BARRY ACHE

Summary

Affiliation: University of Florida
Country: USA

Publications

  1. ncbi request reprint Organizational complexity in lobster olfactory receptor cells
    B W Ache
    Whitney Laboratory, University of Florida, St Augustine 31086, USA
    Ann N Y Acad Sci 855:194-8. 1998
  2. ncbi request reprint Olfaction: diverse species, conserved principles
    Barry W Ache
    Whitney Lab for Marine Bioscience, Department of Zoology, Center for Smell and Taste and McKnight Brain Institute, University of Florida, Gainesville, Florida 32610, USA
    Neuron 48:417-30. 2005
  3. pmc Phosphatidylinositol 4,5-bisphosphate-dependent regulation of the output in lobster olfactory receptor neurons
    Yuriy V Bobkov
    Whitney Laboratory, Center for Smell and Taste, and McKnight Brain Institute, University of Florida, Gainesville, FL 32610, USA
    J Exp Biol 213:1417-24. 2010
  4. pmc Phosphoinositide 3-kinase mediated signaling in lobster olfactory receptor neurons
    Elizabeth A Corey
    Whitney Laboratory, Center for Smell and Taste, McKnight Brain Institute, University of Florida, Gainesville, Florida 32080 8610, USA
    J Neurochem 113:341-50. 2010
  5. pmc Inhibitory odorant signaling in Mammalian olfactory receptor neurons
    Kirill Ukhanov
    Whitney Laboratory, Center for Smell and Taste, University of Florida, Gainesville, FL 32610 0127, USA
    J Neurophysiol 103:1114-22. 2010
  6. pmc Phosphoinositide 3-kinase-dependent antagonism in mammalian olfactory receptor neurons
    Kirill Ukhanov
    Whitney Laboratory, Center for Smell and Taste, and McKnight Brain Institute, University of Florida, Gainesville, Florida 32610, USA
    J Neurosci 31:273-80. 2011
  7. ncbi request reprint Specificity of odorant-evoked inhibition in lobster olfactory receptor neurons
    Richard E Doolin
    Whitney Laboratory, University of Florida, 9505 Ocean Shore Blvd, St Augustine, FL 32080, USA
    Chem Senses 30:105-10. 2005
  8. ncbi request reprint Pharmacological properties and functional role of a TRP-related ion channel in lobster olfactory receptor neurons
    Yuriy V Bobkov
    Whitney Laboratory for Marine Bioscience, University of Florida, 9505 Ocean Shore Blvd, St Augustine, FL 32080 8610, USA
    J Neurophysiol 93:1372-80. 2005
  9. ncbi request reprint Calcium sensitivity of a sodium-activated nonselective cation channel in lobster olfactory receptor neurons
    Yuriy V Bobkov
    Whitney Laboratory, University of Florida, Gainesville, Florida 32601, USA
    J Neurophysiol 90:2928-40. 2003
  10. ncbi request reprint A simple method for focally delivering multiple drugs or ligands to cells
    Richard E Doolin
    Whitney Laboratory, Department of Neuroscience, Center for Smell and Taste, University of Florida, 9505 Ocean Shore Boulevard, Gainesville, FL 32610, USA
    J Neurosci Methods 116:9-14. 2002

Research Grants

  1. MECHANISMS OF OLFACTORY TRANSDUCTION
    BARRY ACHE; Fiscal Year: 2005
  2. MECHANISMS OF OLFACTORY TRANSDUCTION
    BARRY ACHE; Fiscal Year: 2007
  3. Phosphoinositide Signaling in Mammalian Olfaction
    BARRY ACHE; Fiscal Year: 2007
  4. FOSTERING INNOVATION IN THE CHEMICAL SENSES
    BARRY ACHE; Fiscal Year: 2007
  5. Phosphoinositide Signaling in Mammalian Olfaction
    BARRY ACHE; Fiscal Year: 2007
  6. MECHANISMS OF OLFACTORY TRANSDUCTION
    Barry W Ache; Fiscal Year: 2010
  7. MULTIPLE PATHWAYS IN OLFACTORY TRANSDUCTION
    BARRY ACHE; Fiscal Year: 1993
  8. Phosphoinositide Signaling in Mammalian Olfaction
    BARRY ACHE; Fiscal Year: 2003
  9. Phosphoinositide Signaling in Mammalian Olfaction
    Barry W Ache; Fiscal Year: 2011

Detail Information

Publications16

  1. ncbi request reprint Organizational complexity in lobster olfactory receptor cells
    B W Ache
    Whitney Laboratory, University of Florida, St Augustine 31086, USA
    Ann N Y Acad Sci 855:194-8. 1998
    ..The complexity of intracellular signaling in lobster olfactory receptor cells renders the cells capable of fine tuning, and even integrating, the signal they send to the brain...
  2. ncbi request reprint Olfaction: diverse species, conserved principles
    Barry W Ache
    Whitney Lab for Marine Bioscience, Department of Zoology, Center for Smell and Taste and McKnight Brain Institute, University of Florida, Gainesville, Florida 32610, USA
    Neuron 48:417-30. 2005
    ..These common features span a phylogenetically broad array of animals, implying that there is an optimal solution to the problem of detecting and discriminating odors...
  3. pmc Phosphatidylinositol 4,5-bisphosphate-dependent regulation of the output in lobster olfactory receptor neurons
    Yuriy V Bobkov
    Whitney Laboratory, Center for Smell and Taste, and McKnight Brain Institute, University of Florida, Gainesville, FL 32610, USA
    J Exp Biol 213:1417-24. 2010
    ..Collectively, our results argue that PIs can regulate output in lobster ORNs, at least in part through their action on the lobster SGC channel...
  4. pmc Phosphoinositide 3-kinase mediated signaling in lobster olfactory receptor neurons
    Elizabeth A Corey
    Whitney Laboratory, Center for Smell and Taste, McKnight Brain Institute, University of Florida, Gainesville, Florida 32080 8610, USA
    J Neurochem 113:341-50. 2010
    ..Collectively, these findings provide evidence that PI3K is indeed activated by odorant receptors in lobster ORNs and further support the potential involvement of G protein activated PI3K signaling in olfactory transduction...
  5. pmc Inhibitory odorant signaling in Mammalian olfactory receptor neurons
    Kirill Ukhanov
    Whitney Laboratory, Center for Smell and Taste, University of Florida, Gainesville, FL 32610 0127, USA
    J Neurophysiol 103:1114-22. 2010
    ....
  6. pmc Phosphoinositide 3-kinase-dependent antagonism in mammalian olfactory receptor neurons
    Kirill Ukhanov
    Whitney Laboratory, Center for Smell and Taste, and McKnight Brain Institute, University of Florida, Gainesville, Florida 32610, USA
    J Neurosci 31:273-80. 2011
    ..Our findings collectively raise the interesting possibility that the OR serves as a molecular logic gate when mammalian ORNs are activated by natural, complex mixtures containing both excitatory and inhibitory odorants...
  7. ncbi request reprint Specificity of odorant-evoked inhibition in lobster olfactory receptor neurons
    Richard E Doolin
    Whitney Laboratory, University of Florida, 9505 Ocean Shore Blvd, St Augustine, FL 32080, USA
    Chem Senses 30:105-10. 2005
    ....
  8. ncbi request reprint Pharmacological properties and functional role of a TRP-related ion channel in lobster olfactory receptor neurons
    Yuriy V Bobkov
    Whitney Laboratory for Marine Bioscience, University of Florida, 9505 Ocean Shore Blvd, St Augustine, FL 32080 8610, USA
    J Neurophysiol 93:1372-80. 2005
    ..We then use this enhanced antagonist profile together with the agonists Na+ and Ca2+ to implicate the channel in signal amplification in the cells...
  9. ncbi request reprint Calcium sensitivity of a sodium-activated nonselective cation channel in lobster olfactory receptor neurons
    Yuriy V Bobkov
    Whitney Laboratory, University of Florida, Gainesville, Florida 32601, USA
    J Neurophysiol 90:2928-40. 2003
    ....
  10. ncbi request reprint A simple method for focally delivering multiple drugs or ligands to cells
    Richard E Doolin
    Whitney Laboratory, Department of Neuroscience, Center for Smell and Taste, University of Florida, 9505 Ocean Shore Boulevard, Gainesville, FL 32610, USA
    J Neurosci Methods 116:9-14. 2002
    ..The utility of the device is demonstrated for applying odorants to olfactory receptor neurons (ORNs)...
  11. ncbi request reprint Cyclic nucleotide signaling mediates an odorant-suppressible chloride conductance in lobster olfactory receptor neurons
    Richard E Doolin
    Whitney Laboratory, University of Florida, 9505 Ocean Shore Blvd, St Augustine, FL 32080, USA
    Chem Senses 30:127-35. 2005
    ..These findings further our understanding of the cellular mechanisms through which odorants can modulate the output of lobster ORNs...
  12. pmc PI3Kgamma-dependent signaling in mouse olfactory receptor neurons
    Daniela Brunert
    Center for Smell and Taste, University of Florida, Gainesville, FL 32610 0127 USA
    Chem Senses 35:301-8. 2010
    ..We conclude that odorant-dependent PI3K signaling generalizes to the murine olfactory system and that PI3Kgamma plays a role in mediating inhibition of odorant responses in mammalian ORNs...
  13. ncbi request reprint Presynaptic inhibition of olfactory receptor neurons in crustaceans
    Matt Wachowiak
    Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Microsc Res Tech 58:365-75. 2002
    ..Thus, it is possible that presynaptic inhibition of primary olfactory afferents evolved independently in vertebrates and invertebrates to fill a common, fundamental role in processing olfactory information...
  14. ncbi request reprint 3-phosphoinositides modulate cyclic nucleotide signaling in olfactory receptor neurons
    Marc Spehr
    Department of Cell Physiology, Ruhr University Bochum, Bochum, Germany
    Neuron 33:731-9. 2002
    ....
  15. ncbi request reprint Molecular and functional characterization of an I(h)-channel from lobster olfactory receptor neurons
    Gunter Gisselmann
    Ruhr Universitat Bochum, Lehrstuhl fur Zellphysiologie, Universitatsstr 150, D 44780 Bochum, Germany
    Eur J Neurosci 21:1635-47. 2005
    ..Collectively, these results implicate for the first time a functional role for an I(h)-channel in olfactory signal transduction...
  16. ncbi request reprint Gene expression and specificity in the mature zone of the lobster olfactory organ
    Ruben Stepanyan
    Department of Physiology, Cellular and Molecular Neuroscience of Sensory Systems Training Program, University of Kentucky, Lexington, Kentucky 40536 0298, USA
    Physiol Genomics 25:224-33. 2006
    ....

Research Grants29

  1. MECHANISMS OF OLFACTORY TRANSDUCTION
    BARRY ACHE; Fiscal Year: 2005
    ..abstract_text> ..
  2. MECHANISMS OF OLFACTORY TRANSDUCTION
    BARRY ACHE; Fiscal Year: 2007
    ....
  3. Phosphoinositide Signaling in Mammalian Olfaction
    BARRY ACHE; Fiscal Year: 2007
    ....
  4. FOSTERING INNOVATION IN THE CHEMICAL SENSES
    BARRY ACHE; Fiscal Year: 2007
    ..Enhancing this key forum will translate into expanded and improved understanding of the role of olfaction and taste in health and disease. ..
  5. Phosphoinositide Signaling in Mammalian Olfaction
    BARRY ACHE; Fiscal Year: 2007
    ..abstract_text> ..
  6. MECHANISMS OF OLFACTORY TRANSDUCTION
    Barry W Ache; Fiscal Year: 2010
    ..abstract_text> ..
  7. MULTIPLE PATHWAYS IN OLFACTORY TRANSDUCTION
    BARRY ACHE; Fiscal Year: 1993
    ..Understanding olfactory transduction is fundamental to understanding the role of the receptor cell in the sense of smell and, in turn, olfactory dysfunctions caused by environmental and pathogenic insult to the receptor organ...
  8. Phosphoinositide Signaling in Mammalian Olfaction
    BARRY ACHE; Fiscal Year: 2003
    ..This new, exciting line of investigation should have high impact on the field, making it competitive for R01 funding once the proposed additional preliminary data are in hand. ..
  9. Phosphoinositide Signaling in Mammalian Olfaction
    Barry W Ache; Fiscal Year: 2011
    ..A detailed understanding of how odors activate olfactory receptor cells therefore is critical to effectively address disease states such as dementia and the diminished quality of life associated with olfactory dysfunction. ..