Catherine E Adams
Affiliation: University of Colorado Health Sciences Center
- Altered hippocampal circuit function in C3H alpha7 null mutant heterozygous miceC E Adams
Medical Research, Veterans Affairs Medical Center, Denver, CO 80220, USA
Brain Res 1194:138-45. 2008..These data suggest that decreasing hippocampal alpha7 receptor density results in a profound alteration in hippocampal circuit function...
- Inhibition of nitric oxide synthase prevents alpha 7 nicotinic receptor-mediated restoration of inhibitory auditory gating in rat hippocampusC E Adams
Department of Psychiatry, University of Colorado Health Sciences Center, Denver, CO 80262, USA
Brain Res 877:235-44. 2000..Together, these data support the hypothesis that nitric oxide mediates alpha 7 nicotinic receptor activation of gating of auditory response in rat hippocampus...
- Evidence for a role of nicotinic acetylcholine receptors in schizophreniaCatherine E Adams
Department of Psychiatry, Veterans Affairs Medical Center, Denver, CO 80220, USA
Front Biosci 12:4755-72. 2007..The initial results from clinical trials of these new drugs appear promising, potentially opening new avenues of treatment for this devastating disease...
- Alpha7-nicotinic receptor expression and the anatomical organization of hippocampal interneuronsC E Adams
Department of Psychiatry, Veterans Affairs Medical Center, University of Colorado Health Sciences Center, Denver, CO 80262, USA
Brain Res 922:180-90. 2001..This difference in interneuron anatomy may also contribute to functional differences in inhibitory sensory gating between the two strains...
- Comparison of alpha7 nicotinic acetylcholine receptor development in the hippocampal formation of C3H and DBA/2 miceCatherine E Adams
Department of Psychiatry, Veterans Administration Medical Center and University of Colorado Health Sciences Center, Denver, CO 80262, USA
Brain Res Dev Brain Res 143:137-49. 2003....
- Development of hippocampal alpha7 nicotinic receptors in C3H and DBA/2 congenic miceCatherine E Adams
Department of Psychiatry, Veterans Affairs Medical Center, Denver, CO 80220, and University of Colorado at Denver and Health Sciences Center, Aurora, CO 80045, USA
Brain Res 1122:27-35. 2006..The data suggest that hippocampal alpha7 receptor development is controlled predominantly by a region of mouse chromosome 7 that contains the strain-specific Chrna7 allele...
- Permanent improvement in deficient sensory inhibition in DBA/2 mice with increased perinatal cholineKaren E Stevens
Medical Research, Veterans Affairs Medical Center, 1055 Clermont Avenue, Denver, CO 80220, USA
Psychopharmacology (Berl) 198:413-20. 2008..Increasing maternal dietary choline, a selective alpha7 agonist, during gestation has been shown to produce long-term changes in adult offspring behavior (i.e., improved learning and memory in rats)...
- Perinatal choline deficiency produces abnormal sensory inhibition in Sprague-Dawley ratsKaren E Stevens
Medical Research Service, Department of Veterans Affairs Medical Center, Denver, CO, USA
Brain Res 1237:84-90. 2008..These data suggest that attention to maternal choline levels for human pregnancy may be important to the normal functioning of the offspring...
- Research review: Cholinergic mechanisms, early brain development, and risk for schizophreniaRandal G Ross
Department of Psychiatry, University of Colorado Denver, Aurora, CO, USA
J Child Psychol Psychiatry 51:535-49. 2010..Therapeutic implications, including perinatal dietary choline supplementation, are discussed...
- Continuous administration of a selective alpha7 nicotinic partial agonist, DMXBA, improves sensory inhibition without causing tachyphylaxis or receptor upregulation in DBA/2 miceKaren E Stevens
Medical Research Service, Veterans Affairs Medical Center, Denver, CO, USA
Brain Res 1352:140-6. 2010....
- Smoking cessation and schizophreniaSherry Leonard
UT Southwestern Medical Center, Department of Psychiatry, 5323 Harry Hines Blvd, NE5 110, Dallas, TX 75390 9070, USA
Am J Psychiatry 163:1877. 2006
- Development of the alpha7 nicotinic cholinergic receptor in rat hippocampal formationCatherine E Adams
VAMC Department of Psychiatry, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, Box C268 71, Denver, CO 80262, USA
Brain Res Dev Brain Res 139:175-87. 2002..The early appearance and complex, prolonged pattern of development of the alpha7 receptor suggest that it may influence processes as diverse as cell migration, dendritic elaboration and apoptosis during hippocampal maturation...
- Olfactory discrimination varies in mice with different levels of α7-nicotinic acetylcholine receptor expressionJennifer L Hellier
Department of Cell and Developmental Biology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA
Brain Res 1358:140-50. 2010..These data suggest that α7-nicotinic-receptors contribute strongly to olfactory discrimination and detection in mice and may be one of the mechanisms producing olfactory dysfunction in schizophrenics...
- Inhibitory neurophysiological deficit as a phenotype for genetic investigation of schizophreniaR Freedman
Psychiatry and Pharmacology, University of Colorado, CO 80262, USA
Am J Med Genet 97:58-64. 2000..It is certain that there are many genetic factors in schizophrenia and bipolar disorder; what is needed is a complete and precise description of the contribution of each individual factor to the pathophysiology of these illnesses...
- The alpha7-nicotinic acetylcholine receptor and the pathology of hippocampal interneurons in schizophreniaR Freedman
Departments of Psychiatry and Pharmacology, University of Colorado Health Sciences Center and Denver VA Medical Center, Campus Box C 268 71, Room 3F10, 4200 East Ninth Avenue, Denver, CO 80262, USA
J Chem Neuroanat 20:299-306. 2000..The alpha7-receptor is a ligand-gated ion channel that admits calcium ions into cells, and it has been proposed to have various developmental roles. Its malfunction may be part of the developmental pathogenesis of schizophrenia...
- Maternal stress during pregnancy causes sex-specific alterations in offspring memory performance, social interactions, indices of anxiety, and body massKalynn M Schulz
Department of Psychiatry, University of Colorado Denver, Aurora, CO 80045, USA
Physiol Behav 104:340-7. 2011..In summary, these data indicate that PS differentially impacts males and females resulting in sex-specific adult behavioral and bodily phenotypes...
- Expression of immune genes on chromosome 6p21.3-22.1 in schizophreniaMelissa L Sinkus
Department of Psychiatry, University of Colorado Denver, Anschutz Medical Campus, Colorado 80045, USA
Brain Behav Immun 32:51-62. 2013..There were also significant interactions between schizophrenia diagnosis and both inflammatory illness and smoking...
- Early biomarkers of psychosisRobert Freedman
Department of Psychiatry C 268 71, University of Colorado Health Sciences Center, Denver, CO 80262, USA
Dialogues Clin Neurosci 7:17-29. 2005..Examples are given from work on the role of the alpha(T)nicotinic receptor and its gene CHRNA7 on chromosome 15 in the neurobiology and genetic transmission of schizophrenia...
- Brain pH has a significant impact on human postmortem hippocampal gene expression profilesS Mexal
Department of Psychiatry, University of Colorado at Denver and Health Sciences Center, Mail Stop 8344, PO Box 6511, Aurora, CO 80045, USA
Brain Res 1106:1-11. 2006..The predictive value of brain pH in an independent sample set was also greater than the disease, demonstrating that pH represents one of the most important control parameters in human postmortem gene expression studies in schizophrenia...
- Differential modulation of gene expression in the NMDA postsynaptic density of schizophrenic and control smokersS Mexal
Department of Psychiatry, University of Colorado at Denver and Health Sciences Center, Aurora, CO 80045, USA
Brain Res Mol Brain Res 139:317-32. 2005..The biological mechanisms underlying chronic tobacco use are likely to differ substantially between these two groups...