- Efficient conversion of astrocytes to functional midbrain dopaminergic neurons using a single polycistronic vectorRussell C Addis
Department of Cell and Developmental Biology, Institute for Regenerative Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
PLoS ONE 6:e28719. 2011..The present study is the first demonstration that a single vector can mediate reprogramming to dopaminergic neurons, and indicates that astrocytes are an ideal starting population for the direct generation of dopaminergic neurons...
- OCT3/4 regulates transcription of histone deacetylase 4 (Hdac4) in mouse embryonic stem cellsRussell C Addis
Department of Cell and Developmental Biology, and Institute for Regenerative Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
J Cell Biochem 111:391-401. 2010..HDAC4 is not expressed in the nuclei of OCT3/4+ mES cells and is upregulated upon differentiation. These findings demonstrate the participation of OCT3/4 in the repression of Hdac4 in ES cells...