A Aderem

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. ncbi request reprint Mechanisms of phagocytosis in macrophages
    A Aderem
    Department of Immunology, University of Washington, Seattle 98195, USA
    Annu Rev Immunol 17:593-623. 1999
  2. ncbi request reprint The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5
    F Hayashi
    Department of Immunology, University of Washington, Seattle 98195, USA
    Nature 410:1099-103. 2001
  3. ncbi request reprint Cutting edge: functional interactions between toll-like receptor (TLR) 2 and TLR1 or TLR6 in response to phenol-soluble modulin
    A M Hajjar
    Department of Immunology, University of Washington, Seattle, WA 98195, USA
    J Immunol 166:15-9. 2001
  4. pmc The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between toll-like receptors
    A Ozinsky
    Department of Immunology, University of Washington, H 574 Health Sciences, Box 357650, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 97:13766-71. 2000
  5. ncbi request reprint Leptospiral lipopolysaccharide activates cells through a TLR2-dependent mechanism
    C Werts
    Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Nat Immunol 2:346-52. 2001
  6. ncbi request reprint Role of Toll-like receptors in inflammatory response in macrophages
    A Aderem
    Department of Immunology, University of Washington, Seattle 98195, USA
    Crit Care Med 29:S16-8. 2001
  7. ncbi request reprint Functional transitions in macrophages during in vivo infection with Mycobacterium bovis bacillus Calmette-Guérin
    J A Hamerman
    Department of Immunology, University of Washington, Seattle, WA 98195, USA
    J Immunol 167:2227-33. 2001
  8. ncbi request reprint Toll-like receptors in the induction of the innate immune response
    A Aderem
    Department of Immunology, University of Washington, Seattle 98195, USA
    Nature 406:782-7. 2000
  9. ncbi request reprint The Toll-like receptor 2 is recruited to macrophage phagosomes and discriminates between pathogens
    D M Underhill
    Department of Immunology, University of Washington, Seattle 98195, USA
    Nature 401:811-5. 1999
  10. ncbi request reprint MacMARCKS is not essential for phagocytosis in macrophages
    D M Underhill
    Department of Immunology, University of Washington, H 574 Health Sciences, Seattle, Washington 98195, USA
    J Biol Chem 273:33619-23. 1998

Collaborators

  • L A Allen
  • J Chen
  • C J Kirschning
  • S Akira
  • H Wagner
  • D A Haake
  • M Bassetti
  • D M Underhill
  • A Ozinsky
  • A M Hajjar
  • F Hayashi
  • C B Wilson
  • J A Hamerman
  • C Werts
  • K D Smith
  • J C Mathison
  • V Kravchenko
  • D S O'Mahony
  • J K Eng
  • I Saint Girons
  • E C Yi
  • T R Hawn
  • P S Tobias
  • R I Tapping
  • S J Klebanoff
  • D R Goodlett
  • P J Godowski
  • T H Chuang
  • R J Ulevitch
  • L Schroeder
  • J D Fontenot
  • A Stevens

Detail Information

Publications12

  1. ncbi request reprint Mechanisms of phagocytosis in macrophages
    A Aderem
    Department of Immunology, University of Washington, Seattle 98195, USA
    Annu Rev Immunol 17:593-623. 1999
    ..Macrophages also play an important role in the recognition and clearance of apoptotic cells; a notable feature of this process is the absence of an inflammatory response...
  2. ncbi request reprint The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5
    F Hayashi
    Department of Immunology, University of Washington, Seattle 98195, USA
    Nature 410:1099-103. 2001
    ..Our data suggest that TLR5, a member of the evolutionarily conserved Toll-like receptor family, has evolved to permit mammals specifically to detect flagellated bacterial pathogens...
  3. ncbi request reprint Cutting edge: functional interactions between toll-like receptor (TLR) 2 and TLR1 or TLR6 in response to phenol-soluble modulin
    A M Hajjar
    Department of Immunology, University of Washington, Seattle, WA 98195, USA
    J Immunol 166:15-9. 2001
    ..We also demonstrate that a response to phenol-soluble modulin mediated by TLR2 and TLR6 was more refractory to inhibition by TLR1 than one mediated by TLR2 alone...
  4. pmc The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between toll-like receptors
    A Ozinsky
    Department of Immunology, University of Washington, H 574 Health Sciences, Box 357650, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 97:13766-71. 2000
    ....
  5. ncbi request reprint Leptospiral lipopolysaccharide activates cells through a TLR2-dependent mechanism
    C Werts
    Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Nat Immunol 2:346-52. 2001
    ..These data provide a basis for understanding the innate immune response caused by leptospirosis and demonstrate a new ligand specificity for TLR2...
  6. ncbi request reprint Role of Toll-like receptors in inflammatory response in macrophages
    A Aderem
    Department of Immunology, University of Washington, Seattle 98195, USA
    Crit Care Med 29:S16-8. 2001
    ..It is vital that the host detect the pathogen and rapidly mount a defense. The Toll-like family of receptors have evolved to detect conserved patterns on pathogens. When stimulated, these receptors activate the inflammatory response...
  7. ncbi request reprint Functional transitions in macrophages during in vivo infection with Mycobacterium bovis bacillus Calmette-Guérin
    J A Hamerman
    Department of Immunology, University of Washington, Seattle, WA 98195, USA
    J Immunol 167:2227-33. 2001
    ..This functional transition during activation is reminiscent of that seen during maturation/activation of the related dendritic cell lineage induced by bacterial or inflammatory stimuli...
  8. ncbi request reprint Toll-like receptors in the induction of the innate immune response
    A Aderem
    Department of Immunology, University of Washington, Seattle 98195, USA
    Nature 406:782-7. 2000
    ..This reflects a remarkable conservation of function and it is therefore not surprising that studies of the mechanism by which they act has revealed new and important insights into host defence...
  9. ncbi request reprint The Toll-like receptor 2 is recruited to macrophage phagosomes and discriminates between pathogens
    D M Underhill
    Department of Immunology, University of Washington, Seattle 98195, USA
    Nature 401:811-5. 1999
    ....
  10. ncbi request reprint MacMARCKS is not essential for phagocytosis in macrophages
    D M Underhill
    Department of Immunology, University of Washington, H 574 Health Sciences, Seattle, Washington 98195, USA
    J Biol Chem 273:33619-23. 1998
    ..1996) J. Biol. Chem. 271, 12985-12990). We report here that macrophages from MacMARCKS null mice phagocytose and spread normally. Thus, although MacMARCKS is recruited to phagosomes, it is not absolutely required for phagocytosis...