E Abraham

Summary

Affiliation: University of Colorado Health Sciences Center
Country: USA

Publications

  1. ncbi HMG-1 as a mediator of acute lung inflammation
    E Abraham
    Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    J Immunol 165:2950-4. 2000
  2. ncbi Effects of recombinant human activated protein C in human models of endotoxin administration
    Edward Abraham
    Division of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Proc Am Thorac Soc 2:243-7. 2005
  3. ncbi Nuclear factor-kappaB and its role in sepsis-associated organ failure
    Edward Abraham
    Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    J Infect Dis 187:S364-9. 2003
  4. ncbi Computational design of variant TNF molecules: a novel methodology for inhibition of proinflammatory cascades
    Edward Abraham
    Department of Medicine, Head, Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Box C272, 4200 East Ninth Avenue, Denver, CO 80262, USA
    Sci STKE 2003:PE51. 2003
  5. ncbi Effects of propofol containing EDTA on mineral metabolism in medical ICU patients with pulmonary dysfunction
    E Abraham
    University of Colorado Health Sciences Center, Division of Pulmonary Sciences and Critical Care Medicine, Denver 80262, USA
    Intensive Care Med 26:S422-32. 2000
  6. ncbi Activation of extracellular signal-regulated kinases, NF-kappa B, and cyclic adenosine 5'-monophosphate response element-binding protein in lung neutrophils occurs by differing mechanisms after hemorrhage or endotoxemia
    E Abraham
    Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Science Center, Denver, CO 80262, USA
    J Immunol 166:522-30. 2001
  7. ncbi Neutrophils as early immunologic effectors in hemorrhage- or endotoxemia-induced acute lung injury
    E Abraham
    Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Am J Physiol Lung Cell Mol Physiol 279:L1137-45. 2000
  8. ncbi The International Sepsis Forum's controversies in sepsis: how will sepsis be treated in 2051?
    Edward Abraham
    Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Denver, Colorado, USA
    Crit Care 6:277-8. 2002
  9. ncbi Efficacy and safety of tifacogin (recombinant tissue factor pathway inhibitor) in severe sepsis: a randomized controlled trial
    Edward Abraham
    Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Denver 80262, USA
    JAMA 290:238-47. 2003
  10. ncbi Drotrecogin alfa (activated) for adults with severe sepsis and a low risk of death
    Edward Abraham
    Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Denver 80262, USA
    N Engl J Med 353:1332-41. 2005

Detail Information

Publications80

  1. ncbi HMG-1 as a mediator of acute lung inflammation
    E Abraham
    Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    J Immunol 165:2950-4. 2000
    ..Together, these findings indicate that HMG-1 is a distal mediator of acute inflammatory lung injury...
  2. ncbi Effects of recombinant human activated protein C in human models of endotoxin administration
    Edward Abraham
    Division of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Proc Am Thorac Soc 2:243-7. 2005
    ..Such results indicate that the effects of rhAPC in inhibiting the infiltration of neutrophils into the lungs and other inflammatory sites may contribute to its beneficial effects in sepsis...
  3. ncbi Nuclear factor-kappaB and its role in sepsis-associated organ failure
    Edward Abraham
    Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    J Infect Dis 187:S364-9. 2003
    ..Because NF-kappaB occupies a central role in signaling pathways important in sepsis, modulation of NF-kappaB activity may be an appropriate therapeutic target in patients with sepsis...
  4. ncbi Computational design of variant TNF molecules: a novel methodology for inhibition of proinflammatory cascades
    Edward Abraham
    Department of Medicine, Head, Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Box C272, 4200 East Ninth Avenue, Denver, CO 80262, USA
    Sci STKE 2003:PE51. 2003
    ..However, the immunogenicity, as well as efficacy, of the dominant-negative TNF constructs must be more completely examined...
  5. ncbi Effects of propofol containing EDTA on mineral metabolism in medical ICU patients with pulmonary dysfunction
    E Abraham
    University of Colorado Health Sciences Center, Division of Pulmonary Sciences and Critical Care Medicine, Denver 80262, USA
    Intensive Care Med 26:S422-32. 2000
    ..To determine whether the addition of disodium edetate (EDTA) to propofol significantly alters mineral metabolism, adverse events, and outcome in critically ill medical patients with acute pulmonary dysfunction...
  6. ncbi Activation of extracellular signal-regulated kinases, NF-kappa B, and cyclic adenosine 5'-monophosphate response element-binding protein in lung neutrophils occurs by differing mechanisms after hemorrhage or endotoxemia
    E Abraham
    Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Science Center, Denver, CO 80262, USA
    J Immunol 166:522-30. 2001
    ..These data indicate that the pathways leading to lung neutrophil activation after hemorrhage are different from those induced by endotoxemia...
  7. ncbi Neutrophils as early immunologic effectors in hemorrhage- or endotoxemia-induced acute lung injury
    E Abraham
    Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Am J Physiol Lung Cell Mol Physiol 279:L1137-45. 2000
    ..These experiments show that neutrophils play a central role in initiating acute inflammatory responses and causing injury in the lungs after hemorrhage or endotoxemia...
  8. ncbi The International Sepsis Forum's controversies in sepsis: how will sepsis be treated in 2051?
    Edward Abraham
    Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Denver, Colorado, USA
    Crit Care 6:277-8. 2002
  9. ncbi Efficacy and safety of tifacogin (recombinant tissue factor pathway inhibitor) in severe sepsis: a randomized controlled trial
    Edward Abraham
    Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Denver 80262, USA
    JAMA 290:238-47. 2003
    ..Tissue factor pathway inhibitor (TFPI) forms a complex with tissue factor and blood protease factors leading to inhibition of thrombin generation and fibrin formation...
  10. ncbi Drotrecogin alfa (activated) for adults with severe sepsis and a low risk of death
    Edward Abraham
    Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Denver 80262, USA
    N Engl J Med 353:1332-41. 2005
    ..The FDA required a study to evaluate the efficacy of DrotAA for adults who had severe sepsis and a low risk of death...
  11. ncbi Urokinase-type plasminogen activator potentiates lipopolysaccharide-induced neutrophil activation
    Edward Abraham
    Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    J Immunol 170:5644-51. 2003
    ....
  12. ncbi Cytokine modifiers: pipe dream or reality?
    E Abraham
    Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Denver 80262, USA
    Chest 113:224S-227S. 1998
    ....
  13. ncbi Alterations in cell signaling in sepsis
    Edward Abraham
    Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Clin Infect Dis 41:S459-64. 2005
    ....
  14. ncbi Involvement of phosphoinositide 3-kinases in neutrophil activation and the development of acute lung injury
    H K Yum
    Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    J Immunol 167:6601-8. 2001
    ..These results show that PI3-K, and particularly PI3-Kgamma, occupies a central position in regulating endotoxin-induced neutrophil activation, including that involved in ALI...
  15. ncbi Role of p38 MAP kinase in the development of acute lung injury
    J Arcaroli
    Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, Denver, CA 80262, USA
    Clin Immunol 101:211-9. 2001
    ..These results indicate that p38 does not have a central role in the development of ALI after either hemorrhage or endotoxemia...
  16. ncbi Interactions between CBP, NF-kappaB, and CREB in the lungs after hemorrhage and endotoxemia
    R Shenkar
    Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Am J Physiol Lung Cell Mol Physiol 281:L418-26. 2001
    ..The present results show that the coactivator CBP has an important role in modulating transcription in vivo under clinically relevant pathophysiological conditions...
  17. ncbi Role of NF-kappaB in endotoxemia-induced alterations of lung neutrophil apoptosis
    J G Kupfner
    Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Denver, CO 80220, USA
    J Immunol 167:7044-51. 2001
    ..These results demonstrate that mechanisms independent of NF-kappaB activation play an important role in modulating lung neutrophil apoptosis after endotoxemia...
  18. ncbi A low level of TNF-alpha mediates hemorrhage-induced acute lung injury via p55 TNF receptor
    Y Song
    Department of Surgery, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Am J Physiol Lung Cell Mol Physiol 281:L677-84. 2001
    ....
  19. ncbi Neutrophil apoptosis in the lung after hemorrhage or endotoxemia: apoptosis and migration are independent of IL-1beta
    M V Parsey
    Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Clin Immunol 91:219-25. 1999
    ....
  20. ncbi Hyperoxia activates NF-kappaB and increases TNF-alpha and IFN-gamma gene expression in mouse pulmonary lymphocytes
    L M Shea
    Pediatric Critical Care, The Children s Hospital, Denver, CO 80218, USA
    J Immunol 157:3902-8. 1996
    ....
  21. ncbi Lenercept (p55 tumor necrosis factor receptor fusion protein) in severe sepsis and early septic shock: a randomized, double-blind, placebo-controlled, multicenter phase III trial with 1,342 patients
    E Abraham
    Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Denver 80262, USA
    Crit Care Med 29:503-10. 2001
    ..There was no evidence that lenercept was detrimental in the overall population. CONCLUSION: Lenercept had no significant effect on mortality in the study population...
  22. ncbi Assessment of the safety of recombinant tissue factor pathway inhibitor in patients with severe sepsis: a multicenter, randomized, placebo-controlled, single-blind, dose escalation study
    E Abraham
    Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Crit Care Med 29:2081-9. 2001
    ..To identify a safe and potentially effective recombinant tissue factor pathway inhibitor (rTFPI) dose for further clinical evaluation in patients with severe sepsis...
  23. ncbi NF-kappaB activation
    E Abraham
    Department of Medicine, University of Colorado Health Sciences Center, Denver, USA
    Crit Care Med 28:N100-4. 2000
    ....
  24. ncbi Pharmacokinetics of a clarithromycin suspension administered via nasogastric tube to seriously ill patients
    D N Fish
    Department of Pharmacy Practice, School of Pharmacy, University of Colorado Health Sciences Center, Denver, Colorado, USA
    Antimicrob Agents Chemother 43:1277-80. 1999
    ..Minimal intrapatient variability of pharmacokinetic parameters was observed in these seriously ill patients...
  25. ncbi Hemorrhage and resuscitation alter the expression of ICAM-1 and P-selectin in mice
    R Shenkar
    Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Denver 80262, USA
    J Inflamm 45:248-59. 1995
    ....
  26. ncbi Extracellular superoxide dismutase attenuates lung injury after hemorrhage
    R P Bowler
    National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA
    Am J Respir Crit Care Med 164:290-4. 2001
    ..05) and myeloperoxidase activity (5.1 +/- 0.87 units/g for EC-SOD transgenic versus 11.3 +/- 1.8 units/g for wild-type; p < 0.01). Thus, overexpression of pulmonary EC-SOD in the mouse lung attenuates lung injury after hemorrhage...
  27. ncbi Peripheral blood neutrophil activation patterns are associated with pulmonary inflammatory responses to lipopolysaccharide in humans
    Edward Abraham
    Division of Pulmonary Sciences and Critical Care Medicine and Division of Infectious Diseases, University of Colorado Health Sciences Center, Denver, 80262, USA
    J Immunol 176:7753-60. 2006
    ..049 for TNFRII. These results demonstrate that stable patterns in the response of peripheral blood neutrophils to LPS exist in the human population and correlate with inflammatory response following direct exposure to LPS in the lung...
  28. ncbi Contribution of high-mobility group box-1 to the development of ventilator-induced lung injury
    Eileen N Ogawa
    Department of Anesthesiology, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan
    Am J Respir Crit Care Med 174:400-7. 2006
    ..CONCLUSIONS: These observations suggest that HMGB1 could be one of the deteriorating factors in the development of VILI...
  29. ncbi Plasminogen activator inhibitor-1 potentiates LPS-induced neutrophil activation through a JNK-mediated pathway
    Sang Hyun Kwak
    Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Colorado, USA
    Thromb Haemost 95:829-35. 2006
    ..These results demonstrate that PAI-1 and uPA KD enhance LPS-induced neutrophil responses through their effects on JNK mediated pathways...
  30. ncbi Variant IRAK-1 haplotype is associated with increased nuclear factor-kappaB activation and worse outcomes in sepsis
    John Arcaroli
    Intensive Care Unit, Albert Einstein Hospital and Division of Applied Physiology, Heart Institute, University of Sao Paulo, Brazil
    Am J Respir Crit Care Med 173:1335-41. 2006
    ..There are two haplotypes for the IRAK-1 gene in Caucasians, with the variant haplotype consisting of five intron single-nucleotide polymorphisms (SNPs) and three exon SNPs...
  31. ncbi Severe sepsis and septic shock: review of the literature and emergency department management guidelines
    H Bryant Nguyen
    Loma Linda University, Loma Linda, CA, USA
    Ann Emerg Med 48:28-54. 2006
    ....
  32. ncbi Year in review in Critical Care, 2004: sepsis and multi-organ failure
    Naeem A Ali
    Division of Pulmonary, Critical Care and Sleep Medicine, The Ohio State University Medical Center, Columbus, Ohio, USA
    Crit Care 9:409-13. 2005
  33. ncbi LY315920NA/S-5920, a selective inhibitor of group IIA secretory phospholipase A2, fails to improve clinical outcome for patients with severe sepsis
    Bernhardt G Zeiher
    Eli Lilly and Company, Indianapolis, IN, USA
    Crit Care Med 33:1741-8. 2005
    ..This study did not confirm earlier promising subgroup results with LY315920NA/S-5920, which provides a reminder that subgroup effects should be viewed cautiously, especially when primary effects are not significant...
  34. ncbi The kringle domain of urokinase-type plasminogen activator potentiates LPS-induced neutrophil activation through interaction with {alpha}V{beta}3 integrins
    Sang-Hyun Kwak
    Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    J Leukoc Biol 78:937-45. 2005
    ..These results demonstrate that the KD of uPA, through interaction with alpha(V)beta(3) integrins, potentiates neutrophil activation...
  35. ncbi Involvement of SHIP in TLR2-induced neutrophil activation and acute lung injury
    Derek Strassheim
    Division of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    J Immunol 174:8064-71. 2005
    ..These results demonstrate that SHIP has a negative regulatory role in TLR2-induced neutrophil activation and in the development of related in vivo neutrophil-dependent inflammatory processes, such as acute lung injury...
  36. ncbi Pharmacokinetics and pharmacodynamics of imipenem during continuous renal replacement therapy in critically ill patients
    Douglas N Fish
    University of Colorado Health Sciences Center, Department of Clinical Pharmacy, School of Pharmacy, Campus Box C 238, 4200 East Ninth Avenue, Denver, CO 80262, USA
    Antimicrob Agents Chemother 49:2421-8. 2005
    ..Higher doses should only be used after consideration of potential central nervous system toxicities or other risks of therapy in these severely ill patients...
  37. ncbi Functional and genomic changes induced by alveolar transmigration in human neutrophils
    Christopher D Coldren
    Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Am J Physiol Lung Cell Mol Physiol 291:L1267-76. 2006
    ..These results suggest that neutrophils sequestered in the lung become fundamentally different from those resident in the circulation, and this difference is distinct from in vitro activation with endotoxin...
  38. ncbi Participation of superoxide in neutrophil activation and cytokine production
    Sanchayita Mitra
    Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado at Denver and Health Sciences Center, 4200 E. Ninth Avenue, Denver, CO 80262, USA
    Biochim Biophys Acta 1762:732-41. 2006
    ....
  39. ncbi Activation of AMPK attenuates neutrophil proinflammatory activity and decreases the severity of acute lung injury
    Xia Zhao
    Dept of Medicine, Univ of Alabama at Birmingham School of Medicine, BDB 420, 1530 3rd Ave S, Birmingham, AL 35294 0012, USA
    Am J Physiol Lung Cell Mol Physiol 295:L497-504. 2008
    ..These results suggest that AMPK activation reduces TLR4-induced neutrophil activation and diminishes the severity of neutrophil-driven proinflammatory processes, including acute lung injury...
  40. ncbi Mitochondrial respiratory complex I regulates neutrophil activation and severity of lung injury
    Jaroslaw W Zmijewski
    Department of Medicine, University of Alabama at Birmingham School of Medicine, 1530 Third Avenue S, Birmingham, AL 35294 0012, USA
    Am J Respir Crit Care Med 178:168-79. 2008
    ....
  41. ncbi Role of extracellular superoxide in neutrophil activation: interactions between xanthine oxidase and TLR4 induce proinflammatory cytokine production
    Emmanuel Lorne
    Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294 0012, USA
    Am J Physiol Cell Physiol 294:C985-93. 2008
    ....
  42. ncbi HMGB1 develops enhanced proinflammatory activity by binding to cytokines
    Yonggang Sha
    Department of Medicine, University of Alabama, 1530 3rd Avenue South, Birmingham, AL 35294, USA
    J Immunol 180:2531-7. 2008
    ..These results demonstrate that HMGB1 acquires proinflammatory activity through binding to proinflammatory mediators, such as IL-1beta...
  43. ncbi Involvement of vitronectin in lipopolysaccaride-induced acute lung injury
    Yuko Tsuruta
    Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Immunol 179:7079-86. 2007
    ..These findings provide a novel vitronectin-dependent mechanism contributing to the development of acute lung injury...
  44. ncbi Variant IL-1 receptor-associated kinase-1 mediates increased NF-kappa B activity
    Gang Liu
    Department of Medicine, University of Alabama, Birmingham, AL 35294, USA
    J Immunol 179:4125-34. 2007
    ....
  45. ncbi HMGB1 and LPS induce distinct patterns of gene expression and activation in neutrophils from patients with sepsis-induced acute lung injury
    Eliezer Silva
    Intensive Care Unit, Hospital Israelita Albert Einstein, Sao Paulo, SP, Brazil
    Intensive Care Med 33:1829-39. 2007
    ..In the present study we evaluated gene expression and activation of major intracellular signaling pathways in peripheral blood neutrophils obtained from patients with sepsis-induced acute lung injury after culture with HMGB1 or LPS...
  46. ncbi International integrated database for the evaluation of severe sepsis and drotrecogin alfa (activated) therapy: 28-day survival and safety
    Pierre Francois Laterre
    Department of Critical Care Medicine, Hôpital St Luc, Universite Catholique de Louvain, B 1200 Brussels, Belgium
    J Crit Care 22:142-52. 2007
    ..Initial analyses evaluated the 28-day survival in the placebo group and further assessed the treatment effect of drotrecogin alfa (activated) (DrotAA)...
  47. ncbi ADDRESS (ADministration of DRotrecogin alfa [activated] in Early stage Severe Sepsis) long-term follow-up: one-year safety and efficacy evaluation
    Pierre Francois Laterre
    Department of Critical Care Medicine, St Luc University Hospital, UCL, Brussels, Belgium
    Crit Care Med 35:1457-63. 2007
    ..To demonstrate that drotrecogin alfa (activated) has an acceptable safety profile 1 yr from randomization...
  48. ncbi Potential role of high-mobility group box 1 in cystic fibrosis airway disease
    Steven M Rowe
    Department University of Alabama at Birmingham, Birmingham, AL 35294 0006, USA
    Am J Respir Crit Care Med 178:822-31. 2008
    ..High-mobility group box 1 (HMGB1) is a potent inflammatory mediator elevated in sepsis and rheumatoid arthritis, although its role in cystic fibrosis (CF) lung disease is unknown...
  49. ncbi Exposure to hydrogen peroxide diminishes NF-kappaB activation, IkappaB-alpha degradation, and proteasome activity in neutrophils
    Jaroslaw W Zmijewski
    Dept of Medicine, School of Medicine, University of Alabama, BDB 420, 1530 3rd Ave S, Birmingham, AL 35294 0012, USA
    Am J Physiol Cell Physiol 293:C255-66. 2007
    ..These results demonstrate that the effects of H(2)O(2) on NF-kappaB and proteasomal activity are cell population specific...
  50. ncbi Involvement of the urokinase kringle domain in lipopolysaccharide-induced acute lung injury
    Xue Qing Wang
    Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado, and Health Services Center, Denver, CO 80262, USA
    J Immunol 177:5550-7. 2006
    ..Blockade of the uPA KD may prevent the development or ameliorate the severity of acute lung injury induced through TLR4-dependent mechanisms, such as would occur in the setting of Gram-negative pulmonary or systemic infection...
  51. ncbi When is a negative phase II trial truly negative?
    Gordon D Rubenfeld
    Am J Respir Crit Care Med 178:554-5. 2008
  52. ncbi Community-acquired pneumonia and sepsis
    Michelle A Beutz
    Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Campus Box C272, 4200 East Ninth Avenue, Denver, CO 80262, USA
    Clin Chest Med 26:19-28. 2005
    ..Particular consideration is given to the role of mechanical ventilation in amplifying organ dysfunction in sepsis and to treatments that have positive effects on sepsis mortality and respiratory dysfunction...
  53. ncbi A descriptive evaluation of transfusion practices in patients receiving mechanical ventilation
    Mitchell M Levy
    Brown University School of Medicine, Division of Pulmonary and Critical Care Medicine, Rhode Island Hospital, 593 Eddy St, Main 7, Providence, RI, 02903, USA
    Chest 127:928-35. 2005
    ..To characterize and compare transfusion practices in a broad sample of patients receiving mechanical ventilation (MV) and not receiving MV in the ICU...
  54. ncbi Modulation of bone marrow-derived neutrophil signaling by H2O2: disparate effects on kinases, NF-kappaB, and cytokine expression
    Derek Strassheim
    Division of Pulmonary Sciences and Critical Care Medicine, Univ of Colorado Health Sciences Center, Box C272, Denver, CO 80262, USA
    Am J Physiol Cell Physiol 286:C683-92. 2004
    ..Such inhibitory effects on neutrophil activation may limit tissue damage produced by oxidative stress...
  55. ncbi Recombinant platelet-activating factor acetylhydrolase to prevent acute respiratory distress syndrome and mortality in severe sepsis: Phase IIb, multicenter, randomized, placebo-controlled, clinical trial
    Daniel P Schuster
    Washington University School of Medicine, St. Louis, MO, USA
    Crit Care Med 31:1612-9. 2003
    ..11). CONCLUSION: The results from this study indicate that rPAF-AH was well tolerated and should be pursued as a potential new treatment to decrease mortality in patients with severe sepsis...
  56. ncbi Reducing mortality in sepsis: new directions
    Jean Louis Vincent
    Department of Intensive Care, Erasme Hospital Free University of Brussels, Brussels, Belgium
    Crit Care 6:S1-18. 2002
    ....
  57. ncbi Neutrophils and acute lung injury
    Edward Abraham
    Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Denver, CO, USA
    Crit Care Med 31:S195-9. 2003
    ..Nevertheless, modulation of the activation of p38, Akt, and nuclear factor-kappaB in neutrophils appears to be an appropriate therapeutic target in severely ill patients with ALI...
  58. ncbi 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference
    Mitchell M Levy
    Rhode Island Hospital, 593 Eddy Street, MICU Main 7, Providence RI 02903, USA
    Intensive Care Med 29:530-8. 2003
    ..Nevertheless, there has been an impetus from experts in the field to modify these definitions to reflect our current understanding of the pathophysiology of these syndromes...
  59. ncbi Efficacy and safety of LY315920Na/S-5920, a selective inhibitor of 14-kDa group IIA secretory phospholipase A2, in patients with suspected sepsis and organ failure
    Edward Abraham
    University of Colorado Health Sciences Center, Department of Medicine, Division of Pulmonary Sciences and Critical Care Medicine, Denver 80262, USA
    Crit Care Med 31:718-28. 2003
    ..However, prospectively planned secondary analyses suggested that treatment with LY315920Na/S-5920 was associated with an improvement in survival in patients treated within 18 hrs of the first sepsis-induced organ failure...
  60. ncbi Early alterations in neutrophil activation are associated with outcome in acute lung injury
    Kuang-Yao Yang
    Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Mail Code C-272, 4200 East Ninth Avenue, Denver, CO 80262, USA
    Am J Respir Crit Care Med 167:1567-74. 2003
    ..These results suggest that early alterations in neutrophil activation patterns, particularly involving the ability to accumulate NF-kappaB to the nucleus after relevant stimuli, contribute to subsequent clinical course in ALI...
  61. ncbi Activation of gene expression in human neutrophils by high mobility group box 1 protein
    Jong Sung Park
    Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Am J Physiol Cell Physiol 284:C870-9. 2003
    ..These findings indicate that HMGB1 is an effective stimulus of neutrophil activation that can contribute to development of a proinflammatory phenotype in diseases characterized by excessively high levels of HMGB1...
  62. ncbi Evidence for extracellular superoxide dismutase as a mediator of hemorrhage-induced lung injury
    Russell P Bowler
    National Jewish Medical and Research Center, Denver 80206, USA
    Am J Physiol Lung Cell Mol Physiol 284:L680-7. 2003
    ..The increase in hemorrhage-induced neutrophil accumulation in the lungs of EC-SOD-deficient mice suggests that EC-SOD might play a role in mediating neutrophil recruitment to the lung...
  63. ncbi Involvement of phosphatidylinositol 3-kinase gamma in neutrophil apoptosis
    Kuang Yao Yang
    Chest Department, Taipei Veterans General Hospital, School of Medicine, National Yang Ming University, Taipei, Taiwan
    Cell Signal 15:225-33. 2003
    ..These results demonstrate that PI3-Kgamma directly participates in multiple in vivo pathways involved in regulating neutrophil apoptosis...
  64. ncbi Effects of catecholamines on kinase activation in lung neutrophils after hemorrhage or endotoxemia
    John Arcaroli
    Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Denver 80262, USA
    J Leukoc Biol 72:571-9. 2002
    ....
  65. ncbi IL-1 regulates in vivo C-X-C chemokine induction and neutrophil sequestration following endotoxemia
    Casey M Calkins
    Department of Surgery, University of Colorado Health Sciences Center and Veterans Affairs Hospital, 4200 East 9th Avenue, Box C-313, Denver, CO 80262, USA
    J Endotoxin Res 8:59-67. 2002
    ..These data suggest that IL-1 regulates tissue chemokine expression and neutrophil accumulation after LPS...
  66. ncbi Involvement of toll-like receptors 2 and 4 in cellular activation by high mobility group box 1 protein
    Jong Sung Park
    Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    J Biol Chem 279:7370-7. 2004
    ..Interactions of HMGB1 with TLR 2 and TLR 4 may provide an explanation for the ability of HMGB1 to generate inflammatory responses that are similar to those initiated by LPS...
  67. ncbi New approaches to the treatment of sepsis
    JAMES M O'BRIEN
    Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, Box C272, Denver, CO 80262, USA
    Clin Chest Med 24:521-48, v. 2003
    ..These results have provided optimism for reducing sepsis-related mortality...
  68. ncbi Critical care in AJRCCM 2004
    Derek Angus
    Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, 4200 East 9th Avenue, Box C272, Room 5503, Denver, CO 80262-0001, USA
    Am J Respir Crit Care Med 171:537-44. 2005
  69. ncbi Activated protein C inhibits local coagulation after intrapulmonary delivery of endotoxin in humans
    Tom van der Poll
    Department of Medicine, Academic Medical Center, Room G2 130, Meibergdreef 9, 1105AZ Amsterdam, Netherlands
    Am J Respir Crit Care Med 171:1125-8. 2005
    ..Activated protein C (APC) has systemic anticoagulant effects in patients with sepsis...
  70. ncbi HMGB1 contributes to the development of acute lung injury after hemorrhage
    Jae Yeol Kim
    Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Am J Physiol Lung Cell Mol Physiol 288:L958-65. 2005
    ..These results demonstrate that hemorrhage results in increased HMGB1 expression in the lungs, primarily through neutrophil sources, and that HMGB1 participates in hemorrhage-induced acute lung injury...
  71. ncbi Involvement of PKCalpha/beta in TLR4 and TLR2 dependent activation of NF-kappaB
    Karim Asehnoune
    Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Box C272, 4200 East 9th Ave, Denver, CO 80262, USA
    Cell Signal 17:385-94. 2005
    ..PKCalpha/beta can regulate NF-kappaB dependent transcription in neutrophils both by enhancing nuclear translocation of NF-kappaB and also by stimulating phosphorylation of the p65 subunit...
  72. ncbi Immunomodulation and sepsis: impact of the pathogen
    Pierre Moine
    Department of Anesthesiology, University Hospital, University of Colorado Health Sciences Center, Denver, Colorado 80626, USA
    Shock 22:297-308. 2004
    ..In this review, we discuss how pathogens interfere with innate and adaptive immune responses to escape eradication by the host...
  73. ncbi Recombinant human activated protein C reduces human endotoxin-induced pulmonary inflammation via inhibition of neutrophil chemotaxis
    Jerry A Nick
    Department of Medicine, National Jewish Medical and Research Center, D202, 1400 Jackson St, Denver, CO 80206, USA
    Blood 104:3878-85. 2004
    ..These rhAPC-induced effects on neutrophil function may represent a mechanism by which rhAPC improves survival in patients with sepsis...
  74. ncbi Diagnostic and prognostic implications of endotoxemia in critical illness: results of the MEDIC study
    John C Marshall
    University Health Network, University of Toronto, Toronto, Ontario, Canada
    J Infect Dis 190:527-34. 2004
    ..Stepwise logistic regression analysis showed that elevated Acute Physiology and Chronic Health Evaluation II score, gram-negative infection, and emergency admission status were independent predictors of EA...
  75. ncbi Human models of endotoxemia and recombinant human activated protein C
    Edward Abraham
    Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Denver, CO, USA
    Crit Care Med 32:S202-8. 2004
    ..Other putative mechanisms of recombinant human activated protein C, such as inhibition of apoptosis and leukocyte recruitment, remain to be studied...
  76. ncbi Phosphoinositide 3-kinase and Akt occupy central roles in inflammatory responses of Toll-like receptor 2-stimulated neutrophils
    Derek Strassheim
    Division of Pulmonary Science and Critical Care Medicine, Department of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    J Immunol 172:5727-33. 2004
    ..These results demonstrate that the PI3-K-Akt axis occupies a central role in TLR2-induced activation of neutrophils...
  77. ncbi Hemorrhage-induced acute lung injury is TLR-4 dependent
    Katherine A Barsness
    Department of Surgery, University of Colorado Health Sciences Center, 4200 E Ninth Ave, Box C320, Denver, CO 80262, USA
    Am J Physiol Regul Integr Comp Physiol 287:R592-9. 2004
    ..Therefore, we conclude that 1) hemorrhage-induced acute lung injury is TLR-4 dependent and 2) hemorrhage has a different and distinct TLR-4-dependent intracellular activation mechanism compared with endotoxemia...
  78. ncbi Involvement of reactive oxygen species in Toll-like receptor 4-dependent activation of NF-kappa B
    Karim Asehnoune
    Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    J Immunol 172:2522-9. 2004
    ....
  79. ncbi Recombinant human platelet-activating factor acetylhydrolase for treatment of severe sepsis: results of a phase III, multicenter, randomized, double-blind, placebo-controlled, clinical trial
    Steven Opal
    Division of Infectious Diseases, Brown Medical School, Providence, RI, USA
    Crit Care Med 32:332-41. 2004
    ..CONCLUSIONS: rPAF-AH was well tolerated and not antigenic, but did not decrease 28-day all-cause mortality in patients with severe sepsis...
  80. ncbi Lipopolysaccharide-induced neutrophil gene expression under in vivo or in vitro conditions
    John Arcaroli
    Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Science Center, Denver, CO 80262, USA
    Chest 121:76S. 2002