Research Topics
| Mitchell AbrahamsenSummaryAffiliation: University of Minnesota Country: USA Publications
Research Grants
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Detail Information
Publications
Effect of chloroquine on gene expression of Plasmodium yoelii nigeriensis during its sporogonic development in the mosquito vectorHenrique Silveira
Centro de Malaria e Outras Doencas Tropicais, UEI Malária, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa, Portugal
Malar J 6:84. 2007..The present study sets to identify Plasmodium genes that might be regulated by chloroquine in the mosquito vector...- Phylogenomic evidence supports past endosymbiosis, intracellular and horizontal gene transfer in Cryptosporidium parvumJinling Huang
Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, GA 30602, USA
Genome Biol 5:R88. 2004..Given the importance of gene transfers in eukaryotic evolution and the potential implications for chemotherapy, it is important to identify the complement of transferred genes in Cryptosporidium... - Identification of putative cis-regulatory elements in Cryptosporidium parvum by de novo pattern findingNandita Mullapudi
Department of Genetics and Center for Tropical and Emerging Global Diseases, Paul D Coverdell Center, University of Georgia, Athens, GA 30602, USA
BMC Genomics 8:13. 2007..parvum. To support our findings, we have established comparative real-time -PCR expression profiles for the groups of genes examined computationally... 
Complete genome sequence of the apicomplexan, Cryptosporidium parvumMitchell S Abrahamsen
Department of Veterinary and Biomedical Science, College of Veterinary Medicine, University of Minnesota, St Paul, MN 55108, USA
Science 304:441-5. 2004..Elucidation of the core metabolism, including enzymes with high similarities to bacterial and plant counterparts, opens new avenues for drug development...- A critical role of interleukin-10 in the response of bovine macrophages to infection by Mycobacterium avium subsp paratuberculosisDouglas J Weiss
Department of Veterinary Pathobiology, College of Veterinary Medicine, University of Minnesota, Saint Paul, MN 55108, USA
Am J Vet Res 66:721-6. 2005..CONCLUSIONS AND CLINICAL RELEVANCE: The capacity of M avium subsp paratuberculosis to induce IL-10 expression may be a major determinant of virulence for this organism... - Molecular cloning and sequence variation of UDP-glucose pyrophosphorylase cDNAs from potatoes sensitive and resistant to cold sweeteningJoseph R Sowokinos
Department of Horticultural Science, University of Minnesota, St Paul, MN 55108, USA
J Plant Physiol 161:947-55. 2004..All polypeptides had putative glycosylation sites at amino acid positions 168 (NQS) and 307 (NLS). The Ser at position 420 provided a putative site for phosphorylation as well as a binding motif for 14-3-3 proteins... - Sequential patterns of gene expression by bovine monocyte-derived macrophages associated with ingestion of mycobacterial organismsDouglas J Weiss
Department of Veterinary and Biomedical Sciences, College of Veterinary Medicine, University of Minnesota, 1971 Commonwealth Avenue, St Paul, MN 55108, USA
Microb Pathog 37:215-24. 2004..Although multiple genes and metabolic pathways are involved, the capacity of cells to acidify phagosomes and induce apoptosis appears to play a prominent role... - Differential responses of bovine macrophages to Mycobacterium avium subsp. paratuberculosis and Mycobacterium avium subsp. aviumDouglas J Weiss
Department of Veterinary Pathobiology, University of Minnesota, St Paul, Minnesota 55108, USA
Infect Immun 70:5556-61. 2002..Therefore, the combination of inherent resistance to intracellular degradation and suppression of macrophage activation through oversecretion of IL-10 may contribute to the virulence of M. avium subsp. paratuberculosis in cattle... - Cryptosporidium parvum genes containing thrombospondin type 1 domainsMingqi Deng
Department of Veterinary Pathobiology, University of Minnesota, St. Paul 55108, USA
Infect Immun 70:6987-95. 2002..Only CpTSP4 was highly expressed solely at an early stage of infection... - Regulation of apoptotic pathways in bovine gamma/delta T cellsMingqi Deng
Department of Veterinary and Biomedical Sciences, College of Veterinary Medicine, University of Minnesota, St. Paul, MN 55108, USA
Vet Immunol Immunopathol 105:15-23. 2005.... - Cryptosporidium parvum regulation of human epithelial cell gene expressionMingqi Deng
Department of Veterinary Pathobiology, College of Veterinary Medicine, University of Minnesota, 1988 Fitch Avenue, St Paul, MN 55108, USA
Int J Parasitol 34:73-82. 2004..parvum infection results in significant changes in host biochemical pathways and provides new insights into specific biological processes of infectious disease caused by an intracellular protozoan parasite... - Biphasic modulation of apoptotic pathways in Cryptosporidium parvum-infected human intestinal epithelial cellsJin Liu
Department of Veterinary and Biomedical Sciences, University of Minnesota, 1988 Fitch Ave, No 295, St Paul, MN 55108, USA
Infect Immun 77:837-49. 2009..Control of host apoptosis is complex and crucial to the life of C. parvum. Apoptosis control has at least two components, early inhibition and late moderate promotion. For a successful infection, both aspects appear to be required... 
Expression and regulation of IL-22 by bovine peripheral blood gamma/delta T cellsShi Dong Ma
Department of Veterinary and Biomedical Sciences, University of Minnesota, 1988 Fitch Avenue, Room 295 AS VM, St Paul, MN 55108, USA
Gene 451:6-14. 2010..We conclude that bovine gamma/delta T cells are important sources of IL-22 and suggest a role for this cytokine in regulating immune responses at mucosal surfaces, including the gut...- Inhibition of apoptosis in Cryptosporidium parvum-infected intestinal epithelial cells is dependent on survivinJin Liu
Department of Veterinary and Biomedical Sciences, University of Minnesota, 1988 Fitch Ave, No 295, St Paul, MN 55108, USA
Infect Immun 76:3784-92. 2008..parvum 18S rRNA levels. These data suggest that the apoptotic response of infected intestinal epithelial cells is actively suppressed by C. parvum via upregulation of survivin, favoring parasite infection... - Host intestinal epithelial response to Cryptosporidium parvumMingqi Deng
Department of Veterinary Pathobiology, College of Veterinary Medicine, University of Minnesota, 1988 Fitch Avenue, St. Paul, MN 55108, USA
Adv Drug Deliv Rev 56:869-84. 2004..parvum infection, the process by which the host clears and ultimately develops resistance to infection, and the development of chemotherapeutic strategies to intercede infections... - Comparative analysis of apicomplexa and genomic diversity in eukaryotesThomas J Templeton
Department of Microbiology and Immunology, Weill Medical College and the Program in Immunology and Microbial Pathogenesis, Weill Graduate School of Medical Sciences of Cornell University, New York, New York 10021, USA
Genome Res 14:1686-95. 2004..We also describe additional molecular characteristics distinguishing Apicomplexa from other eukaryotes for which complete genome sequences are available... - Comparative gene expression by WC1+ gammadelta and CD4+ alphabeta T lymphocytes, which respond to Anaplasma marginale, demonstrates higher expression of chemokines and other myeloid cell-associated genes by WC1+ gammadelta T cellsKevin K Lahmers
Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, WA 99164-7040, USA
J Leukoc Biol 80:939-52. 2006..It is important that many of these genes were also expressed at higher levels in polyclonal WC1(+) gammadelta T cells when compared with CD4(+) alphabeta T cells selected from peripheral blood... - The Cryptosporidium oocyst wall protein is a member of a multigene family and has a homolog in ToxoplasmaThomas J Templeton
Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, New York 10021, USA
Infect Immun 72:980-7. 2004.... - Intron-containing beta-tubulin transcripts in Cryptosporidium parvum cultured in vitroXiaomin Cai
Department of Veterinary Pathobiology, College of Veterinary Pathobiology, Texas A and M University, 4467 TAMU, College Station, TX 77843-4467, USA
Microbiology 150:1191-5. 2004..Furthermore, the presence of both processed and unprocessed introns in beta-tubulin transcripts in vitro may provide a venue for studying overall mechanisms for intron-splicing in this parasite... - The genome of Cryptosporidium hominisPing Xu
Center for the Study of Biological Complexity, Virginia Commonwealth University, Richmond, Virginia 23284-2030, USA
Nature 431:1107-12. 2004..C. hominis and C. parvum exhibit very similar gene complements, and phenotypic differences between these parasites must be due to subtle sequence divergence... - Genomics and genetics of Cryptosporidium parvum: the key to understanding cryptosporidiosisGiovanni Widmer
Tufts University School of Veterinary Medicine, Division of Infectious Diseases, 200 Westboro Road, North Grafton, MA 01536, USA
Microbes Infect 4:1081-90. 2002..The approach to and the relevance of sequencing the genomes of C. parvum type 1 and type 2 are discussed, as well as new insights into the genetic heterogeneity of this species... - A multidomain adhesion protein family expressed in Plasmodium falciparum is essential for transmission to the mosquitoGabriele Pradel
Department of Microbiology and Immunology, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA
J Exp Med 199:1533-44. 2004..Our results describe members of a conserved apicomplexan protein family expressed in sexual stage Plasmodium parasites that may represent candidates for subunits of a transmission-blocking vaccine... - Establishment of fetal bovine intestinal epithelial cell cultures susceptible to bovine rotavirus infectionRadhey S Kaushik
Vaccine and Infectious Disease Organization, University of Saskatchewan, Saskatoon, Saskatchewan, Canada S7N 5E3
J Virol Methods 148:182-96. 2008..Ileal and jejunal cultures displayed limited growth following continuous passage but early passage epithelial cells provide competent target cells for studying host cell responses to an enteric viral pathogen... - CryptoDB: the Cryptosporidium genome resourceDaniela Puiu
Center for the Study of Biological Complexity, Virginia Commonwealth University, Richmond, VA, USA
Nucleic Acids Res 32:D329-31. 2004..This database, like other apicomplexan parasite databases, has been built utilizing the PlasmoDB model... - Evolution of Cryptosporidium parvum lactate dehydrogenase from malate dehydrogenase by a very recent event of gene duplicationDominique Madern
, Institut de Biologie Structurale CEA-CNRS-UJF, Grenoble, France
Mol Biol Evol 21:489-97. 2004..parvum diverged from other apicomplexans... - BoLA class I allele diversity and polymorphism in a herd of cattleShawn Babiuk
Pyxis Genomics Canada, Saskatoon, Saskatchewan, Canada
Immunogenetics 59:167-76. 2007.... - The CD4+ T cell immunodominant Anaplasma marginale major surface protein 2 stimulates gammadelta T cell clones that express unique T cell receptorsKevin K Lahmers
Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, WA 99164 7040, USA
J Leukoc Biol 77:199-208. 2005..Together, these data indicate that WC1+ gammadelta T cells recognize A. marginale MSP2 through the TCR and contribute to the immunodominant response to this protein... - Genetic complementation in apicomplexan parasitesBoris Striepen
Department of Cellular Biology and Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, GA 30602, USA
Proc Natl Acad Sci U S A 99:6304-9. 2002..The prokaryotic origin of this enzyme might make it a promising target for therapeutics directed against Cryptosporidium...
Research Grants
- CRYPTOSPORIDIUM PARVUM GENOME SEQUENCING PROJECT (MINN)Mitchell Abrahamsen; Fiscal Year: 2002..parvum genome. ..
- Purine salvage in Cryptosporidium parvumMitchell Abrahamsen; Fiscal Year: 2005..In addition, these studies demonstrate our ability to use heterologous expression of C. parvum genes in yeast as a means to develop a high-throughput screening assay for the identification of specific inhibitors. ..
- Host specificity of Cryptospordium gene expressionMitchell Abrahamsen; Fiscal Year: 2006....