Donald I Abrams

Summary

Affiliation: University of California
Country: USA

Publications

  1. doi request reprint Cannabinoid-opioid interaction in chronic pain
    D I Abrams
    Division of Hematology Oncology, San Francisco General Hospital, University of California, San Francisco, San Francisco, California, USA
    Clin Pharmacol Ther 90:844-51. 2011
  2. pmc Antihyperlipidemic effects of Pleurotus ostreatus (oyster mushrooms) in HIV-infected individuals taking antiretroviral therapy
    Donald I Abrams
    Hematology Oncology, University of California San Francisco, 995 Potrero, San Francisco, CA 94110, USA
    BMC Complement Altern Med 11:60. 2011
  3. ncbi request reprint Short-term effects of cannabinoids in patients with HIV-1 infection: a randomized, placebo-controlled clinical trial
    Donald I Abrams
    University of California, San Francisco, and Gladstone Institute of Virology and Immunology, San Francisco, California 94110, USA
    Ann Intern Med 139:258-66. 2003
  4. ncbi request reprint Disadvantages of structured treatment interruption persist in patients with multidrug-resistant HIV-1: final results of the CPCRA 064 study
    Jody Lawrence
    Department of Medicine, Positive Health Program, San Francisco General Hospital, University of California, San Francisco, San Francisco, CA 94110, USA
    J Acquir Immune Defic Syndr 43:169-78. 2006
  5. ncbi request reprint Dehydroepiandrosterone (DHEA) effects on HIV replication and host immunity: a randomized placebo-controlled study
    Donald I Abrams
    Community Consortium, Positive Health Program, University of California, San Francisco, CA 94143, USA
    AIDS Res Hum Retroviruses 23:77-85. 2007
  6. ncbi request reprint Continued CD4 cell count increases in HIV-infected adults experiencing 4 years of viral suppression on antiretroviral therapy
    Peter W Hunt
    Positive Health Program, San Francisco General Hospital, University of California, San Francisco, California, USA
    AIDS 17:1907-15. 2003
  7. ncbi request reprint Structured treatment interruption in patients with multidrug-resistant human immunodeficiency virus
    Jody Lawrence
    Department of Medicine, Positive Health Program, San Francisco General Hospital, University of California, San Francisco, San Francisco, CA 94110, USA
    N Engl J Med 349:837-46. 2003
  8. ncbi request reprint Short-term effects of cannabinoids on immune phenotype and function in HIV-1-infected patients
    Barry M Bredt
    Department of Medicine, General Clinical Research Center at San Francisco General Hospital, CA 94110, USA
    J Clin Pharmacol 42:82S-89S. 2002
  9. ncbi request reprint The efficacy of distant healing for human immunodeficiency virus--results of a randomized trial
    John A Astin
    California Pacific Medical Center, San Francisco, CA, USA
    Altern Ther Health Med 12:36-41. 2006
  10. ncbi request reprint Contrasts, conflicts, and change: A case in cultural oncology
    Anand Dhruva
    Hematology Oncology Division, San Francisco General Hospital, San Francisco, CA 94110, USA
    J Support Oncol 4:301-4. 2006

Research Grants

  1. Antihyperlipidemic Effects of Oyster Mushrooms
    Donald Abrams; Fiscal Year: 2004
  2. COMMUNITY CONSORTIUM (CPCRA)
    Donald Abrams; Fiscal Year: 2006
  3. Opioid and Cannabinoid Pharmacokinetic Interactions
    Donald Abrams; Fiscal Year: 2007

Detail Information

Publications24

  1. doi request reprint Cannabinoid-opioid interaction in chronic pain
    D I Abrams
    Division of Hematology Oncology, San Francisco General Hospital, University of California, San Francisco, San Francisco, California, USA
    Clin Pharmacol Ther 90:844-51. 2011
    ..We therefore concluded that vaporized cannabis augments the analgesic effects of opioids without significantly altering plasma opioid levels. The combination may allow for opioid treatment at lower doses with fewer side effects...
  2. pmc Antihyperlipidemic effects of Pleurotus ostreatus (oyster mushrooms) in HIV-infected individuals taking antiretroviral therapy
    Donald I Abrams
    Hematology Oncology, University of California San Francisco, 995 Potrero, San Francisco, CA 94110, USA
    BMC Complement Altern Med 11:60. 2011
    ..The oyster mushroom, Pleurotus ostreatus, has been shown in animal models to decrease lipid levels--a finding that has been supported by preliminary data in a small human trial...
  3. ncbi request reprint Short-term effects of cannabinoids in patients with HIV-1 infection: a randomized, placebo-controlled clinical trial
    Donald I Abrams
    University of California, San Francisco, and Gladstone Institute of Virology and Immunology, San Francisco, California 94110, USA
    Ann Intern Med 139:258-66. 2003
    ..Cannabinoid use could potentially alter HIV RNA levels by two mechanisms: immune modulation or cannabinoid-protease inhibitor interactions (because both share cytochrome P-450 metabolic pathways)...
  4. ncbi request reprint Disadvantages of structured treatment interruption persist in patients with multidrug-resistant HIV-1: final results of the CPCRA 064 study
    Jody Lawrence
    Department of Medicine, Positive Health Program, San Francisco General Hospital, University of California, San Francisco, San Francisco, CA 94110, USA
    J Acquir Immune Defic Syndr 43:169-78. 2006
    ....
  5. ncbi request reprint Dehydroepiandrosterone (DHEA) effects on HIV replication and host immunity: a randomized placebo-controlled study
    Donald I Abrams
    Community Consortium, Positive Health Program, University of California, San Francisco, CA 94143, USA
    AIDS Res Hum Retroviruses 23:77-85. 2007
    ....
  6. ncbi request reprint Continued CD4 cell count increases in HIV-infected adults experiencing 4 years of viral suppression on antiretroviral therapy
    Peter W Hunt
    Positive Health Program, San Francisco General Hospital, University of California, San Francisco, California, USA
    AIDS 17:1907-15. 2003
    ..To determine the extent to which HIV-infected patients, including those with advanced immunodeficiency, can reverse peripheral CD4 T-cell depletion while maintaining long-term viral suppression on highly active antiretroviral therapy...
  7. ncbi request reprint Structured treatment interruption in patients with multidrug-resistant human immunodeficiency virus
    Jody Lawrence
    Department of Medicine, Positive Health Program, San Francisco General Hospital, University of California, San Francisco, San Francisco, CA 94110, USA
    N Engl J Med 349:837-46. 2003
    ..We compared two strategies for treating patients infected with multidrug-resistant human immunodeficiency virus (HIV)...
  8. ncbi request reprint Short-term effects of cannabinoids on immune phenotype and function in HIV-1-infected patients
    Barry M Bredt
    Department of Medicine, General Clinical Research Center at San Francisco General Hospital, CA 94110, USA
    J Clin Pharmacol 42:82S-89S. 2002
    ..On the basis of these measurements and during this short 21-day study period, few statistically significant effects were noted on immune system phenotypes orfunctions in this patient population...
  9. ncbi request reprint The efficacy of distant healing for human immunodeficiency virus--results of a randomized trial
    John A Astin
    California Pacific Medical Center, San Francisco, CA, USA
    Altern Ther Health Med 12:36-41. 2006
    ..The purpose of this study was to examine the potential efficacy of distant healing in a population of patients with human immunodeficiency virus (HIV)/aquired immune deficiency syndrome (AIDS)...
  10. ncbi request reprint Contrasts, conflicts, and change: A case in cultural oncology
    Anand Dhruva
    Hematology Oncology Division, San Francisco General Hospital, San Francisco, CA 94110, USA
    J Support Oncol 4:301-4. 2006
  11. doi request reprint Nausea at the end of adjuvant cancer treatment in relation to exercise during treatment in patients with breast cancer
    Jiyeon Lee
    School of Nursing, University of California, San Francisco, USA
    Oncol Nurs Forum 35:830-5. 2008
    ..To evaluate the relationship between nausea and exercise during and after adjuvant cancer treatment (chemotherapy and radiation therapy or chemotherapy alone)...
  12. pmc Assessing the Association between Leptin and Bone Mineral Density in HIV-Infected Men
    Madhu N Rao
    Department of Medicine, University of California, San Francisco, CA 94143, USA
    AIDS Res Treat 2012:103072. 2012
    ..This result suggests that fat distribution may modify the relationship between leptin and bone density...
  13. ncbi request reprint The effects of cannabinoids on the pharmacokinetics of indinavir and nelfinavir
    Bradley W Kosel
    Department of Clinical Pharmacy, University of California San Francisco, San Francisco, CA 94110, USA
    AIDS 16:543-50. 2002
    ..We present pharmacokinetic data from a randomized placebo-controlled study designed to evaluate the metabolic effects of smoked marijuana and dronabinol in HIV-infected patients receiving indinavir (IDV) or nelfinavir (NFV)...
  14. ncbi request reprint Randomized, open-label study of the impact of two doses of subcutaneous recombinant interleukin-2 on viral burden in patients with HIV-1 infection and CD4+ cell counts of > or = 300/mm3: CPCRA 059
    Donald I Abrams
    San Francisco General Hospital, University of California at San Francisco, San Francisco, California 94110, USA
    J Acquir Immune Defic Syndr 29:221-31. 2002
    ..0001). No unanticipated adverse experiences were seen in this trial, to our knowledge the largest randomized evaluation of rIL-2 treatment conducted to date...
  15. ncbi request reprint Community-based clinical trials in hiv: the contributions of Mathilde Krim
    Donald I Abrams
    Community Consortium of Bay Area HIV Care Providers, Department of Hematology Oncology, San Francisco General Hospital, San Francisco, California, USA
    AIDS Patient Care STDS 20:480-5. 2006
  16. ncbi request reprint An overview of integrative oncology
    Donald I Abrams
    University of California, San Francisco, CA, USA
    Clin Adv Hematol Oncol 5:45-7. 2007
  17. ncbi request reprint The evaluation of subcutaneous proleukin (interleukin-2) in a randomized international trial: rationale, design, and methods of ESPRIT
    Sean Emery
    National Centre in HIV Epidemiology and Clinical Research, University of New South Wales, Level 2, 376 Victoria Street, Sydney, NSW 2010, Australia
    Control Clin Trials 23:198-220. 2002
    ..This article describes the rationale supporting the trial in addition to reviewing the study design, coordination, and governance...
  18. pmc Episodic antiretroviral therapy increases HIV transmission risk compared with continuous therapy: results of a randomized controlled trial
    William Burman
    Denver Public Health, 605 Bannock Street, Denver, CO 80204, USA
    J Acquir Immune Defic Syndr 49:142-50. 2008
    ..To compare the HIV transmission risk among patients randomized to episodic versus continuous antiretroviral therapy...
  19. pmc Poor initial CD4+ recovery with antiretroviral therapy prolongs immune depletion and increases risk for AIDS and non-AIDS diseases
    Jason V Baker
    Department of Biostatistics, University of Minnesota, Minneapolis, MN, USA
    J Acquir Immune Defic Syndr 48:541-6. 2008
    ..Low CD4+ increases risk for both AIDS- and non-AIDS-related morbidity and mortality. The magnitude of CD4+ recovery early after initial antiretroviral therapy (ART) is important in the ultimate duration of immune depletion...
  20. pmc CD4+ count and risk of non-AIDS diseases following initial treatment for HIV infection
    Jason V Baker
    University of Minnesota, Minneapolis, USA
    AIDS 22:841-8. 2008
    ..Reductions in AIDS-related morbidity and mortality following the advent of combination antiretroviral therapy have coincided with relative increases in chronic non-AIDS end-organ diseases among HIV+ patients...
  21. ncbi request reprint Risk of cancers during interrupted antiretroviral therapy in the SMART study
    Michael J Silverberg
    Division of Research, Kaiser Permanente Northern California, Oakland, California 94110, USA
    AIDS 21:1957-63. 2007
    ..To compare rates of AIDS-defining and non-AIDS-defining malignancies between patients on a CD4 T-cell-guided antiretroviral therapy (ART) strategy and continuous ART...
  22. ncbi request reprint Nadir CD4+ T cell count predicts response to subcutaneous recombinant interleukin-2
    Norman Markowitz
    Division of Infectious Diseases, Henry Ford Hospital, Detroit, Michigan 48202, USA
    Clin Infect Dis 37:e115-20. 2003
    ..Baseline CD4+ cell count had no significant effect. The strong association between nadir CD4+ cell count and CD4+ cell count response suggests that immunologic losses resulting from HIV-mediated CD4+ cell depletion may be irreversible...

Research Grants7

  1. Antihyperlipidemic Effects of Oyster Mushrooms
    Donald Abrams; Fiscal Year: 2004
    ..abstract_text> ..
  2. COMMUNITY CONSORTIUM (CPCRA)
    Donald Abrams; Fiscal Year: 2006
    ..The lost-to-follow-up rate has always been extremely low, and is currently zero percent for all active CPCRA protocols. ..
  3. Opioid and Cannabinoid Pharmacokinetic Interactions
    Donald Abrams; Fiscal Year: 2007
    ..Nausea and vomiting will be assessed daily via self-report. The study will be conducted over a 2-year period. ..