Research Topics
| D I AbramsSummaryAffiliation: University of California Country: USA Publications
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Detail Information
Publications
Vaporization as a smokeless cannabis delivery system: a pilot studyD I Abrams
Community Consortium, Positive Health Program, San Francisco General Hospital, San Francisco, California, USA
Clin Pharmacol Ther 82:572-8. 2007..No adverse events occurred. Vaporization of cannabis is a safe and effective mode of delivery of THC. Further trials of clinical effectiveness of cannabis could utilize vaporization as a smokeless delivery system...- Randomized, open-label study of the impact of two doses of subcutaneous recombinant interleukin-2 on viral burden in patients with HIV-1 infection and CD4+ cell counts of > or = 300/mm3: CPCRA 059Donald I Abrams
San Francisco General Hospital, University of California at San Francisco, San Francisco, California 94110, USA
J Acquir Immune Defic Syndr 29:221-31. 2002..0001). No unanticipated adverse experiences were seen in this trial, to our knowledge the largest randomized evaluation of rIL-2 treatment conducted to date... - Cannabis in painful HIV-associated sensory neuropathy: a randomized placebo-controlled trialD I Abrams
Community Consortium, Positive Health Program, San Francisco General Hospital, San Francisco, CA 94110, USA
Neurology 68:515-21. 2007..To determine the effect of smoked cannabis on the neuropathic pain of HIV-associated sensory neuropathy and an experimental pain model... - Dehydroepiandrosterone (DHEA) effects on HIV replication and host immunity: a randomized placebo-controlled studyDonald I Abrams
Community Consortium, Positive Health Program, University of California, San Francisco, CA 94143, USA
AIDS Res Hum Retroviruses 23:77-85. 2007.... - Epoetin alfa therapy for anaemia in HIV-infected patients: impact on quality of lifeD I Abrams
UCSF Positive Health Program, San Francisco General Hospital, California 94110, USA
Int J STD AIDS 11:659-65. 2000..Adverse events observed during epoetin alfa therapy were consistent with HIV disease and not likely due to the drug. Epoetin alfa therapy should be considered a treatment option for HIV-infected patients with mild-to-moderate anaemia... 
Cannabinoid-opioid interaction in chronic painD I Abrams
Division of Hematology Oncology, San Francisco General Hospital, University of California, San Francisco, San Francisco, California, USA
Clin Pharmacol Ther 90:844-51. 2011..We therefore concluded that vaporized cannabis augments the analgesic effects of opioids without significantly altering plasma opioid levels. The combination may allow for opioid treatment at lower doses with fewer side effects...- Continued CD4 cell count increases in HIV-infected adults experiencing 4 years of viral suppression on antiretroviral therapyPeter W Hunt
Positive Health Program, San Francisco General Hospital, University of California, San Francisco, California, USA
AIDS 17:1907-15. 2003..The immune system's capacity for CD4 T lymphocyte restoration is not limited by low pre-therapy CD4 counts... - Altered fat distribution in HIV-positive men on nucleoside analog reverse transcriptase inhibitor therapyK Mulligan
Department of Medicine, University of California San Francisco, 94110, USA
J Acquir Immune Defic Syndr 26:443-8. 2001..Our results, which have been obtained retrospectively, are intended to provide the impetus for prospective, controlled studies of the interactions among drug and host factors in the development of fat distribution abnormalities... - Potential interventions for HIV/AIDS wasting: an overviewD I Abrams
Positive Health Program, San Francisco General Hospital, University of California, 94110, USA
J Acquir Immune Defic Syndr 25:S74-80. 2000..HIV wasting therapies are reviewed. The evaluation of some of these treatments for management of body habitus alterations associated with antiretroviral therapies may be appropriate... - Disadvantages of structured treatment interruption persist in patients with multidrug-resistant HIV-1: final results of the CPCRA 064 studyJody Lawrence
Department of Medicine, Positive Health Program, San Francisco General Hospital, University of California, San Francisco, San Francisco, CA 94110, USA
J Acquir Immune Defic Syndr 43:169-78. 2006.... - Nausea at the end of adjuvant cancer treatment in relation to exercise during treatment in patients with breast cancerJiyeon Lee
School of Nursing, University of California, San Francisco, USA
Oncol Nurs Forum 35:830-5. 2008..To evaluate the relationship between nausea and exercise during and after adjuvant cancer treatment (chemotherapy and radiation therapy or chemotherapy alone)... - Contrasts, conflicts, and change: A case in cultural oncologyAnand Dhruva
Hematology-Oncology Division, San Francisco General Hospital, San Francisco, CA 94110, USA
J Support Oncol 4:301-4. 2006 - Short-term effects of cannabinoids in patients with HIV-1 infection: a randomized, placebo-controlled clinical trialDonald I Abrams
University of California, San Francisco, and Gladstone Institute of Virology and Immunology, San Francisco, California 94110, USA
Ann Intern Med 139:258-66. 2003..CONCLUSIONS: Smoked and oral cannabinoids did not seem to be unsafe in people with HIV infection with respect to HIV RNA levels, CD4+ and CD8+ cell counts, or protease inhibitor levels over a 21-day treatment... - Structured treatment interruption in patients with multidrug-resistant human immunodeficiency virusJody Lawrence
Department of Medicine, Positive Health Program, San Francisco General Hospital, University of California, San Francisco, San Francisco, CA 94110, USA
N Engl J Med 349:837-46. 2003..We compared two strategies for treating patients infected with multidrug-resistant human immunodeficiency virus (HIV)... - Serum beta 2-microglobulin decreases in patients with AIDS or ARC treated with azidothymidineM A Jacobson
Department of Medicine, University of California, San Francisco
J Infect Dis 159:1029-36. 1989..05). Serum beta 2-microglobulin appears to be a sensitive marker for in vivo antiretroviral drug activity and may be a better marker than serum p24 antigen for early intervention trials involving antiretroviral agents... - The pre-AIDS syndromes. Asymptomatic carriers, thrombocytopenic purpura, persistent generalized lymphadenopathy, and AIDS-related complexD I Abrams
Department of Medicine, University of California, San Francisco
Infect Dis Clin North Am 2:343-51. 1988..All are characterized by the presence of human immunodeficiency virus infection, symptomatic illness, and a tendency to progress to a diagnosis of full-blown AIDS that appears to be ever increasing with the passage of time... - Oral dextran sulfate (UA001) in the treatment of the acquired immunodeficiency syndrome (AIDS) and AIDS-related complexD I Abrams
University of California, San Francisco
Ann Intern Med 110:183-8. 1989..No evidence of systemic absorption of the parent compound is available. However, in view of the promising in vitro effects and acceptable toxicity, oral dextran sulfate as a potential antiretroviral agent continues to be studied... - A phase I/II study of recombinant tumor necrosis factor and recombinant interferon gamma in patients with AIDS-related complexL D Kaplan
Department of Medicine, San Francisco General Hospital, California 94110
Biotechnol Ther 1:229-36. 1989..The mean CD4 cell number did not change significantly (176 +/- 143/mm3 pretherapy versus 279 +/- 305/mm3 posttherapy).(ABSTRACT TRUNCATED AT 250 WORDS).. - Risk of cancers during interrupted antiretroviral therapy in the SMART studyMichael J Silverberg
Division of Research, Kaiser Permanente Northern California, Oakland, California 94110, USA
AIDS 21:1957-63. 2007..To compare rates of AIDS-defining and non-AIDS-defining malignancies between patients on a CD4 T-cell-guided antiretroviral therapy (ART) strategy and continuous ART... - Clinical manifestations of HIV infection, including persistent generalized lymphadenopathy and AIDS-related complexD I Abrams
Department of Medicine, University of California, San Francisco
J Am Acad Dermatol 22:1217-22. 1990..All are characterized by the presence of infection with HIV, symptomatic disease, and, over time, an increasing tendency to progress to "full-blown" AIDS... 
Associations between water-treatment methods and diarrhoea in HIV-positive individualsJ N S Eisenberg
School of Public Health, University of California, Berkeley, CA 94720-7360, USA
Epidemiol Infect 129:315-23. 2002....- The effects of cannabinoids on the pharmacokinetics of indinavir and nelfinavirBradley W Kosel
Department of Clinical Pharmacy, University of California-San Francisco, San Francisco, CA 94110, USA
AIDS 16:543-50. 2002..The use of marijuana or dronabinol is unlikely to impact antiretroviral efficacy... - Short-term effects of cannabinoids on immune phenotype and function in HIV-1-infected patientsBarry M Bredt
Department of Medicine, General Clinical Research Center at San Francisco General Hospital, CA 94110, USA
J Clin Pharmacol 42:82S-89S. 2002..On the basis of these measurements and during this short 21-day study period, few statistically significant effects were noted on immune system phenotypes orfunctions in this patient population... - Community-based clinical trials in hiv: the contributions of Mathilde KrimDonald I Abrams
Community Consortium of Bay Area HIV Care Providers, Department of Hematology-Oncology, San Francisco General Hospital, San Francisco, California, USA
AIDS Patient Care STDS 20:480-5. 2006 - The efficacy of distant healing for human immunodeficiency virus--results of a randomized trialJohn A Astin
California Pacific Medical Center, San Francisco, CA, USA
Altern Ther Health Med 12:36-41. 2006..CONCLUSIONS: Distant healing or prayer from a distance does not appear to improve selected clinical outcomes in HIV patients who are on a combination antiretroviral therapy... - The evaluation of subcutaneous proleukin (interleukin-2) in a randomized international trial: rationale, design, and methods of ESPRITSean Emery
National Centre in HIV Epidemiology and Clinical Research, University of New South Wales, Level 2, 376 Victoria Street, Sydney, NSW 2010, Australia
Control Clin Trials 23:198-220. 2002..This article describes the rationale supporting the trial in addition to reviewing the study design, coordination, and governance... - Medicinal cannabis: rational guidelines for dosingGregory T Carter
Department of Rehabilitation Medicine, University of Washington School of Medicine, Seattle, WA 98531, USA
IDrugs 7:464-70. 2004..This paper will review the known chemistry and pharmacology of cannabis and, on that basis, discuss rational guidelines for dosing... - CD4+ count and risk of non-AIDS diseases following initial treatment for HIV infectionJason V Baker
University of Minnesota, Minneapolis, USA
AIDS 22:841-8. 2008..Reductions in AIDS-related morbidity and mortality following the advent of combination antiretroviral therapy have coincided with relative increases in chronic non-AIDS end-organ diseases among HIV+ patients... - Poor initial CD4+ recovery with antiretroviral therapy prolongs immune depletion and increases risk for AIDS and non-AIDS diseasesJason V Baker
Department of Biostatistics, University of Minnesota, Minneapolis, MN, USA
J Acquir Immune Defic Syndr 48:541-6. 2008..Low CD4+ increases risk for both AIDS- and non-AIDS-related morbidity and mortality. The magnitude of CD4+ recovery early after initial antiretroviral therapy (ART) is important in the ultimate duration of immune depletion... - Episodic antiretroviral therapy increases HIV transmission risk compared with continuous therapy: results of a randomized controlled trialWilliam Burman
Denver Public Health, 605 Bannock Street, Denver, CO 80204, USA
J Acquir Immune Defic Syndr 49:142-50. 2008..To compare the HIV transmission risk among patients randomized to episodic versus continuous antiretroviral therapy... - Nadir CD4+ T cell count predicts response to subcutaneous recombinant interleukin-2Norman Markowitz
Division of Infectious Diseases, Henry Ford Hospital, Detroit, Michigan 48202, USA
Clin Infect Dis 37:e115-20. 2003..Baseline CD4+ cell count had no significant effect. The strong association between nadir CD4+ cell count and CD4+ cell count response suggests that immunologic losses resulting from HIV-mediated CD4+ cell depletion may be irreversible...