Research Topics
| BARRY ACHESummaryAffiliation: University of Florida Country: USA Publications
Research Grants
| Collaborators
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Detail Information
Publications
Organizational complexity in lobster olfactory receptor cellsB W Ache
Whitney Laboratory, University of Florida, St Augustine 31086, USA
Ann N Y Acad Sci 855:194-8. 1998..The complexity of intracellular signaling in lobster olfactory receptor cells renders the cells capable of fine tuning, and even integrating, the signal they send to the brain...- Olfaction: diverse species, conserved principlesBarry W Ache
Whitney Lab for Marine Bioscience, Department of Zoology, Center for Smell and Taste and McKnight Brain Institute, University of Florida, Gainesville, Florida 32610, USA
Neuron 48:417-30. 2005..These common features span a phylogenetically broad array of animals, implying that there is an optimal solution to the problem of detecting and discriminating odors... 
Phosphatidylinositol 4,5-bisphosphate-dependent regulation of the output in lobster olfactory receptor neuronsYuriy V Bobkov
Whitney Laboratory, Center for Smell and Taste, and McKnight Brain Institute, University of Florida, Gainesville, FL 32610, USA
J Exp Biol 213:1417-24. 2010..Collectively, our results argue that PIs can regulate output in lobster ORNs, at least in part through their action on the lobster SGC channel...- Phosphoinositide 3-kinase mediated signaling in lobster olfactory receptor neuronsElizabeth A Corey
Whitney Laboratory, Center for Smell and Taste, McKnight Brain Institute, University of Florida, Gainesville, Florida 32080 8610, USA
J Neurochem 113:341-50. 2010..Collectively, these findings provide evidence that PI3K is indeed activated by odorant receptors in lobster ORNs and further support the potential involvement of G protein activated PI3K signaling in olfactory transduction... - Inhibitory odorant signaling in Mammalian olfactory receptor neuronsKirill Ukhanov
Whitney Laboratory, Center for Smell and Taste, University of Florida, Gainesville, FL 32610 0127, USA
J Neurophysiol 103:1114-22. 2010.... - Phosphoinositide 3-kinase-dependent antagonism in mammalian olfactory receptor neuronsKirill Ukhanov
Whitney Laboratory, Center for Smell and Taste, and McKnight Brain Institute, University of Florida, Gainesville, Florida 32610, USA
J Neurosci 31:273-80. 2011..Our findings collectively raise the interesting possibility that the OR serves as a molecular logic gate when mammalian ORNs are activated by natural, complex mixtures containing both excitatory and inhibitory odorants... - Specificity of odorant-evoked inhibition in lobster olfactory receptor neuronsRichard E Doolin
Whitney Laboratory, University of Florida, 9505 Ocean Shore Blvd, St Augustine, FL 32080, USA
Chem Senses 30:105-10. 2005.... - Pharmacological properties and functional role of a TRP-related ion channel in lobster olfactory receptor neuronsYuriy V Bobkov
Whitney Laboratory for Marine Bioscience, University of Florida, 9505 Ocean Shore Blvd, St Augustine, FL 32080 8610, USA
J Neurophysiol 93:1372-80. 2005..We then use this enhanced antagonist profile together with the agonists Na+ and Ca2+ to implicate the channel in signal amplification in the cells... - Calcium sensitivity of a sodium-activated nonselective cation channel in lobster olfactory receptor neuronsYuriy V Bobkov
Whitney Laboratory, University of Florida, Gainesville, Florida 32601, USA
J Neurophysiol 90:2928-40. 2003.... - A simple method for focally delivering multiple drugs or ligands to cellsRichard E Doolin
Whitney Laboratory, Department of Neuroscience, Center for Smell and Taste, University of Florida, 9505 Ocean Shore Boulevard, Gainesville, FL 32610, USA
J Neurosci Methods 116:9-14. 2002..The utility of the device is demonstrated for applying odorants to olfactory receptor neurons (ORNs)... - Cyclic nucleotide signaling mediates an odorant-suppressible chloride conductance in lobster olfactory receptor neuronsRichard E Doolin
Whitney Laboratory, University of Florida, 9505 Ocean Shore Blvd, St. Augustine, FL 32080, USA
Chem Senses 30:127-35. 2005..These findings further our understanding of the cellular mechanisms through which odorants can modulate the output of lobster ORNs... - PI3Kgamma-dependent signaling in mouse olfactory receptor neuronsDaniela Brunert
Center for Smell and Taste, University of Florida, Gainesville, FL 32610 0127 USA
Chem Senses 35:301-8. 2010..We conclude that odorant-dependent PI3K signaling generalizes to the murine olfactory system and that PI3Kgamma plays a role in mediating inhibition of odorant responses in mammalian ORNs... - Presynaptic inhibition of olfactory receptor neurons in crustaceansMatt Wachowiak
Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
Microsc Res Tech 58:365-75. 2002..Thus, it is possible that presynaptic inhibition of primary olfactory afferents evolved independently in vertebrates and invertebrates to fill a common, fundamental role in processing olfactory information... - 3-phosphoinositides modulate cyclic nucleotide signaling in olfactory receptor neuronsMarc Spehr
Department of Cell Physiology, Ruhr University Bochum, Bochum, Germany
Neuron 33:731-9. 2002.... - Molecular and functional characterization of an I(h)-channel from lobster olfactory receptor neuronsGunter Gisselmann
Ruhr Universitat Bochum, Lehrstuhl fur Zellphysiologie, Universitatsstr 150, D 44780 Bochum, Germany
Eur J Neurosci 21:1635-47. 2005..Collectively, these results implicate for the first time a functional role for an I(h)-channel in olfactory signal transduction... - Gene expression and specificity in the mature zone of the lobster olfactory organRuben Stepanyan
Department of Physiology, Cellular and Molecular Neuroscience of Sensory Systems Training Program, University of Kentucky, Lexington, Kentucky 40536-0298, USA
Physiol Genomics 25:224-33. 2006....
Research Grants
- MECHANISMS OF OLFACTORY TRANSDUCTIONBARRY ACHE; Fiscal Year: 2005..abstract_text> ..
- MECHANISMS OF OLFACTORY TRANSDUCTIONBARRY ACHE; Fiscal Year: 2007....
- Phosphoinositide Signaling in Mammalian OlfactionBARRY ACHE; Fiscal Year: 2007....
- FOSTERING INNOVATION IN THE CHEMICAL SENSESBARRY ACHE; Fiscal Year: 2007..Enhancing this key forum will translate into expanded and improved understanding of the role of olfaction and taste in health and disease. ..
- Phosphoinositide Signaling in Mammalian OlfactionBARRY ACHE; Fiscal Year: 2007..abstract_text> ..
- MECHANISMS OF OLFACTORY TRANSDUCTIONBarry W Ache; Fiscal Year: 2010..abstract_text> ..
- MULTIPLE PATHWAYS IN OLFACTORY TRANSDUCTIONBARRY ACHE; Fiscal Year: 1993..Understanding olfactory transduction is fundamental to understanding the role of the receptor cell in the sense of smell and, in turn, olfactory dysfunctions caused by environmental and pathogenic insult to the receptor organ...
- Phosphoinositide Signaling in Mammalian OlfactionBARRY ACHE; Fiscal Year: 2003..This new, exciting line of investigation should have high impact on the field, making it competitive for R01 funding once the proposed additional preliminary data are in hand. ..
- Phosphoinositide Signaling in Mammalian OlfactionBarry W Ache; Fiscal Year: 2011..A detailed understanding of how odors activate olfactory receptor cells therefore is critical to effectively address disease states such as dementia and the diminished quality of life associated with olfactory dysfunction. ..