Research Topics
Genomes and Genes | John S AdamsSummaryAffiliation: University of California Country: USA Publications
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Publications
Extrarenal expression of the 25-hydroxyvitamin D-1-hydroxylaseJ S Adams
Orthopaedic Hospital Research Center, UCLA Orthopaedic Hospital Department of Orthopaedic Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 7358, USA
Arch Biochem Biophys 523:95-102. 2012....- Update in vitamin DJohn S Adams
UCLA Orthopaedic Hospital Research Center, 615 Charles Young Drive South, Room 410E, Los Angeles, California 90095 7358, USA
J Clin Endocrinol Metab 95:471-8. 2010.... - Vitamin D is required for IFN-gamma-mediated antimicrobial activity of human macrophagesMario Fabri
Division of Dermatology, Department of Medicine, David Geffen School of Medicine at University of California, Los Angeles UCLA, Los Angeles, CA 90095, USA
Sci Transl Med 3:104ra102. 2011..The present findings underscore the importance of adequate amounts of vitamin D in all human populations for sustaining both innate and acquired immunity against infection... - 1alpha-hydroxylase and innate immune responses to 25-hydroxyvitamin D in colonic cell linesVenu Lagishetty
Department of Orthopaedic Surgery, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA
J Steroid Biochem Mol Biol 121:228-33. 2010..Thus, in common with other barrier sites such as the skin or placenta, colonic epithelial cells may require specific factors to initiate intracrine responses to vitamin D... - T-cell cytokines differentially control human monocyte antimicrobial responses by regulating vitamin D metabolismKristina Edfeldt
Division of Dermatology, Department of Medicine, David Geffen School of Medicine at University of California, Los Angeles, CA 90095, USA
Proc Natl Acad Sci U S A 107:22593-8. 2010.... 
Alternative splicing of vitamin D-24-hydroxylase: a novel mechanism for the regulation of extrarenal 1,25-dihydroxyvitamin D synthesisSongyang Ren
Department of Medicine, Division of Endocrinology, Burns and Allen Research Institute, Cedars Sinai Medical Center, Los Angeles, California 90048, USA
J Biol Chem 280:20604-11. 2005..We theorize that expression of the CYP24-SV may contribute to the extracellular accumulation of 1,25(OH)(2)D in human health and disease...- Altered endocrine and autocrine metabolism of vitamin D in a mouse model of gastrointestinal inflammationNancy Liu
Department of Orthopaedic Surgery, David Geffen School of Medicine, UCLA, 615 Charles E Young Drive South, Los Angeles, California 90095, USA
Endocrinology 149:4799-808. 2008..These data indicate that both local and endocrine synthesis of 1,25(OH)2D3 affect colitis in DSS-treated mice. Lack of Cyp27b1 exacerbates disease in this model, suggesting that similar effects may occur with vitamin D deficiency... - Vitamin D deficiency in mice impairs colonic antibacterial activity and predisposes to colitisVenu Lagishetty
Room 410D, Orthopaedic Hospital Research Center, University of California Los Angeles, Los Angeles, California 90095, USA
Endocrinology 151:2423-32. 2010..This may be a pivotal mechanism linking vitamin D status with IBD in humans... - Substrate and enzyme trafficking as a means of regulating 1,25-dihydroxyvitamin D synthesis and action: the human innate immune responseJohn S Adams
Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
J Bone Miner Res 22:V20-4. 2007..In this review, we use vitamin D-directed events in the human innate immune response to Mycobacterium tuberculosis as a physiologically relevant model system in which to highlight the importance of these intracellular traffic patterns... 
Type I interferon suppresses type II interferon-triggered human anti-mycobacterial responsesRosane M B Teles
Division of Dermatology, David Geffen School of Medicine at University of California, Los Angeles, CA 90095, USA
Science 339:1448-53. 2013....- Vitamin D in defense of the human immune responseJohn S Adams
Division of Endocrinology, Diabetes and Metabolism, Burns and Allen Research Institute, Cedars Sinai Medical Center, 8700 Beverly Boulevard, Room B 131, Los Angeles, CA 90048, USA
Ann N Y Acad Sci 1117:94-105. 2007.... - Creation of estrogen resistance in vivo by transgenic overexpression of the heterogeneous nuclear ribonucleoprotein-related estrogen response element binding proteinHong Chen
Burns and Allen Research Institute and Division of Endocrinology, Diabetes, and Metabolism, Cedars Sinai Medical Center, David Geffen School of Medicine at the University of California, Los Angeles, California 90048, USA
Endocrinology 146:4266-73. 2005..This work confirms that tissue-targeted overexpression of the ERE-BP can effectively block estrogen-ERalpha-ERE-directed action in vivo... - Functional characterization of heterogeneous nuclear ribonuclear protein C1/C2 in vitamin D resistance: a novel response element-binding proteinHong Chen
Division of Endocrinology, Diabetes and Metabolism, Burns and Allen Research Institute, Cedars Sinai Medical Center, UCLA School of Medicine, Los Angeles, California 90048, USA
J Biol Chem 281:39114-20. 2006..In particular, chromatin immunoprecipitation data suggest that, in addition to its RNA-processing functions, hnRNP C1/C2 may be a key determinant of the temporal patterns of VDRE occupancy... - Cord blood vitamin D status impacts innate immune responsesValencia P Walker
Department of Pediatrics, Division of Neonatology and Developmental Biology, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, California 90095, USA
J Clin Endocrinol Metab 96:1835-43. 2011.... - Gene targeting by the vitamin D response element binding protein reveals a role for vitamin D in osteoblast mTOR signalingThomas S Lisse
Orthopaedic Hospital Research Center, University of California Los Angeles, 615 Charles E Young Dr, South Los Angeles, CA 90095, USA
FASEB J 25:937-47. 2011..DDIT4, an inhibitor of mTOR signaling, is a direct target for 1,25(OH)(2)D(3) and VDRE-BP, and functions to suppress cell proliferation in response to vitamin D... - Increased prevalence of bisphosphonate-related osteonecrosis of the jaw with vitamin D deficiency in ratsAkishige Hokugo
The Jane and Jerry Weintraub Center for Reconstructive Biotechnology, UCLA School of Dentistry, Los Angeles, CA 90095 1668, USA
J Bone Miner Res 25:1337-49. 2010..It is suggested that the pathophysiologic mechanism(s) underpinning ONJ may involve the interaction between bisphosphonates and compromised vitamin D functions in the realm of skeletal homeostasis and innate immunity... - Extra-renal 25-hydroxyvitamin D3-1alpha-hydroxylase in human health and diseaseMartin Hewison
Burns and Allen Research Institute, Division of Endocrinology, Cedars Sinai Medical Center and David Geffen School of Medicine at UCLA, Los Angeles, CA 90048, USA
J Steroid Biochem Mol Biol 103:316-21. 2007..Data suggest that local synthesis of 1,25(OH)(2)D(3) may be a preferred mode of response to antigenic challenge in many tissues... - Adenosine 5'-triphosphate-dependent vitamin D sterol binding to heat shock protein-70 chaperonesRene Chun
Burns and Allen Research Institute and Division of Endocrinology, Diabetes, and Metabolism, Cedars-Sinai Medical Center, David Geffen School of Medicine at University of California, Los Angeles, 90048, USA
Endocrinology 146:5540-4. 2005.... - Divergence of macrophage phagocytic and antimicrobial programs in leprosyDennis Montoya
Department of Microbiology, Immunology, and Molecular Genetics, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, CA 90095, USA
Cell Host Microbe 6:343-53. 2009..These data indicate that macrophage programs for phagocytosis and antimicrobial responses are distinct and differentially regulated in innate immunity to bacterial infections... - Back to the future: a new look at 'old' vitamin DRene F Chun
Department of Orthopaedic Surgery, David Geffen School of Medicine, UCLA, 615 Charles E Young Drive South, Los Angeles, California 90095, USA
J Endocrinol 198:261-9. 2008..In the following review, we provide a fresh perspective on vitamin D signaling in non-classical target cells such as macrophages by highlighting novel factors associated with the transport and action of this pluripotent secosteroid... - Increase in bone mass after correction of vitamin D insufficiency in bisphosphonate-treated patientsJordan L Geller
Burns and Allen Research Institute and Cedars Sinai Medical Center, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California 90048, USA
Endocr Pract 14:293-7. 2008..To assess the relative contribution of vitamin D insufficiency to loss of bone mineral density (BMD) in patients taking bisphosphonates... - An Hsp27-related, dominant-negative-acting intracellular estradiol-binding proteinHong Chen
Division of Endocrinology, Diabetes, and Metabolism, Cedars-Sinai Medical Center, UCLA School of Medicine, Los Angeles, California 90048, USA
J Biol Chem 279:29944-51. 2004..In summary, by inhibiting the ERalpha-E2 interaction, IEBP acts to squelch ERalpha-directed ERE-regulated transactivation and promote estrogen resistance in NWP cells... - Hormone response element binding proteins: novel regulators of vitamin D and estrogen signalingThomas S Lisse
Department of Orthopaedic Surgery and Molecular Biology Institute, David Geffen School of Medicine at UCLA, 615 Charles E Young Drive South, Los Angeles, CA 90095, USA
Steroids 76:331-9. 2011..In addition the review also describes other molecules that are known to influence nuclear receptor signaling through interaction with hormone response elements... - Vitamin D therapyJordan L Geller
Orthopaedic Hospital Research Center, UCLA Orthopaedic Hospital Department of Orthopaedic Surgery, David Geffen School of Medicine at UCLA, Mail Stop 735822, 615 Charles E Young Drive South, Room 410E, Los Angeles, CA 90095, USA
Curr Osteoporos Rep 6:5-11. 2008..Patients who are taking bisphosphonates and those with coexisting primary hyperparathyroidism are not exempt from taking supplemental vitamin D... - Vitamin D-mediated hypercalcemia and Cushing syndrome as manifestations of malignant pleural mesotheliomaJay M Lee
Division of Thoracic Surgery, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
Endocr Pract 14:1011-6. 2008..To report a case of coincident hypercalcemia and Cushing syndrome arising from mesothelioma... - Fibroblast growth factor 23 inhibits extrarenal synthesis of 1,25-dihydroxyvitamin D in human monocytesJustine Bacchetta
UCLA Orthopaedic Hospital, Department of Orthopaedic Surgery, Orthopedic Hospital Research Center, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA, USA
J Bone Miner Res 28:46-55. 2013..Elevated expression of FGF23 may therefore play a crucial role in defining immune responses to vitamin D and this, in turn, may be a key determinant of infection in patients with chronic kidney disease (CKD)... - Immunomodulation by vitamin D: implications for TBRene F Chun
Department of Orthopaedic Surgery, David Geffen School of Medicine at UCLA, 615 Charles E Young Drive South, Los Angeles, CA 90095, USA
Expert Rev Clin Pharmacol 4:583-91. 2011..The overall aim will be to provide a fresh perspective on the potential benefits of vitamin D supplementation in the prevention and treatment of TB... - Vitamin D in HIV-Infected PatientsJordan E Lake
Center for Clinical AIDS Research and Education, David Geffen School of Medicine at UCLA, USA
Curr HIV/AIDS Rep 8:133-41. 2011..This paper reviews data published on HIV infection and vitamin D health in adults over the last year... - Toll-like receptor triggering of a vitamin D-mediated human antimicrobial responsePhilip T Liu
Department of Microbiology, Immunology, and Molecular Genetics, University of California at Los Angeles, Los Angeles, CA 90095, USA
Science 311:1770-3. 2006..These data support a link between TLRs and vitamin D-mediated innate immunity and suggest that differences in ability of human populations to produce vitamin D may contribute to susceptibility to microbial infection... - Unexpected actions of vitamin D: new perspectives on the regulation of innate and adaptive immunityJohn S Adams
Department of Endocrinology, Diabetes and Metabolism, Cedars Sinai Medical Center, 8700 Beverly Boulevard, Los Angeles, CA 90048, USA
Nat Clin Pract Endocrinol Metab 4:80-90. 2008..Specific examples of this will be detailed in the current Review, with particular emphasis on the immunomodulatory properties of vitamin D... - Response element binding proteins and intracellular vitamin D binding proteins: novel regulators of vitamin D trafficking, action and metabolismJohn S Adams
The Burns and Allen Research Institute, Cedars-Sinai Medical Center, UCLA School of Medicine, B131, Cedars-Sinai Medical Center, 8700 Beverly Blvd, Los Angeles, CA, USA
J Steroid Biochem Mol Biol 89:461-5. 2004..Our ongoing studies indicate directly or indirectly through a series of protein interactions that the IDBPs interact with hydroxylated vitamin D metabolites and facilitate their intracellular targeting... - Cinacalcet in the management of tumor-induced osteomalaciaJordan L Geller
Clinical Research Institute, Cedars Sinai Medical Center and the David Geffen School of Medicine at UCLA, Los Angeles, California, USA
J Bone Miner Res 22:931-7. 2007..Cinacalcet treatment resulted in increased renal phosphate reabsorption, allowed for a decrease in phosphate supplementation, and showed evidence of bone healing in one of the two patients... - "Bound" to work: the free hormone hypothesis revisitedJohn S Adams
Burns and Allen Research Institute, Cedars-Sinai Medical Center, David Geffen School of Medicine at UCLA, University of California, Los Angeles, CA 90048, USA
Cell 122:647-9. 2005..2005) show that resistance (insensitivity) to sex steroid hormones is encountered in animals lacking megalin. These data provide important insights into an endocytic mechanism for the uptake of sex steroids by mammalian cells... - Genetic determinants of osteoporosis susceptibility in a female Ashkenazi Jewish populationXiaohui Li
Burns and Allen Research Institute and Divisions of Medical Genetics and Endocrinology, Diabetes and Metabolism, Cedars-Sinai Medical Center and University of California, Los Angeles, California, USA
Genet Med 6:33-7. 2004..These results warrant further gene mapping studies in this population to identify osteoporosis susceptibility loci... - Heterogeneous nuclear ribonucleoprotein (hnRNP) binding to hormone response elements: a cause of vitamin D resistanceHong Chen
Burns and Allen Research Institute and the Division of Endocrinology, Diabetes, and Metabolism, 8700 Beverly Boulevard, Room B-131, Los Angeles, CA 90048, USA
Proc Natl Acad Sci U S A 100:6109-14. 2003..That this protein is a member of the hnRNP family capable of interacting with double-stranded DNA highlights a potentially important new component of the complex machinery required for steroid hormone signal transduction... - Genetic heterogeneity in familial renal magnesium wastingVitaly Kantorovich
Burns and Allen Research Institute, University of Southern California, School of Medicine, Los Angeles, California 90033, USA
J Clin Endocrinol Metab 87:612-7. 2002..In conclusion, our data demonstrate locus heterogeneity for the phenotype of isolated renal Mg wasting with hypomagnesemia and suggest that hypomagnesemia, at least in this pedigree, may be associated with low bone mass... - Regulation of 1,25-dihydroxyvitamin d synthesis by intracellular vitamin d binding protein-1Shaoxing Wu
Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Cedars-Sinai Medical Center, UCLA School of Medicine, 90048, USA
Endocrinology 143:4135. 2002.... - Vitamin D and barrier function: a novel role for extra-renal 1 alpha-hydroxylaseMartin Hewison
Division of Medical Sciences, Institute of Clinical Research, The University of Birmingham, Queen Elizabeth Hospital, Birmingham B15 2TH, UK
Mol Cell Endocrinol 215:31-8. 2004.... - Vitamin D-mediated hypercalcemia in lymphoma: evidence for hormone production by tumor-adjacent macrophagesMartin Hewison
Division of Medical Sciences, University of Birmingham, Birmingham, United Kingdom
J Bone Miner Res 18:579-82. 2003..Based on this case study, we propose that the abnormal synthesis of 1,25(OH)2D3 associated with some lymphomas is because of paracrine regulation of tumor-associated macrophages... - Proton pump inhibitor therapy and hip fracture riskJordan L Geller
JAMA 297:1429; author reply 1429-30. 2007 - Biological actions of extra-renal 25-hydroxyvitamin D-1alpha-hydroxylase and implications for chemoprevention and treatmentKelly Townsend
Division of Medical Sciences, Institute of Biomedical Research, The University of Birmingham, Birmingham B15 2TH, UK
J Steroid Biochem Mol Biol 97:103-9. 2005..The role of 1alpha-hydroxylase in protection against cancer is likely to be more complicated and may involve anti-tumor immune responses... - Vitamin D-mediated hypercalcemia in slack skin disease: evidence for involvement of extrarenal 25-hydroxyvitamin D 1alpha-hydroxylaseHelen Karakelides
Department of Endocrinology, Metabolism and Nutrition, Mayo Clinic College of Medicine, Rochester, Minnesota, USA
J Bone Miner Res 21:1496-9. 2006..This contrasts with psoriasis and sarcoidosis of the skin, in which overexpression of the enzyme is restricted to keratinocytes and granulomata, respectively...
Research Grants
- CO-FACILITATORS: NOVEL REGULATORS OF HORMONE METABOLISMJohn Adams; Fiscal Year: 2004..e., osteoporosis) or that are improved or stabilized by enhancement of local vitamin D metabolite synthesis and action (i.e., leukemia, breast cancer, prostate cancer, psoriasis, etc.). ..
- Vitamin D and Barrier FunctionJohn Adams; Fiscal Year: 2005..abstract_text> ..
- VITAMIN D RESISTANCE: MONKEY TO MANJohn Adams; Fiscal Year: 2007..abstract_text> ..
- Vitamin D and Estrogen Action in Bone: Concerted Role for hnRNPs in the C FamilyJohn Adams; Fiscal Year: 2009....
- RICKETS AND OSTEOMALACIA IN NEW WORLD PRIMATESJohn Adams; Fiscal Year: 2001....
- RICKETS AND OSTEOMALACIAJohn Adams; Fiscal Year: 1993....
- RICKETS AND OSTEOMALACIA IN NEW WORLD PRIMATESJohn Adams; Fiscal Year: 1992....
- Vitamin D and Estrogen Action in Bone: Concerted Role for hnRNPs in the C FamilyJohn S Adams; Fiscal Year: 2010....