John S Adams

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Extrarenal expression of the 25-hydroxyvitamin D-1-hydroxylase
    J S Adams
    Orthopaedic Hospital Research Center, UCLA Orthopaedic Hospital Department of Orthopaedic Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 7358, USA
    Arch Biochem Biophys 523:95-102. 2012
  2. pmc Update in vitamin D
    John S Adams
    UCLA Orthopaedic Hospital Research Center, 615 Charles Young Drive South, Room 410E, Los Angeles, California 90095 7358, USA
    J Clin Endocrinol Metab 95:471-8. 2010
  3. pmc Vitamin D is required for IFN-gamma-mediated antimicrobial activity of human macrophages
    Mario Fabri
    Division of Dermatology, Department of Medicine, David Geffen School of Medicine at University of California, Los Angeles UCLA, Los Angeles, CA 90095, USA
    Sci Transl Med 3:104ra102. 2011
  4. pmc 1alpha-hydroxylase and innate immune responses to 25-hydroxyvitamin D in colonic cell lines
    Venu Lagishetty
    Department of Orthopaedic Surgery, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA
    J Steroid Biochem Mol Biol 121:228-33. 2010
  5. pmc T-cell cytokines differentially control human monocyte antimicrobial responses by regulating vitamin D metabolism
    Kristina Edfeldt
    Division of Dermatology, Department of Medicine, David Geffen School of Medicine at University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 107:22593-8. 2010
  6. ncbi request reprint Alternative splicing of vitamin D-24-hydroxylase: a novel mechanism for the regulation of extrarenal 1,25-dihydroxyvitamin D synthesis
    Songyang Ren
    Department of Medicine, Division of Endocrinology, Burns and Allen Research Institute, Cedars Sinai Medical Center, Los Angeles, California 90048, USA
    J Biol Chem 280:20604-11. 2005
  7. pmc Vitamin D deficiency in mice impairs colonic antibacterial activity and predisposes to colitis
    Venu Lagishetty
    Room 410D, Orthopaedic Hospital Research Center, University of California Los Angeles, Los Angeles, California 90095, USA
    Endocrinology 151:2423-32. 2010
  8. pmc Altered endocrine and autocrine metabolism of vitamin D in a mouse model of gastrointestinal inflammation
    Nancy Liu
    Department of Orthopaedic Surgery, David Geffen School of Medicine, UCLA, 615 Charles E Young Drive South, Los Angeles, California 90095, USA
    Endocrinology 149:4799-808. 2008
  9. ncbi request reprint Substrate and enzyme trafficking as a means of regulating 1,25-dihydroxyvitamin D synthesis and action: the human innate immune response
    John S Adams
    Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
    J Bone Miner Res 22:V20-4. 2007
  10. pmc Type I interferon suppresses type II interferon-triggered human anti-mycobacterial responses
    Rosane M B Teles
    Division of Dermatology, David Geffen School of Medicine at University of California, Los Angeles, CA 90095, USA
    Science 339:1448-53. 2013

Collaborators

Detail Information

Publications43

  1. pmc Extrarenal expression of the 25-hydroxyvitamin D-1-hydroxylase
    J S Adams
    Orthopaedic Hospital Research Center, UCLA Orthopaedic Hospital Department of Orthopaedic Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 7358, USA
    Arch Biochem Biophys 523:95-102. 2012
    ....
  2. pmc Update in vitamin D
    John S Adams
    UCLA Orthopaedic Hospital Research Center, 615 Charles Young Drive South, Room 410E, Los Angeles, California 90095 7358, USA
    J Clin Endocrinol Metab 95:471-8. 2010
    ....
  3. pmc Vitamin D is required for IFN-gamma-mediated antimicrobial activity of human macrophages
    Mario Fabri
    Division of Dermatology, Department of Medicine, David Geffen School of Medicine at University of California, Los Angeles UCLA, Los Angeles, CA 90095, USA
    Sci Transl Med 3:104ra102. 2011
    ..The present findings underscore the importance of adequate amounts of vitamin D in all human populations for sustaining both innate and acquired immunity against infection...
  4. pmc 1alpha-hydroxylase and innate immune responses to 25-hydroxyvitamin D in colonic cell lines
    Venu Lagishetty
    Department of Orthopaedic Surgery, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA
    J Steroid Biochem Mol Biol 121:228-33. 2010
    ..Thus, in common with other barrier sites such as the skin or placenta, colonic epithelial cells may require specific factors to initiate intracrine responses to vitamin D...
  5. pmc T-cell cytokines differentially control human monocyte antimicrobial responses by regulating vitamin D metabolism
    Kristina Edfeldt
    Division of Dermatology, Department of Medicine, David Geffen School of Medicine at University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 107:22593-8. 2010
    ....
  6. ncbi request reprint Alternative splicing of vitamin D-24-hydroxylase: a novel mechanism for the regulation of extrarenal 1,25-dihydroxyvitamin D synthesis
    Songyang Ren
    Department of Medicine, Division of Endocrinology, Burns and Allen Research Institute, Cedars Sinai Medical Center, Los Angeles, California 90048, USA
    J Biol Chem 280:20604-11. 2005
    ..We theorize that expression of the CYP24-SV may contribute to the extracellular accumulation of 1,25(OH)(2)D in human health and disease...
  7. pmc Vitamin D deficiency in mice impairs colonic antibacterial activity and predisposes to colitis
    Venu Lagishetty
    Room 410D, Orthopaedic Hospital Research Center, University of California Los Angeles, Los Angeles, California 90095, USA
    Endocrinology 151:2423-32. 2010
    ..This may be a pivotal mechanism linking vitamin D status with IBD in humans...
  8. pmc Altered endocrine and autocrine metabolism of vitamin D in a mouse model of gastrointestinal inflammation
    Nancy Liu
    Department of Orthopaedic Surgery, David Geffen School of Medicine, UCLA, 615 Charles E Young Drive South, Los Angeles, California 90095, USA
    Endocrinology 149:4799-808. 2008
    ..These data indicate that both local and endocrine synthesis of 1,25(OH)2D3 affect colitis in DSS-treated mice. Lack of Cyp27b1 exacerbates disease in this model, suggesting that similar effects may occur with vitamin D deficiency...
  9. ncbi request reprint Substrate and enzyme trafficking as a means of regulating 1,25-dihydroxyvitamin D synthesis and action: the human innate immune response
    John S Adams
    Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
    J Bone Miner Res 22:V20-4. 2007
    ..In this review, we use vitamin D-directed events in the human innate immune response to Mycobacterium tuberculosis as a physiologically relevant model system in which to highlight the importance of these intracellular traffic patterns...
  10. pmc Type I interferon suppresses type II interferon-triggered human anti-mycobacterial responses
    Rosane M B Teles
    Division of Dermatology, David Geffen School of Medicine at University of California, Los Angeles, CA 90095, USA
    Science 339:1448-53. 2013
    ....
  11. ncbi request reprint Creation of estrogen resistance in vivo by transgenic overexpression of the heterogeneous nuclear ribonucleoprotein-related estrogen response element binding protein
    Hong Chen
    Burns and Allen Research Institute and Division of Endocrinology, Diabetes, and Metabolism, Cedars Sinai Medical Center, David Geffen School of Medicine at the University of California, Los Angeles, California 90048, USA
    Endocrinology 146:4266-73. 2005
    ..This work confirms that tissue-targeted overexpression of the ERE-BP can effectively block estrogen-ERalpha-ERE-directed action in vivo...
  12. ncbi request reprint Vitamin D in defense of the human immune response
    John S Adams
    Division of Endocrinology, Diabetes and Metabolism, Burns and Allen Research Institute, Cedars Sinai Medical Center, 8700 Beverly Boulevard, Room B 131, Los Angeles, CA 90048, USA
    Ann N Y Acad Sci 1117:94-105. 2007
    ....
  13. ncbi request reprint Functional characterization of heterogeneous nuclear ribonuclear protein C1/C2 in vitamin D resistance: a novel response element-binding protein
    Hong Chen
    Division of Endocrinology, Diabetes and Metabolism, Burns and Allen Research Institute, Cedars Sinai Medical Center, UCLA School of Medicine, Los Angeles, California 90048, USA
    J Biol Chem 281:39114-20. 2006
    ..In particular, chromatin immunoprecipitation data suggest that, in addition to its RNA-processing functions, hnRNP C1/C2 may be a key determinant of the temporal patterns of VDRE occupancy...
  14. pmc Fibroblast growth factor 23 inhibits extrarenal synthesis of 1,25-dihydroxyvitamin D in human monocytes
    Justine Bacchetta
    UCLA Orthopaedic Hospital, Department of Orthopaedic Surgery, Orthopedic Hospital Research Center, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA, USA
    J Bone Miner Res 28:46-55. 2013
    ..Elevated expression of FGF23 may therefore play a crucial role in defining immune responses to vitamin D and this, in turn, may be a key determinant of infection in patients with chronic kidney disease (CKD)...
  15. pmc Cord blood vitamin D status impacts innate immune responses
    Valencia P Walker
    Department of Pediatrics, Division of Neonatology and Developmental Biology, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, California 90095, USA
    J Clin Endocrinol Metab 96:1835-43. 2011
    ....
  16. pmc Gene targeting by the vitamin D response element binding protein reveals a role for vitamin D in osteoblast mTOR signaling
    Thomas S Lisse
    Orthopaedic Hospital Research Center, University of California Los Angeles, 615 Charles E Young Dr, South Los Angeles, CA 90095, USA
    FASEB J 25:937-47. 2011
    ..DDIT4, an inhibitor of mTOR signaling, is a direct target for 1,25(OH)(2)D(3) and VDRE-BP, and functions to suppress cell proliferation in response to vitamin D...
  17. pmc Increased prevalence of bisphosphonate-related osteonecrosis of the jaw with vitamin D deficiency in rats
    Akishige Hokugo
    The Jane and Jerry Weintraub Center for Reconstructive Biotechnology, UCLA School of Dentistry, Los Angeles, CA 90095 1668, USA
    J Bone Miner Res 25:1337-49. 2010
    ..It is suggested that the pathophysiologic mechanism(s) underpinning ONJ may involve the interaction between bisphosphonates and compromised vitamin D functions in the realm of skeletal homeostasis and innate immunity...
  18. ncbi request reprint Extra-renal 25-hydroxyvitamin D3-1alpha-hydroxylase in human health and disease
    Martin Hewison
    Burns and Allen Research Institute, Division of Endocrinology, Cedars Sinai Medical Center and David Geffen School of Medicine at UCLA, Los Angeles, CA 90048, USA
    J Steroid Biochem Mol Biol 103:316-21. 2007
    ..Data suggest that local synthesis of 1,25(OH)(2)D(3) may be a preferred mode of response to antigenic challenge in many tissues...
  19. ncbi request reprint Increase in bone mass after correction of vitamin D insufficiency in bisphosphonate-treated patients
    Jordan L Geller
    Burns and Allen Research Institute and Cedars Sinai Medical Center, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California 90048, USA
    Endocr Pract 14:293-7. 2008
    ..To assess the relative contribution of vitamin D insufficiency to loss of bone mineral density (BMD) in patients taking bisphosphonates...
  20. pmc Divergence of macrophage phagocytic and antimicrobial programs in leprosy
    Dennis Montoya
    Department of Microbiology, Immunology, and Molecular Genetics, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, CA 90095, USA
    Cell Host Microbe 6:343-53. 2009
    ..These data indicate that macrophage programs for phagocytosis and antimicrobial responses are distinct and differentially regulated in innate immunity to bacterial infections...
  21. ncbi request reprint Adenosine 5'-triphosphate-dependent vitamin D sterol binding to heat shock protein-70 chaperones
    Rene Chun
    Burns and Allen Research Institute and Division of Endocrinology, Diabetes, and Metabolism, Cedars Sinai Medical Center, David Geffen School of Medicine at University of California, Los Angeles, 90048, USA
    Endocrinology 146:5540-4. 2005
    ....
  22. pmc Back to the future: a new look at 'old' vitamin D
    Rene F Chun
    Department of Orthopaedic Surgery, David Geffen School of Medicine, UCLA, 615 Charles E Young Drive South, Los Angeles, California 90095, USA
    J Endocrinol 198:261-9. 2008
    ..In the following review, we provide a fresh perspective on vitamin D signaling in non-classical target cells such as macrophages by highlighting novel factors associated with the transport and action of this pluripotent secosteroid...
  23. ncbi request reprint An Hsp27-related, dominant-negative-acting intracellular estradiol-binding protein
    Hong Chen
    Division of Endocrinology, Diabetes, and Metabolism, Cedars Sinai Medical Center, UCLA School of Medicine, Los Angeles, California 90048, USA
    J Biol Chem 279:29944-51. 2004
    ..In summary, by inhibiting the ERalpha-E2 interaction, IEBP acts to squelch ERalpha-directed ERE-regulated transactivation and promote estrogen resistance in NWP cells...
  24. pmc Hormone response element binding proteins: novel regulators of vitamin D and estrogen signaling
    Thomas S Lisse
    Department of Orthopaedic Surgery and Molecular Biology Institute, David Geffen School of Medicine at UCLA, 615 Charles E Young Drive South, Los Angeles, CA 90095, USA
    Steroids 76:331-9. 2011
    ..In addition the review also describes other molecules that are known to influence nuclear receptor signaling through interaction with hormone response elements...
  25. ncbi request reprint Vitamin D therapy
    Jordan L Geller
    Orthopaedic Hospital Research Center, UCLA Orthopaedic Hospital Department of Orthopaedic Surgery, David Geffen School of Medicine at UCLA, Mail Stop 735822, 615 Charles E Young Drive South, Room 410E, Los Angeles, CA 90095, USA
    Curr Osteoporos Rep 6:5-11. 2008
    ..Patients who are taking bisphosphonates and those with coexisting primary hyperparathyroidism are not exempt from taking supplemental vitamin D...
  26. ncbi request reprint Vitamin D-mediated hypercalcemia and Cushing syndrome as manifestations of malignant pleural mesothelioma
    Jay M Lee
    Division of Thoracic Surgery, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Endocr Pract 14:1011-6. 2008
    ..To report a case of coincident hypercalcemia and Cushing syndrome arising from mesothelioma...
  27. pmc Vitamin D activation of functionally distinct regulatory miRNAs in primary human osteoblasts
    Thomas S Lisse
    Orthopaedic Hospital Research Center, University of California Los Angeles, Los Angeles, CA, USA
    J Bone Miner Res 28:1478-88. 2013
    ..These data show for the first time that the effects of 1,25D on human bone cells are not restricted to classical VDR-mediated transcriptional responses but also involve miRNA-directed posttranscriptional mechanisms...
  28. pmc Immunomodulation by vitamin D: implications for TB
    Rene F Chun
    Department of Orthopaedic Surgery, David Geffen School of Medicine at UCLA, 615 Charles E Young Drive South, Los Angeles, CA 90095, USA
    Expert Rev Clin Pharmacol 4:583-91. 2011
    ..The overall aim will be to provide a fresh perspective on the potential benefits of vitamin D supplementation in the prevention and treatment of TB...
  29. pmc Vitamin D in HIV-Infected Patients
    Jordan E Lake
    Center for Clinical AIDS Research and Education, David Geffen School of Medicine at UCLA, USA
    Curr HIV/AIDS Rep 8:133-41. 2011
    ..This paper reviews data published on HIV infection and vitamin D health in adults over the last year...
  30. ncbi request reprint Response element binding proteins and intracellular vitamin D binding proteins: novel regulators of vitamin D trafficking, action and metabolism
    John S Adams
    The Burns and Allen Research Institute, Cedars Sinai Medical Center, UCLA School of Medicine, B131, Cedars Sinai Medical Center, 8700 Beverly Blvd, Los Angeles, CA, USA
    J Steroid Biochem Mol Biol 89:461-5. 2004
    ..Our ongoing studies indicate directly or indirectly through a series of protein interactions that the IDBPs interact with hydroxylated vitamin D metabolites and facilitate their intracellular targeting...
  31. ncbi request reprint Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response
    Philip T Liu
    Department of Microbiology, Immunology, and Molecular Genetics, University of California at Los Angeles, Los Angeles, CA 90095, USA
    Science 311:1770-3. 2006
    ..These data support a link between TLRs and vitamin D-mediated innate immunity and suggest that differences in ability of human populations to produce vitamin D may contribute to susceptibility to microbial infection...
  32. pmc Unexpected actions of vitamin D: new perspectives on the regulation of innate and adaptive immunity
    John S Adams
    Department of Endocrinology, Diabetes and Metabolism, Cedars Sinai Medical Center, 8700 Beverly Boulevard, Los Angeles, CA 90048, USA
    Nat Clin Pract Endocrinol Metab 4:80-90. 2008
    ..Specific examples of this will be detailed in the current Review, with particular emphasis on the immunomodulatory properties of vitamin D...
  33. ncbi request reprint Cinacalcet in the management of tumor-induced osteomalacia
    Jordan L Geller
    Clinical Research Institute, Cedars Sinai Medical Center and the David Geffen School of Medicine at UCLA, Los Angeles, California, USA
    J Bone Miner Res 22:931-7. 2007
    ..Cinacalcet treatment resulted in increased renal phosphate reabsorption, allowed for a decrease in phosphate supplementation, and showed evidence of bone healing in one of the two patients...
  34. ncbi request reprint "Bound" to work: the free hormone hypothesis revisited
    John S Adams
    Burns and Allen Research Institute, Cedars Sinai Medical Center, David Geffen School of Medicine at UCLA, University of California, Los Angeles, CA 90048, USA
    Cell 122:647-9. 2005
    ..2005) show that resistance (insensitivity) to sex steroid hormones is encountered in animals lacking megalin. These data provide important insights into an endocytic mechanism for the uptake of sex steroids by mammalian cells...
  35. pmc Heterogeneous nuclear ribonucleoprotein (hnRNP) binding to hormone response elements: a cause of vitamin D resistance
    Hong Chen
    Burns and Allen Research Institute and the Division of Endocrinology, Diabetes, and Metabolism, 8700 Beverly Boulevard, Room B 131, Los Angeles, CA 90048, USA
    Proc Natl Acad Sci U S A 100:6109-14. 2003
    ..That this protein is a member of the hnRNP family capable of interacting with double-stranded DNA highlights a potentially important new component of the complex machinery required for steroid hormone signal transduction...
  36. ncbi request reprint Genetic determinants of osteoporosis susceptibility in a female Ashkenazi Jewish population
    Xiaohui Li
    Burns and Allen Research Institute and Divisions of Medical Genetics and Endocrinology, Diabetes and Metabolism, Cedars Sinai Medical Center and University of California, Los Angeles, California, USA
    Genet Med 6:33-7. 2004
    ..To determine the heritability of low bone mineral density (BMD) at the hip in Ashkenazi Jewish families...
  37. ncbi request reprint Genetic heterogeneity in familial renal magnesium wasting
    Vitaly Kantorovich
    Burns and Allen Research Institute, University of Southern California, School of Medicine, Los Angeles, California 90033, USA
    J Clin Endocrinol Metab 87:612-7. 2002
    ..In conclusion, our data demonstrate locus heterogeneity for the phenotype of isolated renal Mg wasting with hypomagnesemia and suggest that hypomagnesemia, at least in this pedigree, may be associated with low bone mass...
  38. ncbi request reprint Biological actions of extra-renal 25-hydroxyvitamin D-1alpha-hydroxylase and implications for chemoprevention and treatment
    Kelly Townsend
    Division of Medical Sciences, Institute of Biomedical Research, The University of Birmingham, Birmingham B15 2TH, UK
    J Steroid Biochem Mol Biol 97:103-9. 2005
    ..The role of 1alpha-hydroxylase in protection against cancer is likely to be more complicated and may involve anti-tumor immune responses...
  39. ncbi request reprint Vitamin D and barrier function: a novel role for extra-renal 1 alpha-hydroxylase
    Martin Hewison
    Division of Medical Sciences, Institute of Clinical Research, The University of Birmingham, Queen Elizabeth Hospital, Birmingham B15 2TH, UK
    Mol Cell Endocrinol 215:31-8. 2004
    ....
  40. ncbi request reprint Vitamin D-mediated hypercalcemia in slack skin disease: evidence for involvement of extrarenal 25-hydroxyvitamin D 1alpha-hydroxylase
    Helen Karakelides
    Department of Endocrinology, Metabolism and Nutrition, Mayo Clinic College of Medicine, Rochester, Minnesota, USA
    J Bone Miner Res 21:1496-9. 2006
    ..Immunolocalization of 1alpha-OH in skin showed simultaneous dysregulation in epithelial and granulomatous cells...
  41. ncbi request reprint Vitamin D-mediated hypercalcemia in lymphoma: evidence for hormone production by tumor-adjacent macrophages
    Martin Hewison
    Division of Medical Sciences, University of Birmingham, Birmingham, United Kingdom
    J Bone Miner Res 18:579-82. 2003
    ..Based on this case study, we propose that the abnormal synthesis of 1,25(OH)2D3 associated with some lymphomas is because of paracrine regulation of tumor-associated macrophages...
  42. ncbi request reprint Regulation of 1,25-dihydroxyvitamin d synthesis by intracellular vitamin d binding protein-1
    Shaoxing Wu
    Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Cedars Sinai Medical Center, UCLA School of Medicine, 90048, USA
    Endocrinology 143:4135. 2002
    ....
  43. ncbi request reprint Proton pump inhibitor therapy and hip fracture risk
    Jordan L Geller
    JAMA 297:1429; author reply 1429-30. 2007

Research Grants28

  1. CO-FACILITATORS: NOVEL REGULATORS OF HORMONE METABOLISM
    John Adams; Fiscal Year: 2004
    ..e., osteoporosis) or that are improved or stabilized by enhancement of local vitamin D metabolite synthesis and action (i.e., leukemia, breast cancer, prostate cancer, psoriasis, etc.). ..
  2. Vitamin D and Barrier Function
    John Adams; Fiscal Year: 2005
    ..abstract_text> ..
  3. VITAMIN D RESISTANCE: MONKEY TO MAN
    John Adams; Fiscal Year: 2007
    ..abstract_text> ..
  4. Vitamin D and Estrogen Action in Bone: Concerted Role for hnRNPs in the C Family
    John Adams; Fiscal Year: 2009
    ....
  5. RICKETS AND OSTEOMALACIA IN NEW WORLD PRIMATES
    John Adams; Fiscal Year: 2001
    ....
  6. RICKETS AND OSTEOMALACIA
    John Adams; Fiscal Year: 1993
    ....
  7. RICKETS AND OSTEOMALACIA IN NEW WORLD PRIMATES
    John Adams; Fiscal Year: 1992
    ....
  8. Vitamin D and Estrogen Action in Bone: Concerted Role for hnRNPs in the C Family
    John S Adams; Fiscal Year: 2010
    ....