J M Abrams

Summary

Affiliation: University of Texas Southwestern Medical Center
Country: USA

Publications

  1. ncbi request reprint An emerging blueprint for apoptosis in Drosophila
    J M Abrams
    Dept of Cell Biology, The University of Texas, Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75235 9039, USA
    Trends Cell Biol 9:435-40. 1999
  2. pmc Altered cytochrome c display precedes apoptotic cell death in Drosophila
    J Varkey
    Department of Cell Biology and Neuroscience, University of Texas, Southwestern Medical Center, Dallas, Texas 75235 9039, USA
    J Cell Biol 144:701-10. 1999
  3. pmc Drosophila apoptosis and Bcl-2 genes: outliers fly in
    P Chen
    Department of Cell Biology, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9039, USA
    J Cell Biol 148:625-7. 2000
  4. ncbi request reprint Bifunctional killing activity encoded by conserved reaper proteins
    P Chen
    Department of Cell Biology, UT Southwestern Medical Center, Dallas, TX 75390, USA
    Cell Death Differ 11:704-13. 2004
  5. ncbi request reprint Dredd, a novel effector of the apoptosis activators reaper, grim, and hid in Drosophila
    P Chen
    Department of Cell Biology and Neuroscience, University of Texas, Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75235 9039, USA
    Dev Biol 201:202-16. 1998
  6. ncbi request reprint Release of mechanical tension triggers apoptosis of human fibroblasts in a model of regressing granulation tissue
    F Grinnell
    Department of Cell Biology and Neuroscience, UT Southwestern Medical Center, Dallas, Texas, 75235 9039, USA
    Exp Cell Res 248:608-19. 1999
  7. ncbi request reprint Lessons from p53 in non-mammalian models
    W J Lu
    Department of Cell Biology, UT Southwestern Medical Center, Dallas, TX 75390, USA
    Cell Death Differ 13:909-12. 2006
  8. pmc Morpholino antisense oligonucleotides: tools for investigating vertebrate development
    D R Corey
    Departments of Pharmacology and Biochemistry, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9041, USA
    Genome Biol 2:REVIEWS1015. 2001
  9. ncbi request reprint p53 directs focused genomic responses in Drosophila
    F Akdemir
    Department of Cell Biology, UT Southwestern Medical Center, Dallas, TX 75390, USA
    Oncogene 26:5184-93. 2007
  10. pmc The Drosophila caspase Dredd is required to resist gram-negative bacterial infection
    F Leulier
    Centre de Genetique Moleculaire, Centre National de la Recherche Scientifique, France
    EMBO Rep 1:353-8. 2000

Collaborators

Detail Information

Publications19

  1. ncbi request reprint An emerging blueprint for apoptosis in Drosophila
    J M Abrams
    Dept of Cell Biology, The University of Texas, Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75235 9039, USA
    Trends Cell Biol 9:435-40. 1999
    ..This animal model promises continued insights into the determinants of cell death in 'naturally occurring' and pathological contexts...
  2. pmc Altered cytochrome c display precedes apoptotic cell death in Drosophila
    J Varkey
    Department of Cell Biology and Neuroscience, University of Texas, Southwestern Medical Center, Dallas, Texas 75235 9039, USA
    J Cell Biol 144:701-10. 1999
    ..Our observations provide compelling validation of an early role for altered cytochrome c in PCD and suggest propagation of apoptotic physiology through reciprocal, feed-forward amplification involving cytochrome c and caspases...
  3. pmc Drosophila apoptosis and Bcl-2 genes: outliers fly in
    P Chen
    Department of Cell Biology, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9039, USA
    J Cell Biol 148:625-7. 2000
  4. ncbi request reprint Bifunctional killing activity encoded by conserved reaper proteins
    P Chen
    Department of Cell Biology, UT Southwestern Medical Center, Dallas, TX 75390, USA
    Cell Death Differ 11:704-13. 2004
    ..Collectively, these findings are inconsistent with single effector models for cell killing by Reaper and suggest, instead, that Reaper encodes conserved bifunctional death activities that propagate through distinct effector pathways...
  5. ncbi request reprint Dredd, a novel effector of the apoptosis activators reaper, grim, and hid in Drosophila
    P Chen
    Department of Cell Biology and Neuroscience, University of Texas, Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75235 9039, USA
    Dev Biol 201:202-16. 1998
    ..Taken together, these observations establish mechanistic connections between activators of apoptosis and a new downstream death effector in Drosophila...
  6. ncbi request reprint Release of mechanical tension triggers apoptosis of human fibroblasts in a model of regressing granulation tissue
    F Grinnell
    Department of Cell Biology and Neuroscience, UT Southwestern Medical Center, Dallas, Texas, 75235 9039, USA
    Exp Cell Res 248:608-19. 1999
    ....
  7. ncbi request reprint Lessons from p53 in non-mammalian models
    W J Lu
    Department of Cell Biology, UT Southwestern Medical Center, Dallas, TX 75390, USA
    Cell Death Differ 13:909-12. 2006
  8. pmc Morpholino antisense oligonucleotides: tools for investigating vertebrate development
    D R Corey
    Departments of Pharmacology and Biochemistry, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9041, USA
    Genome Biol 2:REVIEWS1015. 2001
    ..The recent use of morpholino antisense oligonucleotides in zebrafish embryos may prove a major advance, but rigorous controls are essential...
  9. ncbi request reprint p53 directs focused genomic responses in Drosophila
    F Akdemir
    Department of Cell Biology, UT Southwestern Medical Center, Dallas, TX 75390, USA
    Oncogene 26:5184-93. 2007
    ..A second gene, RnrL, is an apoptogenic effector required for caspase activation in a model of p53-dependent killing. Together, these studies identify ancient and convergent features of the p53 regulatory network...
  10. pmc The Drosophila caspase Dredd is required to resist gram-negative bacterial infection
    F Leulier
    Centre de Genetique Moleculaire, Centre National de la Recherche Scientifique, France
    EMBO Rep 1:353-8. 2000
    ....
  11. ncbi request reprint Dark is a Drosophila homologue of Apaf-1/CED-4 and functions in an evolutionarily conserved death pathway
    A Rodriguez
    Department of Cell Biology and Neuroscience, University of Texas Southwestern Medical Center, Dallas 75235 9039, USA
    Nat Cell Biol 1:272-9. 1999
    ..These findings establish dark as an important apoptosis effector in Drosophila and raise profound evolutionary considerations concerning the relationship between mitochondrial components and the apoptosis-promoting machinery...
  12. ncbi request reprint The head involution defective gene of Drosophila melanogaster functions in programmed cell death
    M E Grether
    Howard Hughes Medical Institute, Department of Brain and Cognitive Sciences, Cambridge, Massachusetts, USA
    Genes Dev 9:1694-708. 1995
    ..This phenotype can be suppressed completely by expression of the anti-apoptotic p35 protein from baculovirus, indicating that p35 may act genetically downstream from hid...
  13. ncbi request reprint Ceramide generation by the Reaper protein is not blocked by the caspase inhibitor, p35
    R Bose
    Laboratory of Signal Transduction, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    J Biol Chem 273:28852-9. 1998
    ..fmk inhibited ceramide generation and apoptosis. These data show that Rpr-induced ceramide generation is upstream or independent of p35-inhibitable caspases and demonstrate differences in the actions of peptide and p35 caspase inhibitors...
  14. ncbi request reprint grim, a novel cell death gene in Drosophila
    P Chen
    Department of Cell Biology and Neuroscience, University of Texas Southwestern Medical Center, Dallas 75235 9039, USA
    Genes Dev 10:1773-82. 1996
    ..The grim gene product might thus function in a parallel circuit of cell death signaling that ultimately activates a common set of downstream apoptotic effectors...
  15. ncbi request reprint Genetic control of programmed cell death in Drosophila
    K White
    Howard Hughes Medical Institute, Department of Brain and Cognitive Sciences, Cambridge, MA
    Science 264:677-83. 1994
    ..The reaper gene appears to encode a small peptide that shows no homology to known proteins, and reaper messenger RNA is expressed in cells destined to undergo apoptosis...
  16. ncbi request reprint Drosophila p53 binds a damage response element at the reaper locus
    M H Brodsky
    Howard Hughes Medical Institute, Department of Molecular and Cell Biology, University of California, Berkeley, 94720, USA
    Cell 101:103-13. 2000
    ..These results indicate that reaper is a direct transcriptional target of Drosophila p53 following DNA damage...
  17. ncbi request reprint Activation of the reaper gene during ectopic cell killing in Drosophila
    W Nordstrom
    Department of Cell Biology and Neuroscience, University of Texas Southwestern Medical Center, Dallas 75235 9039, USA
    Dev Biol 180:213-26. 1996
    ..Overall, these results suggest that diverse signals converge at, or upstream of, rpr-associated transcriptional regulatory elements that can function to initiate a common apoptotic pathway involving ICE-like protease activity...
  18. ncbi request reprint Programmed cell death in Drosophila
    H Steller
    Howard Hughes Medical Institute, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge 02139
    Philos Trans R Soc Lond B Biol Sci 345:247-50. 1994
    ..Our results suggest that reaper represents a key regulatory switch for the activation of apoptosis in response to a variety of distinct signals...
  19. pmc No death without life: vital functions of apoptotic effectors
    L Galluzzi
    INSERM, U848, Villejuif, France
    Cell Death Differ 15:1113-23. 2008
    ....