P N Adler

Summary

Affiliation: University of Virginia
Country: USA

Publications

  1. ncbi request reprint Tissue polarity points from cells that have higher Frizzled levels towards cells that have lower Frizzled levels
    P N Adler
    Biology Department, University of Virginia, Charlottesville, Virginia 22903, USA
    Curr Biol 7:940-9. 1997
  2. pmc dusky-like is required to maintain the integrity and planar cell polarity of hairs during the development of the Drosophila wing
    Paul N Adler
    Biology Department, Institute for Morphogenesis and Regenerative Medicine, University of Virginia, Charlottesville, VA 22903, USA
    Dev Biol 379:76-91. 2013
  3. pmc The frizzled/stan pathway and planar cell polarity in the Drosophila wing
    Paul N Adler
    Biology Department, University of Virginia, Charlottesville, Virginia, USA
    Curr Top Dev Biol 101:1-31. 2012
  4. pmc The frizzled pathway regulates the development of arista laterals
    Biao He
    Biology Department and Cancer Center, Gilmer Hall, University of Virginia, Charlottesville, VA 22903, USA
    BMC Dev Biol 2:7. 2002
  5. pmc The Drosophila Fry protein interacts with Trc and is highly mobile in vivo
    Xiaolan Fang
    Biology Department, Cell Biology Department, Cancer Center, Morphogenesis and Regenerative Medicine Institute, University of Virginia, Charlottesville, VA 22903, USA
    BMC Dev Biol 10:40. 2010
  6. ncbi request reprint Asymmetric cell division: plane but not simple
    P N Adler
    University of Virginia, Department of Biology and Cancer Center, Charlottesville, Virginia 22903, USA
    Curr Biol 11:R233-6. 2001
  7. ncbi request reprint Cell size and the morphogenesis of wing hairs in Drosophila
    P N Adler
    Biology Department and Cancer Center, University of Virginia, Charlottesville, Virginia 22903, USA
    Genesis 28:82-91. 2000
  8. ncbi request reprint Mutations in the cadherin superfamily member gene dachsous cause a tissue polarity phenotype by altering frizzled signaling
    P N Adler
    Biology Department, University of Virginia, Charlottesville, VA 22903, USA
    Development 125:959-68. 1998
  9. ncbi request reprint The domineering non-autonomy of frizzled and van Gogh clones in the Drosophila wing is a consequence of a disruption in local signaling
    P N Adler
    Biology Department and Cancer Center, University of Virginia, Charlottesville 22903, USA
    Mech Dev 96:197-207. 2000
  10. ncbi request reprint Frizzled signaling and cell-cell interactions in planar polarity
    P N Adler
    Biology Department and Cancer Center, Gilmer Hall, University of Virginia, Charlottesville, Virginia 22903, USA
    Curr Opin Cell Biol 13:635-40. 2001

Research Grants

  1. GENETIC CONTROL OF TISSUE POLARITY
    Paul Adler; Fiscal Year: 2001
  2. GENETIC CONTROL OF TISSUE POLARITY
    Paul N Adler; Fiscal Year: 2010
  3. GENETIC ANALYSIS OF PREHAIR MORPHOGENESIS
    Paul Adler; Fiscal Year: 2001
  4. GENETIC ANALYSIS OF PREHAIR MORPHOGENESIS
    Paul Adler; Fiscal Year: 2005
  5. GENETIC CONTROL OF TISSUE POLARITY
    Paul Adler; Fiscal Year: 2005
  6. GENETIC CONTROL OF TISSUE POLARITY
    Paul Adler; Fiscal Year: 2009
  7. GENETIC CONTROL OF TISSUE POLARITY
    Paul Adler; Fiscal Year: 2009
  8. MOLECULAR GENETICS OF THE FZ LOCUS
    Paul Adler; Fiscal Year: 1993

Collaborators

  • Jianqi Liu
  • J Charlton
  • Biao He
  • M Wang
  • L Klein
  • J Yan
  • Nan Ren
  • Xiaolan Fang
  • Ying He
  • Haeryun Lee
  • Qiuheng Lu
  • Kazuo Emoto
  • Yuh Nung Jan
  • Job Taylor
  • W J Park
  • SeYeon Chung
  • W Geng
  • E J Sharp
  • C M Turner
  • Xiaoyin Fei
  • J Cong
  • Kazou Emoto
  • R E Krasnow
  • Jeongbin Yim
  • Jeongsook Yoon
  • Sangjoon Kim
  • Sreenatha Kirakodu
  • J Taylor
  • David Stone
  • Xiaojing Tian
  • Chunming Zhu
  • Wesley B Grueber
  • Lily Yeh Jan
  • Bing Ye
  • E C Martin
  • K H Jones
  • L L Wong
  • N Abramova
  • N A Abramova
  • B P Brunk
  • C R Vinson
  • S Conover

Detail Information

Publications55

  1. ncbi request reprint Tissue polarity points from cells that have higher Frizzled levels towards cells that have lower Frizzled levels
    P N Adler
    Biology Department, University of Virginia, Charlottesville, Virginia 22903, USA
    Curr Biol 7:940-9. 1997
    ..Mutations in components of the fz signal transduction pathway disrupt tissue polarity; on the wing, hairs normally point distally but their polarity is altered by these mutations...
  2. pmc dusky-like is required to maintain the integrity and planar cell polarity of hairs during the development of the Drosophila wing
    Paul N Adler
    Biology Department, Institute for Morphogenesis and Regenerative Medicine, University of Virginia, Charlottesville, VA 22903, USA
    Dev Biol 379:76-91. 2013
    ..We carried out a small directed screen to identify genes that might function with dyl and identified Chitinase 6 (Cht6) as a strong candidate, as knocking down Cht6 function led to weak versions of all of the dyl hair phenotypes...
  3. pmc The frizzled/stan pathway and planar cell polarity in the Drosophila wing
    Paul N Adler
    Biology Department, University of Virginia, Charlottesville, Virginia, USA
    Curr Top Dev Biol 101:1-31. 2012
    ..These complexes appear to recruit downstream proteins that function to spatially restrict the activation of the cytoskeleton in wing cells. This leads to the formation of the array of distally pointing hairs found on wings...
  4. pmc The frizzled pathway regulates the development of arista laterals
    Biao He
    Biology Department and Cancer Center, Gilmer Hall, University of Virginia, Charlottesville, VA 22903, USA
    BMC Dev Biol 2:7. 2002
    ..Selected cells in the arista (the terminal segment of the antenna) elaborate a lateral projection that shares characteristics with both hairs and bristles...
  5. pmc The Drosophila Fry protein interacts with Trc and is highly mobile in vivo
    Xiaolan Fang
    Biology Department, Cell Biology Department, Cancer Center, Morphogenesis and Regenerative Medicine Institute, University of Virginia, Charlottesville, VA 22903, USA
    BMC Dev Biol 10:40. 2010
    ..Tricornered function requires interacting with the large Furry protein (3479 amino acid)...
  6. ncbi request reprint Asymmetric cell division: plane but not simple
    P N Adler
    University of Virginia, Department of Biology and Cancer Center, Charlottesville, Virginia 22903, USA
    Curr Biol 11:R233-6. 2001
    ..The orientation of these divisions is under the control of the Frizzled pathway that generates planar polarity in a number of cell types...
  7. ncbi request reprint Cell size and the morphogenesis of wing hairs in Drosophila
    P N Adler
    Biology Department and Cancer Center, University of Virginia, Charlottesville, Virginia 22903, USA
    Genesis 28:82-91. 2000
    ..We conclude that both of these cellular systems are limited in their ability to scale to accommodate larger cell size...
  8. ncbi request reprint Mutations in the cadherin superfamily member gene dachsous cause a tissue polarity phenotype by altering frizzled signaling
    P N Adler
    Biology Department, University of Virginia, Charlottesville, VA 22903, USA
    Development 125:959-68. 1998
    ..The direction of this domineering nonautonomy was coincident with the direction of the abnormal hair polarity. We conclude that dachsous causes a tissue polarity phenotype because it alters the direction of frizzled signaling...
  9. ncbi request reprint The domineering non-autonomy of frizzled and van Gogh clones in the Drosophila wing is a consequence of a disruption in local signaling
    P N Adler
    Biology Department and Cancer Center, University of Virginia, Charlottesville 22903, USA
    Mech Dev 96:197-207. 2000
    ..We suggest that fz and Vang clones result in altered levels of a locally acting signal and the domineering non-autonomy results from wild-type cells responding to this abnormal signal...
  10. ncbi request reprint Frizzled signaling and cell-cell interactions in planar polarity
    P N Adler
    Biology Department and Cancer Center, Gilmer Hall, University of Virginia, Charlottesville, Virginia 22903, USA
    Curr Opin Cell Biol 13:635-40. 2001
    ..This cortical mark leads to the local activation of downstream gene products and the subsequent activation of the cytoskeleton to form a hair...
  11. ncbi request reprint Inturned localizes to the proximal side of wing cells under the instruction of upstream planar polarity proteins
    Paul N Adler
    Biology Department, Morphogenesis and Regenerative Medicine, Institute and Cancer Center, University of Virginia, Charlottesville, Virginia 22903, USA
    Curr Biol 14:2046-51. 2004
    ..These data indicate that accumulation of proteins at the proximal side of wing cells is a key event for the distal activation of the cytoskeleton to form a hair...
  12. ncbi request reprint Planar signaling and morphogenesis in Drosophila
    Paul N Adler
    Biology Department and Cancer Center, University of Virginia, Charlottesville, VA 22903, USA
    Dev Cell 2:525-35. 2002
    ..A comparison of the function of these gene products in the different cell types suggests cell-specific modifications of the pathway...
  13. ncbi request reprint Frizzled gene expression and development of tissue polarity in the Drosophila wing
    W J Park
    Biology Department, University of Virginia, Charlottesville 22903
    Dev Genet 15:383-9. 1994
    ..We have also found that fz function is not required for normal fz expression. We have further found that mutations in several other tissue polarity genes do not noticeably alter the expression or the modification state of the Fz protein...
  14. ncbi request reprint The cold-sensitive period for frizzled in the development of wing hair polarity ends prior to the start of hair morphogenesis
    P N Adler
    Biology Department, University of Virginia, Charlottesville 22903 2477
    Mech Dev 46:101-7. 1994
    ..Our data argue that fz has a regulatory function in specifying where the prehair forms, but no role in the actual morphogenesis of the prehair...
  15. ncbi request reprint The furry gene of Drosophila is important for maintaining the integrity of cellular extensions during morphogenesis
    J Cong
    Biology Department and Cancer Center, University of Virginia, Charlottesville, VA 22903, USA
    Development 128:2793-802. 2001
    ..We used a P-element insertion allele as a tag to clone the furry gene and found it to be a large and complicated gene that encodes a pair of large conserved proteins of unknown biochemical function...
  16. ncbi request reprint Dishevelled is a component of the frizzled signaling pathway in Drosophila
    R E Krasnow
    Biology Department, University of Virginia, Charlottesville 22903, USA
    Development 121:4095-102. 1995
    ..Our findings suggest that dsh may have a general role in signal transduction, perhaps as a component of a receptor complex...
  17. pmc The tricornered gene, which is required for the integrity of epidermal cell extensions, encodes the Drosophila nuclear DBF2-related kinase
    W Geng
    Biology Department and Cancer Center, University of Virginia, Charlottesville, Virginia 22903, USA
    Genetics 156:1817-28. 2000
    ..This is a conserved ser/thr protein kinase found in Caenorhabditis elegans and humans that is related to a number of kinases that have been found to be important in controlling cell structure and proliferation...
  18. pmc Tissue polarity genes of Drosophila regulate the subcellular location for prehair initiation in pupal wing cells
    L L Wong
    Biology Department, University of Virginia, Charlottesville 22901
    J Cell Biol 123:209-21. 1993
    ..This suggests that the tissue polarity genes function in or on a pathway that controls hair polarity by regulating the subcellular location for prehair formation...
  19. ncbi request reprint The Drosophila tissue polarity gene inturned acts cell autonomously and encodes a novel protein
    W J Park
    Biology Department, University of Virginia, Charlottesville 22903, USA
    Development 122:961-9. 1996
    ..The ability of an in cDNA, the expression of which is driven by the basal activity of the hsp70 promoter to rescue an in mutation suggests that patterned expression of in is unlikely to play a role in the function of the gene...
  20. pmc Van Gogh: a new Drosophila tissue polarity gene
    J Taylor
    Biology Department and Cancer Center, University of Virginia, Charlottesville, Virginia 22903, USA
    Genetics 150:199-210. 1998
    ..In both cases the domineering nonautonomy was suppressed consistent with Van Gogh being essential for frizzled signaling...
  21. ncbi request reprint The conserved HR domain of the Drosophila suppressor 2 of zeste [Su(z)2] and murine bmi-1 proteins constitutes a locus-specific chromosome binding domain
    E J Sharp
    Biology Department and Cancer Center, University of Virginia, Charlottesville, VA 22903, USA
    Chromosoma 106:70-80. 1997
    ..Other results show that a second, low affinity, non-specific chromosome binding function is localized outside the HR in the Su(z)2 protein, and that the Su(z)2 protein contains at least two nuclear localization signals...
  22. pmc The Drosophila tissue polarity gene inturned functions prior to wing hair morphogenesis in the regulation of hair polarity and number
    P N Adler
    Biology Department, University of Virginia, Charlottesville 22903
    Genetics 137:829-36. 1994
    ..That the temperature during hair morphogenesis is irrelevant for the phenotype of in is consistent with the hypothesis that the only role that in has in wing hair development is to regulate the initiation of hair morphogenesis...
  23. ncbi request reprint The grainy head transcription factor is essential for the function of the frizzled pathway in the Drosophila wing
    Haeryun Lee
    Department of Biology and Cancer Center, University of Virginia, Charlottesville, VA 22903, USA
    Mech Dev 121:37-49. 2004
    ..In addition, we found that grh has frizzled pathway independent functions during the development of the adult cuticle...
  24. ncbi request reprint The genetic control of tissue polarity in Drosophila
    P N Adler
    Biology Department, University of Virginia, Charlottesville
    Bioessays 14:735-41. 1992
    ..Based on their behavior in genetic mosaics, it has proved possible to determine that individual genes are required either for the generation of an intercellular polarity signal and/or the transduction of that signal to the cytoskeleton...
  25. ncbi request reprint Distinct roles for the actin and microtubule cytoskeletons in the morphogenesis of epidermal hairs during wing development in Drosophila
    C M Turner
    Biology Department and Cancer Center, University of Virginia, Charlottesville 22903, USA
    Mech Dev 70:181-92. 1998
    ..This is a phenocopy of mutations in crinkled, and suggests mutations that cause branched hairs will be in genes that encode products that interact with the actin cytoskeleton...
  26. pmc Molecular analysis of EMS-induced frizzled mutations in Drosophila melanogaster
    K H Jones
    Biology Department, University of Virginia, Charlottesville 22903, USA
    Genetics 142:205-15. 1996
    ..virilis. Conceptual translation of the D. virilis open reading frame indicates that the Fz protein is unusually well conserved. Indeed, in the putative cytoplasmic domains the Fz proteins of the two species are identical...
  27. pmc The function of the frizzled pathway in the Drosophila wing is dependent on inturned and fuzzy
    Haeryun Lee
    Biology Department and Cancer Center, University of Virginia, Charlottesville, Virginia 22903, USA
    Genetics 160:1535-47. 2002
    ..g., abdomen) the inturned-like genes were epistatic to the frizzled-like genes, but in other body regions (e.g., eye) that was not the case. Thus, the genetic control of tissue polarity is body region specific...
  28. ncbi request reprint The frizzled gene of Drosophila encodes a membrane protein with an odd number of transmembrane domains
    W J Park
    Biology Department, University of Virginia, Charlottesville 22901
    Mech Dev 45:127-37. 1994
    ..Immunostaining of pupal wings showed that the Fz protein is evenly distributed throughout the wing arguing that the Fz protein does not act as a graded morphogen...
  29. ncbi request reprint Genetic interactions of the suppressor 2 of zeste region genes
    P N Adler
    Biology Department, University of Virginia, Charlottesville
    Dev Genet 10:249-60. 1989
    ..However, we have found that mutations in Su(z)2 do interact in a variety of interesting ways with mutations in Pc group genes...
  30. ncbi request reprint Cellular mechanisms in the development of the Drosophila arista
    B He
    Biology Department and Cancer Center, University of Virginia, Charlottesville, VA 22903, USA
    Mech Dev 104:69-78. 2001
    ..We conclude that the arista laterals are a valuable complementary cell type system for studying the morphogenesis of polarized cellular extensions in Drosophila...
  31. ncbi request reprint A single frizzled protein has a dual function in tissue polarity
    R E Krasnow
    Biology Department, University of Virginia, Charlottesville 22903
    Development 120:1883-93. 1994
    ..Overexpression of the hsfzI transgene resulted in two distinct tissue polarity phenotypes depending on the time of heat shock...
  32. ncbi request reprint Directional non-cell autonomy and the transmission of polarity information by the frizzled gene of Drosophila
    C R Vinson
    Biology Department, University of Virginia, Charlottesville 22901
    Nature 329:549-51. 1987
    ..One function involves the transmittance and/or generation of a polarity signal along the proximal-distal axis of the wing. The second function involves the cellular interpretation of a polarity signal...
  33. ncbi request reprint The Polycomb group gene Posterior Sex Combs encodes a chromosomal protein
    E C Martin
    Biology Department, University of Virginia, Charlottesville 22903
    Development 117:641-55. 1993
    ..In all cases, it is nuclear, as is its mammalian homolog, the bmi-1 protein. On polytene chromosomes, we find Psc at 45 chromosomal loci where two other Pc-G proteins are present...
  34. pmc The shavenoid gene of Drosophila encodes a novel actin cytoskeleton interacting protein that promotes wing hair morphogenesis
    Nan Ren
    Biology Department, Cancer Center and Morphogenesis and Regenerative Medicine Institute, University of Virginia, Charlottesville, Virginia 22903, USA
    Genetics 172:1643-53. 2006
    ..We found a strong genetic interaction between mutations in these genes consistent with their having a close but parallel functional relationship...
  35. pmc Molecular structure of frizzled, a Drosophila tissue polarity gene
    P N Adler
    Biology Department, University of Virginia, Charlottesville 22901
    Genetics 126:401-16. 1990
    ..Conceptual translation of this mRNA indicates that it encodes an integral membrane protein that is likely to contain both extracellular and cytoplasmic domains...
  36. pmc The flare gene, which encodes the AIP1 protein of Drosophila, functions to regulate F-actin disassembly in pupal epidermal cells
    Nan Ren
    Biology Department, Institute for Morphogenesis and Regenerative Medicine and Cancer Center, University of Virginia, Charlottesville, VA 22903, USA
    Genetics 176:2223-34. 2007
    ..Surprisingly, we found that mutations in flr and tsr also result in greatly increased tubulin staining, suggesting a tight linkage between the actin and microtubule cytoskeleton in these cells...
  37. ncbi request reprint A Drosophila tissue polarity locus encodes a protein containing seven potential transmembrane domains
    C R Vinson
    Biology Department, University of Virginia, Charlottesville 22901
    Nature 338:263-4. 1989
    ..This is the first reported sequence for the protein product of a tissue polarity gene...
  38. ncbi request reprint Directed overexpression of suppressor 2 of zeste and Posterior Sex Combs results in bristle abnormalities in Drosophila melanogaster
    E J Sharp
    Department of Biology, University of Virginia, Charlottesville 22903
    Dev Biol 161:379-92. 1994
    ..These data suggest that the bristle abnormalities seen with overexpression of Su(z)2 and Psc may result from altered expression of genes involved in bristle sense organ development that are not normal regulatory targets of these genes...
  39. ncbi request reprint Morphogenesis of Drosophila pupal wings in vitro
    C M Turner
    Biology Department, University of Virginia, Charlottesville 22903, USA
    Mech Dev 52:247-55. 1995
    ..Later in development exposure to chitinase caused a loss of normal prehair and bristle polarity, and high doses resulted in a severe disruption of the actin cytoskeleton...
  40. ncbi request reprint Drosophila genes Posterior Sex Combs and Suppressor two of zeste encode proteins with homology to the murine bmi-1 oncogene
    B P Brunk
    Biology Department, University of Virginia, Charlottesville 22901
    Nature 353:351-3. 1991
    ..4% that is also conserved in the murine oncogene bmi-1. At the amino terminus of this domain is a cysteine-rich sequence that has been proposed as a novel type of zinc finger...
  41. pmc Molecular genetics of the Posterior sex combs/Suppressor 2 of zeste region of Drosophila: aberrant expression of the Suppressor 2 of zeste gene results in abnormal bristle development
    B P Brunk
    Biology Department, University of Virginia, Charlottesville 22903
    Genetics 128:119-32. 1991
    ..Northern and in situ hybridization analyses show that the mutations result in increased accumulation of the Su(z)2 mRNA, which we argue is responsible for the bristle loss phenotype...
  42. pmc The sequence of the Drosophila regulatory gene Suppressor two of zeste
    B P Brunk
    Biology Department, University of Virginia, Charlottesville 22901
    Nucleic Acids Res 19:3149. 1991
  43. pmc Rho1 has multiple functions in Drosophila wing planar polarity
    Jie Yan
    Biology Department, Department of Cell Biology, Morphogenesis and Regenerative Medicine Institute and Cancer Center, University of Virginia, Charlottesville, VA 22903, USA
    Dev Biol 333:186-99. 2009
    ..The upstream function may be an indirect one and associated with the requirement for normal apical basal polarity and adherens junctions for the accumulation of PCP protein complexes...
  44. ncbi request reprint Phenotypic consequences and genetic interactions of a null mutation in the Drosophila Posterior Sex Combs gene
    P N Adler
    Biology Department, University of Virginia, Charlottesville 22903
    Dev Genet 12:349-61. 1991
    ..The differences in the phenotypes of the doubly mutant embryos allow us to eliminate one class of molecular models to explain the dramatic synergism seen with mutations in this group of genes...
  45. pmc The tricornered Ser/Thr protein kinase is regulated by phosphorylation and interacts with furry during Drosophila wing hair development
    Ying He
    Department of Biology, Center for Morphogenesis and Regenerative Medicine and Cancer Center, University of Virginia, Charlottesville, VA 22903, USA
    Mol Biol Cell 16:689-700. 2005
    ..Our data suggest a feedback mechanism involving Trc activity regulates the accumulation of Fry in developing hairs...
  46. pmc The Drosophila planar polarity proteins inturned and multiple wing hairs interact physically and function together
    Qiuheng Lu
    Biology Department, Morphogenesis and Regenerative Medicine Institute and Cancer Center, University of Virginia, Charlottesville, Virginia 22903, USA
    Genetics 185:549-58. 2010
    ..The fusion protein localized to the proximal side of wing cells prior to hair formation and in growing hairs as expected if protein localization is a key for the function of these proteins...
  47. ncbi request reprint The genetic control of arista lateral morphogenesis in Drosophila
    Biao He
    Biology Department and Cancer Center, University of Virginia, Charlottesville, VA 22903, USA
    Dev Genes Evol 212:218-29. 2002
    ..We also found that mutations that lead to lateral splitting typically alter the stereotypic arrangement of actin filament bundles and microtubules in laterals...
  48. pmc The multiple-wing-hairs gene encodes a novel GBD-FH3 domain-containing protein that functions both prior to and after wing hair initiation
    Jie Yan
    Biology Department, Department of Cell Biology, Morphogenesis and Regenerative Medicine Institute and Cancer Center, University of Virginia, Charlottesville, Virginia 22903, USA
    Genetics 180:219-28. 2008
    ..This later function appears to be a feedback mechanism that limits cytoskeleton activation to ensure a single hair is formed...
  49. pmc Cell rearrangement and cell division during the tissue level morphogenesis of evaginating Drosophila imaginal discs
    Job Taylor
    Biology Department, Institute for Morphogenesis and Regenerative Medicine, Cancer Center, University of Virginia, Charlottesville, VA 22903, USA
    Dev Biol 313:739-51. 2008
    ..Interestingly, these divisions were not typically oriented parallel to the axis of elongation. Our observations show that disc evagination involves multiple cellular behaviors, as is the case for many other morphogenetic processes...
  50. ncbi request reprint The growth of Drosophila bristles and laterals is not restricted to the tip or base
    Xiaoyin Fei
    Biology Department and Cancer Center, University of Virginia, Charlottesville, VA 22903, USA
    J Cell Sci 115:3797-806. 2002
    ..The bristle microtubules are less stable. The retrograde movement of the peripheral actin appears to be counterbalanced by the distally directed movement of cytoplasm in the center of the bristle...
  51. pmc Drosophila Mob family proteins interact with the related tricornered (Trc) and warts (Wts) kinases
    Ying He
    Department of Biology, Center for Morphogenesis and Regenerative Medicine and Cancer Center, University of Virginia, Charlottesville, VA 22903, USA
    Mol Biol Cell 16:4139-52. 2005
    ..We further provide evidence that Mo25, the Drosophila homolog of the RAM pathway hym1 gene does not function along with Trc...
  52. pmc Regulation of cell shape, wing hair initiation and the actin cytoskeleton by Trc/Fry and Wts/Mats complexes
    Xiaolan Fang
    Department of Biology, University of Virginia, Charlottesville, VA 22903, USA
    Dev Biol 341:360-74. 2010
    ..In addition, we showed that the effects on cell shape and the timing of differentiation appear to be not linked to changes in relative growth rate of cells compared to their neighbors...
  53. pmc Gene expression during Drosophila wing morphogenesis and differentiation
    Nan Ren
    Biology Department, Cancer Center and Morphogenesis and Regenerative Medicine Institute, University of Virginia, Charlottesville, 22903, USA
    Genetics 171:625-38. 2005
    ..The collection of identified genes should be a valuable data set for future studies on hair and bristle morphogenesis, cuticle synthesis, and planar polarity...
  54. pmc The balance between the novel protein target of wingless and the Drosophila Rho-associated kinase pathway regulates planar cell polarity in the Drosophila wing
    SeYeon Chung
    School of Biological Sciences, Seoul National University, Seoul 151 742, Korea
    Genetics 176:891-903. 2007
    ..Genetic interaction and gain-of-function studies provide evidence that Tow acts downstream of Fz/Dsh and plays a role in restricting the number of hairs that wing cells form...
  55. ncbi request reprint Control of dendritic branching and tiling by the Tricornered-kinase/Furry signaling pathway in Drosophila sensory neurons
    Kazuo Emoto
    Howard Hughes Medical Institute, Department of Physiology and Biochemistry, University of California San Francisco, 1550 4th Street, San Francisco, CA 94143, USA
    Cell 119:245-56. 2004
    ..Thus, the Trc/Fry signaling pathway plays a key role in patterning dendritic fields by promoting avoidance between homologous dendrites as well as by limiting dendritic branching...

Research Grants34

  1. GENETIC CONTROL OF TISSUE POLARITY
    Paul Adler; Fiscal Year: 2001
    ..We will also carry out experiments designed to distinguish between models proposed to explain the function of the fz signaling/signal transduction pathway in the development of tissue polarity. ..
  2. GENETIC CONTROL OF TISSUE POLARITY
    Paul N Adler; Fiscal Year: 2010
    ..We propose to continue to study a group of planar polarity effector genes to understand how they function at the cellular level and the molecular genetic basis for their control of cell shape and morphology. ..
  3. GENETIC ANALYSIS OF PREHAIR MORPHOGENESIS
    Paul Adler; Fiscal Year: 2001
    ..DESCRIPTION: The long term goal is to understand the genetic basis for the formation of cellular projections by epithelial cells. Dr. Adler uses the wing imaginal epidermis of Drosophila as a model system. ..
  4. GENETIC ANALYSIS OF PREHAIR MORPHOGENESIS
    Paul Adler; Fiscal Year: 2005
    ....
  5. GENETIC CONTROL OF TISSUE POLARITY
    Paul Adler; Fiscal Year: 2005
    ..For one of these genes we will determine the relative importance of adhesion versus signal transduction for the mutant phenotype. ..
  6. GENETIC CONTROL OF TISSUE POLARITY
    Paul Adler; Fiscal Year: 2009
    ..We propose to continue to study a group of planar polarity effector genes to understand how they function at the cellular level and the molecular genetic basis for their control of cell shape and morphology. ..
  7. GENETIC CONTROL OF TISSUE POLARITY
    Paul Adler; Fiscal Year: 2009
    ..We propose to continue to study a group of planar polarity effector genes to understand how they function at the cellular level and the molecular genetic basis for their control of cell shape and morphology. ..
  8. MOLECULAR GENETICS OF THE FZ LOCUS
    Paul Adler; Fiscal Year: 1993
    ....