RAO ADIBHATLA

Summary

Affiliation: University of Wisconsin
Country: USA

Publications

  1. ncbi Altered lipid metabolism in brain injury and disorders
    Rao Muralikrishna Adibhatla
    Department of Neurological Surgery, Cardiovascular Research Center, Neuroscience Training Program, University of Wisconsin School of Medicine and Public Health, Madison, WI, William S Middleton Veterans Affairs Hospital, Madison, WI 53792, USA
    Subcell Biochem 49:241-68. 2008
  2. ncbi Lipid oxidation and peroxidation in CNS health and disease: from molecular mechanisms to therapeutic opportunities
    Rao Muralikrishna Adibhatla
    Department of Neurological Surgery, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53792 3232, USA
    Antioxid Redox Signal 12:125-69. 2010
  3. ncbi Tricyclodecan-9-yl-xanthogenate (D609) mechanism of actions: a mini-review of literature
    Rao Muralikrishna Adibhatla
    Department of Neurological Surgery, Clinical Science Center, University of Wisconsin School of Medicine and Public Health, 600 Highland Avenue, Madison, WI 53792 3232, USA
    Neurochem Res 37:671-9. 2012
  4. ncbi CDP-choline significantly restores phosphatidylcholine levels by differentially affecting phospholipase A2 and CTP: phosphocholine cytidylyltransferase after stroke
    Rao Muralikrishna Adibhatla
    Department of Neurological Surgery, University of Wisconsin, Madison, WI 53792 3232, USA
    J Biol Chem 281:6718-25. 2006
  5. ncbi Phospholipase A2, reactive oxygen species, and lipid peroxidation in cerebral ischemia
    Rao Muralikrishna Adibhatla
    Department of Neurological Surgery, University of Wisconsin, Madison, WI 53792 3232, USA
    Free Radic Biol Med 40:376-87. 2006
  6. ncbi Lipids and lipidomics in brain injury and diseases
    Rao Muralikrishna Adibhatla
    Department of Neurological Surgery, H4 330, Clinical Science Center, 600 Highland Avenue, University of Wisconsin Madison, Madison, WI 53792 3232, USA
    AAPS J 8:E314-21. 2006
  7. ncbi Secretory phospholipase A2 IIA is up-regulated by TNF-alpha and IL-1alpha/beta after transient focal cerebral ischemia in rat
    Rao Muralikrishna Adibhatla
    Department of Neurological Surgery, University of Wisconsin, and Veterans Administration Hospital, Madison, WI 53705, USA
    Brain Res 1134:199-205. 2007
  8. ncbi Integration of cytokine biology and lipid metabolism in stroke
    Rao Muralikrishna Adibhatla
    Department of Neurological Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792 3232, USA
    Front Biosci 13:1250-70. 2008
  9. ncbi Tissue plasminogen activator (tPA) and matrix metalloproteinases in the pathogenesis of stroke: therapeutic strategies
    Rao Muralikrishna Adibhatla
    Department of Neurological Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA
    CNS Neurol Disord Drug Targets 7:243-53. 2008
  10. ncbi Phospholipase A(2), reactive oxygen species, and lipid peroxidation in CNS pathologies
    Rao Muralikrishna Adibhatla
    Department of Neurological Surgery, Cardiovascular Research Center, Neuroscience Training Program, University of Wisconsin, Madison, WI, USA
    BMB Rep 41:560-7. 2008

Research Grants

  1. CDP-choline: Mechanisms in Cerebral Ischemia
    RAO ADIBHATLA; Fiscal Year: 2006
  2. Deregulated lipid metabolism in stroke
    RAO M ADIBHATLA; Fiscal Year: 2010

Collaborators

Detail Information

Publications24

  1. ncbi Altered lipid metabolism in brain injury and disorders
    Rao Muralikrishna Adibhatla
    Department of Neurological Surgery, Cardiovascular Research Center, Neuroscience Training Program, University of Wisconsin School of Medicine and Public Health, Madison, WI, William S Middleton Veterans Affairs Hospital, Madison, WI 53792, USA
    Subcell Biochem 49:241-68. 2008
    ..Understanding cytokine-induced changes in lipid metabolism will promote novel concepts and steer towards bench-to-bedside transition for therapies...
  2. ncbi Lipid oxidation and peroxidation in CNS health and disease: from molecular mechanisms to therapeutic opportunities
    Rao Muralikrishna Adibhatla
    Department of Neurological Surgery, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53792 3232, USA
    Antioxid Redox Signal 12:125-69. 2010
    ..This review will discuss the role of lipid oxidation/peroxidation in various CNS injuries/disorders...
  3. ncbi Tricyclodecan-9-yl-xanthogenate (D609) mechanism of actions: a mini-review of literature
    Rao Muralikrishna Adibhatla
    Department of Neurological Surgery, Clinical Science Center, University of Wisconsin School of Medicine and Public Health, 600 Highland Avenue, Madison, WI 53792 3232, USA
    Neurochem Res 37:671-9. 2012
    ..The purpose of this review is to comprehensively evaluate the literature and summarize the findings and relevance to cell cycle and CNS pathologies...
  4. ncbi CDP-choline significantly restores phosphatidylcholine levels by differentially affecting phospholipase A2 and CTP: phosphocholine cytidylyltransferase after stroke
    Rao Muralikrishna Adibhatla
    Department of Neurological Surgery, University of Wisconsin, Madison, WI 53792 3232, USA
    J Biol Chem 281:6718-25. 2006
    ..A hypothetical scheme is proposed integrating results from this study and from other reports in the literature...
  5. ncbi Phospholipase A2, reactive oxygen species, and lipid peroxidation in cerebral ischemia
    Rao Muralikrishna Adibhatla
    Department of Neurological Surgery, University of Wisconsin, Madison, WI 53792 3232, USA
    Free Radic Biol Med 40:376-87. 2006
    ....
  6. ncbi Lipids and lipidomics in brain injury and diseases
    Rao Muralikrishna Adibhatla
    Department of Neurological Surgery, H4 330, Clinical Science Center, 600 Highland Avenue, University of Wisconsin Madison, Madison, WI 53792 3232, USA
    AAPS J 8:E314-21. 2006
    ....
  7. ncbi Secretory phospholipase A2 IIA is up-regulated by TNF-alpha and IL-1alpha/beta after transient focal cerebral ischemia in rat
    Rao Muralikrishna Adibhatla
    Department of Neurological Surgery, University of Wisconsin, and Veterans Administration Hospital, Madison, WI 53705, USA
    Brain Res 1134:199-205. 2007
    ..This suggests that cytokine induction up-regulates sPLA2 IIA protein expression, resulting in altered lipid metabolism that contributes to stroke injury...
  8. ncbi Integration of cytokine biology and lipid metabolism in stroke
    Rao Muralikrishna Adibhatla
    Department of Neurological Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792 3232, USA
    Front Biosci 13:1250-70. 2008
    ..Cytokine antagonism attenuated secretory PLA2 IIA actions, suggesting cytokine-lipid integration studies will lead to new concepts contributing to bench-to-bedside transition for stroke therapy...
  9. ncbi Tissue plasminogen activator (tPA) and matrix metalloproteinases in the pathogenesis of stroke: therapeutic strategies
    Rao Muralikrishna Adibhatla
    Department of Neurological Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA
    CNS Neurol Disord Drug Targets 7:243-53. 2008
    ....
  10. ncbi Phospholipase A(2), reactive oxygen species, and lipid peroxidation in CNS pathologies
    Rao Muralikrishna Adibhatla
    Department of Neurological Surgery, Cardiovascular Research Center, Neuroscience Training Program, University of Wisconsin, Madison, WI, USA
    BMB Rep 41:560-7. 2008
    ..In this review, we summarize the role of PLA(2) in CNS pathologies, including stroke, spinal cord injury, Alzheimer's, Parkinson's, Multiple sclerosis-Experimental autoimmune encephalomyelitis and Wallerian degeneration...
  11. ncbi Protection by D609 through cell-cycle regulation after stroke
    Rao Muralikrishna Adibhatla
    Department of Neurological Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792 3232, USA
    Mol Neurobiol 41:206-17. 2010
    ....
  12. ncbi CDP-choline liposomes provide significant reduction in infarction over free CDP-choline in stroke
    Rao Muralikrishna Adibhatla
    Department of Neurological Surgery, H4 330, Clinical Science Center, University of Wisconsin Madison, Madison, WI 53792 3232, USA
    Brain Res 1058:193-7. 2005
    ..Beneficial effects of CDP-choline liposomes in stroke may derive from a synergistic effect between the phospholipid components of the liposomes and the encapsulated CDP-choline...
  13. ncbi Cytidine 5'-diphosphocholine (CDP-choline) in stroke and other CNS disorders
    Rao Muralikrishna Adibhatla
    Department of Neurological Surgery, University of Wisconsin, Madison, WI 53792 3232, USA
    Neurochem Res 30:15-23. 2005
    ..CDP-choline is non-xenobiotic, safe, well tolerated, and can be considered as one of the agents in multi-drug treatment of stroke...
  14. ncbi Cytidine-5'-diphosphocholine affects CTP-phosphocholine cytidylyltransferase and lyso-phosphatidylcholine after transient brain ischemia
    Rao Muralikrishna Adibhatla
    Department of Neurological Surgery, University of Wisconsin, Madison, Wisconsin 53792 3232, USA
    J Neurosci Res 76:390-6. 2004
    ..01 compared to saline). These data indicate that PtdCho synthesis is impaired after brain ischemia, and CDP-choline may increase PtdCho levels by attenuating the loss of CCT activity and lyso-PtdCho formation...
  15. ncbi Neuroprotection by group I metabotropic glutamate receptor antagonists in forebrain ischemia of gerbil
    A M Rao
    Department of Neurological Surgery, Clinical Science Center, University of Wisconsin, Veterans Administration Hospital, Madison 53792, USA
    Neurosci Lett 293:1-4. 2000
    ..AIDA was less effective in decreasing ArAc release and had no effect on neuronal death. These results suggest that activation of mGluR 5 may be an important pathway in ArAc release and neuronal death after transient ischemia...
  16. ncbi Lipid alterations in transient forebrain ischemia: possible new mechanisms of CDP-choline neuroprotection
    A M Rao
    Department of Neurological Surgery, University of Wisconsin, Madison, Wisconsin 53792 3232, USA
    J Neurochem 75:2528-35. 2000
    ....
  17. ncbi Does CDP-choline modulate phospholipase activities after transient forebrain ischemia?
    A M Rao
    Department of Neurological Surgery, H4 330, Clinical Science Center, 600 Highland Avenue, University of Wisconsin Madison, Madison, WI 53792 3232, USA
    Brain Res 893:268-72. 2001
    ..CDP-choline also provided significant protection for hippocampal CA(1) neurons...
  18. ncbi Effects of citicoline on phospholipid and glutathione levels in transient cerebral ischemia
    R M Adibhatla
    Department of Neurological Surgery, The Cardiovascular Research Center, University of Wisconsin, Madison, WI 53792 3232, USA
    Stroke 32:2376-81. 2001
    ..This study was undertaken to examine changes and effects of citicoline on phospholipids and glutathione synthesis after transient cerebral ischemia and reperfusion...
  19. ncbi Citicoline: neuroprotective mechanisms in cerebral ischemia
    Rao Muralikrishna Adibhatla
    Department of Neurological Surgery and Cardiovascular Research Center, University of Wisconsin, Madison, Wisconsin 53792 3232, USA
    J Neurochem 80:12-23. 2002
    ..Based on these findings, a singular unifying mechanism has been hypothesized. Citicoline also provides choline for synthesis of neurotransmitter acetylcholine, stimulation of tyrosine hydroxylase activity and dopamine release...
  20. ncbi Polyamines and central nervous system injury: spermine and spermidine decrease following transient focal cerebral ischemia in spontaneously hypertensive rats
    Rao Muralikrishna Adibhatla
    Department of Neurological Surgery, H4 330, Clinical Science Center, 600 Highland Avenue, University of Wisconsin Madison, Madison, WI 53792 3232, USA
    Brain Res 938:81-6. 2002
    ..Based on our and other studies, we propose a tentative antioxidant mechanism of spermine neuroprotection...
  21. ncbi Citicoline mechanisms and clinical efficacy in cerebral ischemia
    Rao Muralikrishna Adibhatla
    Department of Neurological Surgery, Clinical Science Center, University of Wisconsin, Madison, Wisconsin 53792 3232, USA
    J Neurosci Res 70:133-9. 2002
    ..The clinical efficacy of citicoline should be examined further in light of the recent phase III stroke clinical trials and experimental data for cerebral ischemia...
  22. ncbi Citicoline decreases phospholipase A2 stimulation and hydroxyl radical generation in transient cerebral ischemia
    Rao Muralikrishna Adibhatla
    Department of Neurological Surgery, University of Wisconsin, Madison, Wisconsin 53792 3232, USA
    J Neurosci Res 73:308-15. 2003
    ..30 +/- 0.23; sham, 2.56 +/- 0.27; ischemia/24 hr reperfusion + citicoline, 4.85 +/- 0.35). These results suggest that citicoline affects PLA(2) stimulation and decreases OH. generation after transient cerebral ischemia...
  23. ncbi Phospholipase A2, hydroxyl radicals, and lipid peroxidation in transient cerebral ischemia
    Rao Muralikrishna Adibhatla
    Department of Neurological Surgery, Cardiovascular Research Center, University of Wisconsin, Madison, WI 53792, USA
    Antioxid Redox Signal 5:647-54. 2003
    ..These results suggest that citicoline provides neuroprotection by attenuating the stimulation of PLA2...
  24. ncbi Arachidonic acid and leukotriene C4: role in transient cerebral ischemia of gerbils
    A M Rao
    Department of Neurological Surgery, University of Wisconsin, Madison 53792 3232, USA
    Neurochem Res 24:1225-32. 1999
    ..85: 112-116) and CA1 neuronal death. Accumulation of AA and LTC4, together with highly reactive oxygen radicals and lipid peroxides, may alter membrane permeability, resulting in BBB dysfunction, edema and ultimately to neuronal death...

Research Grants5

  1. CDP-choline: Mechanisms in Cerebral Ischemia
    RAO ADIBHATLA; Fiscal Year: 2006
    ..Arachidonic acid activates neutral sphingomyelinase, resulting in membrane disintegration. PCCT activity was stimulated by exogenous CDP-choline. Aim 2 will be tested in gerbil transient forebrain ischemia. ..
  2. Deregulated lipid metabolism in stroke
    RAO M ADIBHATLA; Fiscal Year: 2010
    ..The long-range thrust of this research is to develop strategies to minimize disabilities due to stroke. ..