M A Acker

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. doi request reprint Statement regarding the pre and post market assessment of durable, implantable ventricular assist devices in the United States
    Michael A Acker
    Division of Cardiothoracic Surgery, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    J Heart Lung Transplant 31:1241-52. 2012
  2. doi request reprint Statement regarding the pre and post market assessment of durable, implantable ventricular assist devices in the United States
    Michael A Acker
    Division of Cardiothoracic Surgery, University of Pennsylvania, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Ann Thorac Surg 94:2147-58. 2012
  3. doi request reprint Statement regarding the pre and post market assessment of durable, implantable ventricular assist devices in the United States: executive summary
    Michael A Acker
    Division of Cardiothoracic Surgery, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Ann Thorac Surg 94:e163-8. 2012
  4. pmc Cardiac retransplantation is an efficacious therapy for primary cardiac allograft failure
    Pavan Atluri
    Division of Cardiovascular Surgery, Department of Surgery, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    J Cardiothorac Surg 3:26. 2008
  5. ncbi request reprint Clinical results with the Acorn cardiac restraint device with and without mitral valve surgery
    Michael A Acker
    Department of Surgery, Hospital of the University of Pennsylvania, Silverstein, PA 19104, USA
    Semin Thorac Cardiovasc Surg 17:361-3. 2005
  6. ncbi request reprint Mechanical circulatory support for patients with acute-fulminant myocarditis
    M A Acker
    Department of Surgery, University of Pennsylvania Medical Center, Philadelphia 19104, USA
    Ann Thorac Surg 71:S73-6; discussion S82-5. 2001
  7. ncbi request reprint Passive ventricular constraint to improve left ventricular function and mechanics in an ovine model of heart failure secondary to acute myocardial infarction
    James J Pilla
    Department of Surgery, University of Pennsylvania Medical Center, Philadelphia, 19104, USA
    J Thorac Cardiovasc Surg 126:1467-76. 2003
  8. ncbi request reprint Frequency, risk factors, and clinical outcomes of left ventricular assist device-associated ventricular thrombus
    M P Reilly
    Department of Medicine, University of Pennsylvania Health System, Philadelphia 19014, USA
    Am J Cardiol 86:1156-9, A10. 2000
  9. ncbi request reprint Emergent mechanical support in the community: improvement with early transplant center referral
    Rohinton J Morris
    John Rhea Barton Surgical Associates, Philadelphia, Pennsylvania 19104, USA
    J Heart Lung Transplant 24:764-8. 2005
  10. ncbi request reprint Infarct size reduction and attenuation of global left ventricular remodeling with the CorCap cardiac support device following acute myocardial infarction in sheep
    Aaron S Blom
    Department of Surgery, University of Pennsylvania Medical Center, Philadelphia, USA
    Heart Fail Rev 10:125-39. 2005

Research Grants

Detail Information

Publications42

  1. doi request reprint Statement regarding the pre and post market assessment of durable, implantable ventricular assist devices in the United States
    Michael A Acker
    Division of Cardiothoracic Surgery, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    J Heart Lung Transplant 31:1241-52. 2012
    ....
  2. doi request reprint Statement regarding the pre and post market assessment of durable, implantable ventricular assist devices in the United States
    Michael A Acker
    Division of Cardiothoracic Surgery, University of Pennsylvania, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Ann Thorac Surg 94:2147-58. 2012
    ....
  3. doi request reprint Statement regarding the pre and post market assessment of durable, implantable ventricular assist devices in the United States: executive summary
    Michael A Acker
    Division of Cardiothoracic Surgery, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Ann Thorac Surg 94:e163-8. 2012
    ....
  4. pmc Cardiac retransplantation is an efficacious therapy for primary cardiac allograft failure
    Pavan Atluri
    Division of Cardiovascular Surgery, Department of Surgery, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    J Cardiothorac Surg 3:26. 2008
    ..Cardiac retransplantation remains the only viable long-term solution for end-stage cardiac allograft failure. Given the limited number of available donor hearts, the long term results of this treatment option need to be evaluated...
  5. ncbi request reprint Clinical results with the Acorn cardiac restraint device with and without mitral valve surgery
    Michael A Acker
    Department of Surgery, Hospital of the University of Pennsylvania, Silverstein, PA 19104, USA
    Semin Thorac Cardiovasc Surg 17:361-3. 2005
    ..The study demonstrated both safety and effectiveness of the CorCap in patients with advanced heart failure and remodeled ventricles...
  6. ncbi request reprint Mechanical circulatory support for patients with acute-fulminant myocarditis
    M A Acker
    Department of Surgery, University of Pennsylvania Medical Center, Philadelphia 19104, USA
    Ann Thorac Surg 71:S73-6; discussion S82-5. 2001
    ..An aggressive approach to the use of mechanical support is strongly justified. Survival, either by bridge to transplant or recovery, should approach 70%. Transplantation can often be avoided...
  7. ncbi request reprint Passive ventricular constraint to improve left ventricular function and mechanics in an ovine model of heart failure secondary to acute myocardial infarction
    James J Pilla
    Department of Surgery, University of Pennsylvania Medical Center, Philadelphia, 19104, USA
    J Thorac Cardiovasc Surg 126:1467-76. 2003
    ..We hypothesized that placement of the cardiac support device results in a decrease in myocardial wall stress and improvement in cardiac function and myocardial energetics...
  8. ncbi request reprint Frequency, risk factors, and clinical outcomes of left ventricular assist device-associated ventricular thrombus
    M P Reilly
    Department of Medicine, University of Pennsylvania Health System, Philadelphia 19014, USA
    Am J Cardiol 86:1156-9, A10. 2000
    ..LV cannulation, when using short-term LVADs, may decrease the incidence of LV thrombosis, and early transition to Heartmate-LVAD support may improve outcome...
  9. ncbi request reprint Emergent mechanical support in the community: improvement with early transplant center referral
    Rohinton J Morris
    John Rhea Barton Surgical Associates, Philadelphia, Pennsylvania 19104, USA
    J Heart Lung Transplant 24:764-8. 2005
    ..In contrast to previous reports, survival rates may be improved by earlier referral, before VAD placement at non-transplant centers and use of a VAD with longer-term capability...
  10. ncbi request reprint Infarct size reduction and attenuation of global left ventricular remodeling with the CorCap cardiac support device following acute myocardial infarction in sheep
    Aaron S Blom
    Department of Surgery, University of Pennsylvania Medical Center, Philadelphia, USA
    Heart Fail Rev 10:125-39. 2005
    ....
  11. ncbi request reprint The surgical treatment of end-stage heart failure
    Aaron S Blom
    University of Pennsylvania Medical Center, USA
    Curr Probl Cardiol 32:553-99. 2007
    ....
  12. doi request reprint Acute myocardial infarction requiring mechanical bridge to transplantation in a patient with undiagnosed anti-phospholipid antibody syndrome
    Clifton C Reade
    Division of Cardiovascular Surgery, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Heart Lung Transplant 27:682-4. 2008
    ..To our knowledge this is the first reported case of severe acute heart failure due to anti-phospholipid antibody syndrome in which the patient survived through assist device placement and successful transplantation...
  13. ncbi request reprint Clinically silent cerebral ischemic events after cardiac surgery: their incidence, regional vascular occurrence, and procedural dependence
    Thomas F Floyd
    Department of Anesthesiology and Critical Care, University of Pennsylvania, Philadelphia, Pennsylvani, USA
    Ann Thorac Surg 81:2160-6. 2006
    ..We also document the association of preexisting white matter lesions with new postoperative ischemic lesions...
  14. ncbi request reprint Integrity of the cerebral blood-flow response to hyperoxia after cardiopulmonary bypass
    Thomas F Floyd
    Department of Anesthesiology, Penn Presbyterian Hospital, University of Pennsylvania, Philadelphia, PA 19104 4283, USA
    J Cardiothorac Vasc Anesth 21:212-7. 2007
    ..In this study, the hypothesis that cardiopulmonary bypass (CPB) alters the cerebral blood flow (CBF) vasoconstrictive response to hyperoxia was tested...
  15. doi request reprint Implantable ventricular assist device exchange with focused intravascular deairing techniques
    Y Joseph Woo
    Department of Surgery, Division of Cardiovascular Surgery, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Ann Thorac Surg 91:306-7. 2011
    ....
  16. doi request reprint Limb ischemia during femoral cannulation for cardiopulmonary support
    Paul J Foley
    Division of Vascular Surgery and Endovascular Therapy, Department of Surgery, Hospital of the University of Pennsylvania, Philadelphia, PA 19104, USA
    J Vasc Surg 52:850-3. 2010
    ..Complications include lower extremity ischemia from femoral artery cannulation. We examined the outcomes of patients placed on ECMO/CPS, including the rate of limb ischemia...
  17. ncbi request reprint Surgical therapies for heart failure
    Michael A Acker
    Section of Cardiac Surgery, Division of Cardiothoracic Surgery, Department of Surgery, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Card Fail 10:S220-4. 2004
    ..Resynchronization therapy also may favorably affect remodeling. The potential of these procedures to slow the progression of heart failure needs to be confirmed in prospective studies...
  18. ncbi request reprint Successful explantation of a ventricular assist device following fulminant influenza type A-associated myocarditis
    Paul C McGovern
    Division of Infectious Diseases, University of Pennsylvania Health System, Philadelphia, Pennsylvania 19104, USA
    J Heart Lung Transplant 21:290-3. 2002
    ..This case suggests those patients with fulminant viral myocarditis and refractory ventricular arrhythmias may be supported successfully with ventricular assist devices until myocardial recovery takes place...
  19. ncbi request reprint Left ventricular assist device for right side assistance in patients with transposition
    Allan S Stewart
    Department of Surgery, Hospital of the University of Pennsylvania, Philadelphia 19103, USA
    Ann Thorac Surg 74:912-4. 2002
    ..This report details the implantation of a TCI Heartmate (Thoratec Corp., Pleaston, CA) as a morphologic right ventricular assist device to bridge these patients to transplantation...
  20. ncbi request reprint Perioperative changes in cerebral blood flow after cardiac surgery: influence of anemia and aging
    Thomas F Floyd
    Department of Anesthesia, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Ann Thorac Surg 76:2037-42. 2003
    ..To better understand changes in perioperative CBF physiology we have measured changes in CBF and the influence of anemia and aging on these changes...
  21. ncbi request reprint Application of "double bridge mechanical" resuscitation for profound cardiogenic shock leading to cardiac transplantation
    F W Bowen
    Department of Surgery, School of Medicine, University of Pennsylvania, Philadelphia, USA
    Ann Thorac Surg 72:86-90. 2001
    ..In neurologically intact patients, the early transfer to a VAD quickly stabilizes hemodynamics, avoids complications, and is essential for long-term circulatory support before definitive treatment with cardiac transplantation...
  22. ncbi request reprint Mechanical circulatory support for acute heart failure
    D G Pennington
    Department of Surgery, East Tennessee State University, Johnson City 37614, USA
    Ann Thorac Surg 71:S56-9; discussion S82-5. 2001
    ..Current postcardiotomy survival rates of postcardiotomy patients of 20% to 40% are worthwhile, but can be improved. Temporary devices such as ECMO can be changed to more long-term devices when necessary...
  23. ncbi request reprint Dynamic cardiomyoplasty: at the crossroads
    M A Acker
    Division of Cardiothoracic Surgery, University of Pennsylvania School of Medicine, Philadelphia, USA
    Ann Thorac Surg 68:750-5. 1999
    ..This review seeks to update current clinical results and practice of dynamic cardiomyoplasty and to present its likely mechanism of action...
  24. ncbi request reprint Ventricular constraint using the acorn cardiac support device reduces myocardial akinetic area in an ovine model of acute infarction
    James J Pilla
    Department of Surgery, University of Pennsylvania Medical Center, Philadelphia, PA, USA
    Circulation 106:I207-11. 2002
    ..Left ventricular remodeling secondary to acute myocardial infarction (AMI) is characterized by ventricular dilatation and regional akinesis. In this study, we investigated the effect of passive constraint on akinetic area development...
  25. ncbi request reprint Cardiac support device modifies left ventricular geometry and myocardial structure after myocardial infarction
    Aaron S Blom
    Department of Surgery, University of Pennsylvania Medical Center, Philadelphia, PA, USA
    Circulation 112:1274-83. 2005
    ..This study surgically placed a cardiac support device (CSD) over the entire LV and examined LV and myocyte geometry and function after MI...
  26. ncbi request reprint Surgical management of heart failure: an overview
    David Zeltsman
    Section of Cardiac Surgery, Division of Cardiothoracic Surgery, Department of Surgery, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, New Brunswick, New Jersey 08901, USA
    Annu Rev Med 53:383-91. 2002
    ..Developments in mechanical assist therapy and a new generation of implantable intracorporeal assist devices are also discussed...
  27. ncbi request reprint CD3 monitoring of antithymocyte globulin therapy in thoracic organ transplantation
    Alyssa M Krasinskas
    Department of Pathology, University of Pennsylvania Medical Center, 3400 Spruce Street, Philadelphia, PA 19104 4283, USA
    Transplantation 73:1339-41. 2002
    ..This study evaluates the utility of monitoring peripheral CD3 lymphocytes to rationally adjust antithymocyte globulin therapy in this patient population...
  28. ncbi request reprint Changes in lipoprotein(a) concentration after orthotopic heart transplantation
    D DeNofrio
    Cardiovascular Division, Department of Medicine, University of Pennsylvania Health System, Philadelphia, USA
    Am Heart J 139:729-33. 2000
    ....
  29. ncbi request reprint Cardiovascular effects of inhaled nitric oxide in a canine model of cardiomyopathy
    E Loh
    Department of Medicine, University of Pennsylvania Health System, Philadelphia, USA
    Ann Thorac Surg 67:1380-5. 1999
    ..The inhalation of nitric oxide (NO) in patients with heart failure decreases pulmonary vascular resistance (PVR) and is associated with an increase in pulmonary artery wedge pressure (PAWP). The mechanism for this effect remains unclear...
  30. ncbi request reprint Prone positioning to treat acute severe pulmonary edema in the post-cardiac surgical patient: a case report
    Pavan Atluri
    Division of Cardiothoracic Surgery, Department of Surgery, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Heart Surg Forum 9:E762-4. 2006
    ..Prone positioning corrects ventilation-perfusion mismatch and allows gravity-dependent drainage of capillary leak-mediated endobronchial pulmonary fluid...
  31. doi request reprint INTERMACS: interval analysis of registry data
    William L Holman
    Department of Surgery, University of Alabama at Birmingham, Birmingham, AL 35294 0007, USA
    J Am Coll Surg 208:755-61; discussion 761-2. 2009
    ..INTERMACS data were analyzed through the most recent quarter ending March 31, 2008...
  32. ncbi request reprint Mitral valve surgery in heart failure: insights from the Acorn Clinical Trial
    Michael A Acker
    Department of Surgery, University of Pennsylvania, Philadelphia, PA 19104 6070, USA
    J Thorac Cardiovasc Surg 132:568-77, 577.e1-4. 2006
    ....
  33. ncbi request reprint Safety and efficacy of left ventricular assist device support in postmyocardial infarction cardiogenic shock
    Bradley G Leshnower
    Department of Surgery, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Ann Thorac Surg 81:1365-70; discussion 1370-1. 2006
    ..We present a decade of experience with the use of LVAD with apical cannulation in patients with CS-AMI...
  34. ncbi request reprint Emergency endovascular deployment of stent graft in the ascending aorta for contained rupture of innominate artery pseudoaneurysm in a pediatric patient
    Wilson Y Szeto
    Division of Cardiothoracic Surgery, Department of Surgery, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Ann Thorac Surg 81:1872-5. 2006
    ..A pseudoaneurysm of the previously ligated innominate artery subsequently developed, and despite coil embolization, it continued to enlarge, which required emergency endovascular intervention...
  35. pmc Early planned institution of biventricular mechanical circulatory support results in improved outcomes compared with delayed conversion of a left ventricular assist device to a biventricular assist device
    J Raymond Fitzpatrick
    Division of Cardiovascular Surgery, Department of Surgery, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Thorac Cardiovasc Surg 137:971-7. 2009
    ..We hypothesized that planned biventricular assist device insertion improves survival compared with delayed conversion of left ventricular assist device support to biventricular assist device support...
  36. ncbi request reprint Sustained benefits of the CorCap Cardiac Support Device on left ventricular remodeling: three year follow-up results from the Acorn clinical trial
    Randall C Starling
    The Cleveland Clinic, Kaufman Center for Heart Failure, Cleveland, Ohio 44195, USA
    Ann Thorac Surg 84:1236-42. 2007
    ..However, long-term effects in patients with heart failure have not been reported...
  37. ncbi request reprint Diaphragmatic hernias associated with ventricular assist devices and heart transplantation
    Subhasis Chatterjee
    Cardiothoracic Surgery, Philadelphia, Pennsylvania 19104 4227, USA
    Ann Thorac Surg 77:2111-4. 2004
    ..This review examined the incidence, diagnostic strategies, surgical management, and prevention of diaphragmatic hernias in these patients...
  38. ncbi request reprint Global surgical experience with the Acorn cardiac support device
    Mehmet C Oz
    Columbia Presbyterian Medical Center, 117 Ft Washington Ave, New York, NY 10032, USA
    J Thorac Cardiovasc Surg 126:983-91. 2003
    ..The objective of this study was to review the global clinical safety and feasibility experience of this device...
  39. ncbi request reprint Rationale, design, and methods for a pivotal randomized clinical trial for the assessment of a cardiac support device in patients with New York health association class III-IV heart failure
    Douglas L Mann
    Center for Heart Failure, Baylor College of Medicine, Houston, Texas 77030, USA
    J Card Fail 10:185-92. 2004
    ....
  40. ncbi request reprint Ventricular restraint prevents infarct expansion and improves borderzone function after myocardial infarction: a study using magnetic resonance imaging, three-dimensional surface modeling, and myocardial tagging
    Aaron S Blom
    Harrison Department of Surgical Research, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 4283, USA
    Ann Thorac Surg 84:2004-10. 2007
    ..We hypothesized that left ventricular restraint early after myocardial infarction limits infarct expansion, preserves borderzone function, and reduces remodeling...
  41. ncbi request reprint Clinical evaluation of the CorCap Cardiac Support Device in patients with dilated cardiomyopathy
    Douglas L Mann
    Baylor College of Medicine, Houston, Texas, USA
    Ann Thorac Surg 84:1226-35. 2007
    ..Left ventricular (LV) remodeling is related to adverse outcomes in heart failure. The CorCap Cardiac Support Device (CSD; Acorn Cardiovascular, Inc, St. Paul, MN) is an implantable device that attenuates LV remodeling...
  42. ncbi request reprint Early postinfarction ventricular restraint improves borderzone wall thickening dynamics during remodeling
    James J Pilla
    Harrison Department of Surgical Research, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 4283, USA
    Ann Thorac Surg 80:2257-62. 2005
    ..Using an ovine model of infarct induced remodeling and MRI, we tested the hypothesis that ventricular restraint early after MI preserves BZM function and reduces remodeling...

Research Grants2

  1. Cardiac surgery techniques to treat ventricular and aortic remodeling
    Michael Acker; Fiscal Year: 2007
    ..Participants in the skills core will have the opportunity to work on Network clinical trials as well as on other clinical trials within the Division of Cardiovascular Surgery. (End of Abstract) ..