YOUSEF A ABU KWAIK

Summary

Affiliation: University of Louisville
Country: USA

Publications

  1. pmc Exploitation of Host Polyubiquitination Machinery through Molecular Mimicry by Eukaryotic-Like Bacterial F-Box Effectors
    Christopher T D Price
    Department of Microbiology and Immunology, College of Medicine, University of Louisville Louisville, KY, USA
    Front Microbiol 1:122. 2010
  2. pmc Host-mediated post-translational prenylation of novel dot/icm-translocated effectors of legionella pneumophila
    Christopher T D Price
    Department of Microbiology and Immunology, College of Medicine, University of Louisville Louisville, KY, USA
    Front Microbiol 1:131. 2010
  3. pmc Exploitation of host cell biology and evasion of immunity by francisella tularensis
    Rexford Asare
    Department of Microbiology and Immunology, School of Medicine, University of Louisville Louisville, KY, USA
    Front Microbiol 1:145. 2010
  4. pmc Francisella-arthropod vector interaction and its role in patho-adaptation to infect mammals
    Christine Akimana
    Department of Microbiology and Immunology, College of Medicine, University of Louisville Louisville, KY, USA
    Front Microbiol 2:34. 2011
  5. pmc Molecular Characterization of Exploitation of the Polyubiquitination and Farnesylation Machineries of Dictyostelium Discoideum by the AnkB F-Box Effector of Legionella Pneumophila
    Tasneem Al-Quadan
    Department of Microbiology and Immunology, College of Medicine, University of Louisville Louisville, KY, USA
    Front Microbiol 2:23. 2011
  6. pmc Exploitation of conserved eukaryotic host cell farnesylation machinery by an F-box effector of Legionella pneumophila
    Christopher T D Price
    Department of Microbiology and Immunology, School of Medicine and 2 Department of Biology, University of Louisville, Louisville, KY 40292, USA
    J Exp Med 207:1713-26. 2010
  7. pmc Host factors required for modulation of phagosome biogenesis and proliferation of Francisella tularensis within the cytosol
    Christine Akimana
    Department of Microbiology and Immunology, College of Medicine, University of Louisville, Louisville, Kentucky, USA
    PLoS ONE 5:e11025. 2010
  8. pmc Molecular mimicry by an F-box effector of Legionella pneumophila hijacks a conserved polyubiquitination machinery within macrophages and protozoa
    Christopher T Price
    Department of Microbiology and Immunology, College of Medicine, University of Louisville, Kentucky, USA
    PLoS Pathog 5:e1000704. 2009
  9. doi request reprint Microbial quest for food in vivo: 'nutritional virulence' as an emerging paradigm
    Yousef Abu Kwaik
    Department of Microbiology and Immunology, College of Medicine, University of Louisville, Louisville, KY 40202, USA
    Cell Microbiol 15:882-90. 2013
  10. pmc The PmrA/PmrB two-component system of Legionella pneumophila is a global regulator required for intracellular replication within macrophages and protozoa
    Souhaila Al-Khodor
    Department of Microbiology and Immunology, College of Medicine, University of Louisville, Room 412, Louisville, KY 40202, USA
    Infect Immun 77:374-86. 2009

Research Grants

  1. Receptor-Mediated Endocytosis of Legionella Pneumophila
    Yousef Abu Kwaik; Fiscal Year: 2000
  2. Molecular pathogenesis of Francisella tularnesis
    YOUSEF A ABU KWAIK; Fiscal Year: 2010
  3. Modulation of apoptosis by Legionella Pneumophila
    Yousef Abu Kwaik; Fiscal Year: 2009
  4. Molecular pathogenesis of Francisella tularnesis
    Yousef Abu Kwaik; Fiscal Year: 2009
  5. Modulation of apoptosis by Legionella Pneumophila
    Yousef Abu Kwaik; Fiscal Year: 2007
  6. Molecular pathogenesis of Francisella Tularensis
    Yousef Abu Kwaik; Fiscal Year: 2007
  7. Molecular pathogenesis of Francisella tularnesis
    Yousef Abu Kwaik; Fiscal Year: 2006
  8. Receptor-Mediated Endocytosis of Legionella Pneumophila
    Yousef Abu Kwaik; Fiscal Year: 2003
  9. The Pore-forming Toxin of Legionella Pneumophila
    Yousef Abu Kwaik; Fiscal Year: 2003
  10. Receptor-Mediated Endocytosis of Legionella Pneumophila
    Yousef Abu Kwaik; Fiscal Year: 2004

Collaborators

Detail Information

Publications13

  1. pmc Exploitation of Host Polyubiquitination Machinery through Molecular Mimicry by Eukaryotic-Like Bacterial F-Box Effectors
    Christopher T D Price
    Department of Microbiology and Immunology, College of Medicine, University of Louisville Louisville, KY, USA
    Front Microbiol 1:122. 2010
    ....
  2. pmc Host-mediated post-translational prenylation of novel dot/icm-translocated effectors of legionella pneumophila
    Christopher T D Price
    Department of Microbiology and Immunology, College of Medicine, University of Louisville Louisville, KY, USA
    Front Microbiol 1:131. 2010
    ..pneumophila that are post-translationally modified by the host prenylation machinery, which enables their anchoring into cellular membranes, and the prenylated effectors contribute to evasion of lysosomal fusion by the LCV...
  3. pmc Exploitation of host cell biology and evasion of immunity by francisella tularensis
    Rexford Asare
    Department of Microbiology and Immunology, School of Medicine, University of Louisville Louisville, KY, USA
    Front Microbiol 1:145. 2010
    ..tularensis that also inhibits caspase-1 and ASC activity. During late stages of intracellular proliferation, caspase-3 is activated but apoptosis is delayed through activation of NF-κB and Ras, which ensures cell viability...
  4. pmc Francisella-arthropod vector interaction and its role in patho-adaptation to infect mammals
    Christine Akimana
    Department of Microbiology and Immunology, College of Medicine, University of Louisville Louisville, KY, USA
    Front Microbiol 2:34. 2011
    ..melanogaster have been identified, and F. tularensis targets some of the evolutionarily conserved eukaryotic processes to enable intracellular survival and proliferation in evolutionarily distant hosts...
  5. pmc Molecular Characterization of Exploitation of the Polyubiquitination and Farnesylation Machineries of Dictyostelium Discoideum by the AnkB F-Box Effector of Legionella Pneumophila
    Tasneem Al-Quadan
    Department of Microbiology and Immunology, College of Medicine, University of Louisville Louisville, KY, USA
    Front Microbiol 2:23. 2011
    ..We propose that L. pneumophila has acquired ankB through inter-kingdom horizontal gene transfer from primitive eukaryotes, which facilitated proliferation of L. pneumophila within human cells and the emergence of Legionnaires' disease...
  6. pmc Exploitation of conserved eukaryotic host cell farnesylation machinery by an F-box effector of Legionella pneumophila
    Christopher T D Price
    Department of Microbiology and Immunology, School of Medicine and 2 Department of Biology, University of Louisville, Louisville, KY 40292, USA
    J Exp Med 207:1713-26. 2010
    ..In conclusion, this study shows novel localized recruitment of the host farnesylation machinery and its anchoring of an F-box effector to the LCV membrane, and this is essential for biological function in vitro and in vivo...
  7. pmc Host factors required for modulation of phagosome biogenesis and proliferation of Francisella tularensis within the cytosol
    Christine Akimana
    Department of Microbiology and Immunology, College of Medicine, University of Louisville, Louisville, Kentucky, USA
    PLoS ONE 5:e11025. 2010
    ..tularensis. Our data will facilitate deciphering molecular ecology, patho-adaptation of F. tularensis to the arthropod vector and its role in bacterial ecology and patho-evolution to infect mammals...
  8. pmc Molecular mimicry by an F-box effector of Legionella pneumophila hijacks a conserved polyubiquitination machinery within macrophages and protozoa
    Christopher T Price
    Department of Microbiology and Immunology, College of Medicine, University of Louisville, Kentucky, USA
    PLoS Pathog 5:e1000704. 2009
    ..Therefore, AnkB exhibits a novel molecular and functional mimicry of eukaryotic F-box proteins that exploits conserved polyubiquitination machinery for intracellular proliferation within evolutionarily distant hosts...
  9. doi request reprint Microbial quest for food in vivo: 'nutritional virulence' as an emerging paradigm
    Yousef Abu Kwaik
    Department of Microbiology and Immunology, College of Medicine, University of Louisville, Louisville, KY 40202, USA
    Cell Microbiol 15:882-90. 2013
    ..Host-pathogen synchronization of amino acid auxotrophy indicates that this nutritional synchronization has been a major driving force in the evolution of many intracellular bacterial pathogens...
  10. pmc The PmrA/PmrB two-component system of Legionella pneumophila is a global regulator required for intracellular replication within macrophages and protozoa
    Souhaila Al-Khodor
    Department of Microbiology and Immunology, College of Medicine, University of Louisville, Room 412, Louisville, KY 40202, USA
    Infect Immun 77:374-86. 2009
    ..pneumophila within human macrophages and protozoa. Differences in gene regulation and intracellular growth phenotypes between the pmrA and pmrB mutant suggests a cross talk with other TCSs...
  11. pmc Genetic susceptibility and caspase activation in mouse and human macrophages are distinct for Legionella longbeachae and L. pneumophila
    Rexford Asare
    Department of Microbiology and Immunology, University of Louisville College of Medicine, 319 Abraham Flexner Way, Louisville, KY 40292, USA
    Infect Immun 75:1933-45. 2007
    ..longbeachae does not trigger the activation of caspase 1, caspase 3, or late-stage apoptosis in mouse and human macrophages. Neither species triggers caspase 1 activation in human macrophages...

Research Grants16

  1. Receptor-Mediated Endocytosis of Legionella Pneumophila
    Yousef Abu Kwaik; Fiscal Year: 2000
    ..Our studies may uncover potential pathogenic evolution of Lpn to invade the more evolved mammalian cells, and may contribute to the understanding of invasion of protozoa by Mycobacterium and Chlamydia. ..
  2. Molecular pathogenesis of Francisella tularnesis
    YOUSEF A ABU KWAIK; Fiscal Year: 2010
    ..The bacterial effectors involved in exploiting the macrophage are potential targets for treatment as well as potential vaccine candidates. ..
  3. Modulation of apoptosis by Legionella Pneumophila
    Yousef Abu Kwaik; Fiscal Year: 2009
    ..The bacterial effector involved in this process is a potential target for therapy and prevention of the disease. ..
  4. Molecular pathogenesis of Francisella tularnesis
    Yousef Abu Kwaik; Fiscal Year: 2009
    ..The bacterial effectors involved in exploiting the macrophage are potential targets for treatment as well as potential vaccine candidates. ..
  5. Modulation of apoptosis by Legionella Pneumophila
    Yousef Abu Kwaik; Fiscal Year: 2007
    ..The bacterial effector involved in this process is a potential target for therapy and prevention of the disease. ..
  6. Molecular pathogenesis of Francisella Tularensis
    Yousef Abu Kwaik; Fiscal Year: 2007
    ..The bacterial effectors involved in exploiting the macrophage are potential targets for treatment as well as potential vaccine candidates. ..
  7. Molecular pathogenesis of Francisella tularnesis
    Yousef Abu Kwaik; Fiscal Year: 2006
    ..The bacterial effectors involved in exploiting the macrophage are potential targets for treatment as well as potential vaccine candidates. ..
  8. Receptor-Mediated Endocytosis of Legionella Pneumophila
    Yousef Abu Kwaik; Fiscal Year: 2003
    ..Our studies may uncover potential pathogenic evolution of Lpn to invade the more evolved mammalian cells, and may contribute to the understanding of invasion of protozoa by Mycobacterium and Chlamydia. ..
  9. The Pore-forming Toxin of Legionella Pneumophila
    Yousef Abu Kwaik; Fiscal Year: 2003
    ..Our studies on L. pneumophila may provide a paradigm for other vacuolar intracellular pathogens such as Mycobacterium, Salmonella, and Chlamydia. ..
  10. Receptor-Mediated Endocytosis of Legionella Pneumophila
    Yousef Abu Kwaik; Fiscal Year: 2004
    ..Our studies may uncover potential pathogenic evolution of Lpn to invade the more evolved mammalian cells, and may contribute to the understanding of invasion of protozoa by Mycobacterium and Chlamydia. ..
  11. Receptor-Mediated Endocytosis of Legionella Pneumophila
    Yousef Abu Kwaik; Fiscal Year: 2003
    ..Our studies may uncover potential pathogenic evolution of Lpn to invade the more evolved mammalian cells, and may contribute to the understanding of invasion of protozoa by Mycobacterium and Chlamydia. ..
  12. Receptor-Mediated Endocytosis of Legionella Pneumophila
    Yousef Abu Kwaik; Fiscal Year: 2002
    ..Our studies may uncover potential pathogenic evolution of Lpn to invade the more evolved mammalian cells, and may contribute to the understanding of invasion of protozoa by Mycobacterium and Chlamydia. ..
  13. Receptor-Mediated Endocytosis of Legionella Pneumophila
    Yousef Abu Kwaik; Fiscal Year: 2001
    ..Our studies may uncover potential pathogenic evolution of Lpn to invade the more evolved mammalian cells, and may contribute to the understanding of invasion of protozoa by Mycobacterium and Chlamydia. ..
  14. Modulation of apoptosis by Legionella Pneumophila
    YOUSEF A ABU KWAIK; Fiscal Year: 2010
    ..The bacterial effector involved in this process is a potential target for therapy and prevention of the disease. ..