BRYON H ADINOFF

Summary

Affiliation: University of Texas Southwestern Medical Center
Country: USA

Publications

  1. ncbi request reprint Dose-response measures of rCBF and subjective changes following procaine in healthy female volunteers
    Bryon Adinoff
    Department of Psychiatry, University of Texas Southwestern Medical Center, 4500 S Lancaster Rd, TX 75216, Dallas, USA
    Psychiatry Res 114:123-35. 2002
  2. pmc Association of race and ethnicity with withdrawal symptoms, attrition, opioid use, and side-effects during buprenorphine therapy
    E Sherwood Brown
    Department of Psychiatry, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 8849, USA
    J Ethn Subst Abuse 9:106-14. 2010
  3. pmc Time to Relapse Questionnaire (TRQ): a measure of sudden relapse in substance dependence
    Bryon Adinoff
    UT Southwestern Medical Center at Dallas, Psychiatry, Dallas, Texas 75390 8564, USA
    Am J Drug Alcohol Abuse 36:140-9. 2010
  4. doi request reprint Adrenocortical and pituitary glucocorticoid feedback in abstinent alcohol-dependent women
    Bryon Adinoff
    Department of Psychiatry, University of Texas Southwestern Medical Center at Dallas, USA
    Alcohol Clin Exp Res 34:915-24. 2010
  5. pmc A randomized, double-blind, placebo-controlled pilot study of naltrexone in outpatients with bipolar disorder and alcohol dependence
    E Sherwood Brown
    Department of Psychiatry, The University of Texas Southwestern Medical Center, Dallas, TX, USA
    Alcohol Clin Exp Res 33:1863-9. 2009
  6. pmc Study design to examine the potential role of assessment reactivity in the Screening, Motivational Assessment, Referral, and Treatment in Emergency Departments (SMART-ED) protocol
    Dennis M Donovan
    Alcohol and Drug Abuse Institute, University of Washington, 1107 NE 45th Street, Suite 120, Seattle, WA 98105, USA
    Addict Sci Clin Pract 7:16. 2012
  7. pmc Caudolateral orbitofrontal regional cerebral blood flow is decreased in abstinent cocaine-addicted subjects in two separate cohorts
    Bryon Adinoff
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX 75390 8564, USA
    Addict Biol 17:1001-12. 2012
  8. pmc Neural response to lidocaine in healthy subjects
    Bryon Adinoff
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, United States
    Psychiatry Res 173:135-42. 2009
  9. pmc Altered neural cholinergic receptor systems in cocaine-addicted subjects
    Bryon Adinoff
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX 75390 8564, USA
    Neuropsychopharmacology 35:1485-99. 2010
  10. pmc Sex differences in medial and lateral orbitofrontal cortex hypoperfusion in cocaine-dependent men and women
    Bryon Adinoff
    Department of Psychiatry, University of Texas Southwestern Medical Center, and VA North Texas Health Care System, Dallas, Texas 75390 8564, USA
    Gend Med 3:206-22. 2006

Research Grants

  1. LIMBIC SENSITIVITY IN COCAINE ADDICTION
    Bryon Adinoff; Fiscal Year: 2000
  2. PHARMACOLOGIC DISSECTION OF THE HPA AXIS IN ALCOHOLISM
    Bryon Adinoff; Fiscal Year: 2002
  3. Concept Project
    Bryon Adinoff; Fiscal Year: 2005
  4. Psychiatrist Research Education & Training in Drug Abuse
    Bryon Adinoff; Fiscal Year: 2007
  5. Stress, HPA Axis Dysfunction, and Relapse in Alcoholism
    Bryon Adinoff; Fiscal Year: 2007
  6. Impulsivity, Neural Deficits, and Cocaine Relapse
    Bryon Adinoff; Fiscal Year: 2007
  7. Clinical Trials Network: North Texas Node
    Bryon Adinoff; Fiscal Year: 2007
  8. LIMBIC SENSITIVITY IN COCAINE ADDICTION
    Bryon Adinoff; Fiscal Year: 2005
  9. Impulsivity, Neural Deficits, and Cocaine Relapse
    BRYON H ADINOFF; Fiscal Year: 2010

Detail Information

Publications26

  1. ncbi request reprint Dose-response measures of rCBF and subjective changes following procaine in healthy female volunteers
    Bryon Adinoff
    Department of Psychiatry, University of Texas Southwestern Medical Center, 4500 S Lancaster Rd, TX 75216, Dallas, USA
    Psychiatry Res 114:123-35. 2002
    ..We conclude that a dose of 1.38 mg/kg procaine provides a more limited and specific activation of limbic structures than 1.00 mg/kg procaine and thus may be more useful as a specific probe of limbic function...
  2. pmc Association of race and ethnicity with withdrawal symptoms, attrition, opioid use, and side-effects during buprenorphine therapy
    E Sherwood Brown
    Department of Psychiatry, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 8849, USA
    J Ethn Subst Abuse 9:106-14. 2010
    ..Although ethnic and racial differences were observed prior to buprenorphine treatment, scores following buprenorphine treatment were similar between groups...
  3. pmc Time to Relapse Questionnaire (TRQ): a measure of sudden relapse in substance dependence
    Bryon Adinoff
    UT Southwestern Medical Center at Dallas, Psychiatry, Dallas, Texas 75390 8564, USA
    Am J Drug Alcohol Abuse 36:140-9. 2010
    ..Relapse may occur suddenly, following a short period of craving, or after extended consideration. The time to relapse may reveal underlying mechanisms of relapse and have important implications for treatment...
  4. doi request reprint Adrenocortical and pituitary glucocorticoid feedback in abstinent alcohol-dependent women
    Bryon Adinoff
    Department of Psychiatry, University of Texas Southwestern Medical Center at Dallas, USA
    Alcohol Clin Exp Res 34:915-24. 2010
    ....
  5. pmc A randomized, double-blind, placebo-controlled pilot study of naltrexone in outpatients with bipolar disorder and alcohol dependence
    E Sherwood Brown
    Department of Psychiatry, The University of Texas Southwestern Medical Center, Dallas, TX, USA
    Alcohol Clin Exp Res 33:1863-9. 2009
    ..In this pilot study, the efficacy of naltrexone in reducing alcohol use and on mood symptoms was assessed in bipolar disorder and alcohol dependence...
  6. pmc Study design to examine the potential role of assessment reactivity in the Screening, Motivational Assessment, Referral, and Treatment in Emergency Departments (SMART-ED) protocol
    Dennis M Donovan
    Alcohol and Drug Abuse Institute, University of Washington, 1107 NE 45th Street, Suite 120, Seattle, WA 98105, USA
    Addict Sci Clin Pract 7:16. 2012
    ....
  7. pmc Caudolateral orbitofrontal regional cerebral blood flow is decreased in abstinent cocaine-addicted subjects in two separate cohorts
    Bryon Adinoff
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX 75390 8564, USA
    Addict Biol 17:1001-12. 2012
    ..This may contribute to an addicted individual's persistent drug use despite negative consequences...
  8. pmc Neural response to lidocaine in healthy subjects
    Bryon Adinoff
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, United States
    Psychiatry Res 173:135-42. 2009
    ..These findings suggest that lidocaine can be safely used to assess sodium channel function in persons with addictive and other psychiatric disorders...
  9. pmc Altered neural cholinergic receptor systems in cocaine-addicted subjects
    Bryon Adinoff
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX 75390 8564, USA
    Neuropsychopharmacology 35:1485-99. 2010
    ..Cholinergic systems may offer a pharmacologic target for cocaine addiction treatment...
  10. pmc Sex differences in medial and lateral orbitofrontal cortex hypoperfusion in cocaine-dependent men and women
    Bryon Adinoff
    Department of Psychiatry, University of Texas Southwestern Medical Center, and VA North Texas Health Care System, Dallas, Texas 75390 8564, USA
    Gend Med 3:206-22. 2006
    ..Hypoperfusion of the orbitofrontal cortex (OFC) has previously been reported in individuals addicted to cocaine and has been posited as a biological mediator of relapse due to impulsivity or impaired decision making...
  11. pmc Dissection of hypothalamic-pituitary-adrenal axis pathology in 1-month-abstinent alcohol-dependent men, part 2: response to ovine corticotropin-releasing factor and naloxone
    Bryon Adinoff
    Department of Psychiatry, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75216, USA
    Alcohol Clin Exp Res 29:528-37. 2005
    ..In addition, pulsatile characteristics of corticotropin and cortisol were assessed over a 12-hr period (0800 to 2000 hr)...
  12. pmc Dissection of hypothalamic-pituitary-adrenal axis pathology in 1-month-abstinent alcohol-dependent men, part 1: adrenocortical and pituitary glucocorticoid responsiveness
    Bryon Adinoff
    Department of Psychiatry, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75216, USA
    Alcohol Clin Exp Res 29:517-27. 2005
    ....
  13. pmc Neurobiologic processes in drug reward and addiction
    Bryon Adinoff
    Department of Psychiatry, University of Texas Southwestern Medical Center at Dallas, VA North Texas Health Care System, Dallas, TX, USA
    Harv Rev Psychiatry 12:305-20. 2004
    ..Within this framework, future targets for pharmacologic treatment are suggested...
  14. ncbi request reprint Resting regional cerebral blood flow and gambling task performance in cocaine-dependent subjects and healthy comparison subjects
    Bryon Adinoff
    Department of Psychiatry, Radiotlogy, Family Practice and Neurology, Nuclear Medicine Center, Univeristy of Texas, Southwestern Medical Center, Dallas, TX 75216, USA
    Am J Psychiatry 160:1892-4. 2003
    ..The authors tested the hypothesis that lower Gambling Task scores would be associated with lower resting orbitofrontal cortex rCBF in cocaine-dependent subjects...
  15. ncbi request reprint Increased salivary cortisol concentrations during chronic alcohol intoxication in a naturalistic clinical sample of men
    Bryon Adinoff
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, USA
    Alcohol Clin Exp Res 27:1420-7. 2003
    ..Although moderate levels of acute alcohol ingestion are reported to produce an increase in cortisol levels, it is uncertain whether cortisol remains persistently increased during long-term chronic intoxication...
  16. ncbi request reprint Regional cerebral blood flow in female cocaine-addicted subjects following limbic activation
    Bryon Adinoff
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Drug Alcohol Depend 71:255-68. 2003
    ..In this study, we assessed the limbic rCBF response to procaine in female cocaine-addicted subjects (n=10) and female controls (n=10)...
  17. ncbi request reprint Gender differences in limbic responsiveness, by SPECT, following a pharmacologic challenge in healthy subjects
    Bryon Adinoff
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Neuroimage 18:697-706. 2003
    ..Studies assessing pharmacologic challenges of limbic system structures should consider gender as a critical variable in assessing biologic responsiveness...
  18. doi request reprint Impulsivity, neural deficits, and the addictions: the "oops" factor in relapse
    Bryon Adinoff
    Department of Psychiatry, University of Texas Southwestern Medical Center at Dallas and VA North Texas Health Care System, Dallas, TX 75390 8564, USA
    J Addict Dis 26:25-39. 2007
    ..Empirical investigations documenting the hypothesized relationship between specific deficits in impulsive behaviors, coupled with their neurobiological correlates, and relapse should be the focus of future studies...
  19. pmc Differential hypothalamic-pituitary-adrenal activation of the neuroactive steroids pregnenolone sulfate and deoxycorticosterone in healthy controls and alcohol-dependent subjects
    Patrizia Porcu
    Department of Psychiatry, Bowles Center for Alcohol Studies, University of North Carolina School of Medicine, 3027 Thurston Bowles Building, CB 7178, Chapel Hill, NC 27599 7178, USA
    Psychoneuroendocrinology 33:214-26. 2008
    ..Further, alcohol-dependent patients show a blunted PREG-S response to adrenal stimulation and a delayed deoxycorticosterone response to oCRH challenge...
  20. pmc Neurobiological processes in adolescent addictive disorders
    Ty S Schepis
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
    Am J Addict 17:6-23. 2008
    ..A clearer understanding of adolescent neurobiology is a necessary step in the development of prevention and treatment interventions for adolescent SUD...
  21. ncbi request reprint Motivation for treatment preceding and following a substance abuse program
    Melissa A Cahill
    Dallas County Community Supervision and Corrections Department, 9th Floor, 133 North Industrial Boulevard, Dallas, TX 75207, USA
    Addict Behav 28:67-79. 2003
    ..Objective measures have seldom been used, however, to assess how motivation is altered during treatment, or the impact of depression/anxiety on motivation...
  22. pmc Disseminating contingency management to increase attendance in two community substance abuse treatment centers: lessons learned
    Robrina Walker
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX 75390 8564, USA
    J Subst Abuse Treat 39:202-9. 2010
    ..The discussion focuses on practical lessons learned during the planning and implementation of the interventions...
  23. ncbi request reprint Association of baseline characteristics and motivation to change among patients seeking treatment for substance dependence
    Craig A Field
    Health Promotion and Behavioral Sciences, University of Texas School of Public Health at Houston, Dallas Regional Campus, 5323 Harry Hines Blvd, V8 112, Dallas, TX 75390 9128, United States
    Drug Alcohol Depend 91:77-84. 2007
    ..The current study evaluated the bottoming out hypothesis by determining the extent to which composite measures of motivation to change are associated with baseline characteristics among patients seeking treatment for substance dependence...
  24. pmc The role of acetylcholine in cocaine addiction
    Mark J Williams
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX 75390 8564, USA
    Neuropsychopharmacology 33:1779-97. 2008
    ....
  25. doi request reprint Family history of alcoholism does not influence adrenocortical hyporesponsiveness in abstinent alcohol-dependent men
    Elizabeth Hardin
    Department of Psychiatry, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 8564, USA
    Am J Drug Alcohol Abuse 34:151-60. 2008
    ..In the present study, the authors investigated the influence of a family history (FH) of alcoholism upon suppressed glucocorticoid reactivity...
  26. doi request reprint Tanning as a behavioral addiction
    Arianne S Kourosh
    University of Texas Southwestern Medical Center at Dallas, USA
    Am J Drug Alcohol Abuse 36:284-90. 2010
    ..Persistent tanning despite potentially fatal consequences suggests a compulsive behavior similar to other addictive disorders...

Research Grants23

  1. LIMBIC SENSITIVITY IN COCAINE ADDICTION
    Bryon Adinoff; Fiscal Year: 2000
    ....
  2. PHARMACOLOGIC DISSECTION OF THE HPA AXIS IN ALCOHOLISM
    Bryon Adinoff; Fiscal Year: 2002
    ....
  3. Concept Project
    Bryon Adinoff; Fiscal Year: 2005
    ..Thus, they can be used both in research and clinical practice. They are user-friendly and offer step-by-step medication decision trees as well as procedural details for implementation. ..
  4. Psychiatrist Research Education & Training in Drug Abuse
    Bryon Adinoff; Fiscal Year: 2007
    ..Together, these features place the UTSWMC Department of Psychiatry in an ideal position to stimulate and train the next generation of psychiatric basic and clinical researchers in drug abuse. ..
  5. Stress, HPA Axis Dysfunction, and Relapse in Alcoholism
    Bryon Adinoff; Fiscal Year: 2007
    ..In addition, elucidating the concurrent contributions of stress-response biologic systems and externals stressors will provide the therapist and patient with a constellation of specific risk factors for focused treatment. ..
  6. Impulsivity, Neural Deficits, and Cocaine Relapse
    Bryon Adinoff; Fiscal Year: 2007
    ....
  7. Clinical Trials Network: North Texas Node
    Bryon Adinoff; Fiscal Year: 2007
    ..We believe the structure and organization of the NTN, as well as its committed and highly experienced investigators, complements and extends the work of the CTN. ..
  8. LIMBIC SENSITIVITY IN COCAINE ADDICTION
    Bryon Adinoff; Fiscal Year: 2005
    ..Our competing renewal will be used to identify specific changes in these neuroreceptor systems, providing avenues for new pharmacologic investigations in the treatment of cocaine dependence. ..
  9. Impulsivity, Neural Deficits, and Cocaine Relapse
    BRYON H ADINOFF; Fiscal Year: 2010
    ....