R T Acton
Affiliation: University of Alabama at Birmingham
- Knowledge, attitudes, and behaviors of Alabama's primary care physicians regarding cancer geneticsR T Acton
Department of Microbiology, Schools of Medicine, Dentistry, and Public Health, University of Alabama at Birmingham, 35294 4400, USA
Acad Med 75:850-2. 2000..To determine Alabama's primary care physicians' knowledge, attitudes, and behaviors regarding cancer genetics...
- A rapid PCR-SSP assay for the hemochromatosis-associated Tyr250Stop mutation in the TFR2 geneC A Rivers
Department of Microbiology, University of Alabama at Birmingham, 35294, USA
Genet Test 5:131-4. 2001..The modified assay is robust and cost-efficient, and may be more useful for large-scale population studies because it can be performed rapidly on DNA extracted from buccal swabs...
- Associations of MHC genes with levels of caries-inducing organisms and caries severity in African-American womenR T Acton
Department of Microbiology, Schools of Dentistry, Medicine and Public Health, University of Alabama at Birmingham 35294 4400, USA
Hum Immunol 60:984-9. 1999..These results support an hypothesis of an association between host HLA class II and TNFa genetic profile and colonization of S. mutans, L. casei, and L. acidophilus thought to be pathogens involved in the etiology of dental caries...
- Influence of CYP2C9 and VKORC1 1173C/T genotype on the risk of hemorrhagic complications in African-American and European-American patients on warfarinN A Limdi
Department of Neurology, University of Alabama at Birmingham, Birmingham, Alabama, USA
Clin Pharmacol Ther 83:312-21. 2008..7; 95% CI: 0.7-4.4) or minor (HR 0.8; 95% CI: 0.5-1.3) hemorrhage. The variant CYP2C9 genotype is associated with an increased risk of major hemorrhage, which persists even after stabilization of therapy...
- A genome-wide linkage scan for iron phenotype quantitative trait loci: the HEIRS Family StudyR T Acton
Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35209 0005, USA
Clin Genet 71:518-29. 2007..12, p = 0.002) and to chromosome 17q (LOD = 2.19, p = 0.002). We conclude that these regions should be considered for fine mapping studies to identify QTL that contribute to variation in SF and UIBC...
- DMPK-associated myotonic dystrophy and CTG repeats in Alabama African AmericansR T Acton
Department of Microbiology, University of Alabama, Birmingham, AL 35294 0005, USA
Clin Genet 72:448-53. 2007..These data suggest that the risk for DM1 in AAs is intermediate between that of African blacks and whites of European descent...
- Racial differences in the prevalence of Factor V Leiden mutation among patients on chronic warfarin therapyN A Limdi
Department of Neurology, University of Alabama at Birmingham, 1719 6th Avenue South, CIRC 312, 35294 0021, USA
Blood Cells Mol Dis 37:100-6. 2006..In European Americans, but not in African Americans, the GA genotype was more prevalent in patients with venous compared to arterial thromboembolic events...
- Initial screening transferrin saturation values, serum ferritin concentrations, and HFE genotypes in Native Americans and whites in the Hemochromatosis and Iron Overload Screening StudyJ C Barton
Southern Iron Disorders Center, University of Alabama at Birmingham Birmingham, AL 35209, USA
Clin Genet 69:48-57. 2006..0001). We conclude that the screening TfSat and SF phenotypes of Native Americans are similar to those of whites. The allele frequencies of HFE C282Y and H63D are significantly lower in Native Americans than in whites...
- HFE genotype frequencies in consecutive reference laboratory specimens: comparisons among referral sources and association with initial diagnosisR T Acton
Immunogenetics Program, Department of Microbiology, University of Alabama at Birmingham, AL 35294, USA
Genet Test 5:299-306. 2001....
- HFE mutations in African-American women with non-insulin-dependent diabetes mellitusR T Acton
Department of Microbiology, University of Alabama at Birmingham, USA
Ethn Dis 11:578-84. 2001....
- Serial serum ferritin measurements in untreated HFE C282Y homozygotes in the Hemochromatosis and Iron Overload Screening StudyP C Adams
Department of Medicine, University Hospital, London, Ontario, Canada
Int J Lab Hematol 30:300-5. 2008..6 g, 0.42-7.1, P < 0.05). SF was as likely to decrease as increase in untreated C282Y homozygotes over this relatively brief observation period. Incremental increases in SF are not inevitable in untreated C282Y homozygotes...
- Inheritance of two HFE mutations in African Americans: cases with hemochromatosis phenotypes and estimates of hemochromatosis phenotype frequencyJ C Barton
Southern Iron Disorders Center, Birmingham, Alabama, USA
Genet Med 3:294-300. 2001..Two unrelated African Americans had hemochromatosis phenotypes and genotypes. We sought to identify origins of their HFE mutations and estimate frequencies of similar cases...
- Investigation of association of 13 polymorphisms in eight genes in southeastern African American Alzheimer disease patients as compared to age-matched controlsR T Perry
Department of Epidemiology and International Health, University of Alabama at Birmingham, 35294, USA
Am J Med Genet 105:332-42. 2001..In addition, TNF appears to have some modifying effect in AD, primarily on age of onset, or it could be in linkage disequilibrium with a modifier locus nearby...
- Transferrin receptor-2 (TFR2) mutation Y250X in Alabama Caucasian and African American subjects with and without primary iron overloadE H Barton
Immunogenetics Program, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
Blood Cells Mol Dis 27:279-84. 2001....
- Two novel missense mutations of the HFE gene (I105T and G93R) and identification of the S65C mutation in Alabama hemochromatosis probandsJ C Barton
Southern Iron Disorders Center, Birmingham, Alabama 35209, USA
Blood Cells Mol Dis 25:147-55. 1999..We conclude that uncommon HFE exon and intron mutations may be discovered among hemochromatosis patients who have "atypical" HFE genotypes...
- Variability of the pancreatic islet beta cell/liver (GLUT 2) glucose transporter gene in NIDDM patientsY Tanizawa
Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri 63110
Diabetologia 37:420-7. 1994..The allelic frequency of the ATT (Ile110) in NIDDM patients (39.6%, n = 48) and that in controls (47.1%, n = 52) did not differ (p = 0.32, Fisher's exact test).(ABSTRACT TRUNCATED AT 250 WORDS)..
- SSCP analysis and sequencing of the human prion protein gene (PRNP) detects two different 24 bp deletions in an atypical Alzheimer's disease familyR T Perry
University of Alabama at Birmingham, USA
Am J Med Genet 60:12-8. 1995..It does not appear that mutations at the PRNP locus are frequently associated with AD in this population...
- Variations among sublines of inbred AKR miceR T Acton
Nat New Biol 245:8-10. 1973