Jacqueline Abranches

Summary

Affiliation: University of Rochester
Country: USA

Publications

  1. pmc The collagen-binding protein Cnm is required for Streptococcus mutans adherence to and intracellular invasion of human coronary artery endothelial cells
    Jacqueline Abranches
    Center for Oral Biology, University of Rochester Medical Center, Box 611, 601 Elmwood Ave, Rochester, NY 14642, USA
    Infect Immun 79:2277-84. 2011
  2. pmc Two Spx proteins modulate stress tolerance, survival, and virulence in Streptococcus mutans
    Jessica K Kajfasz
    Center for Oral Biology, University of Rochester Medical Center, Box 611, 601 Elmwood Ave, Rochester, NY 14642, USA
    J Bacteriol 192:2546-56. 2010
  3. pmc Role of Clp proteins in expression of virulence properties of Streptococcus mutans
    Jessica K Kajfasz
    Center for Oral Biology, University of Rochester Medical Center, NY 14642, USA
    J Bacteriol 191:2060-8. 2009
  4. pmc The Spx regulator modulates stress responses and virulence in Enterococcus faecalis
    Jessica K Kajfasz
    Center for Oral Biology, University of Rochester Medical Center, Rochester, New York, USA
    Infect Immun 80:2265-75. 2012
  5. pmc Basal levels of (p)ppGpp in Enterococcus faecalis: the magic beyond the stringent response
    Anthony O Gaca
    Center for Oral Biology and Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, New York, USA
    MBio 4:e00646-13. 2013
  6. doi request reprint Global transcriptional analysis of the stringent response in Enterococcus faecalis
    Anthony O Gaca
    Center for Oral Biology and Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA
    Microbiology 158:1994-2004. 2012
  7. pmc Transcriptome analysis reveals that ClpXP proteolysis controls key virulence properties of Streptococcus mutans
    Jessica K Kajfasz
    Center for Oral Biology, University of Rochester Medical Center, Rochester, NY 14642, USA
    Microbiology 157:2880-90. 2011
  8. pmc Transcriptional and Phenotypic Characterization of Novel Spx-Regulated Genes in Streptococcus mutans
    Livia C C Galvão
    Center for Oral Biology, University of Rochester Medical Center, Rochester, New York, United States of America Department of Physiological Sciences, Dentistry School of Piracicaba, State University of Campinas, Piracicaba, SP, Brazil
    PLoS ONE 10:e0124969. 2015
  9. pmc Streptococcus mutans: a new Gram-positive paradigm?
    JOSE A LEMOS
    Center for Oral Biology and Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA
    Microbiology 159:436-45. 2013
  10. pmc Modification of Streptococcus mutans Cnm by PgfS contributes to adhesion, endothelial cell invasion, and virulence
    Alejandro Avilés-Reyes
    Center for Oral Biology, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
    J Bacteriol 196:2789-97. 2014

Collaborators

  • JOSE A LEMOS
  • Hyun Koo
  • William H Bowen
  • Jue D Wang
  • Melanie Wellington
  • Robert E Marquis
  • Jessica K Kajfasz
  • James H Miller
  • Anthony O Gaca
  • Alejandro Avilés-Reyes
  • Isamar Rivera-Ramos
  • Kathy Scott-Anne
  • Stacy Gregoire
  • Livia C C Galvão
  • Pedro L Rosalen
  • Alaina R Martinez
  • Robert G Quivey
  • Gilson C N Franco
  • Edith Sampson
  • Irlan A Freires
  • Ann Progulske-Fox
  • GENE E WATSON
  • Kathleen Scott-Anne
  • Patricia J Simpson-Haidaris
  • Fred K Hagen
  • Kuanqing Liu
  • Jorge E Mendoza
  • Kristy A Koselny
  • Marcia Giambiagi-deMarval
  • Adam M Derr

Detail Information

Publications17

  1. pmc The collagen-binding protein Cnm is required for Streptococcus mutans adherence to and intracellular invasion of human coronary artery endothelial cells
    Jacqueline Abranches
    Center for Oral Biology, University of Rochester Medical Center, Box 611, 601 Elmwood Ave, Rochester, NY 14642, USA
    Infect Immun 79:2277-84. 2011
    ..Thus, Cnm is required for S. mutans invasion of endothelial cells and possibly represents an important virulence factor of S. mutans that may contribute to cardiovascular infections and pathologies...
  2. pmc Two Spx proteins modulate stress tolerance, survival, and virulence in Streptococcus mutans
    Jessica K Kajfasz
    Center for Oral Biology, University of Rochester Medical Center, Box 611, 601 Elmwood Ave, Rochester, NY 14642, USA
    J Bacteriol 192:2546-56. 2010
    ..Given the high degree of conservation between Spx proteins of low-GC gram-positive bacteria, these results are likely to have broad implications...
  3. pmc Role of Clp proteins in expression of virulence properties of Streptococcus mutans
    Jessica K Kajfasz
    Center for Oral Biology, University of Rochester Medical Center, NY 14642, USA
    J Bacteriol 191:2060-8. 2009
    ..mutans and indicates that the underlying mechanisms by which ClpXP affect virulence traits are associated with the accumulation of two Spx orthologues...
  4. pmc The Spx regulator modulates stress responses and virulence in Enterococcus faecalis
    Jessica K Kajfasz
    Center for Oral Biology, University of Rochester Medical Center, Rochester, New York, USA
    Infect Immun 80:2265-75. 2012
    ..Collectively, our results show that Spx is a major stress gene regulator and is implicated in the pathophysiology of E. faecalis. The relationship of Spx to other oxidative stress regulators is also discussed...
  5. pmc Basal levels of (p)ppGpp in Enterococcus faecalis: the magic beyond the stringent response
    Anthony O Gaca
    Center for Oral Biology and Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, New York, USA
    MBio 4:e00646-13. 2013
    ..Collectively, this study highlights the critical but still underappreciated role of basal (p)ppGpp pools under balanced growth conditions...
  6. doi request reprint Global transcriptional analysis of the stringent response in Enterococcus faecalis
    Anthony O Gaca
    Center for Oral Biology and Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA
    Microbiology 158:1994-2004. 2012
    ..Thus, while ΔrelA and ΔrelAΔrelQ cannot use (p)ppGpp to sense and respond to stresses, fitness of ΔrelAΔrelQ may be further impaired due to an unbalanced metabolism...
  7. pmc Transcriptome analysis reveals that ClpXP proteolysis controls key virulence properties of Streptococcus mutans
    Jessica K Kajfasz
    Center for Oral Biology, University of Rochester Medical Center, Rochester, NY 14642, USA
    Microbiology 157:2880-90. 2011
    ..Collectively, our results reveal the broad scope of ClpXP regulation in S. mutans homeostasis and identify several virulence-related traits that are influenced by ClpXP proteolysis...
  8. pmc Transcriptional and Phenotypic Characterization of Novel Spx-Regulated Genes in Streptococcus mutans
    Livia C C Galvão
    Center for Oral Biology, University of Rochester Medical Center, Rochester, New York, United States of America Department of Physiological Sciences, Dentistry School of Piracicaba, State University of Campinas, Piracicaba, SP, Brazil
    PLoS ONE 10:e0124969. 2015
    ..These results serve as an entryway into the characterization of novel genes and pathways that allow S. mutans to cope with oxidative stress. ..
  9. pmc Streptococcus mutans: a new Gram-positive paradigm?
    JOSE A LEMOS
    Center for Oral Biology and Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA
    Microbiology 159:436-45. 2013
    ..In this article, we provide an argument that places S. mutans, an organism that evolved in close association with the human host, as a novel Gram-positive model organism...
  10. pmc Modification of Streptococcus mutans Cnm by PgfS contributes to adhesion, endothelial cell invasion, and virulence
    Alejandro Avilés-Reyes
    Center for Oral Biology, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
    J Bacteriol 196:2789-97. 2014
    ..In conclusion, this study demonstrates that Cnm is a glycoprotein and that posttranslational modification mediated by PgfS contributes to the virulence-associated phenotypes linked to Cnm. ..
  11. pmc The Collagen Binding Protein Cnm Contributes to Oral Colonization and Cariogenicity of Streptococcus mutans OMZ175
    James H Miller
    Center for Oral Biology, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
    Infect Immun 83:2001-10. 2015
    ..Taken together, our findings reveal that Cnm is a colonization factor that contributes to the pathogenicity of certain S. mutans strains in their native habitat, the oral cavity. ..
  12. pmc Transcription of Oxidative Stress Genes Is Directly Activated by SpxA1 and, to a Lesser Extent, by SpxA2 in Streptococcus mutans
    Jessica K Kajfasz
    Center for Oral Biology, University of Rochester Medical Center, Rochester, New York, USA
    J Bacteriol 197:2160-70. 2015
    ..Moreover, addition of purified SpxA1G52R completely failed to activate transcription of ahpC, sodA, and tpx, further confirming that the G52 residue is critical for Spx functionality...
  13. pmc Protocols to study the physiology of oral biofilms
    JOSE A LEMOS
    Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY, USA
    Methods Mol Biol 666:87-102. 2010
    ..In this chapter, we use oral streptococci as examples for studying the physiology of oral biofilms...
  14. pmc The molecular alarmone (p)ppGpp mediates stress responses, vancomycin tolerance, and virulence in Enterococcus faecalis
    Jacqueline Abranches
    Center for Oral Biology, University of Rochester Medical Center, NY 14642, USA
    J Bacteriol 191:2248-56. 2009
    ..Taken together, these results indicate that (p)ppGpp pools modulate environmental stress responses, vancomycin tolerance, and virulence in this important nosocomial pathogen...
  15. pmc Global regulation by (p)ppGpp and CodY in Streptococcus mutans
    JOSE A LEMOS
    Department of Microbiology and Immunology and Center for Oral Biology, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Bacteriol 190:5291-9. 2008
    ..Notably, the identification of putative CodY-binding boxes upstream of genes that were downregulated in the codY mutant indicates that CodY may also function as a transcriptional activator in S. mutans...
  16. pmc The cell wall-targeting antibiotic stimulon of Enterococcus faecalis
    Jacqueline Abranches
    Center for Oral Biology, University of Rochester Medical Center, Rochester, New York, United States of America
    PLoS ONE 8:e64875. 2014
    ..The phenotypes obtained for two of these mutants, ΔEF1533 and ΔEF3245, support further characterization of these genes as potential candidates for the development of novel preventive or therapeutic approaches...
  17. pmc Influence of apigenin on gtf gene expression in Streptococcus mutans UA159
    Hyun Koo
    Eastman Department of Dentistry and Center for Oral Biology, University of Rochester Medical Center, 625 Elmwood Ave, Box 683, Rochester, NY 14620, USA
    Antimicrob Agents Chemother 50:542-6. 2006
    ..The data show that apigenin modulates the genetic expression of virulence factors in S. mutans...