 12:169-77. 2002..Two important mechanisms for recognition of emotions are the construction of a simulation of the observed emotion in the perceiver, and the modulation of sensory cortices via top-down influences... - Investigating the cognitive neuroscience of social behaviorRalph Adolphs
Department of Neurology, University of Iowa College of Medicine, 200 Hawkins Drive, Iowa City, IA 52242, USA
Neuropsychologia 41:119-26. 2003..These issues can be addressed, in part, by giving theory and experiment equal time, and by fostering an interdisciplinary approach that includes neuroscience, psychology, philosophy, anthropology and allied disciplines... - Impaired recognition of social emotions following amygdala damageRalph Adolphs
Department of Neurology, University of Iowa, Iowa City 52242, USA
J Cogn Neurosci 14:1264-74. 2002..The results also provide further support for the idea that some of the impairments in social cognition seen in patients with autism may result from dysfunction of the amygdala... - Cognitive neuroscience of human social behaviourRalph Adolphs
Deparment of Neurology, University of Iowa, 200 Hawkins Drive, Iowa City, Iowa 52242, USA
Nat Rev Neurosci 4:165-78. 2003..No less important are the links that are also being established across disciplines to understand social behaviour, as neuroscientists, social psychologists, anthropologists, ethologists and philosophers forge new collaborations... - Is the human amygdala specialized for processing social information?Ralph Adolphs
Department of Neurology, Division of Cognitive Neuroscience, University of Iowa College of Medicine, Iowa City, Iowa 52242, USA
Ann N Y Acad Sci 985:326-40. 2003..While the issue is unresolved, future experiments could provide additional support... - Amygdala damage impairs emotion recognition from scenes only when they contain facial expressionsRalph Adolphs
Department of Neurology, Division of Cognitive Neuroscience, University Hospitals and Clinics, University of Iowa, 200 Hawkins Drive, Iowa City, IA 52242, USA
Neuropsychologia 41:1281-9. 2003..Bilateral amygdala damage thus disproportionately impairs recognition of certain emotions from complex visual stimuli when subjects utilize information from facial expressions... - Recognizing emotion from facial expressions: psychological and neurological mechanismsRalph Adolphs
University of Iowa College of Medicine, USA
Behav Cogn Neurosci Rev 1:21-62. 2002..Although recent studies have provided a wealth of detail regarding these mechanisms in the adult human brain, investigations are also being extended to nonhuman primates, to infants, and to patients with psychiatric disorders... - Dissociable neural systems for recognizing emotionsRalph Adolphs
Department of Neurology, Division of Cognitive Neuroscience, University of Iowa College of Medicine, Iowa City, IA 52242, USA
Brain Cogn 52:61-9. 2003..Thus the retrieval of knowledge regarding emotions draws upon widely distributed and partly distinct sets of neural structures, depending on the attributes of the stimulus... - Neural systems for recognition of emotional prosody: a 3-D lesion studyRalph Adolphs
Department of Neurology, University of Iowa College of Medicine, Iowa City 52242, USA
Emotion 2:23-51. 2002..Furthermore, there were regions in the left and right temporal lobes that contributed disproportionately to recognition of emotion from faces or prosody, respectively... - The amygdala's role in long-term declarative memory for gist and detailR Adolphs
Department of Neurology, University of Iowa College of Medicine, Iowa City 52242, USA
Behav Neurosci 115:983-92. 2001..The pattern of findings provides preliminary support for the idea that the amygdala may help filter the encoding of relevant information from stimuli that signal threat or danger... - Emotion recognition from faces and prosody following temporal lobectomyR Adolphs
Department of Neurology, University of Iowa, Iowa City 52242, USA
Neuropsychology 15:396-404. 2001..Consistent with some prior studies, these findings support a role for the right anteromedial temporal lobe (including amygdala) in recognizing emotion from faces but caution in drawing conclusions from small group samples... - The human amygdala in social judgmentR Adolphs
Department of Neurology, University of Iowa College of Medicine, Iowa City 52242, USA
Nature 393:470-4. 1998..The amygdala appears to be an important component of the neural systems that help retrieve socially relevant knowledge on the basis of facial appearance... - Recognition of facial emotion in nine individuals with bilateral amygdala damageR Adolphs
Department of Neurology, University of Iowa College of Medicine, Iowa City 52242, USA
Neuropsychologia 37:1111-7. 1999.... - Intact recognition of emotional prosody following amygdala damageR Adolphs
Department of Neurology, University of Iowa College of Medicine, Iowa City, USA
Neuropsychologia 37:1285-92. 1999..It remains possible that recognition of emotion in classes of auditory stimuli other than prosody will require the amygdala... - Preferences for visual stimuli following amygdala damageR Adolphs
Department of Neurology, University of Iowa, 200 Hawkins Dr, Iowa City, IA 52242, USA
J Cogn Neurosci 11:610-6. 1999..The impairment was most pronounced in regard to those stimuli that are normally liked the least. The human amygdala thus appears to play a general role in guiding preferences for visual stimuli that are normally judged to be aversive... - A role for somatosensory cortices in the visual recognition of emotion as revealed by three-dimensional lesion mappingR Adolphs
Department of Neurology, Division of Cognitive Neuroscience, University of Iowa College of Medicine, Iowa City, Iowa 52242, USA
J Neurosci 20:2683-90. 2000..Right somatosensory-related cortices thus constitute an additional critical component that functions together with structures such as the amygdala and right visual cortices in retrieving socially relevant information from faces... 
Impaired emotional declarative memory following unilateral amygdala damageR Adolphs
Department of Neurology, Division of Cognitive Neuroscience, University of Iowa College of Medicine, Iowa City, Iowa 52242, USA
Learn Mem 7:180-6. 2000..We stress the complex and temporally extended nature of memory consolidation and suggest that the amygdala may influence specific components of this process...- The neurobiology of social cognitionR Adolphs
The University of Iowa, Department of Neurology, Division of Cognitive Neuroscience, 200 Hawkins Drive, Iowa City, IA 52242, USA
Curr Opin Neurobiol 11:231-9. 2001..Open questions remain about the domain-specificity of social cognition, about its overlap with emotion and with communication, and about the methods best suited for its investigation... - Abnormal processing of social information from faces in autismR Adolphs
Department of Neurology, University of Iowa Hospitals and Clinics, University of Iowa, Iowa City, 52242, USA
J Cogn Neurosci 13:232-40. 2001..We suggest that amygdala dysfunction in autism might contribute to an impaired ability to link visual perception of socially relevant stimuli with retrieval of social knowledge and with elicitation of social behavior... - Verbal and nonverbal emotional memory following unilateral amygdala damageT W Buchanan
Department of Neurology, Division of Cognitive Neuroscience, University of Iowa, College of Medicine, Iowa City, Iowa 52242, USA
Learn Mem 8:326-35. 2001..The latter finding offers partial support for a lateralized and material-specific pattern of the amygdala's contribution to emotional memory... - Single-neuron responses to emotional visual stimuli recorded in human ventral prefrontal cortexH Kawasaki
Department of Neurology, Division of Cognitive Neuroscience, University Hospitals and Clinics, 200 Hawkins Drive, Iowa City, Iowa 52242, USA
Nat Neurosci 4:15-6. 2001..Recording from neurons within healthy tissue in ventral sites of the right prefrontal cortex, we found short-latency (120-160 ms) responses selective for aversive visual stimuli... - The neuroanatomical correlates of route learning impairmentJ Barrash
Department of Neurology, Division of Behavioral Neurology and Cognitive Neuroscience, University of Iowa College of Medicine, 200 Hawkins Drive, Iowa City, IA, USA
Neuropsychologia 38:820-36. 2000..e., the appearance of places and spatial relationships between specific places), and consolidating that representation into multifaceted contextual knowledge of the environment... - A mechanism for impaired fear recognition after amygdala damageRalph Adolphs
Department of Neurology, University of Iowa, Iowa City, Iowa 52242, USA
Nature 433:68-72. 2005..This finding provides a mechanism to explain the amygdala's role in fear recognition, and points to new approaches for the possible rehabilitation of patients with defective emotion perception... - Impaired judgments of sadness but not happiness following bilateral amygdala damageRalph Adolphs
University of Iowa, Iowa, USA
J Cogn Neurosci 16:453-62. 2004..The findings suggest that the amygdala's role in processing of emotional facial expressions encompasses multiple negatively valenced emotions, including fear and sadness... - Damage to association fiber tracts impairs recognition of the facial expression of emotionCarissa L Philippi
Laboratory of Brain Imaging and Cognitive Neuroscience, Department of Neurology, Division of Behavioral Neurology and Cognitive Neuroscience, University of Iowa College of Medicine, Iowa City, Iowa 52242, USA
J Neurosci 29:15089-99. 2009..Our findings demonstrate the key role of white matter association tracts in the recognition of the facial expression of emotion and identify specific tracts that may be most critical... - Memories for emotional autobiographical events following unilateral damage to medial temporal lobeTony W Buchanan
Division of Cognitive Neuroscience, Department of Neurology, University of Iowa, Iowa City, IA 52242, USA
Brain 129:115-27. 2006..This finding is consistent with the notion that the right, but not the left, anteromedial temporal lobe is involved in the retrieval of negatively valenced, high-intensity memories... - The influence of autonomic arousal and semantic relatedness on memory for emotional wordsTony W Buchanan
Department of Neurology, University of Iowa, 200 Hawkins Drive, Iowa City, IA 52242, USA
Int J Psychophysiol 61:26-33. 2006..Relatedness confers an advantage to memory (as in the school-words), but the combination of relatedness and arousal (as in the taboo words) results in the best memory performance... - Emotional autobiographical memories in amnesic patients with medial temporal lobe damageTony W Buchanan
Division of Cognitive Neuroscience, Department of Neurology, University of Iowa, Iowa City, Iowa 52242, USA
J Neurosci 25:3151-60. 2005..The amygdala and surrounding cortices of the medial temporal lobe may be a necessary component in the neural circuitry necessary for vivid recollection of unpleasant emotional events... - Impaired memory retrieval correlates with individual differences in cortisol response but not autonomic responseTony W Buchanan
Department of Neurology, University of Iowa, Iowa City, Iowa 52242, USA
Learn Mem 13:382-7. 2006..These results suggest that individual differences in cortisol reactivity affect memory retrieval performance, and help to explain the differential effects of stress on memory... - The human amygdala and the induction and experience of fearJustin S Feinstein
University of Iowa, Iowa City, IA 52242, USA
Curr Biol 21:34-8. 2011..The findings support the conclusion that the human amygdala plays a pivotal role in triggering a state of fear and that the absence of such a state precludes the experience of fear itself... - Altered experience of emotion following bilateral amygdala damageDaniel Tranel
University of Iowa College of Medicine, Iowa City, Iowa 52242, USA
Cogn Neuropsychiatry 11:219-32. 2006..Bauman, Lavenex, Mason, Capitanio, & Amaral, 2004a), and they provide valuable insights into the emotional life of an individual with complete bilateral amygdala damage... - A neuroanatomical dissociation for emotion induced by musicErica L Johnsen
Department of Neurology, Division of Behavioral Neurology and Cognitive Neuroscience, University of Iowa College of Medicine, 200 Hawkins Drive, Iowa City, IA 52242, USA
Int J Psychophysiol 72:24-33. 2009..The findings provide evidence for a double dissociation between feeling emotions and autonomic responses to emotions, in response to music stimuli... - Manifestation of ocular-muscle EMG contamination in human intracranial recordingsChristopher K Kovach
Department of Neurosurgery, The University of Iowa College of Medicine, Iowa City, IA 52242, USA
Neuroimage 54:213-33. 2011..We conclude that eye movement-related contamination should be ruled out when reporting high gamma responses in human intracranial recordings, especially those obtained near anterior and medial temporal lobe... - Dominance attributions following damage to the ventromedial prefrontal cortexMatthew S Karafin
University of Iowa, USA
J Cogn Neurosci 16:1796-804. 2004.... - Evidence for preserved emotional memory in normal older personsNatalie L Denburg
University of Iowa College of Medicine, Department of Neurology, Division of Cognitive Neuroscience, Iowa City, 52242, US
Emotion 3:239-53. 2003..The results raise the interesting possibility that aging has a differential effect on hippocampal versus amygdala function... - A specific role for the human amygdala in olfactory memoryTony W Buchanan
Department of Neurology, University of Iowa, Iowa City, Iowa 52242, USA
Learn Mem 10:319-25. 2003..Taken together, the data provide neuropsychological evidence that the human amygdala is essential for olfactory memory... - Selective effects of triazolam on memory for emotional, relative to neutral, stimuli: differential effects on gist versus detailTony W Buchanan
Department of Neurology, University of Iowa College of Medicine, 200 Hawkins Drive, Iowa City, Iowa 52242, USA
Behav Neurosci 117:517-25. 2003..This pattern of performance is similar to that seen in patients with amygdala damage. Results suggest an effect of GABAergic neurotransmission at the level of the amygdala on memory modulation... - Anteromedial temporal lobe damage blocks startle modulation by fear and disgustTony W Buchanan
Division of Cognitive Neuroscience, Department of Neurology, University of Iowa, Iowa City, IA 52242, USA
Behav Neurosci 118:429-37. 2004..The findings suggest that potentiation of the ASR by disgust and fear depends on the integrity of the anteromedial temporal lobe... - Electrophysiological responses in the human amygdala discriminate emotion categories of complex visual stimuliHiroyuki Oya
Department of Neurology, University of Iowa College of Medicine, Iowa City, Iowa 52242, USA
J Neurosci 22:9502-12. 2002.... - Neural systems behind word and concept retrievalH Damasio
Department of Neurology, Division of Behavioral Neurology and Cognitive Neuroscience, University of Iowa College of Medicine, Iowa City, IA 52242, USA
Cognition 92:179-229. 2004..By comparing different approaches the article also addresses a number of method issues that have surfaced in recent studies in this field... - Detestable or marvelous? Neuroanatomical correlates of character judgmentsKatie E Croft
Department of Neurology, Division of Behavioral Neurology and Cognitive Neuroscience, University of Iowa College of Medicine, IA, USA
Neuropsychologia 48:1789-801. 2010.... - Cortical regions for judgments of emotions and personality traits from point-light walkersAndrea S Heberlein
University of Iowa, USA
J Cogn Neurosci 16:1143-58. 2004..These findings suggest that attributions of emotional states and personality traits are accomplished by partially dissociable neural systems... - Impaired spontaneous anthropomorphizing despite intact perception and social knowledgeAndrea S Heberlein
Neuroscience Graduate Program, University of Iowa, Iowa City, IA 52242, USA
Proc Natl Acad Sci U S A 101:7487-91. 2004.... - Analysis of single-unit responses to emotional scenes in human ventromedial prefrontal cortexHiroto Kawasaki
University of Iowa College of Medicine, USA
J Cogn Neurosci 17:1509-18. 2005..The findings suggest sparse and widely distributed processing of emotional value in the prefrontal cortex, with a predominance of responses to aversive stimuli... - Damage to the prefrontal cortex increases utilitarian moral judgementsMichael Koenigs
Department of Neurology, University of Iowa Hospitals and Clinics, Iowa City, Iowa 52242, USA
Nature 446:908-11. 2007..These findings indicate that, for a selective set of moral dilemmas, the VMPC is critical for normal judgements of right and wrong. The findings support a necessary role for emotion in the generation of those judgements... - Preferring one taste over another without recognizing eitherRalph Adolphs
Department of Neurology and Neuroscience Graduate Program, The University of Iowa, 200 Hawkins Drive, Iowa City, Iowa 52242, USA
Nat Neurosci 8:860-1. 2005..The pattern of brain damage responsible for the dissociation suggests that reliable behavioral choice among tastes can occur in the absence of the gustatory cortex necessary for taste recognition... - Electrophysiological correlates of reward prediction error recorded in the human prefrontal cortexHiroyuki Oya
Department of Neurosurgery and Neurology, University of Iowa College of Medicine, Iowa City, IA 52242, USA
Proc Natl Acad Sci U S A 102:8351-6. 2005..The finding implicates this brain region in the acquisition of choice bias by means of a continuous updating of expectations about reward and punishment... - Amygdala damage impairs eye contact during conversations with real peopleMichael L Spezio
Division of the Humanities and Social Sciences, California Institute of Technology, Pasadena, California 91125, USA
J Neurosci 27:3994-7. 2007..These novel findings from real social interactions are consistent with an hypothesized role for the amygdala in autism and the approach taken here opens up new directions for quantifying social behavior in humans... - Orienting to social stimuli differentiates social cognitive impairment in autism and schizophreniaNoah Sasson
University of North Carolina at Chapel Hill, Neurodevelopmental Disorders Research Center, Chapel Hill, NC 27599 3366, USA
Neuropsychologia 45:2580-8. 2007..Impairments in social orienting are discussed within the context of evidence suggesting the role of the amygdala in orienting to emotionally meaningful information... - Spared ability to recognise fear from static and moving whole-body cues following bilateral amygdala damageAnthony P Atkinson
Department of Psychology, Durham University, Science Laboratories, South Road, Durham DH1 3LE, UK
Neuropsychologia 45:2772-82. 2007..Thus, whatever the role of the amygdala in processing whole-body fear cues, it is apparently not necessary for the normal recognition of fear from either static or dynamic body expressions... - Contributions of the amygdala to reward expectancy and choice signals in human prefrontal cortexAlan N Hampton
Computation and Neural Systems Program, California Institute of Technology, Pasadena, CA 91125, USA
Neuron 55:545-55. 2007..These findings support a critical role for the human amygdala in establishing expected reward representations in PFC, which in turn may be used to guide behavioral choice... - Distinct face-processing strategies in parents of autistic childrenRalph Adolphs
California Institute of Technology, Pasadena, California 91125, USA
Curr Biol 18:1090-3. 2008.... - EMPATH: a neural network that categorizes facial expressionsMatthew N Dailey
Computer Science and Engineering, University of California, San Diego 92093, USA
J Cogn Neurosci 14:1158-73. 2002..We thus explain many of the seemingly complex psychological phenomena related to facial expression perception as natural consequences of the tasks' implementations in the brain... - Trust in the brainRalph Adolphs
Nat Neurosci 5:192-3. 2002 - Neuroanatomical substrates of social cognition dysfunction in autismKevin Pelphrey
Department of Psychiatry, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC 27710, USA
Ment Retard Dev Disabil Res Rev 10:259-71. 2004..We conclude with a discussion of several potential future directions in the cognitive neuroscience of social deficits in autism... - Looking at other people: mechanisms for social perception revealed in subjects with focal amygdala damageRalph Adolphs
Division of Humanities and Social Sciences, California Institute of Technology, Pasadena, CA 91125, USA
Novartis Found Symp 278:146-59; discussion 160-4, 216-21. 2007..Ongoing studies in our laboratory examine face-to-face social interactions with real people in an attempt to link the above impairments in the laboratory to the dysfunctional social cognition seen in everyday life... - Emotional arousal in agenesis of the corpus callosumLynn K Paul
California Institute of Technology, Division of Humanities and Social Sciences, CA 91125, USA
Int J Psychophysiol 61:47-56. 2006.... - Cardiovascular and respiratory responses during musical mood inductionJoset A Etzel
Iowa State University, 2274 Howe Hall, Room 1620, VRAC, Ames, IA 50011 2274, USA
Int J Psychophysiol 61:57-69. 2006.... - Perception of socially relevant stimuli in schizophreniaNirav O Bigelow
University of Iowa, Department of Psychiatry, United States
Schizophr Res 83:257-67. 2006..The findings point towards circumscribed domains of impaired social cognition in schizophrenia and suggest specific further hypotheses about the neural dysfunction that may underlie them... - How do we know the minds of others? Domain-specificity, simulation, and enactive social cognitionRalph Adolphs
Division of Humanities and Social Sciences, California Institute of Technology, HSS 228 77, Caltech, Pasadena, CA 91125, USA
Brain Res 1079:25-35. 2006..Experiments from our own laboratory point to the amygdala as one structure that is critically involved in such processes... - Amygdala damage impairs emotional memory for gist but not details of complex stimuliRalph Adolphs
Division of Humanities and Social Sciences, California Institute of Technology, Pasadena, California 91125, USA
Nat Neurosci 8:512-8. 2005..The data support a model whereby the amygdala focuses processing resources on gist, possibly accounting for features of traumatic memories and eyewitness testimony in real life... - Analysis of face gaze in autism using "Bubbles"Michael L Spezio
Division of Humanities and Social Sciences, California Institute of Technology, HSS 228 77, Caltech, Pasadena, CA 91125, USA
Neuropsychologia 45:144-51. 2007..The findings provide novel detail to the abnormal way in which people with autism look at faces, an impairment that likely influences all subsequent face processing... - Emotional responses to unpleasant music correlates with damage to the parahippocampal cortexNathalie Gosselin
Department of Psychology, University of Montreal, Montreal, Quebec, Canada
Brain 129:2585-92. 2006..These findings are consistent with a two-dimensional model of defensive responses to aversive stimuli, in which the PHC and the amygdala subserve different roles... - Processing of the arousal of subliminal and supraliminal emotional stimuli by the human amygdalaJan Gläscher
NeuroImage Nord, Department of Neurology, University Hospital Hamburg Eppendorf, University of Hamburg, D 20246 Hamburg, Germany
J Neurosci 23:10274-82. 2003.... - Abnormal use of facial information in high-functioning autismMichael L Spezio
Division of Humanities and Social Sciences, 228 77, California Institute of Technology, Caltech, Pasadena, CA 91125, USA
J Autism Dev Disord 37:929-39. 2007..These findings provide a novel quantitative assessment of how people with autism utilize information in faces when making social judgments... - Role of the amygdala in processing visual social stimuliRalph Adolphs
Division of the Humanities and Social Sciences, HSS 228 77, California Institute of Technology, Pasadena, CA 91125, USA
Prog Brain Res 156:363-78. 2006..Finally, we argue that the term emotion be broadened to include increased attention to bodily responses and their representation in cortex... - Neural systems responding to degrees of uncertainty in human decision-makingMing Hsu
Division of Humanities and Social Sciences, 228-77, California Institute of Technology, Pasadena, CA 91125, USA
Science 310:1680-3. 2005..Neurological subjects with orbitofrontal lesions were insensitive to the level of ambiguity and risk in behavioral choices. These data suggest a general neural circuit responding to degrees of uncertainty, contrary to decision theory... - Emotional visionRalph Adolphs
Nat Neurosci 7:1167-8. 2004 - Emotion and consciousnessNaotsugu Tsuchiya
California Institute of Technology, HSS 228 77, Caltech, Pasadena, CA 91125, USA
Trends Cogn Sci 11:158-67. 2007..The intersection of consciousness and emotion is ripe for experimental investigation, and we outline possible examples for future studies... - Agenesis of the corpus callosum: genetic, developmental and functional aspects of connectivityLynn K Paul
California Institute of Technology, MC 228 77 Pasadena, California 91125, USA
Nat Rev Neurosci 8:287-99. 2007..The study of AgCC could provide insight into the integrated cerebral functioning of healthy brains, and may offer a model for understanding certain psychiatric illnesses, such as schizophrenia and autism... - Amygdala damage impairs emotion recognition from musicNathalie Gosselin
Department of Psychology, University of Montreal, CP 6128, Succ Centre Ville, Montreal, Que, Canada
Neuropsychologia 45:236-44. 2007..The use of tempo and mode cues in distinguishing happy from sad music was also spared in S.M. Thus, the amygdala appears to be necessary for emotional processing of music rather than the perceptual processing itself...