Catherine E Adams

Summary

Affiliation: University of Colorado Health Sciences Center
Country: USA

Publications

  1. ncbi Evidence for a role of nicotinic acetylcholine receptors in schizophrenia
    Catherine E Adams
    Department of Psychiatry, Veterans Affairs Medical Center, Denver, CO 80220, USA
    Front Biosci 12:4755-72. 2007
  2. ncbi Development of hippocampal alpha7 nicotinic receptors in C3H and DBA/2 congenic mice
    Catherine E Adams
    Department of Psychiatry, Veterans Affairs Medical Center, Denver, CO 80220, and University of Colorado at Denver and Health Sciences Center, Aurora, CO 80045, USA
    Brain Res 1122:27-35. 2006
  3. pmc Altered hippocampal circuit function in C3H alpha7 null mutant heterozygous mice
    C E Adams
    Medical Research, Veterans Affairs Medical Center, Denver, CO 80220, USA
    Brain Res 1194:138-45. 2008
  4. ncbi Comparison of alpha7 nicotinic acetylcholine receptor development in the hippocampal formation of C3H and DBA/2 mice
    Catherine E Adams
    Department of Psychiatry, Veterans Administration Medical Center and University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Brain Res Dev Brain Res 143:137-49. 2003
  5. ncbi Alpha7-nicotinic receptor expression and the anatomical organization of hippocampal interneurons
    C E Adams
    Department of Psychiatry, Veterans Affairs Medical Center, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Brain Res 922:180-90. 2001
  6. ncbi Inhibition of nitric oxide synthase prevents alpha 7 nicotinic receptor-mediated restoration of inhibitory auditory gating in rat hippocampus
    C E Adams
    Department of Psychiatry, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Brain Res 877:235-44. 2000
  7. pmc Perinatal choline deficiency produces abnormal sensory inhibition in Sprague-Dawley rats
    Karen E Stevens
    Medical Research Service, Department of Veterans Affairs Medical Center, Denver, CO, USA
    Brain Res 1237:84-90. 2008
  8. doi Permanent improvement in deficient sensory inhibition in DBA/2 mice with increased perinatal choline
    Karen E Stevens
    Medical Research, Veterans Affairs Medical Center, 1055 Clermont Avenue, Denver, CO 80220, USA
    Psychopharmacology (Berl) 198:413-20. 2008
  9. pmc Research review: Cholinergic mechanisms, early brain development, and risk for schizophrenia
    Randal G Ross
    Department of Psychiatry, University of Colorado Denver, Aurora, CO, USA
    J Child Psychol Psychiatry 51:535-49. 2010
  10. ncbi The effects of prenatal stress on alpha4 beta2 and alpha7 hippocampal nicotinic acetylcholine receptor levels in adult offspring
    Kalynn M Schulz
    Veterans Affairs Medical Center, Denver, Colorado Department of Psychiatry, University of Colorado Anschutz Medical Campus, Colorado
    Dev Neurobiol 73:806-14. 2013

Detail Information

Publications23

  1. ncbi Evidence for a role of nicotinic acetylcholine receptors in schizophrenia
    Catherine E Adams
    Department of Psychiatry, Veterans Affairs Medical Center, Denver, CO 80220, USA
    Front Biosci 12:4755-72. 2007
    ..The initial results from clinical trials of these new drugs appear promising, potentially opening new avenues of treatment for this devastating disease...
  2. ncbi Development of hippocampal alpha7 nicotinic receptors in C3H and DBA/2 congenic mice
    Catherine E Adams
    Department of Psychiatry, Veterans Affairs Medical Center, Denver, CO 80220, and University of Colorado at Denver and Health Sciences Center, Aurora, CO 80045, USA
    Brain Res 1122:27-35. 2006
    ..The data suggest that hippocampal alpha7 receptor development is controlled predominantly by a region of mouse chromosome 7 that contains the strain-specific Chrna7 allele...
  3. pmc Altered hippocampal circuit function in C3H alpha7 null mutant heterozygous mice
    C E Adams
    Medical Research, Veterans Affairs Medical Center, Denver, CO 80220, USA
    Brain Res 1194:138-45. 2008
    ..These data suggest that decreasing hippocampal alpha7 receptor density results in a profound alteration in hippocampal circuit function...
  4. ncbi Comparison of alpha7 nicotinic acetylcholine receptor development in the hippocampal formation of C3H and DBA/2 mice
    Catherine E Adams
    Department of Psychiatry, Veterans Administration Medical Center and University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Brain Res Dev Brain Res 143:137-49. 2003
    ....
  5. ncbi Alpha7-nicotinic receptor expression and the anatomical organization of hippocampal interneurons
    C E Adams
    Department of Psychiatry, Veterans Affairs Medical Center, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Brain Res 922:180-90. 2001
    ..This difference in interneuron anatomy may also contribute to functional differences in inhibitory sensory gating between the two strains...
  6. ncbi Inhibition of nitric oxide synthase prevents alpha 7 nicotinic receptor-mediated restoration of inhibitory auditory gating in rat hippocampus
    C E Adams
    Department of Psychiatry, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Brain Res 877:235-44. 2000
    ..Together, these data support the hypothesis that nitric oxide mediates alpha 7 nicotinic receptor activation of gating of auditory response in rat hippocampus...
  7. pmc Perinatal choline deficiency produces abnormal sensory inhibition in Sprague-Dawley rats
    Karen E Stevens
    Medical Research Service, Department of Veterans Affairs Medical Center, Denver, CO, USA
    Brain Res 1237:84-90. 2008
    ..These data suggest that attention to maternal choline levels for human pregnancy may be important to the normal functioning of the offspring...
  8. doi Permanent improvement in deficient sensory inhibition in DBA/2 mice with increased perinatal choline
    Karen E Stevens
    Medical Research, Veterans Affairs Medical Center, 1055 Clermont Avenue, Denver, CO 80220, USA
    Psychopharmacology (Berl) 198:413-20. 2008
    ..Increasing maternal dietary choline, a selective alpha7 agonist, during gestation has been shown to produce long-term changes in adult offspring behavior (i.e., improved learning and memory in rats)...
  9. pmc Research review: Cholinergic mechanisms, early brain development, and risk for schizophrenia
    Randal G Ross
    Department of Psychiatry, University of Colorado Denver, Aurora, CO, USA
    J Child Psychol Psychiatry 51:535-49. 2010
    ..Therapeutic implications, including perinatal dietary choline supplementation, are discussed...
  10. ncbi The effects of prenatal stress on alpha4 beta2 and alpha7 hippocampal nicotinic acetylcholine receptor levels in adult offspring
    Kalynn M Schulz
    Veterans Affairs Medical Center, Denver, Colorado Department of Psychiatry, University of Colorado Anschutz Medical Campus, Colorado
    Dev Neurobiol 73:806-14. 2013
    ..Taken together, our results suggest that PS impacts the development of hippocampal nAChRs, which may be an important link between PS exposure and risk for neuropsychiatric illness...
  11. pmc Continuous administration of a selective alpha7 nicotinic partial agonist, DMXBA, improves sensory inhibition without causing tachyphylaxis or receptor upregulation in DBA/2 mice
    Karen E Stevens
    Medical Research Service, Veterans Affairs Medical Center, Denver, CO, USA
    Brain Res 1352:140-6. 2010
    ....
  12. pmc Expression of immune genes on chromosome 6p21.3-22.1 in schizophrenia
    Melissa L Sinkus
    Department of Psychiatry, University of Colorado Denver, Anschutz Medical Campus, Colorado 80045, USA
    Brain Behav Immun 32:51-62. 2013
    ..There were also significant interactions between schizophrenia diagnosis and both inflammatory illness and smoking...
  13. ncbi Smoking cessation and schizophrenia
    Sherry Leonard
    UT Southwestern Medical Center, Department of Psychiatry, 5323 Harry Hines Blvd, NE5 110, Dallas, TX 75390 9070, USA
    Am J Psychiatry 163:1877. 2006
  14. ncbi Dietary choline supplementation to dams during pregnancy and lactation mitigates the effects of in utero stress exposure on adult anxiety-related behaviors
    Kalynn M Schulz
    Veterans Affairs Medical Center, 1055 Clermont Street, Denver, CO 80220, USA Department of Psychiatry, University of Colorado Anschutz Medical Campus, Building 500, 1300 East 17th Place, Aurora, CO 80045, USA Electronic address
    Behav Brain Res 268:104-10. 2014
    ..Taken together, these data suggest that perinatal choline supplementation ameliorates the sex-specific effects of prenatal stress. ..
  15. ncbi Development of the alpha7 nicotinic cholinergic receptor in rat hippocampal formation
    Catherine E Adams
    VAMC Department of Psychiatry, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, Box C268 71, Denver, CO 80262, USA
    Brain Res Dev Brain Res 139:175-87. 2002
    ..The early appearance and complex, prolonged pattern of development of the alpha7 receptor suggest that it may influence processes as diverse as cell migration, dendritic elaboration and apoptosis during hippocampal maturation...
  16. pmc Olfactory discrimination varies in mice with different levels of α7-nicotinic acetylcholine receptor expression
    Jennifer L Hellier
    Department of Cell and Developmental Biology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA
    Brain Res 1358:140-50. 2010
    ..These data suggest that α7-nicotinic-receptors contribute strongly to olfactory discrimination and detection in mice and may be one of the mechanisms producing olfactory dysfunction in schizophrenics...
  17. ncbi The alpha7-nicotinic acetylcholine receptor and the pathology of hippocampal interneurons in schizophrenia
    R Freedman
    Departments of Psychiatry and Pharmacology, University of Colorado Health Sciences Center and Denver VA Medical Center, Campus Box C 268 71, Room 3F10, 4200 East Ninth Avenue, Denver, CO 80262, USA
    J Chem Neuroanat 20:299-306. 2000
    ..The alpha7-receptor is a ligand-gated ion channel that admits calcium ions into cells, and it has been proposed to have various developmental roles. Its malfunction may be part of the developmental pathogenesis of schizophrenia...
  18. ncbi Inhibitory neurophysiological deficit as a phenotype for genetic investigation of schizophrenia
    R Freedman
    Psychiatry and Pharmacology, University of Colorado, CO 80262, USA
    Am J Med Genet 97:58-64. 2000
    ..It is certain that there are many genetic factors in schizophrenia and bipolar disorder; what is needed is a complete and precise description of the contribution of each individual factor to the pathophysiology of these illnesses...
  19. doi Maternal stress during pregnancy causes sex-specific alterations in offspring memory performance, social interactions, indices of anxiety, and body mass
    Kalynn M Schulz
    Department of Psychiatry, University of Colorado Denver, Aurora, CO 80045, USA
    Physiol Behav 104:340-7. 2011
    ..In summary, these data indicate that PS differentially impacts males and females resulting in sex-specific adult behavioral and bodily phenotypes...
  20. doi Long-term improvements in sensory inhibition with gestational choline supplementation linked to α7 nicotinic receptors through studies in Chrna7 null mutation mice
    Karen E Stevens
    Medical Research Service, Veterans Affairs Medical Center, Denver, CO, USA Department of Psychiatry, University of Colorado, Anchutz Medical Campus, 12800 East 19th Avenue, Aurora, CO, USA Electronic address
    Brain Res 1552:26-33. 2014
    ..These data parallel a human study wherein the offspring of pregnant women receiving choline supplementation during gestation, showed better sensory inhibition than offspring of women on placebo...
  21. pmc Early biomarkers of psychosis
    Robert Freedman
    Department of Psychiatry C 268 71, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Dialogues Clin Neurosci 7:17-29. 2005
    ..Examples are given from work on the role of the alpha(T)nicotinic receptor and its gene CHRNA7 on chromosome 15 in the neurobiology and genetic transmission of schizophrenia...
  22. ncbi Brain pH has a significant impact on human postmortem hippocampal gene expression profiles
    S Mexal
    Department of Psychiatry, University of Colorado at Denver and Health Sciences Center, Mail Stop 8344, PO Box 6511, Aurora, CO 80045, USA
    Brain Res 1106:1-11. 2006
    ..The predictive value of brain pH in an independent sample set was also greater than the disease, demonstrating that pH represents one of the most important control parameters in human postmortem gene expression studies in schizophrenia...
  23. ncbi Differential modulation of gene expression in the NMDA postsynaptic density of schizophrenic and control smokers
    S Mexal
    Department of Psychiatry, University of Colorado at Denver and Health Sciences Center, Aurora, CO 80045, USA
    Brain Res Mol Brain Res 139:317-32. 2005
    ..The biological mechanisms underlying chronic tobacco use are likely to differ substantially between these two groups...