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Genomes and Genes | Geza AcsSummaryAffiliation: University of Pennsylvania Country: USA Publications
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Publications
Hypoxia-inducible erythropoietin signaling in squamous dysplasia and squamous cell carcinoma of the uterine cervix and its potential role in cervical carcinogenesis and tumor progressionGeza Acs
Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA
Am J Pathol 162:1789-806. 2003..Hypoxia-inducible Epo signaling may play a significant role in the aggressive behavior and treatment resistance of hypoxic cervical cancers...- RNA interference-mediated inhibition of erythropoietin receptor expression suppresses tumor growth and invasiveness in A2780 human ovarian carcinoma cellsGyorgy Paragh
Experimental Therapeutics Program, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
Am J Pathol 174:1504-14. 2009..Our findings suggest that EpoR may be constitutively active in some cancer cells in the absence of Epo and provide the first evidence for a potential role of an Epo-independent, EpoR-mediated pathway in the growth of some human cancers... 
Extensive retraction artifact correlates with lymphatic invasion and nodal metastasis and predicts poor outcome in early stage breast carcinomaGeza Acs
Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
Am J Surg Pathol 31:129-40. 2007..Rather, it likely signifies important biologic changes that alter tumor-stromal interactions and contribute to lymphatic spread and tumor progression...- Lymphatic invasion revealed by multispectral imaging is common in primary melanomas and associates with prognosisXiaowei Xu
Department of Pathology and Laboratory Medicine, and the Melanoma Program of the Abramson Cancer Center, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Hum Pathol 39:901-9. 2008..Lymphatic invasion is an underobserved phenomenon in primary melanomas that can be better detected by immunohistochemical staining. The presence of lymphatic invasion may be a clinically useful predictor of regionally metastatic disease... - Nuclear orphan receptor TR3/Nur77 mediates melanoma cell apoptosisHong Yu
Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
Cancer Biol Ther 6:405-12. 2007..Decreased expression of TR3 in metastatic melanoma cells may contribute to their reduced apoptotic potential and increased resistance to chemotherapy... - Autocrine erythropoietin signaling inhibits hypoxia-induced apoptosis in human breast carcinoma cellsGeza Acs
Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, 6 Founders Pavilion, 3400 Spruce Street, Philadelphia, PA 19104, USA
Cancer Lett 214:243-51. 2004..The resulting decreased apoptotic potential of hypoxic tumor cells may contribute to increased aggressiveness and therapy resistance of breast cancers... - Prognostic significance of erythropoietin expression in human endometrial carcinomaGeza Acs
Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA
Cancer 100:2376-86. 2004..The authors recently demonstrated hypoxia-stimulated expression of Epo and Epo receptor (EpoR) in human breast and cervical carcinomas, suggesting a role for autocrine Epo signaling in the hypoxic adaptations of carcinomas... - Functional erythropoietin autocrine loop in melanomaSuresh M Kumar
Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, 3400 Spruce Street, Philadelphia, PA 19104, USA
Am J Pathol 166:823-30. 2005..The results suggest that the autocrine and paracrine functions of Epo might play a role in malignant transformation of melanocytes and in the survival of melanoma cells in hypoxia and other adverse conditions... - Erythropoietin activates the phosphoinositide 3-kinase/Akt pathway in human melanoma cellsSuresh M Kumar
Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine bThe Wistar Institute, Philadelphia, Pennsylvania 19104, USA
Melanoma Res 16:275-83. 2006..LY294002 also inhibited the cytoprotective effects of Epo in melanoma cells under both normoxic and hypoxic conditions. Our results suggest that Epo promotes melanoma cell survival by activating an Akt-dependent signaling pathway... - Low D2-40 immunoreactivity correlates with lymphatic invasion and nodal metastasis in early-stage squamous cell carcinoma of the uterine cervixKimberly L Dumoff
Department of Pathology and Laboratory Medicine, Division of Gynecologic Oncology, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
Mod Pathol 18:97-104. 2005..Further study of the biological function of the M2A antigen may shed some light on the interaction of tumor cells with lymphatics... - Mutant V600E BRAF increases hypoxia inducible factor-1alpha expression in melanomaSuresh M Kumar
Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine and The Wistar Institute, Philadelphia, Pennsylvania, USA
Cancer Res 67:3177-84. 2007.... - Low podoplanin expression in pretreatment biopsy material predicts poor prognosis in advanced-stage squamous cell carcinoma of the uterine cervix treated by primary radiationKimberly L Dumoff
Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia, PA, USA
Mod Pathol 19:708-16. 2006..Prospective studies involving larger numbers of patients are needed to further evaluate the clinical utility of examination of podoplanin expression in patients with cervix carcinoma... - Can Melan-A replace S-100 and HMB-45 in the evaluation of sentinel lymph nodes from patients with malignant melanoma?Cynthia Kucher
Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
Appl Immunohistochem Mol Morphol 14:324-7. 2006..Melan-A, although very specific, cannot replace the use of S-100 and HMB-45 for the detection of metastatic melanoma in SLNs. It can, however, substitute for HMB-45 with equally good results... - Podoplanin is a highly sensitive and specific marker to distinguish primary skin adnexal carcinomas from adenocarcinomas metastatic to skinHaohai Liang
Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Am J Surg Pathol 31:304-10. 2007..Our results suggest that podoplanin can be a useful tool to distinguish primary skin adnexal carcinomas form adenocarcinomas metastatic to skin with high sensitivity (94.5%) and specificity (97.2%)... - Peritumoral lymphatic vessel density and vascular endothelial growth factor C expression in early-stage squamous cell carcinoma of the uterine cervixZoltan Gombos
Department of Pathology and Laboratory Medicine and Division of Gynecologic Oncology, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA
Clin Cancer Res 11:8364-71. 2005..Lymphatic invasion and nodal metastasis plays a major role in the spread of cervical cancer; however, little is known about the mechanisms whereby tumor cells enter the lymphatic system... - Isolation of a novel population of multipotent adult stem cells from human hair folliclesHong Yu
Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Am J Pathol 168:1879-88. 2006..Human hair follicles may provide an accessible, autologous source of adult stem cells for therapeutic application... 
Cytoplasmic overexpression of WT-1 in gastrointestinal stromal tumor and other soft tissue tumorsZhanyong Bing
Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA 19094, USA
Appl Immunohistochem Mol Morphol 16:316-21. 2008..The significance of cytoplasmic expression of WT-1 in GIST and some smooth muscle tumors is unclear and warrant further investigation. The potential roles of WT-1 in the diagnosis and treatment of GIST were discussed...- Immunohistochemical expression of erythropoietin and erythropoietin receptor in breast carcinomaGeza Acs
Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia 19104, USA
Cancer 95:969-81. 2002.... - Posterior acoustic shadowing in benign breast lesions: sonographic-pathologic correlationSusan P Weinstein
Department of Radiology, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104 4283, USA
J Ultrasound Med 23:73-83. 2004..To show a variety of benign breast lesions that exhibit posterior acoustic shadowing on sonography... - Intraoperative consultation in gynecologic pathologyGeza Acs
Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
Semin Diagn Pathol 19:237-54. 2002..It is important for pathologists to have a clear idea of the role and limitations of frozen section diagnosis in gynecological surgery in order to play a meaningful and optimal role in the management of the gynecologic oncology patient... - Microglandular adenosis with transition into adenoid cystic carcinoma of the breastGeza Acs
Department of Pathology and Laboratory of Medicine, University of Pensilvania Medical Center, Philacelphia, Pensylvania 19104, USA
Am J Surg Pathol 27:1052-60. 2003..Their unusual interaction with the surrounding stroma may play a role in this benign biologic behavior... - Immunoprofile of endocervical and endometrial stromal cells and its potential application in localization of tumor involvementJulieta E Barroeta
Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania, USA
Int J Gynecol Pathol 26:76-82. 2007..The functional status of the endometrium had no effect on the immunoprofile. The pattern of CD34 and CD10 immunostaining in stromal cells might be helpful in determining tumor involvement in uterine and cervical sites... - Repeat operative sentinel lymph node biopsyBenjamin M Jackson
Department of Surgery, Hospital of the University of Pennsylvania, Philadelphia, PA 19104, USA
Clin Breast Cancer 6:530-2. 2006.... - Intraoperative consultation: an historical perspectiveGeza Acs
Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
Semin Diagn Pathol 19:190-1. 2002 - Utility of D2-40, a novel mesothelial marker, in the diagnosis of malignant mesotheliomaAlbert Y Chu
Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA 19104, USA
Mod Pathol 18:105-10. 2005..We conclude that D2-40 immunoreactivity is sensitive for cells of mesothelial origin, and may be useful in the differential diagnosis of epithelioid malignant mesothelioma vs adenocarcinoma... - WT1 is differentially expressed in serous, endometrioid, clear cell, and mucinous carcinomas of the peritoneum, fallopian tube, ovary, and endometriumGeza Acs
Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA
Int J Gynecol Pathol 23:110-8. 2004..Our results suggest that WT1 expression in epithelial tumors of the female genital tract may be related to cell differentiation and histologic subtypes of carcinomas, rather than to primary site of origin... - Immune responses of breast cancer patients to mutated epidermal growth factor receptor (EGF-RvIII, Delta EGF-R, and de2-7 EGF-R)Enkhtsetseg Purev
The Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104, USA
J Immunol 173:6472-80. 2004.... - Serous and mucinous borderline (low malignant potential) tumors of the ovaryGeza Acs
Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, Philadephia, PA 19104, USA
Am J Clin Pathol 123:S13-57. 2005..Rare primary ovarian mucinous tumors associated with pseudomyxoma peritonei are those arising in mature cystic teratomas. Advanced-stage ovarian mucinous carcinomas typically show frank, infiltrative-type invasion; the prognosis is poor... - Role of different immunostaining patterns in HercepTest interpretation and criteria for gene amplification as determined by fluorescence in situ hybridizationGeza Acs
Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, 6 Founders Pavilion, 3400 Spruce Street, Philadelphia, PA 19104, USA
Appl Immunohistochem Mol Morphol 11:222-9. 2003..Our results suggest that a high concordance (95.8%) between HER-Z overexpression and GA can be achieved by using more stringent pattern-modified criteria for judging protein overexpression and combined criteria for GA... - Case 59: Angiolipoma of the breastSusan P Weinstein
Department of Radiology, University of Pennsylvania Medical Center, 1 Silverstein Bldg, 3400 Spruce St, Philadelphia, PA 19104, USA
Radiology 227:773-5. 2003 - C-kit immunoreactivity in endometrial adenocarcinomas and its clinicopathologic significanceJanice V Scobie
Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA
Int J Gynecol Pathol 22:149-55. 2003..Expression of c-kit may be a potentially adverse prognostic feature in endometrial adenocarcinoma. Patients with c-kit-positive advanced endometrial adenocarcinoma might benefit from tyrosine-kinase-inhibitor therapy... - High-risk benign breast lesions: current strategies in managementJohn V Kiluk
Comprehensive Breast Cancer Program, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA
Cancer Control 14:321-9. 2007..High-risk benign breast lesions can create confusion for both the patient and the clinician. This paper reviews the characteristics of these lesions to help direct appropriate management... - Survival and invasiveness of astrocytomas promoted by erythropoietinAhmed Mohyeldin
Department of Neurology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA
J Neurosurg 106:338-50. 2007..Since hypoxia has been implicated in the malignant progression of some human cancers, the authors investigated whether EPO signaling influenced the malignant properties of human astrocytoma cells... - Erythropoietin signaling promotes invasiveness of human head and neck squamous cell carcinomaAhmed Mohyeldin
Department of Neurology, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814, USA
Neoplasia 7:537-43. 2005..This mechanism may also be activated by recombinant Epo therapy and could potentially produce detrimental effects in rhEpo-treated cancer patients... - Renal carcinomas with the t(6;11)(p21;q12): clinicopathologic features and demonstration of the specific alpha-TFEB gene fusion by immunohistochemistry, RT-PCR, and DNA PCRPedram Argani
Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD, USA
Am J Surg Pathol 29:230-40. 2005..Finally, the special molecular features of the Alpha-TFEB gene fusion allow its molecular detection by DNA PCR as a robust alternative to RT-PCR in clinical tumor samples... - Erythropoietin receptor function and expression in epithelial ovarian carcinomaJohn W McBroom
Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Tripler Army Medical Center, Honolulu, HI 96859, USA
Gynecol Oncol 99:571-7. 2005..Furthermore, adversely effects sensitivity to cisplatin in the ovarian cancer cell lines. These data add to the growing body of evidence suggesting possible detrimental effects of erythropoietin... - Erythropoietin receptors on cancer cells: exciting perspectives, difficult to appreciateMichael Henke
Blood 108:1107-8; author reply 1108-9. 2006 - HIF transcription factor expression and induction of hypoxic response genes in a retroperitoneal angiosarcomaW Kimryn Rathmell
Division of Hematology Oncology, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, 27599, USA
Anticancer Res 24:167-9. 2004..Disordered regulation of the hypoxic response pathway can result in the expression of factors such as VEGF and erythropoietin, which may promote autocrine tumor growth in angiosarcoma...