Geza Acs

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. pmc Hypoxia-inducible erythropoietin signaling in squamous dysplasia and squamous cell carcinoma of the uterine cervix and its potential role in cervical carcinogenesis and tumor progression
    Geza Acs
    Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA
    Am J Pathol 162:1789-806. 2003
  2. pmc RNA interference-mediated inhibition of erythropoietin receptor expression suppresses tumor growth and invasiveness in A2780 human ovarian carcinoma cells
    Gyorgy Paragh
    Experimental Therapeutics Program, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Am J Pathol 174:1504-14. 2009
  3. ncbi request reprint Extensive retraction artifact correlates with lymphatic invasion and nodal metastasis and predicts poor outcome in early stage breast carcinoma
    Geza Acs
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Am J Surg Pathol 31:129-40. 2007
  4. pmc Lymphatic invasion revealed by multispectral imaging is common in primary melanomas and associates with prognosis
    Xiaowei Xu
    Department of Pathology and Laboratory Medicine, and the Melanoma Program of the Abramson Cancer Center, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Hum Pathol 39:901-9. 2008
  5. ncbi request reprint Erythropoietin activates the phosphoinositide 3-kinase/Akt pathway in human melanoma cells
    Suresh M Kumar
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine bThe Wistar Institute, Philadelphia, Pennsylvania 19104, USA
    Melanoma Res 16:275-83. 2006
  6. ncbi request reprint Nuclear orphan receptor TR3/Nur77 mediates melanoma cell apoptosis
    Hong Yu
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Cancer Biol Ther 6:405-12. 2007
  7. pmc Functional erythropoietin autocrine loop in melanoma
    Suresh M Kumar
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Am J Pathol 166:823-30. 2005
  8. ncbi request reprint Prognostic significance of erythropoietin expression in human endometrial carcinoma
    Geza Acs
    Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA
    Cancer 100:2376-86. 2004
  9. ncbi request reprint Autocrine erythropoietin signaling inhibits hypoxia-induced apoptosis in human breast carcinoma cells
    Geza Acs
    Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, 6 Founders Pavilion, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Cancer Lett 214:243-51. 2004
  10. ncbi request reprint Mutant V600E BRAF increases hypoxia inducible factor-1alpha expression in melanoma
    Suresh M Kumar
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine and The Wistar Institute, Philadelphia, Pennsylvania, USA
    Cancer Res 67:3177-84. 2007

Collaborators

Detail Information

Publications40

  1. pmc Hypoxia-inducible erythropoietin signaling in squamous dysplasia and squamous cell carcinoma of the uterine cervix and its potential role in cervical carcinogenesis and tumor progression
    Geza Acs
    Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA
    Am J Pathol 162:1789-806. 2003
    ..Hypoxia-inducible Epo signaling may play a significant role in the aggressive behavior and treatment resistance of hypoxic cervical cancers...
  2. pmc RNA interference-mediated inhibition of erythropoietin receptor expression suppresses tumor growth and invasiveness in A2780 human ovarian carcinoma cells
    Gyorgy Paragh
    Experimental Therapeutics Program, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Am J Pathol 174:1504-14. 2009
    ..Our findings suggest that EpoR may be constitutively active in some cancer cells in the absence of Epo and provide the first evidence for a potential role of an Epo-independent, EpoR-mediated pathway in the growth of some human cancers...
  3. ncbi request reprint Extensive retraction artifact correlates with lymphatic invasion and nodal metastasis and predicts poor outcome in early stage breast carcinoma
    Geza Acs
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Am J Surg Pathol 31:129-40. 2007
    ..Rather, it likely signifies important biologic changes that alter tumor-stromal interactions and contribute to lymphatic spread and tumor progression...
  4. pmc Lymphatic invasion revealed by multispectral imaging is common in primary melanomas and associates with prognosis
    Xiaowei Xu
    Department of Pathology and Laboratory Medicine, and the Melanoma Program of the Abramson Cancer Center, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Hum Pathol 39:901-9. 2008
    ..Lymphatic invasion is an underobserved phenomenon in primary melanomas that can be better detected by immunohistochemical staining. The presence of lymphatic invasion may be a clinically useful predictor of regionally metastatic disease...
  5. ncbi request reprint Erythropoietin activates the phosphoinositide 3-kinase/Akt pathway in human melanoma cells
    Suresh M Kumar
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine bThe Wistar Institute, Philadelphia, Pennsylvania 19104, USA
    Melanoma Res 16:275-83. 2006
    ..LY294002 also inhibited the cytoprotective effects of Epo in melanoma cells under both normoxic and hypoxic conditions. Our results suggest that Epo promotes melanoma cell survival by activating an Akt-dependent signaling pathway...
  6. ncbi request reprint Nuclear orphan receptor TR3/Nur77 mediates melanoma cell apoptosis
    Hong Yu
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Cancer Biol Ther 6:405-12. 2007
    ..Decreased expression of TR3 in metastatic melanoma cells may contribute to their reduced apoptotic potential and increased resistance to chemotherapy...
  7. pmc Functional erythropoietin autocrine loop in melanoma
    Suresh M Kumar
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Am J Pathol 166:823-30. 2005
    ..The results suggest that the autocrine and paracrine functions of Epo might play a role in malignant transformation of melanocytes and in the survival of melanoma cells in hypoxia and other adverse conditions...
  8. ncbi request reprint Prognostic significance of erythropoietin expression in human endometrial carcinoma
    Geza Acs
    Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA
    Cancer 100:2376-86. 2004
    ..The authors recently demonstrated hypoxia-stimulated expression of Epo and Epo receptor (EpoR) in human breast and cervical carcinomas, suggesting a role for autocrine Epo signaling in the hypoxic adaptations of carcinomas...
  9. ncbi request reprint Autocrine erythropoietin signaling inhibits hypoxia-induced apoptosis in human breast carcinoma cells
    Geza Acs
    Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, 6 Founders Pavilion, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Cancer Lett 214:243-51. 2004
    ..The resulting decreased apoptotic potential of hypoxic tumor cells may contribute to increased aggressiveness and therapy resistance of breast cancers...
  10. ncbi request reprint Mutant V600E BRAF increases hypoxia inducible factor-1alpha expression in melanoma
    Suresh M Kumar
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine and The Wistar Institute, Philadelphia, Pennsylvania, USA
    Cancer Res 67:3177-84. 2007
    ....
  11. ncbi request reprint Low D2-40 immunoreactivity correlates with lymphatic invasion and nodal metastasis in early-stage squamous cell carcinoma of the uterine cervix
    Kimberly L Dumoff
    Department of Pathology and Laboratory Medicine, Division of Gynecologic Oncology, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
    Mod Pathol 18:97-104. 2005
    ..Further study of the biological function of the M2A antigen may shed some light on the interaction of tumor cells with lymphatics...
  12. ncbi request reprint Low podoplanin expression in pretreatment biopsy material predicts poor prognosis in advanced-stage squamous cell carcinoma of the uterine cervix treated by primary radiation
    Kimberly L Dumoff
    Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia, PA, USA
    Mod Pathol 19:708-16. 2006
    ..Prospective studies involving larger numbers of patients are needed to further evaluate the clinical utility of examination of podoplanin expression in patients with cervix carcinoma...
  13. ncbi request reprint Can Melan-A replace S-100 and HMB-45 in the evaluation of sentinel lymph nodes from patients with malignant melanoma?
    Cynthia Kucher
    Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
    Appl Immunohistochem Mol Morphol 14:324-7. 2006
    ..Melan-A, although very specific, cannot replace the use of S-100 and HMB-45 for the detection of metastatic melanoma in SLNs. It can, however, substitute for HMB-45 with equally good results...
  14. ncbi request reprint Podoplanin is a highly sensitive and specific marker to distinguish primary skin adnexal carcinomas from adenocarcinomas metastatic to skin
    Haohai Liang
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Am J Surg Pathol 31:304-10. 2007
    ..Our results suggest that podoplanin can be a useful tool to distinguish primary skin adnexal carcinomas form adenocarcinomas metastatic to skin with high sensitivity (94.5%) and specificity (97.2%)...
  15. pmc Lymphatic invasion predicts aggressive behavior in melanocytic tumors of uncertain malignant potential (MELTUMP)
    Ronnie M Abraham
    Department of Pathology, University of Pennsylvania, 3400 Spruce St, Philadelphia, PA 19104, USA
    Am J Surg Pathol 37:669-75. 2013
    ....
  16. ncbi request reprint Peritumoral lymphatic vessel density and vascular endothelial growth factor C expression in early-stage squamous cell carcinoma of the uterine cervix
    Zoltan Gombos
    Department of Pathology and Laboratory Medicine and Division of Gynecologic Oncology, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA
    Clin Cancer Res 11:8364-71. 2005
    ..Lymphatic invasion and nodal metastasis plays a major role in the spread of cervical cancer; however, little is known about the mechanisms whereby tumor cells enter the lymphatic system...
  17. pmc Isolation of a novel population of multipotent adult stem cells from human hair follicles
    Hong Yu
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Am J Pathol 168:1879-88. 2006
    ..Human hair follicles may provide an accessible, autologous source of adult stem cells for therapeutic application...
  18. doi request reprint Cytoplasmic overexpression of WT-1 in gastrointestinal stromal tumor and other soft tissue tumors
    Zhanyong Bing
    Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA 19094, USA
    Appl Immunohistochem Mol Morphol 16:316-21. 2008
    ..The significance of cytoplasmic expression of WT-1 in GIST and some smooth muscle tumors is unclear and warrant further investigation. The potential roles of WT-1 in the diagnosis and treatment of GIST were discussed...
  19. ncbi request reprint Immunohistochemical expression of erythropoietin and erythropoietin receptor in breast carcinoma
    Geza Acs
    Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia 19104, USA
    Cancer 95:969-81. 2002
    ....
  20. ncbi request reprint Posterior acoustic shadowing in benign breast lesions: sonographic-pathologic correlation
    Susan P Weinstein
    Department of Radiology, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104 4283, USA
    J Ultrasound Med 23:73-83. 2004
    ..To show a variety of benign breast lesions that exhibit posterior acoustic shadowing on sonography...
  21. ncbi request reprint Intraoperative consultation in gynecologic pathology
    Geza Acs
    Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
    Semin Diagn Pathol 19:237-54. 2002
    ..It is important for pathologists to have a clear idea of the role and limitations of frozen section diagnosis in gynecological surgery in order to play a meaningful and optimal role in the management of the gynecologic oncology patient...
  22. ncbi request reprint Microglandular adenosis with transition into adenoid cystic carcinoma of the breast
    Geza Acs
    Department of Pathology and Laboratory of Medicine, University of Pensilvania Medical Center, Philacelphia, Pensylvania 19104, USA
    Am J Surg Pathol 27:1052-60. 2003
    ..Their unusual interaction with the surrounding stroma may play a role in this benign biologic behavior...
  23. ncbi request reprint Repeat operative sentinel lymph node biopsy
    Benjamin M Jackson
    Department of Surgery, Hospital of the University of Pennsylvania, Philadelphia, PA 19104, USA
    Clin Breast Cancer 6:530-2. 2006
    ....
  24. ncbi request reprint Immunoprofile of endocervical and endometrial stromal cells and its potential application in localization of tumor involvement
    Julieta E Barroeta
    Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania, USA
    Int J Gynecol Pathol 26:76-82. 2007
    ..The functional status of the endometrium had no effect on the immunoprofile. The pattern of CD34 and CD10 immunostaining in stromal cells might be helpful in determining tumor involvement in uterine and cervical sites...
  25. ncbi request reprint Intraoperative consultation: an historical perspective
    Geza Acs
    Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
    Semin Diagn Pathol 19:190-1. 2002
  26. doi request reprint Melanocytic tumors express connexin 43 but not 26: immunohistochemical analysis with potential significance in melanocytic oncogenesis
    Michael R Sargen
    Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA Department of Neurology, Children Hospital of Philadelphia, Philadelphia, PA Department of Pathology, Moffitt Cancer Center, Tampa, FL
    Am J Dermatopathol 35:813-7. 2013
    ....
  27. ncbi request reprint Role of different immunostaining patterns in HercepTest interpretation and criteria for gene amplification as determined by fluorescence in situ hybridization
    Geza Acs
    Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, 6 Founders Pavilion, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Appl Immunohistochem Mol Morphol 11:222-9. 2003
    ..Our results suggest that a high concordance (95.8%) between HER-Z overexpression and GA can be achieved by using more stringent pattern-modified criteria for judging protein overexpression and combined criteria for GA...
  28. ncbi request reprint Serous and mucinous borderline (low malignant potential) tumors of the ovary
    Geza Acs
    Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, Philadephia, PA 19104, USA
    Am J Clin Pathol 123:S13-57. 2005
    ..Rare primary ovarian mucinous tumors associated with pseudomyxoma peritonei are those arising in mature cystic teratomas. Advanced-stage ovarian mucinous carcinomas typically show frank, infiltrative-type invasion; the prognosis is poor...
  29. ncbi request reprint WT1 is differentially expressed in serous, endometrioid, clear cell, and mucinous carcinomas of the peritoneum, fallopian tube, ovary, and endometrium
    Geza Acs
    Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA
    Int J Gynecol Pathol 23:110-8. 2004
    ..Our results suggest that WT1 expression in epithelial tumors of the female genital tract may be related to cell differentiation and histologic subtypes of carcinomas, rather than to primary site of origin...
  30. ncbi request reprint Utility of D2-40, a novel mesothelial marker, in the diagnosis of malignant mesothelioma
    Albert Y Chu
    Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA 19104, USA
    Mod Pathol 18:105-10. 2005
    ..We conclude that D2-40 immunoreactivity is sensitive for cells of mesothelial origin, and may be useful in the differential diagnosis of epithelioid malignant mesothelioma vs adenocarcinoma...
  31. ncbi request reprint Immune responses of breast cancer patients to mutated epidermal growth factor receptor (EGF-RvIII, Delta EGF-R, and de2-7 EGF-R)
    Enkhtsetseg Purev
    The Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104, USA
    J Immunol 173:6472-80. 2004
    ....
  32. ncbi request reprint Case 59: Angiolipoma of the breast
    Susan P Weinstein
    Department of Radiology, University of Pennsylvania Medical Center, 1 Silverstein Bldg, 3400 Spruce St, Philadelphia, PA 19104, USA
    Radiology 227:773-5. 2003
  33. ncbi request reprint C-kit immunoreactivity in endometrial adenocarcinomas and its clinicopathologic significance
    Janice V Scobie
    Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA
    Int J Gynecol Pathol 22:149-55. 2003
    ..Expression of c-kit may be a potentially adverse prognostic feature in endometrial adenocarcinoma. Patients with c-kit-positive advanced endometrial adenocarcinoma might benefit from tyrosine-kinase-inhibitor therapy...
  34. ncbi request reprint Erythropoietin receptor function and expression in epithelial ovarian carcinoma
    John W McBroom
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Tripler Army Medical Center, Honolulu, HI 96859, USA
    Gynecol Oncol 99:571-7. 2005
    ..Our objectives were to determine if the erythropoietin receptor (EpoR) has increased expression in epithelial ovarian carcinoma, and if erythropoietin (Epo) confers malignant properties to ovarian cancer cell lines...
  35. pmc Erythropoietin signaling promotes invasiveness of human head and neck squamous cell carcinoma
    Ahmed Mohyeldin
    Department of Neurology, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814, USA
    Neoplasia 7:537-43. 2005
    ..This mechanism may also be activated by recombinant Epo therapy and could potentially produce detrimental effects in rhEpo-treated cancer patients...
  36. ncbi request reprint Renal carcinomas with the t(6;11)(p21;q12): clinicopathologic features and demonstration of the specific alpha-TFEB gene fusion by immunohistochemistry, RT-PCR, and DNA PCR
    Pedram Argani
    Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Am J Surg Pathol 29:230-40. 2005
    ..Finally, the special molecular features of the Alpha-TFEB gene fusion allow its molecular detection by DNA PCR as a robust alternative to RT-PCR in clinical tumor samples...
  37. ncbi request reprint High-risk benign breast lesions: current strategies in management
    John V Kiluk
    Comprehensive Breast Cancer Program, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA
    Cancer Control 14:321-9. 2007
    ..High-risk benign breast lesions can create confusion for both the patient and the clinician. This paper reviews the characteristics of these lesions to help direct appropriate management...
  38. ncbi request reprint Survival and invasiveness of astrocytomas promoted by erythropoietin
    Ahmed Mohyeldin
    Department of Neurology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA
    J Neurosurg 106:338-50. 2007
    ..Since hypoxia has been implicated in the malignant progression of some human cancers, the authors investigated whether EPO signaling influenced the malignant properties of human astrocytoma cells...
  39. ncbi request reprint Erythropoietin receptors on cancer cells: exciting perspectives, difficult to appreciate
    Michael Henke
    Blood 108:1107-8; author reply 1108-9. 2006
  40. ncbi request reprint HIF transcription factor expression and induction of hypoxic response genes in a retroperitoneal angiosarcoma
    W Kimryn Rathmell
    Division of Hematology Oncology, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, 27599, USA
    Anticancer Res 24:167-9. 2004
    ..Disordered regulation of the hypoxic response pathway can result in the expression of factors such as VEGF and erythropoietin, which may promote autocrine tumor growth in angiosarcoma...