K M Adams Waldorf

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. pmc Choriodecidual group B streptococcal inoculation induces fetal lung injury without intra-amniotic infection and preterm labor in Macaca nemestrina
    Kristina M Adams Waldorf
    Department of Obstetrics and Gynecology, University of Washington, Seattle, Washington, USA
    PLoS ONE 6:e28972. 2011
  2. pmc Pretreatment with toll-like receptor 4 antagonist inhibits lipopolysaccharide-induced preterm uterine contractility, cytokines, and prostaglandins in rhesus monkeys
    Kristina M Adams Waldorf
    University of Washington, Seattle, WA 98195, USA
    Reprod Sci 15:121-7. 2008
  3. pmc LPS induces translocation of TLR4 in amniotic epithelium
    K M Adams
    Department of Obstetrics and Gynecology, University of Washington, Seattle, WA, USA
    Placenta 28:477-81. 2007
  4. pmc Dynamic changes in fetal microchimerism in maternal peripheral blood mononuclear cells, CD4+ and CD8+ cells in normal pregnancy
    K M Adams Waldorf
    Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA 98195 6460, USA
    Placenta 31:589-94. 2010
  5. ncbi request reprint The changing maternal "self" hypothesis: a mechanism for maternal tolerance of the fetus
    K M Adams
    Division of Clinical Research, Fred Hutchinson Cancer Research Center, Human Immunogenetics Program, 1100 Fairview Ave N, D2 100, P O Box 19024, Seattle, WA 98109 1024, USA
    Placenta 28:378-82. 2007
  6. pmc Autoimmune disease during pregnancy and the microchimerism legacy of pregnancy
    Kristina M Adams Waldorf
    Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    Immunol Invest 37:631-44. 2008
  7. pmc Use of nonhuman primate models to investigate mechanisms of infection-associated preterm birth
    K M Adams Waldorf
    Department of Obstetrics and Gynecology, University of Washington, Seattle, 98195, USA
    BJOG 118:136-44. 2011
  8. pmc Healthcare challenges from the developing world: post-immigration refugee medicine
    Kristina M Adams
    Department of Obstetrics and Gynecology, University of Washington, School of Medicine, Seattle, WA, USA
    BMJ 328:1548-52. 2004
  9. ncbi request reprint Risk factors for syngeneic graft-versus-host disease after adult hematopoietic cell transplantation
    Kristina M Adams
    Division of Clinical Research, Fred Hutchinson Cancer Research Center, Human Immunogenetics Program, 1100 Fairview Ave N, D2 100, PO Box 19024, Seattle, WA 98109 19024, USA
    Blood 104:1894-7. 2004
  10. ncbi request reprint Male DNA in female donor apheresis and CD34-enriched products
    Kristina M Adams
    Division of Clinical Research, Fred Hutchinson Cancer Research Center, Human Immunogenetics Program, 1100 Fairview Ave N, D2 100, PO Box 19024, Seattle, WA 98109 1024, USA
    Blood 102:3845-7. 2003

Research Grants

Collaborators

Detail Information

Publications19

  1. pmc Choriodecidual group B streptococcal inoculation induces fetal lung injury without intra-amniotic infection and preterm labor in Macaca nemestrina
    Kristina M Adams Waldorf
    Department of Obstetrics and Gynecology, University of Washington, Seattle, Washington, USA
    PLoS ONE 6:e28972. 2011
    ..Our objective was to establish a nonhuman primate model of an early stage of chorioamnionitis in order to determine the time course and mechanisms of fetal lung injury in utero...
  2. pmc Pretreatment with toll-like receptor 4 antagonist inhibits lipopolysaccharide-induced preterm uterine contractility, cytokines, and prostaglandins in rhesus monkeys
    Kristina M Adams Waldorf
    University of Washington, Seattle, WA 98195, USA
    Reprod Sci 15:121-7. 2008
    ..05). Toll-like receptor antagonists, together with antibiotics, may delay or prevent infection-associated preterm birth...
  3. pmc LPS induces translocation of TLR4 in amniotic epithelium
    K M Adams
    Department of Obstetrics and Gynecology, University of Washington, Seattle, WA, USA
    Placenta 28:477-81. 2007
    ..TLR4 translocation to the basal membrane may decrease LPS signaling early in an infection, but allow the amniotic epithelium to remain competent to invasive or intracellular bacteria...
  4. pmc Dynamic changes in fetal microchimerism in maternal peripheral blood mononuclear cells, CD4+ and CD8+ cells in normal pregnancy
    K M Adams Waldorf
    Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA 98195 6460, USA
    Placenta 31:589-94. 2010
    ..We have investigated FMc in maternal peripheral blood mononuclear cells (PBMC) longitudinally across gestation...
  5. ncbi request reprint The changing maternal "self" hypothesis: a mechanism for maternal tolerance of the fetus
    K M Adams
    Division of Clinical Research, Fred Hutchinson Cancer Research Center, Human Immunogenetics Program, 1100 Fairview Ave N, D2 100, P O Box 19024, Seattle, WA 98109 1024, USA
    Placenta 28:378-82. 2007
    ..Thus, during pregnancy maternal immunologic "self" includes fetal HLA Class II as a result of apoptotic syncytiotrophoblast uptake by maternal tolerogenic dendritic cells...
  6. pmc Autoimmune disease during pregnancy and the microchimerism legacy of pregnancy
    Kristina M Adams Waldorf
    Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    Immunol Invest 37:631-44. 2008
    ..Fetal and maternal microchimerism will be reviewed with a focus on systemic sclerosis (scleroderma), autoimmune thyroid disease, neonatal lupus and type I diabetes mellitus...
  7. pmc Use of nonhuman primate models to investigate mechanisms of infection-associated preterm birth
    K M Adams Waldorf
    Department of Obstetrics and Gynecology, University of Washington, Seattle, 98195, USA
    BJOG 118:136-44. 2011
    ..The contributions of the NHP model to preterm birth research are reviewed, emphasising the role of infections and the potential development of preventative and therapeutic strategies...
  8. pmc Healthcare challenges from the developing world: post-immigration refugee medicine
    Kristina M Adams
    Department of Obstetrics and Gynecology, University of Washington, School of Medicine, Seattle, WA, USA
    BMJ 328:1548-52. 2004
  9. ncbi request reprint Risk factors for syngeneic graft-versus-host disease after adult hematopoietic cell transplantation
    Kristina M Adams
    Division of Clinical Research, Fred Hutchinson Cancer Research Center, Human Immunogenetics Program, 1100 Fairview Ave N, D2 100, PO Box 19024, Seattle, WA 98109 19024, USA
    Blood 104:1894-7. 2004
    ..01). Overall, risk factors were similar to those described in GVHD. Although an independent effect of parity could not be completely separated from other factors, donor and recipient pregnancy history merits further investigation...
  10. ncbi request reprint Male DNA in female donor apheresis and CD34-enriched products
    Kristina M Adams
    Division of Clinical Research, Fred Hutchinson Cancer Research Center, Human Immunogenetics Program, 1100 Fairview Ave N, D2 100, PO Box 19024, Seattle, WA 98109 1024, USA
    Blood 102:3845-7. 2003
    ..In summary, male DNA was frequently detected in G-PBMC and CD34-enriched products from female donors. Whether fetal microchimerism contributes to GVHD merits further investigation...
  11. pmc Differential host response to LPS variants in amniochorion and the TLR4/MD-2 system in Macaca nemestrina
    J Chang
    Department of Obstetrics and Gynecology, Magee Women s Hospital, Pittsburgh, PA, USA
    Placenta 31:811-7. 2010
    ..We also cloned Macaca nemestrina TLR4 and MD-2 and compared this complex functionally to the human homologue to establish whether nonhuman primates could be used to study TLR4 signaling in preterm birth...
  12. ncbi request reprint Microchimerism: an investigative frontier in autoimmunity and transplantation
    Kristina M Adams
    Program in Human Immunogenetics, Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    JAMA 291:1127-31. 2004
    ..Advances in this new frontier of research with varied and numerous implications for human health are summarized...
  13. ncbi request reprint Preterm labor is induced by intraamniotic infusions of interleukin-1beta and tumor necrosis factor-alpha but not by interleukin-6 or interleukin-8 in a nonhuman primate model
    Drew W Sadowsky
    Division of Reproductive Sciences, Oregon National Primate Research Center, Beaverton, OR, USA
    Am J Obstet Gynecol 195:1578-89. 2006
    ..The purpose of this study was to determine the relative contributions of individual proinflammatory cytokines and chemokines to the triggering of preterm labor...
  14. pmc Immunomodulators plus antibiotics delay preterm delivery after experimental intraamniotic infection in a nonhuman primate model
    Michael G Gravett
    Department of Obstetrics and Gynecology, University of Washington School of Medicine, Seattle, WA 98195 6460, USA
    Am J Obstet Gynecol 197:518.e1-8. 2007
    ..The purpose of this study was to determine whether treatment with ampicillin together with dexamethasone and indomethacin delays preterm birth that is induced by intraamniotic group B Streptococcus in a nonhuman primate model...
  15. ncbi request reprint Prospective study of fetal DNA in serum and disease activity during pregnancy in women with inflammatory arthritis
    Zhen Yan
    Immunogenetics D2 100, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, PO Box 19024, Seattle, WA 98109, USA
    Arthritis Rheum 54:2069-73. 2006
    ....
  16. ncbi request reprint Autoimmunity in CLL: grave consequences of gravidity?
    Kristina M Adams
    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Leuk Lymphoma 47:1445-6. 2006
  17. ncbi request reprint Gastrointestinal graft-versus-host disease in recipients of autologous hematopoietic stem cells: incidence, risk factors, and outcome
    Leona Holmberg
    Medical Oncology, Clinical Research Division, Fred Hutchinson Cancer Research Center and the University of Washington School of Medicine, Seattle, Washington 98109, USA
    Biol Blood Marrow Transplant 12:226-34. 2006
    ..We conclude that women with breast cancer or hematologic malignancy are more likely to develop GI GVHD after autologous transplantation, and that treatment with prednisone was effective...
  18. ncbi request reprint Adverse outcomes after preterm labor are associated with tumor necrosis factor-alpha polymorphism -863, but not -308, in mother-infant pairs
    Josephine H Amory
    Department of Obstetrics and Gynecology, University of Washington, Seattle, WA, USA
    Am J Obstet Gynecol 191:1362-7. 2004
    ..TNF-alpha genotypes were tested for association with adverse outcomes in mother-infant pairs with preterm labor...
  19. ncbi request reprint Interleukin-18 in the plasma of women with preeclampsia
    Kristina M Adams
    Department of Obstetrics and Gynecology and Fred Hutchinson Cancer Research Center, University of Washington School of Medicine, Seattle, WA 98195, USA
    Am J Obstet Gynecol 188:1234-7. 2003
    ..Our purpose was to determine whether abnormal levels of IL-18 in maternal plasma correlate with the diagnosis of preeclampsia...

Research Grants2

  1. Toll-Like Receptor Antagonism as a Potential Treatment for Preterm Labor
    KRISTINA ADAMS WALDORF; Fiscal Year: 2007
    ..Completion of these studies in conjunction with the training plan will enable the principal investigator to become an independent researcher of immune responses in infection-induced preterm birth. ..