Mitchell Abrahamsen

Summary

Affiliation: University of Minnesota
Country: USA

Publications

  1. pmc Effect of chloroquine on gene expression of Plasmodium yoelii nigeriensis during its sporogonic development in the mosquito vector
    Henrique Silveira
    Centro de Malaria e Outras Doencas Tropicais, UEI Malária, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa, Portugal
    Malar J 6:84. 2007
  2. pmc Phylogenomic evidence supports past endosymbiosis, intracellular and horizontal gene transfer in Cryptosporidium parvum
    Jinling Huang
    Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, GA 30602, USA
    Genome Biol 5:R88. 2004
  3. pmc Identification of putative cis-regulatory elements in Cryptosporidium parvum by de novo pattern finding
    Nandita Mullapudi
    Department of Genetics and Center for Tropical and Emerging Global Diseases, Paul D Coverdell Center, University of Georgia, Athens, GA 30602, USA
    BMC Genomics 8:13. 2007
  4. ncbi Complete genome sequence of the apicomplexan, Cryptosporidium parvum
    Mitchell S Abrahamsen
    Department of Veterinary and Biomedical Science, College of Veterinary Medicine, University of Minnesota, St Paul, MN 55108, USA
    Science 304:441-5. 2004
  5. ncbi A critical role of interleukin-10 in the response of bovine macrophages to infection by Mycobacterium avium subsp paratuberculosis
    Douglas J Weiss
    Department of Veterinary Pathobiology, College of Veterinary Medicine, University of Minnesota, Saint Paul, MN 55108, USA
    Am J Vet Res 66:721-6. 2005
  6. ncbi Molecular cloning and sequence variation of UDP-glucose pyrophosphorylase cDNAs from potatoes sensitive and resistant to cold sweetening
    Joseph R Sowokinos
    Department of Horticultural Science, University of Minnesota, St Paul, MN 55108, USA
    J Plant Physiol 161:947-55. 2004
  7. pmc Differential responses of bovine macrophages to Mycobacterium avium subsp. paratuberculosis and Mycobacterium avium subsp. avium
    Douglas J Weiss
    Department of Veterinary Pathobiology, University of Minnesota, St Paul, Minnesota 55108, USA
    Infect Immun 70:5556-61. 2002
  8. ncbi Sequential patterns of gene expression by bovine monocyte-derived macrophages associated with ingestion of mycobacterial organisms
    Douglas J Weiss
    Department of Veterinary and Biomedical Sciences, College of Veterinary Medicine, University of Minnesota, 1971 Commonwealth Avenue, St Paul, MN 55108, USA
    Microb Pathog 37:215-24. 2004
  9. ncbi Cryptosporidium parvum regulation of human epithelial cell gene expression
    Mingqi Deng
    Department of Veterinary Pathobiology, College of Veterinary Medicine, University of Minnesota, 1988 Fitch Avenue, St Paul, MN 55108, USA
    Int J Parasitol 34:73-82. 2004
  10. pmc Cryptosporidium parvum genes containing thrombospondin type 1 domains
    Mingqi Deng
    Department of Veterinary Pathobiology, University of Minnesota, St Paul 55108, USA
    Infect Immun 70:6987-95. 2002

Research Grants

  1. CRYPTOSPORIDIUM PARVUM GENOME SEQUENCING PROJECT (MINN)
    Mitchell Abrahamsen; Fiscal Year: 2002
  2. Purine salvage in Cryptosporidium parvum
    Mitchell Abrahamsen; Fiscal Year: 2005
  3. Host specificity of Cryptospordium gene expression
    Mitchell Abrahamsen; Fiscal Year: 2006

Collaborators

Detail Information

Publications29

  1. pmc Effect of chloroquine on gene expression of Plasmodium yoelii nigeriensis during its sporogonic development in the mosquito vector
    Henrique Silveira
    Centro de Malaria e Outras Doencas Tropicais, UEI Malária, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa, Portugal
    Malar J 6:84. 2007
    ..The present study sets to identify Plasmodium genes that might be regulated by chloroquine in the mosquito vector...
  2. pmc Phylogenomic evidence supports past endosymbiosis, intracellular and horizontal gene transfer in Cryptosporidium parvum
    Jinling Huang
    Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, GA 30602, USA
    Genome Biol 5:R88. 2004
    ..Given the importance of gene transfers in eukaryotic evolution and the potential implications for chemotherapy, it is important to identify the complement of transferred genes in Cryptosporidium...
  3. pmc Identification of putative cis-regulatory elements in Cryptosporidium parvum by de novo pattern finding
    Nandita Mullapudi
    Department of Genetics and Center for Tropical and Emerging Global Diseases, Paul D Coverdell Center, University of Georgia, Athens, GA 30602, USA
    BMC Genomics 8:13. 2007
    ..parvum. To support our findings, we have established comparative real-time -PCR expression profiles for the groups of genes examined computationally...
  4. ncbi Complete genome sequence of the apicomplexan, Cryptosporidium parvum
    Mitchell S Abrahamsen
    Department of Veterinary and Biomedical Science, College of Veterinary Medicine, University of Minnesota, St Paul, MN 55108, USA
    Science 304:441-5. 2004
    ..Elucidation of the core metabolism, including enzymes with high similarities to bacterial and plant counterparts, opens new avenues for drug development...
  5. ncbi A critical role of interleukin-10 in the response of bovine macrophages to infection by Mycobacterium avium subsp paratuberculosis
    Douglas J Weiss
    Department of Veterinary Pathobiology, College of Veterinary Medicine, University of Minnesota, Saint Paul, MN 55108, USA
    Am J Vet Res 66:721-6. 2005
    ..To evaluate the role of interleukin (IL)-10 in the inability of monocyte-derived bovine macrophages to kill Mycobacterium avium subsp paratuberculosis organisms in vitro...
  6. ncbi Molecular cloning and sequence variation of UDP-glucose pyrophosphorylase cDNAs from potatoes sensitive and resistant to cold sweetening
    Joseph R Sowokinos
    Department of Horticultural Science, University of Minnesota, St Paul, MN 55108, USA
    J Plant Physiol 161:947-55. 2004
    ..All polypeptides had putative glycosylation sites at amino acid positions 168 (NQS) and 307 (NLS). The Ser at position 420 provided a putative site for phosphorylation as well as a binding motif for 14-3-3 proteins...
  7. pmc Differential responses of bovine macrophages to Mycobacterium avium subsp. paratuberculosis and Mycobacterium avium subsp. avium
    Douglas J Weiss
    Department of Veterinary Pathobiology, University of Minnesota, St Paul, Minnesota 55108, USA
    Infect Immun 70:5556-61. 2002
    ..Therefore, the combination of inherent resistance to intracellular degradation and suppression of macrophage activation through oversecretion of IL-10 may contribute to the virulence of M. avium subsp. paratuberculosis in cattle...
  8. ncbi Sequential patterns of gene expression by bovine monocyte-derived macrophages associated with ingestion of mycobacterial organisms
    Douglas J Weiss
    Department of Veterinary and Biomedical Sciences, College of Veterinary Medicine, University of Minnesota, 1971 Commonwealth Avenue, St Paul, MN 55108, USA
    Microb Pathog 37:215-24. 2004
    ..Although multiple genes and metabolic pathways are involved, the capacity of cells to acidify phagosomes and induce apoptosis appears to play a prominent role...
  9. ncbi Cryptosporidium parvum regulation of human epithelial cell gene expression
    Mingqi Deng
    Department of Veterinary Pathobiology, College of Veterinary Medicine, University of Minnesota, 1988 Fitch Avenue, St Paul, MN 55108, USA
    Int J Parasitol 34:73-82. 2004
    ..parvum infection results in significant changes in host biochemical pathways and provides new insights into specific biological processes of infectious disease caused by an intracellular protozoan parasite...
  10. pmc Cryptosporidium parvum genes containing thrombospondin type 1 domains
    Mingqi Deng
    Department of Veterinary Pathobiology, University of Minnesota, St Paul 55108, USA
    Infect Immun 70:6987-95. 2002
    ..Only CpTSP4 was highly expressed solely at an early stage of infection...
  11. ncbi Regulation of apoptotic pathways in bovine gamma/delta T cells
    Mingqi Deng
    Department of Veterinary and Biomedical Sciences, College of Veterinary Medicine, University of Minnesota, St Paul, MN 55108, USA
    Vet Immunol Immunopathol 105:15-23. 2005
    ....
  12. pmc Biphasic modulation of apoptotic pathways in Cryptosporidium parvum-infected human intestinal epithelial cells
    Jin Liu
    Department of Veterinary and Biomedical Sciences, University of Minnesota, 1988 Fitch Ave, No 295, St Paul, MN 55108, USA
    Infect Immun 77:837-49. 2009
    ..Control of host apoptosis is complex and crucial to the life of C. parvum. Apoptosis control has at least two components, early inhibition and late moderate promotion. For a successful infection, both aspects appear to be required...
  13. doi Expression and regulation of IL-22 by bovine peripheral blood gamma/delta T cells
    Shi Dong Ma
    Department of Veterinary and Biomedical Sciences, University of Minnesota, 1988 Fitch Avenue, Room 295 AS VM, St Paul, MN 55108, USA
    Gene 451:6-14. 2010
    ..We conclude that bovine gamma/delta T cells are important sources of IL-22 and suggest a role for this cytokine in regulating immune responses at mucosal surfaces, including the gut...
  14. ncbi Host intestinal epithelial response to Cryptosporidium parvum
    Mingqi Deng
    Department of Veterinary Pathobiology, College of Veterinary Medicine, University of Minnesota, 1988 Fitch Avenue, St Paul, MN 55108, USA
    Adv Drug Deliv Rev 56:869-84. 2004
    ..parvum infection, the process by which the host clears and ultimately develops resistance to infection, and the development of chemotherapeutic strategies to intercede infections...
  15. pmc Inhibition of apoptosis in Cryptosporidium parvum-infected intestinal epithelial cells is dependent on survivin
    Jin Liu
    Department of Veterinary and Biomedical Sciences, University of Minnesota, 1988 Fitch Ave, No 295, St Paul, MN 55108, USA
    Infect Immun 76:3784-92. 2008
    ..parvum 18S rRNA levels. These data suggest that the apoptotic response of infected intestinal epithelial cells is actively suppressed by C. parvum via upregulation of survivin, favoring parasite infection...
  16. pmc The Cryptosporidium oocyst wall protein is a member of a multigene family and has a homolog in Toxoplasma
    Thomas J Templeton
    Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, New York 10021, USA
    Infect Immun 72:980-7. 2004
    ....
  17. ncbi Comparative gene expression by WC1+ gammadelta and CD4+ alphabeta T lymphocytes, which respond to Anaplasma marginale, demonstrates higher expression of chemokines and other myeloid cell-associated genes by WC1+ gammadelta T cells
    Kevin K Lahmers
    Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, WA 99164 7040, USA
    J Leukoc Biol 80:939-52. 2006
    ..It is important that many of these genes were also expressed at higher levels in polyclonal WC1(+) gammadelta T cells when compared with CD4(+) alphabeta T cells selected from peripheral blood...
  18. pmc Comparative analysis of apicomplexa and genomic diversity in eukaryotes
    Thomas J Templeton
    Department of Microbiology and Immunology, Weill Medical College and the Program in Immunology and Microbial Pathogenesis, Weill Graduate School of Medical Sciences of Cornell University, New York, New York 10021, USA
    Genome Res 14:1686-95. 2004
    ..We also describe additional molecular characteristics distinguishing Apicomplexa from other eukaryotes for which complete genome sequences are available...
  19. ncbi Intron-containing beta-tubulin transcripts in Cryptosporidium parvum cultured in vitro
    Xiaomin Cai
    Department of Veterinary Pathobiology, College of Veterinary Pathobiology, Texas A and M University, 4467 TAMU, College Station, TX 77843 4467, USA
    Microbiology 150:1191-5. 2004
    ..Furthermore, the presence of both processed and unprocessed introns in beta-tubulin transcripts in vitro may provide a venue for studying overall mechanisms for intron-splicing in this parasite...
  20. ncbi The genome of Cryptosporidium hominis
    Ping Xu
    Center for the Study of Biological Complexity, Virginia Commonwealth University, Richmond, Virginia 23284 2030, USA
    Nature 431:1107-12. 2004
    ..C. hominis and C. parvum exhibit very similar gene complements, and phenotypic differences between these parasites must be due to subtle sequence divergence...
  21. pmc CryptoDB: the Cryptosporidium genome resource
    Daniela Puiu
    Center for the Study of Biological Complexity, Virginia Commonwealth University, Richmond, VA, USA
    Nucleic Acids Res 32:D329-31. 2004
    ..This database, like other apicomplexan parasite databases, has been built utilizing the PlasmoDB model...
  22. ncbi Genomics and genetics of Cryptosporidium parvum: the key to understanding cryptosporidiosis
    Giovanni Widmer
    Tufts University School of Veterinary Medicine, Division of Infectious Diseases, 200 Westboro Road, North Grafton, MA 01536, USA
    Microbes Infect 4:1081-90. 2002
    ..The approach to and the relevance of sequencing the genomes of C. parvum type 1 and type 2 are discussed, as well as new insights into the genetic heterogeneity of this species...
  23. doi Establishment of fetal bovine intestinal epithelial cell cultures susceptible to bovine rotavirus infection
    Radhey S Kaushik
    Vaccine and Infectious Disease Organization, University of Saskatchewan, Saskatoon, Saskatchewan, Canada S7N 5E3
    J Virol Methods 148:182-96. 2008
    ..Ileal and jejunal cultures displayed limited growth following continuous passage but early passage epithelial cells provide competent target cells for studying host cell responses to an enteric viral pathogen...
  24. ncbi Evolution of Cryptosporidium parvum lactate dehydrogenase from malate dehydrogenase by a very recent event of gene duplication
    Dominique Madern
    Laboratoire de Biophysique Moleculaire, Institut de Biologie Structurale CEA CNRS UJF, Grenoble, France
    Mol Biol Evol 21:489-97. 2004
    ..parvum diverged from other apicomplexans...
  25. ncbi BoLA class I allele diversity and polymorphism in a herd of cattle
    Shawn Babiuk
    Pyxis Genomics Canada, Saskatoon, Saskatchewan, Canada
    Immunogenetics 59:167-76. 2007
    ....
  26. pmc A multidomain adhesion protein family expressed in Plasmodium falciparum is essential for transmission to the mosquito
    Gabriele Pradel
    Department of Microbiology and Immunology, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA
    J Exp Med 199:1533-44. 2004
    ..Our results describe members of a conserved apicomplexan protein family expressed in sexual stage Plasmodium parasites that may represent candidates for subunits of a transmission-blocking vaccine...
  27. ncbi The CD4+ T cell immunodominant Anaplasma marginale major surface protein 2 stimulates gammadelta T cell clones that express unique T cell receptors
    Kevin K Lahmers
    Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, WA 99164 7040, USA
    J Leukoc Biol 77:199-208. 2005
    ..Together, these data indicate that WC1+ gammadelta T cells recognize A. marginale MSP2 through the TCR and contribute to the immunodominant response to this protein...
  28. pmc Genetic complementation in apicomplexan parasites
    Boris Striepen
    Department of Cellular Biology and Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, GA 30602, USA
    Proc Natl Acad Sci U S A 99:6304-9. 2002
    ..The prokaryotic origin of this enzyme might make it a promising target for therapeutics directed against Cryptosporidium...

Research Grants3

  1. CRYPTOSPORIDIUM PARVUM GENOME SEQUENCING PROJECT (MINN)
    Mitchell Abrahamsen; Fiscal Year: 2002
    ..parvum genome. ..
  2. Purine salvage in Cryptosporidium parvum
    Mitchell Abrahamsen; Fiscal Year: 2005
    ..In addition, these studies demonstrate our ability to use heterologous expression of C. parvum genes in yeast as a means to develop a high-throughput screening assay for the identification of specific inhibitors. ..
  3. Host specificity of Cryptospordium gene expression
    Mitchell Abrahamsen; Fiscal Year: 2006
    ....