Becky Adkins

Summary

Affiliation: University of Miami
Country: USA

Publications

  1. pmc The murine Th2 locus undergoes epigenetic modification in the thymus during fetal and postnatal ontogeny
    Momoko Yoshimoto
    Herman B Wells Center for Pediatric Research, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana, USA
    PLoS ONE 8:e51587. 2013
  2. ncbi request reprint Neonatal immunology: responses to pathogenic microorganisms and epigenetics reveal an "immunodiverse" developmental state
    Becky Adkins
    Department of Microbiology and Immunology, University of Miami Miller School of Medicine, Miami, FL, 33136, USA
    Immunol Res 57:246-57. 2013
  3. ncbi request reprint Exclusive Th2 primary effector function in spleens but mixed Th1/Th2 function in lymph nodes of murine neonates
    B Adkins
    Department of Microbiology and Immunology, University of Miami Medical School, Miami, FL 33136, USA
    J Immunol 164:2347-53. 2000
  4. ncbi request reprint Neonatal T cell function
    Becky Adkins
    University of Miami Medical School, Miami, Florida, USA
    J Pediatr Gastroenterol Nutr 40:S5-7. 2005
  5. ncbi request reprint Neonatal adaptive immunity comes of age
    Becky Adkins
    Department of Microbiology and Immunology, University of Miami Medical School, Miami, Florida 33136, USA
    Nat Rev Immunol 4:553-64. 2004
  6. ncbi request reprint Neonatal tolerance revisited again: specific CTL priming in mouse neonates exposed to small numbers of semi- or fully allogeneic spleen cells
    Becky Adkins
    Department of Microbiology and Immunology, University of Miami School of Medicine, Miami, FL 33136, USA
    Eur J Immunol 34:1901-9. 2004
  7. ncbi request reprint Peripheral CD4+ lymphocytes derived from fetal versus adult thymic precursors differ phenotypically and functionally
    Becky Adkins
    Department of Microbiology and Immunology, University of Miami Medical School, Miami, FL 33136, USA
    J Immunol 171:5157-64. 2003
  8. pmc The primary responses of murine neonatal lymph node CD4+ cells are Th2-skewed and are sufficient for the development of Th2-biased memory
    Becky Adkins
    Department of Microbiology and Immunology, University of Miami Medical School, Miami, FL 33136, USA
    Clin Dev Immunol 10:43-51. 2003
  9. ncbi request reprint Murine neonatal lymphocytes show rapid early cell cycle entry and cell division
    Becky Adkins
    Department of Microbiology and Immunology, University of Miami Medical School, Miami, FL 33136, USA
    J Immunol 170:4548-56. 2003
  10. ncbi request reprint Murine neonatal CD4+ lymph node cells are highly deficient in the development of antigen-specific Th1 function in adoptive adult hosts
    Becky Adkins
    Department of Microbiology and Immunology, University of Miami Medical School, FL 33136, USA
    J Immunol 169:4998-5004. 2002

Research Grants

  1. NEONATAL TH1/TH2 PRIMARY AND MEMORY CELL DEVELOPMENT
    REBECCA ADKINS; Fiscal Year: 2001
  2. NEONATAL TH1/TH2 PRIMARY AND MEMORY CELL DEVELOPMENT
    REBECCA ADKINS; Fiscal Year: 2002
  3. NEONATAL TH1/TH2 PRIMARY AND MEMORY CELL DEVELOPMENT
    REBECCA ADKINS; Fiscal Year: 2003
  4. NEONATAL TH1/TH2 PRIMARY AND MEMORY CELL DEVELOPMENT
    REBECCA ADKINS; Fiscal Year: 2004
  5. Regulation of murine neonatal Th2 function
    REBECCA ADKINS; Fiscal Year: 2006
  6. Regulation of murine neonatal Th2 function
    REBECCA ADKINS; Fiscal Year: 2007
  7. Regulation of murine neonatal Th2 function
    REBECCA ADKINS; Fiscal Year: 2009
  8. Regulation of murine neonatal Th2 function
    REBECCA D ADKINS; Fiscal Year: 2010

Collaborators

Detail Information

Publications25

  1. pmc The murine Th2 locus undergoes epigenetic modification in the thymus during fetal and postnatal ontogeny
    Momoko Yoshimoto
    Herman B Wells Center for Pediatric Research, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana, USA
    PLoS ONE 8:e51587. 2013
    ..However, the fetal program is rapidly terminated post birth by the development of signals leading to the acquisition of adult-like epigenetic patterns...
  2. ncbi request reprint Neonatal immunology: responses to pathogenic microorganisms and epigenetics reveal an "immunodiverse" developmental state
    Becky Adkins
    Department of Microbiology and Immunology, University of Miami Miller School of Medicine, Miami, FL, 33136, USA
    Immunol Res 57:246-57. 2013
    ..Here, we review recent findings from our group and others describing cellular responses to infection and developmentally regulated epigenetic processes in the newborn. ..
  3. ncbi request reprint Exclusive Th2 primary effector function in spleens but mixed Th1/Th2 function in lymph nodes of murine neonates
    B Adkins
    Department of Microbiology and Immunology, University of Miami Medical School, Miami, FL 33136, USA
    J Immunol 164:2347-53. 2000
    ....
  4. ncbi request reprint Neonatal T cell function
    Becky Adkins
    University of Miami Medical School, Miami, Florida, USA
    J Pediatr Gastroenterol Nutr 40:S5-7. 2005
  5. ncbi request reprint Neonatal adaptive immunity comes of age
    Becky Adkins
    Department of Microbiology and Immunology, University of Miami Medical School, Miami, Florida 33136, USA
    Nat Rev Immunol 4:553-64. 2004
  6. ncbi request reprint Neonatal tolerance revisited again: specific CTL priming in mouse neonates exposed to small numbers of semi- or fully allogeneic spleen cells
    Becky Adkins
    Department of Microbiology and Immunology, University of Miami School of Medicine, Miami, FL 33136, USA
    Eur J Immunol 34:1901-9. 2004
    ..These results have important implications for the known exposure of human fetuses and infants to small numbers of maternal cells...
  7. ncbi request reprint Peripheral CD4+ lymphocytes derived from fetal versus adult thymic precursors differ phenotypically and functionally
    Becky Adkins
    Department of Microbiology and Immunology, University of Miami Medical School, Miami, FL 33136, USA
    J Immunol 171:5157-64. 2003
    ..These results demonstrate that cells arising from fetal thymic precursors are functionally different both qualitatively and quantitatively from adult-derived cells...
  8. pmc The primary responses of murine neonatal lymph node CD4+ cells are Th2-skewed and are sufficient for the development of Th2-biased memory
    Becky Adkins
    Department of Microbiology and Immunology, University of Miami Medical School, Miami, FL 33136, USA
    Clin Dev Immunol 10:43-51. 2003
    ..These results suggest that the early development of Th2-dominant responses by lymph node CD4+ cells contributes substantially to the subsequent development of Th2-dominant memory in neonates...
  9. ncbi request reprint Murine neonatal lymphocytes show rapid early cell cycle entry and cell division
    Becky Adkins
    Department of Microbiology and Immunology, University of Miami Medical School, Miami, FL 33136, USA
    J Immunol 170:4548-56. 2003
    ..Thus, early cell cycle entry by large proportions of cells may allow the naive lymphocyte population to efficiently mobilize responses against the broad range of pathogens first encountered in neonatal life...
  10. ncbi request reprint Murine neonatal CD4+ lymph node cells are highly deficient in the development of antigen-specific Th1 function in adoptive adult hosts
    Becky Adkins
    Department of Microbiology and Immunology, University of Miami Medical School, FL 33136, USA
    J Immunol 169:4998-5004. 2002
    ..These results offer a candidate explanation for the reduced graft-vs-host responses observed following transplantation of cord blood cells or murine neonatal lymphoid cells to allogeneic adult hosts...
  11. ncbi request reprint The generation of Th memory in neonates versus adults: prolonged primary Th2 effector function and impaired development of Th1 memory effector function in murine neonates
    B Adkins
    Department of Microbiology and Immunology, University of Miami Medical School, Miami, FL 33136, USA
    J Immunol 166:918-25. 2001
    ..These experiments demonstrated that neonates are selectively impaired in the development of Th1 memory effector function. Together, these results indicate that neonates are biased to Th2 function at all phases of an immune response...
  12. pmc Immune responses of female BALB/c and C57BL/6 neonatal mice to vaccination or intestinal infection are unaltered by exposure to breast milk lycopene
    Becky Adkins
    Department of Microbiology and Immunology, Miller School of Medicine, University of Miami, Miami, FL 33136, USA
    J Nutr 141:1326-30. 2011
    ..Thus, suckling pups exposed to lycopene in breast milk appear to develop normal innate and adaptive responses both systemically and at intestinal mucosal surfaces...
  13. pmc Murine neonates infected with Yersinia enterocolitica develop rapid and robust proinflammatory responses in intestinal lymphoid tissues
    David T Siefker
    Department of Microbiology and Immunology, University of Miami Miller School of Medicine, Miami, Florida, USA
    Infect Immun 82:762-72. 2014
    ..Moreover, these results reveal that the neonatal intestinal lymphoid tissues have great potential to rapidly mobilize innate components in response to infection with bacterial enteropathogens. ..
  14. pmc Yersinia enterocolitica promotes robust mucosal inflammatory T-cell immunity in murine neonates
    Andrea Echeverry
    Department of Microbiology and Immunology, University of Miami Miller School of Medicine, 1600 NW 10th Ave, Miami, FL 33136, USA
    Infect Immun 78:3595-608. 2010
    ..enterocolitica promotes the development of highly inflammatory mucosal responses in neonates and that intestinal T-cell function may be a key immune component in protection from gastrointestinal pathogens in early life...
  15. pmc Murine neonatal CD4+ cells are poised for rapid Th2 effector-like function
    Shawn Rose
    Department of Microbiology and Immunology, Miller School of Medicine, University of Miami, 1600 NW 10th Avenue, Miami, FL 33136, USA
    J Immunol 178:2667-78. 2007
    ..Together, these results indicate that neonatal CD4+ T cells possess distinct qualities that could predispose them toward rapid, effector-like Th2 function...
  16. pmc Essential role of TNF receptor superfamily 25 (TNFRSF25) in the development of allergic lung inflammation
    Lei Fang
    Department of Microbiology and Immunology, Leonard Miller School of Medicine, University of Miami, Miami, FL 33136, USA
    J Exp Med 205:1037-48. 2008
    ..The TNFR25/TL1A pair appears to provide an early signal for Th2 cytokine production in the lung, and therefore may be a drug target in attempts to attenuate lung inflammation in asthmatics...
  17. pmc Murine neonates are highly resistant to Yersinia enterocolitica following orogastric exposure
    Andrea Echeverry
    Department of Microbiology and Immunology, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    Infect Immun 75:2234-43. 2007
    ..Together, these experiments support the hypothesis that the neonatal intestinal immune system can rapidly mobilize innate phagocytes and thereby confine the bacterial infection to the gut, resulting in a high level of resistance...
  18. pmc Murine neonatal recent thymic emigrants are phenotypically and functionally distinct from adult recent thymic emigrants
    Shannon J Opiela
    Department of Microbiology and Immunology, Miller School of Medicine, University of Miami, FL 33136, USA
    Blood 113:5635-43. 2009
    ..These quantitative and qualitative differences in the neonatal and adult RTEs populations may at least partially explain the diverse responses that are elicited in vivo in neonates in response to different conditions of antigen exposure...
  19. pmc Murine neonates develop vigorous in vivo cytotoxic and Th1/Th2 responses upon exposure to low doses of NIMA-like alloantigens
    Shannon J Opiela
    Department of Microbiology and Immunology, University of Miami Miller School of Medicine, FL 33136, USA
    Blood 112:1530-8. 2008
    ..These findings suggest that early exposure to low levels of NIMA may lead to long-term immunologic priming of all arms of T-cell adaptive immunity, rather than tolerance...
  20. pmc The key regulators of adult T helper cell responses, STAT6 and T-bet, are established in early life in mice
    Shawn Rose
    Department of Microbiology and Immunology, Miller School of Medicine at the University of Miami, Miami, FL 33136, USA
    Eur J Immunol 36:1241-53. 2006
    ....
  21. ncbi request reprint Polynucleotide phosphorylase independently controls virulence factor expression levels and export in Yersinia spp
    Jason A Rosenzweig
    Department of Microbiology and Immunology, Miller School of Medicine, University of Miami, Miami, FL 33101, USA
    FEMS Microbiol Lett 270:255-64. 2007
    ..The results suggest that PNPase affects the expression and activity of the T3SS by distinct mechanisms and that the S1-dependent effect on T3SS activity involves an RNA intermediate...
  22. ncbi request reprint Influence of breast cancer on thymic function in mice
    Diana M Lopez
    Department of Microbiology and Immunology, University of Miami School of Medicine, 1600 NW 10th Avenue R 138, Miami, Florida 33136, USA
    J Mammary Gland Biol Neoplasia 7:191-9. 2002
    ..Thus, downregulation of cell-mediated immune functions occurring at late stages of the disease may be causally related to the thymic involution occurring during mammary tumorigenesis...
  23. pmc Host innate recognition of an intestinal bacterial pathogen induces TRIF-dependent protective immunity
    John Sotolongo
    Division of Gastroenterology, Department of Medicine, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    J Exp Med 208:2705-16. 2011
    ..Our results demonstrate a previously unknown role of TRIF in host resistance to Gram-negative enteropathogens, which may lead to effective strategies for combating enteric infections...
  24. doi request reprint Murine Neonates Infected with Yersinia enterocolitica Develop Rapid and Robust Proinflammatory Responses in Intestinal Lymphoid Tissues
    David T Siefker
    Department of Microbiology and Immunology, University of Miami Miller School of Medicine, Miami, Florida, USA
    Infect Immun 82:762-72. 2014
    ..Moreover, these results reveal that the neonatal intestinal lymphoid tissues have great potential to rapidly mobilize innate components in response to infection with bacterial enteropathogens. ..
  25. ncbi request reprint Immunomodulatory effects of sensory nerves during respiratory syncytial virus infection in rats
    Alexander Auais
    Department of Pediatrics, University of Miami School of Medicine, Miami, Florida 33136, USA
    Am J Physiol Lung Cell Mol Physiol 285:L105-13. 2003
    ....

Research Grants9

  1. NEONATAL TH1/TH2 PRIMARY AND MEMORY CELL DEVELOPMENT
    REBECCA ADKINS; Fiscal Year: 2001
    ..Finally, the capacity of coadministered IL-12 and IL-18 to enhance adjuvant- induced primary Th1 function in neonates will be tested. ..
  2. NEONATAL TH1/TH2 PRIMARY AND MEMORY CELL DEVELOPMENT
    REBECCA ADKINS; Fiscal Year: 2002
    ..Finally, the capacity of coadministered IL-12 and IL-18 to enhance adjuvant- induced primary Th1 function in neonates will be tested. ..
  3. NEONATAL TH1/TH2 PRIMARY AND MEMORY CELL DEVELOPMENT
    REBECCA ADKINS; Fiscal Year: 2003
    ..Finally, the capacity of coadministered IL-12 and IL-18 to enhance adjuvant- induced primary Th1 function in neonates will be tested. ..
  4. NEONATAL TH1/TH2 PRIMARY AND MEMORY CELL DEVELOPMENT
    REBECCA ADKINS; Fiscal Year: 2004
    ..Finally, the capacity of coadministered IL-12 and IL-18 to enhance adjuvant- induced primary Th1 function in neonates will be tested. ..
  5. Regulation of murine neonatal Th2 function
    REBECCA ADKINS; Fiscal Year: 2006
    ..Therefore, Specific Aim 3 will address the hypothesis that RTE are the source of Th2 function in neonates. This idea is supported by our findings that the function of peripheral CD4+ cells in neonates resembles that of RTE in adults. ..
  6. Regulation of murine neonatal Th2 function
    REBECCA ADKINS; Fiscal Year: 2007
    ..Therefore, Specific Aim 3 will address the hypothesis that RTE are the source of Th2 function in neonates. This idea is supported by our findings that the function of peripheral CD4+ cells in neonates resembles that of RTE in adults. ..
  7. Regulation of murine neonatal Th2 function
    REBECCA ADKINS; Fiscal Year: 2009
    ..This idea is supported by our findings that the function of peripheral CD4+ cells in neonates resembles that of RTE in adults. ..
  8. Regulation of murine neonatal Th2 function
    REBECCA D ADKINS; Fiscal Year: 2010
    ..This idea is supported by our findings that the function of peripheral CD4+ cells in neonates resembles that of RTE in adults. ..