S H Abman

Summary

Affiliation: University of Colorado Health Sciences Center
Country: USA

Publications

  1. doi request reprint Bronchopulmonary dysplasia: a genetic disease
    Steven H Abman
    Children s Hospital, Pulmonary Medicine, B395, 13123 E Sixteenth Ave, Aurora, CO 80045, USA
    Pediatrics 122:658-9. 2008
  2. ncbi request reprint Pulmonary hypertension in older children: new approaches and therapies
    Steven H Abman
    Pulmonary Medicine, Pediatric Heart Lung Center, University of Colorado School of Medicine, and The Children s Hospital, 1056 E Nineteenth Avenue, Denver, CO 80218 1088, USA
    Paediatr Respir Rev 7:S177-9. 2006
  3. ncbi request reprint Recent advances in the pathogenesis and treatment of persistent pulmonary hypertension of the newborn
    Steven H Abman
    Department of Pediatrics, University of Colorado School of Medicine and The Children s Hospital, Denver, CO 80218 1088, USA
    Neonatology 91:283-90. 2007
  4. doi request reprint Role of endothelin receptor antagonists in the treatment of pulmonary arterial hypertension
    Steven H Abman
    Pediatric Heart Lung Center, University of Colorado School of Medicine and The Children s Hospital, Aurora, Colorado 80045, USA
    Annu Rev Med 60:13-23. 2009
  5. doi request reprint Impaired vascular endothelial growth factor signaling in the pathogenesis of neonatal pulmonary vascular disease
    Steven H Abman
    Pediatric Heart Lung Center, The Children s Hospital, B395, 13123 E 16th Avenue, Aurora, CO, 80045, USA
    Adv Exp Med Biol 661:323-35. 2010
  6. ncbi request reprint Neonatal pulmonary hypertension: a physiologic approach to treatment
    Steven H Abman
    Department of Pulmonary Medicine, Children s Hospital, 1056 E Nineteenth Ave, Denver, CO 80218 1088, USA
    Pediatr Pulmonol Suppl 26:127-8. 2004
  7. pmc Role of inducible nitric oxide synthase in regulation of pulmonary vascular tone in the late gestation ovine fetus
    R L Rairigh
    Pediatric Heart Lung Center, Department of Pediatrics, University of Colorado School of Medicine, Denver, Colorado 80218, USA
    J Clin Invest 101:15-21. 1998
  8. pmc Prolonged endothelin A receptor blockade attenuates chronic pulmonary hypertension in the ovine fetus
    D D Ivy
    Section of Cardiology, University of Colorado School of Medicine, Denver 80218, USA
    J Clin Invest 99:1179-86. 1997
  9. ncbi request reprint Developmental changes in endothelin expression and activity in the ovine fetal lung
    D D Ivy
    Pediatric Heart Lung Center, University of Colorado School of Medicine and The Children s Hospital, Denver, Colorado 80218, USA
    Am J Physiol Lung Cell Mol Physiol 278:L785-93. 2000
  10. ncbi request reprint Abnormal lung growth and the development of pulmonary hypertension in the Fawn-Hooded rat
    T D Le Cras
    Pediatric Heart Lung Center, Department of Pediatrics, Denver, Colorado 80206, USA
    Am J Physiol 277:L709-18. 1999

Detail Information

Publications92

  1. doi request reprint Bronchopulmonary dysplasia: a genetic disease
    Steven H Abman
    Children s Hospital, Pulmonary Medicine, B395, 13123 E Sixteenth Ave, Aurora, CO 80045, USA
    Pediatrics 122:658-9. 2008
  2. ncbi request reprint Pulmonary hypertension in older children: new approaches and therapies
    Steven H Abman
    Pulmonary Medicine, Pediatric Heart Lung Center, University of Colorado School of Medicine, and The Children s Hospital, 1056 E Nineteenth Avenue, Denver, CO 80218 1088, USA
    Paediatr Respir Rev 7:S177-9. 2006
  3. ncbi request reprint Recent advances in the pathogenesis and treatment of persistent pulmonary hypertension of the newborn
    Steven H Abman
    Department of Pediatrics, University of Colorado School of Medicine and The Children s Hospital, Denver, CO 80218 1088, USA
    Neonatology 91:283-90. 2007
    ..Overall, these laboratory studies suggest novel pharmacologic strategies for the treatment of refractory PPHN...
  4. doi request reprint Role of endothelin receptor antagonists in the treatment of pulmonary arterial hypertension
    Steven H Abman
    Pediatric Heart Lung Center, University of Colorado School of Medicine and The Children s Hospital, Aurora, Colorado 80045, USA
    Annu Rev Med 60:13-23. 2009
    ..This article briefly reviews preclinical data and the current status of ETRAs in the clinical management of PAH...
  5. doi request reprint Impaired vascular endothelial growth factor signaling in the pathogenesis of neonatal pulmonary vascular disease
    Steven H Abman
    Pediatric Heart Lung Center, The Children s Hospital, B395, 13123 E 16th Avenue, Aurora, CO, 80045, USA
    Adv Exp Med Biol 661:323-35. 2010
    ..This chapter will briefly discuss VEGF signaling during normal lung development and how disruption of VEGF signaling contribute to the pathogenesis of neonatal pulmonary vascular disease in these settings...
  6. ncbi request reprint Neonatal pulmonary hypertension: a physiologic approach to treatment
    Steven H Abman
    Department of Pulmonary Medicine, Children s Hospital, 1056 E Nineteenth Ave, Denver, CO 80218 1088, USA
    Pediatr Pulmonol Suppl 26:127-8. 2004
  7. pmc Role of inducible nitric oxide synthase in regulation of pulmonary vascular tone in the late gestation ovine fetus
    R L Rairigh
    Pediatric Heart Lung Center, Department of Pediatrics, University of Colorado School of Medicine, Denver, Colorado 80218, USA
    J Clin Invest 101:15-21. 1998
    ..We speculate that type II NOS may play a physiological role in the modulation of vascular tone in the developing fetal lung...
  8. pmc Prolonged endothelin A receptor blockade attenuates chronic pulmonary hypertension in the ovine fetus
    D D Ivy
    Section of Cardiology, University of Colorado School of Medicine, Denver 80218, USA
    J Clin Invest 99:1179-86. 1997
    ..We conclude that ET(A) receptor stimulation contributes to the pathogenesis and pathophysiology of experimental perinatal pulmonary hypertension...
  9. ncbi request reprint Developmental changes in endothelin expression and activity in the ovine fetal lung
    D D Ivy
    Pediatric Heart Lung Center, University of Colorado School of Medicine and The Children s Hospital, Denver, Colorado 80218, USA
    Am J Physiol Lung Cell Mol Physiol 278:L785-93. 2000
    ..We speculate that changes in ET receptor activity play important roles in regulation of pulmonary vascular tone in the ovine fetus...
  10. ncbi request reprint Abnormal lung growth and the development of pulmonary hypertension in the Fawn-Hooded rat
    T D Le Cras
    Pediatric Heart Lung Center, Department of Pediatrics, Denver, Colorado 80206, USA
    Am J Physiol 277:L709-18. 1999
    ..We speculate that altered oxygen sensing may cause impaired lung alveolar and vascular growth in the FHR...
  11. ncbi request reprint Effects of dipyridamole and inhaled nitric oxide in pediatric patients with pulmonary hypertension
    J W Ziegler
    Department of Pediatrics, University of Colorado School of Medicine, and Children s Hospital, Denver, Colorado, USA
    Am J Respir Crit Care Med 158:1388-95. 1998
    ....
  12. ncbi request reprint Intrauterine hypertension decreases lung VEGF expression and VEGF inhibition causes pulmonary hypertension in the ovine fetus
    Theresa R Grover
    Pediatric Heart Lung Center, Department of Pediatrics, University of Colorado School of Medicine, Denver, Colorado 80262, USA
    Am J Physiol Lung Cell Mol Physiol 284:L508-17. 2003
    ..We speculate that hypertension downregulates VEGF expression in the developing lung and that impaired VEGF signaling may contribute to the pathogenesis of PPHN...
  13. ncbi request reprint Endothelin B receptor deficiency potentiates ET-1 and hypoxic pulmonary vasoconstriction
    D Ivy
    Pediatric Heart Lung Center, University of Colorado School of Medicine and The Children s Hospital, Denver, Colorado 80218, USA
    Am J Physiol Lung Cell Mol Physiol 280:L1040-8. 2001
    ..We speculate that impaired ET(B) receptor activity can contribute to the pathogenesis of pulmonary hypertension...
  14. ncbi request reprint Inhaled carbon monoxide does not cause pulmonary vasodilation in the late-gestation fetal lamb
    T R Grover
    Pediatric Heart Lung Center and Department of Pediatrics, University of Colorado School of Medicine, Denver, Colorado 80262, USA
    Am J Physiol Lung Cell Mol Physiol 278:L779-84. 2000
    ....
  15. ncbi request reprint Prolonged endothelin B receptor blockade causes pulmonary hypertension in the ovine fetus
    D D Ivy
    Section of Cardiology, Pediatric Heart Lung Center, University of Colorado School of Medicine, and The Children s Hospital, Denver, Colorado 80218, USA
    Am J Physiol Lung Cell Mol Physiol 279:L758-65. 2000
    ..05). We conclude that prolonged selective ET(B) receptor blockade causes severe pulmonary hypertension and pulmonary vascular remodeling in the late-gestation ovine fetus...
  16. ncbi request reprint NO and prostaglandin interactions during hemodynamic stress in the fetal ovine pulmonary circulation
    J P Zenge
    Section of Neonatology, Pediatric Heart Lung Center, Department of Pediatrics, University of Colorado School of Medicine, Denver, Colorado 80262, USA
    Am J Physiol Lung Cell Mol Physiol 281:L1157-63. 2001
    ..001). We conclude that NO has a greater role than PGs in fetal pulmonary vasoregulation during acute hemodynamic stress and that PGI(2)-induced pulmonary vasodilation is largely mediated by NO release in the fetal lung...
  17. ncbi request reprint Vascular endothelial growth factor causes pulmonary vasodilation through activation of the phosphatidylinositol-3-kinase-nitric oxide pathway in the late-gestation ovine fetus
    Theresa R Grover
    Pediatric Heart Lung Center and Department of Pediatrics, University of Colorado School of Medicine, Denver, Colorado 80045, USA
    Pediatr Res 52:907-12. 2002
    ..005). These findings suggest that recombinant human VEGF causes fetal pulmonary vasodilation, and that this response is likely mediated by the release of NO through activation of phosphatidylinositol-3-kinase...
  18. pmc Effects of chronic hypoxia and altered hemodynamics on endothelial nitric oxide synthase expression in the adult rat lung
    T D Le Cras
    Pediatric Heart Lung Center, Department of Pediatrics, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    J Clin Invest 101:795-801. 1998
    ..These findings demonstrate that hemodynamic forces maintain eNOS content in the normoxic pulmonary circulation of the adult rat, and suggest that chronic hypoxia increases eNOS expression independently of changes in hemodynamics...
  19. ncbi request reprint Treatment of newborn rats with a VEGF receptor inhibitor causes pulmonary hypertension and abnormal lung structure
    Timothy D Le Cras
    Departments of Pediatrics, University of Colorado School of Medicine, Denver 80262, USA
    Am J Physiol Lung Cell Mol Physiol 283:L555-62. 2002
    ....
  20. pmc Cinaciguat, a soluble guanylate cyclase activator, causes potent and sustained pulmonary vasodilation in the ovine fetus
    Marc Chester
    Pediatric Heart Lung Center, Department of Pediatrics, University of Colorado School of Medicine, Aurora, 80045, USA
    Am J Physiol Lung Cell Mol Physiol 297:L318-25. 2009
    ....
  21. ncbi request reprint rhVEGF treatment preserves pulmonary vascular reactivity and structure in an experimental model of pulmonary hypertension in fetal sheep
    Theresa R Grover
    Pediatric Heart Lung Center and Department of Pediatrics, University of Colorado School of Medicine, Denver, CO 80045, USA
    Am J Physiol Lung Cell Mol Physiol 289:L315-21. 2005
    ..PPHN lambs. We conclude that VEGF165 preserves endothelium-dependent vasodilation, upregulates eNOS expression, and reduces the severity of pulmonary vascular remodeling in experimental PPHN...
  22. ncbi request reprint Developmental changes in endothelial nitric oxide synthase expression and activity in ovine fetal lung
    T A Parker
    Pediatric Heart Lung Center, Department of Pediatrics, University of Colorado School of Medicine, Denver, Colorado 80262, USA
    Am J Physiol Lung Cell Mol Physiol 278:L202-8. 2000
    ..We speculate that the rise in fetal lung eNOS may contribute to the marked lung growth and angiogenesis that occurs during the same period of time...
  23. ncbi request reprint Effects of chronic estrogen-receptor blockade on ovine perinatal pulmonary circulation
    T A Parker
    The Pediatric Heart Lung Center, Department of Pediatrics, University of Colorado School of Medicine, Denver, Colorado 80262, USA
    Am J Physiol Heart Circ Physiol 281:H1005-14. 2001
    ..We speculate that estrogen exposure during late gestation prepares the pulmonary circulation for postnatal adaptation...
  24. ncbi request reprint Neonatal dexamethasone treatment increases the risk for pulmonary hypertension in adult rats
    T D Le Cras
    Pediatric Heart Lung Center, Department of Pediatrics, University of Colorado School of Medicine, Denver, Colorado 80262, USA
    Am J Physiol Lung Cell Mol Physiol 278:L822-9. 2000
    ..05). We conclude that Dex treatment of neonatal rats caused sustained lung hypoplasia and increased pulmonary arterial pressures and augmented the severity of hypoxia-induced pulmonary hypertension in adult rats...
  25. doi request reprint Inhaled nitric oxide improves lung structure and pulmonary hypertension in a model of bleomycin-induced bronchopulmonary dysplasia in neonatal rats
    Pierre Tourneux
    Pediatric Heart Lung Center, Department of Pediatrics, University of Colorado School of Medicine, Aurora, USA
    Am J Physiol Lung Cell Mol Physiol 297:L1103-11. 2009
    ..We conclude that Bleo induces lung structural changes that mimic BPD in neonatal rats, and that early and prolonged iNO therapy prevents right ventricle hypertrophy and pulmonary vascular remodeling and partially improves lung structure...
  26. ncbi request reprint Effects of BAY 41-2272, a soluble guanylate cyclase activator, on pulmonary vascular reactivity in the ovine fetus
    Philippe Deruelle
    Pediatric Heart Lung Center, University of Colorado School of Medicine, Denver, CO 80218 1088, USA
    Am J Physiol Lung Cell Mol Physiol 288:L727-33. 2005
    ..We speculate that BAY 41-2272 may have therapeutic potential for pulmonary hypertension associated with failure to circulatory adaptation at birth, especially in the setting of impaired NO production...
  27. ncbi request reprint Inhaled nitric oxide attenuates pulmonary hypertension and improves lung growth in infant rats after neonatal treatment with a VEGF receptor inhibitor
    Jen Ruey Tang
    Pediatric Heart Lung Center, University of Colorado School of Medicine, Denver Colorado 80218, USA
    Am J Physiol Lung Cell Mol Physiol 287:L344-51. 2004
    ..We speculate that decreased NO production contributes to PH and decreases distal lung growth caused by impaired VEGF signaling...
  28. ncbi request reprint Role of inducible nitric oxide synthase in the pulmonary vascular response to birth-related stimuli in the ovine fetus
    R L Rairigh
    Pediatric Heart Lung Center and the Sections of Neonatology, Department of Pediatrics, University of Colorado School of Medicine, Denver, Colorado, USA
    Circ Res 88:721-6. 2001
    ..We additionally speculate that stimulation of the airway epithelium by rhythmic distension and increased FIO(2) may activate NOS II release at birth...
  29. ncbi request reprint Inhaled nitric oxide: current and future uses in neonates
    J P Kinsella
    Department of Pediatrics, and The Children s Hospital and the University of Colorado School of Medicine, Denver, CO, USA
    Semin Perinatol 24:387-95. 2000
    ..Non-ECMO centers should be able to provide iNO during transport to an ECMO center. Data suggest a possible role for iNO in preterms with hypoxemic respiratory failure and studies in this group should proceed...
  30. pmc Short- and long-term effects of inhaled iloprost therapy in children with pulmonary arterial hypertension
    D Dunbar Ivy
    The Pulmonary Hypertension Program and Pediatric Heart Lung Center, Department of Pediatrics, The University of Colorado School of Medicine and The Children s Hospital, Denver, Colorado 80045, USA
    J Am Coll Cardiol 51:161-9. 2008
    ..This study investigated the short- and long-term outcome of children with pulmonary arterial hypertension (PAH) treated with inhaled iloprost...
  31. ncbi request reprint BAY 41-2272, a direct activator of soluble guanylate cyclase, reduces right ventricular hypertrophy and prevents pulmonary vascular remodeling during chronic hypoxia in neonatal rats
    Philippe Deruelle
    Department of Pediatrics, Pediatric Heart Lung Center, University of Colorado School of Medicine, Denver, Colo, USA
    Biol Neonate 90:135-44. 2006
    ..We speculate that BAY 41-2272 may provide a new therapy for chronic PH...
  32. ncbi request reprint Pulmonary vascular effects of nitric oxide-cGMP augmentation in a model of chronic pulmonary hypertension in fetal and neonatal sheep
    Philippe Deruelle
    Pediatric Heart Lung Center, University of Colorado School of Medicine, Denver, Colorado, USA
    Am J Physiol Lung Cell Mol Physiol 289:L798-806. 2005
    ..We speculate that BAY 41-2272 may provide a novel treatment for severe PPHN, especially in newborns with partial response to iNO therapy...
  33. ncbi request reprint Inhibition of 20-HETE abolishes the myogenic response during NOS antagonism in the ovine fetal pulmonary circulation
    Thomas A Parker
    Pediatric Heart Lung Center, University of Colorado School of Medicine, Denver, Colorado 80045, USA
    Am J Physiol Lung Cell Mol Physiol 289:L261-7. 2005
    ....
  34. ncbi request reprint Pulmonary hypertension impairs alveolarization and reduces lung growth in the ovine fetus
    Theresa R Grover
    University of Colorado Health Sciences Center, Department of Pediatrics, PO Box 6508, Box F441, Aurora, CO 80045, USA
    Am J Physiol Lung Cell Mol Physiol 288:L648-54. 2005
    ....
  35. ncbi request reprint Hypoxia-inducible factors HIF-1alpha and HIF-2alpha are decreased in an experimental model of severe respiratory distress syndrome in preterm lambs
    Theresa R Grover
    University of Colorado School of Medicine, Pediatric Heart Lung Center, Department of Pediatrics, and National Jewish Medical and Research Center, Denver, Colorado, USA
    Am J Physiol Lung Cell Mol Physiol 292:L1345-51. 2007
    ..We speculate that early disruption of HIF and VEGF expression after preterm birth and RDS may contribute to long-term abnormalities in lung growth, leading to bronchopulmonary dysplasia...
  36. ncbi request reprint Rho kinase activation maintains high pulmonary vascular resistance in the ovine fetal lung
    Thomas A Parker
    Pediatric Heart Lung Center and Section of Neonatology, University of Colorado School of Medicine, Denver, USA
    Am J Physiol Lung Cell Mol Physiol 291:L976-82. 2006
    ..We speculate that Rho kinase plays an essential role in the normal fetal pulmonary circulation and that Rho kinase inhibitors may provide novel therapy for neonatal pulmonary hypertension...
  37. pmc Effects of long-term sildenafil treatment for pulmonary hypertension in infants with chronic lung disease
    Peter M Mourani
    Division of Critical Care, The Children s Hospital and University of Colorado Denver, School of Medicine, Aurora, CO, USA
    J Pediatr 154:379-84, 384.e1-2. 2009
    ..To determine the clinical course and outcomes of infants with chronic lung disease (CLD) and pulmonary hypertension (PH) who received prolonged sildenafil therapy...
  38. pmc Bone marrow-derived angiogenic cells restore lung alveolar and vascular structure after neonatal hyperoxia in infant mice
    Vivek Balasubramaniam
    Pediatric Heart Lung Center, Department of Pediatrics, University of Colorado Denver, 12800 E 19th Ave, Aurora, CO 80045, USA
    Am J Physiol Lung Cell Mol Physiol 298:L315-23. 2010
    ..We conclude that treatment with BMDAC after neonatal hyperoxia restores lung structure in this model of bronchopulmonary dysplasia...
  39. pmc Hyperoxia disrupts vascular endothelial growth factor-nitric oxide signaling and decreases growth of endothelial colony-forming cells from preterm infants
    Hideshi Fujinaga
    Pediatric Heart Lung Center Univ of Colorado Denver School of Medicine, Aurora, CO 80045, USA
    Am J Physiol Lung Cell Mol Physiol 297:L1160-9. 2009
    ..NO treatment also increases growth during hyperoxia. Exogenous VEGF or NO may protect preterm ECFCs from the adverse effects of hyperoxia and preservation of ECFC function may improve outcomes of preterm infants...
  40. ncbi request reprint Impaired VEGF and nitric oxide signaling after nitrofen exposure in rat fetal lung explants
    Vincent Muehlethaler
    Pediatric Heart Lung Center, Dept of Pediatrics, Univ of Colorado School of Medicine and The Children s Hospital, Mail Stop 8317, PO Box 6511, Aurora, CO 80045 USA
    Am J Physiol Lung Cell Mol Physiol 294:L110-20. 2008
    ..Disruption of lung architecture after VEGF receptor blockade was similar to nitrofen-induced changes but was more responsive to NO...
  41. pmc Fasudil inhibits the myogenic response in the fetal pulmonary circulation
    Pierre Tourneux
    The Pediatric Heart Lung Center, Sections of Neonatology and Pulmonary Medicine, Department of Pediatrics, University of Colorado School of Medicine, Aurora, Colorado, USA
    Am J Physiol Heart Circ Physiol 295:H1505-13. 2008
    ..001). We conclude that high ROCK activity opposes pulmonary vasodilation in utero and that the myogenic response maintains high PVR in the normal fetal lung through ROCK activation...
  42. doi request reprint Development and pathology of pulmonary hypertension
    Rubin M Tuder
    Division of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, University of Colorado, Denver, Colorado 80045, USA
    J Am Coll Cardiol 54:S3-9. 2009
    ..These important goals provide a blueprint for future research that may significantly impact our present and future understanding of pulmonary hypertension...
  43. pmc Monitoring cardiovascular function in infants with chronic lung disease of prematurity
    S H Abman
    Department of Pediatrics, B 395, The Children s Hospital, 1056 E, Denver, CO 80218, USA
    Arch Dis Child Fetal Neonatal Ed 87:F15-8. 2002
    ..The major treatment of pulmonary hypertension is supplemental oxygen, but drugs such as calcium channel blockers may also be required. The use of inhaled nitric oxide for its long term management is being investigated..
  44. ncbi request reprint Infant lung function after inhaled nitric oxide therapy for persistent pulmonary hypertension of the newborn
    E L Dobyns
    Department of Pediatrics, University of Colorado School of Medicine, USA
    Pediatr Pulmonol 28:24-30. 1999
    ..We conclude that inhaled nitric oxide therapy for the treatment of severe PPHN does not alter lung function as determined by lung volume and passive respiratory mechanics measurements during early infancy...
  45. doi request reprint Pulmonary hypertension in children: a historical overview
    Steven H Abman
    Department of Pediatrics, Pediatric Heart Lung Center, University of Colorado School of Medicine, and The Children s Hospital, Aurora, CO, USA
    Pediatr Crit Care Med 11:S4-9. 2010
    ....
  46. ncbi request reprint Noninvasive delivery of inhaled nitric oxide therapy for late pulmonary hypertension in newborn infants with congenital diaphragmatic hernia
    John P Kinsella
    Department of Pediatrics, Divisions of Neonatology, Cardiology, and Pulmonary and Critical Care Medicine, The Children s Hospital and the University of Colorado School of Medicine, Denver, Colorado 80218 1088, USA
    J Pediatr 142:397-401. 2003
    ....
  47. ncbi request reprint Increased lung preproET-1 and decreased ETB-receptor gene expression in fetal pulmonary hypertension
    D D Ivy
    Pediatric Heart Lung Center, University of Colorado School of Medicine, Denver, USA
    Am J Physiol 274:L535-41. 1998
    ..These findings suggest that increased ET-1 production and decreased ETB-receptor expression may contribute to increased vasoconstrictor tone in this experimental model of neonatal pulmonary hypertension...
  48. ncbi request reprint Chronic intrauterine pulmonary hypertension decreases calcium-sensitive potassium channel mRNA expression
    D N Cornfield
    Division of Pediatric Pulmonology and Critical Care Medicine, Department of Pediatrics, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    Am J Physiol Lung Cell Mol Physiol 279:L857-62. 2000
    ..We conclude that lung K(Ca) channel mRNA expression is decreased in an ovine model of PPHN. Decreased K(Ca) channel gene expression may contribute to the abnormal pulmonary vascular reactivity associated with PPHN...
  49. pmc The pulmonary circulation of homozygous or heterozygous eNOS-null mice is hyperresponsive to mild hypoxia
    K A Fagan
    Cardiovascular Pulmonary Research Laboratory, University of Colorado Health Sciences Center, Denver 80262, USA
    J Clin Invest 103:291-9. 1999
    ..We conclude that eNOS-derived NO is an important modulator of the pulmonary vascular response to chronic hypoxia and that more than 50% of eNOS expression is required to maintain normal pulmonary vascular tone...
  50. ncbi request reprint Recombinant human VEGF treatment transiently increases lung edema but enhances lung structure after neonatal hyperoxia
    Anette M Kunig
    Pediatric Heart Lung Center, University of Colorado School of Medicine and The Children s Hospital, Pediatrics, Mail Stop 8317, PO Box 6511, Aurora, 80045, USA
    Am J Physiol Lung Cell Mol Physiol 291:L1068-78. 2006
    ..We speculate that VEGF has diverse roles in hyperoxia-induced neonatal lung injury, contributing to lung edema during the acute stage of ALI but promoting repair of the lung during recovery...
  51. ncbi request reprint Early inhaled nitric oxide therapy in premature newborns with respiratory failure
    John P Kinsella
    Pediatric Heart Lung Center, University of Colorado School of Medicine, and Children s Hospital, Denver, USA
    N Engl J Med 355:354-64. 2006
    ..The safety and efficacy of early, low-dose, prolonged therapy with inhaled nitric oxide in premature newborns with respiratory failure are uncertain...
  52. ncbi request reprint Hyperoxia reduces bone marrow, circulating, and lung endothelial progenitor cells in the developing lung: implications for the pathogenesis of bronchopulmonary dysplasia
    Vivek Balasubramaniam
    Pediatric Heart Lung Center, Department of Pediatrics, University of Colorado School of Medicine, Denver, Colorado, USA
    Am J Physiol Lung Cell Mol Physiol 292:L1073-84. 2007
    ..This developmental difference may contribute to the increased susceptibility of the developing lung to hyperoxia and may contribute to impaired lung vascular and alveolar growth in BPD...
  53. pmc Endothelial colony-forming cells from preterm infants are increased and more susceptible to hyperoxia
    Christopher D Baker
    Pediatric Heart Lung Center, University of Colorado, Denver School of Medicine, Aurora, CO 80045, USA
    Am J Respir Crit Care Med 180:454-61. 2009
    ..Endothelial progenitor cells, such as self-renewing highly proliferative endothelial colony-forming cells (ECFCs), may participate in vascular repair. The effect of hyperoxia on ECFC growth is unknown...
  54. pmc Scope and impact of early and late preterm infants admitted to the PICU with respiratory illness
    Cameron F Gunville
    Section of Critical Care, University of Colorado Denver, School of Medicine, University of Colorado, Denver, CO, USA
    J Pediatr 157:209-214.e1. 2010
    ....
  55. pmc Intrauterine pulmonary hypertension impairs angiogenesis in vitro: role of vascular endothelial growth factor nitric oxide signaling
    Jason Gien
    Section of Neonatology, Pediatric Heart Lung Center, Department of Pediatrics, University of Colorado School of Medicine, Denver, Colorado, USA
    Am J Respir Crit Care Med 176:1146-53. 2007
    ..Mechanisms that impair angiogenesis in neonatal persistent pulmonary hypertension (PPHN) are poorly understood...
  56. ncbi request reprint Early inhaled nitric oxide treatment decreases apoptosis of endothelial cells in neonatal rat lungs after vascular endothelial growth factor inhibition
    Jen Ruey Tang
    Pediatric Heart Lung Center, Dept of Pediatrics, Univ of Colorado Health Sciences Center, Mail Stop 8317, 12800 E 19th Ave, PO Box 6511, Aurora, CO 80045, USA
    Am J Physiol Lung Cell Mol Physiol 293:L1271-80. 2007
    ..Early iNO treatment after VEGF inhibition reduces endothelial cell apoptosis in neonatal lungs. We speculate that enhancing endothelial cell survival after lung injury may preserve neonatal lung growth in bronchopulmonary dysplasia...
  57. pmc Clinical utility of echocardiography for the diagnosis and management of pulmonary vascular disease in young children with chronic lung disease
    Peter M Mourani
    Division of Critical Care, Children s Hospital and University of Colorado Denver School of Medicine, Denver, Colorado 80045, USA
    Pediatrics 121:317-25. 2008
    ..The goal was to determine the clinical utility of Doppler echocardiography in predicting the presence and severity of pulmonary hypertension in patients with chronic lung disease who subsequently underwent cardiac catheterization...
  58. pmc Chronic intrauterine pulmonary hypertension increases endothelial cell Rho kinase activity and impairs angiogenesis in vitro
    Jason Gien
    Department of Pediatrics, University of Colorado School of Medicine, Denver, CO, USA
    Am J Physiol Lung Cell Mol Physiol 295:L680-7. 2008
    ..We conclude that Rho kinase activity is increased in PPHN PAECs and impairs angiogenesis and downregulates eNOS protein and NO production in vitro...
  59. ncbi request reprint Medical therapy for pulmonary arterial hypertension: updated ACCP evidence-based clinical practice guidelines
    David B Badesch
    University of Colorado Health Sciences Center, Box C 272, 4200 E Ninth Ave, Denver, CO 80262, USA
    Chest 131:1917-28. 2007
    ..Due to the complexity of the diagnostic evaluation required and the treatment options available, referral of patients with PAH to a specialized center continues to be strongly recommended...
  60. ncbi request reprint Bronchopulmonary dysplasia
    John P Kinsella
    Department of Paediatrics, University of Colorado School of Medicine, Denver, USA
    Lancet 367:1421-31. 2006
    ..No safe and effective preventive therapy has been identified, but promising new treatments directed either at reducing lung injury or improving lung growth are under study...
  61. ncbi request reprint The pulmonary circulation in bronchopulmonary dysplasia
    Thomas A Parker
    Pediatric Heart Lung Center, University of Colorado School of Medicine, 80206, Denver, CO, USA
    Semin Neonatol 8:51-61. 2003
    ..Finally, we review how disordered pulmonary vascular growth may contribute to the pathogenesis of BPD and emphasize the importance of the reciprocal development of the airspace and the pulmonary circulation...
  62. ncbi request reprint Mild hypoxia impairs alveolarization in the endothelial nitric oxide synthase-deficient mouse
    Vivek Balasubramaniam
    Pediatric Heart Lung Center and Section of Pediatric Pulmonary Medicine, University of Colorado School of Medicine, Denver, Colorado 80218, USA
    Am J Physiol Lung Cell Mol Physiol 284:L964-71. 2003
    ..We speculate that NO preserves normal distal lung growth during hypoxic stress, perhaps through preservation of VEGFR-2 signaling...
  63. ncbi request reprint Role of platelet-derived growth factor in vascular remodeling during pulmonary hypertension in the ovine fetus
    Vivek Balasubramaniam
    Pediatric Heart Lung Center and Section of Pediatric Pulmonary Medicine, University of Colorado School of Medicine and The Children s Hospital, Denver, Colorado 80218, USA
    Am J Physiol Lung Cell Mol Physiol 284:L826-33. 2003
    ..We speculate that PDGF signaling contributes to structural vascular remodeling in perinatal PH and that selective PDGF inhibition may provide a novel therapeutic strategy for the treatment of chronic PH...
  64. ncbi request reprint Pulmonary vascular effects of inhaled nitric oxide and oxygen tension in bronchopulmonary dysplasia
    Peter M Mourani
    Division of Critical Care, The Pediatric Heart Lung Center, Department of Pediatrics, The Children s Hospital, Denver, Colorado 80218, USA
    Am J Respir Crit Care Med 170:1006-13. 2004
    ..We conclude that hyperoxia plus iNO causes marked pulmonary vasodilatation in older patients with BPD, suggesting that heightened pulmonary vascular tone contributes to pulmonary vascular disease in BPD...
  65. ncbi request reprint Lung vascular development: implications for the pathogenesis of bronchopulmonary dysplasia
    Kurt R Stenmark
    Developmental Lung Biology Laboratory, Department of Pediatrics, University of Colorado Health Sciences Center and The Children s Hospital, Denver, Colorado 80262, USA
    Annu Rev Physiol 67:623-61. 2005
    ..We speculate that understanding basic mechanisms that regulate and determine vascular growth will lead to new clinical strategies to improve the long-term outcome of premature babies with BPD...
  66. ncbi request reprint Inhaled nitric oxide in the premature newborn
    John P Kinsella
    Pediatric Heart Lung Center, Section of Neonatology, Denver, Colorado, USA
    J Pediatr 151:10-5. 2007
  67. ncbi request reprint Acute hemodynamic effects and home therapy using a novel pulsed nasal nitric oxide delivery system in children and young adults with pulmonary hypertension
    D Dunbar Ivy
    Section of Cardiology, Department of Pediatrics, Pediatric Heart Lung Center, University of Colorado School of Medicine and CChildren s Hospital, Denver, Colorado 80218 1088, USA
    Am J Cardiol 92:886-90. 2003
    ..In 2 patients, NO delivered in the home using this pulsing system was well tolerated for up to 2 years. The long-term safety, efficacy, and acceptability of NO delivered in the home remains to be studied...
  68. ncbi request reprint Recombinant human VEGF treatment enhances alveolarization after hyperoxic lung injury in neonatal rats
    Anette M Kunig
    Pediatric Heart Lung Center, University of Colorado Health Science Center, The Children s Hospital, Denver, CO, USA
    Am J Physiol Lung Cell Mol Physiol 289:L529-35. 2005
    ..rhVEGF treatment during recovery enhanced vessel growth and alveolarization. We speculate that lung structure abnormalities after hyperoxia may be partly due to impaired VEGF signaling...
  69. pmc Superoxide dismutase improves gas exchange and pulmonary hemodynamics in premature lambs
    John P Kinsella
    Department of Pediatrics, Pediatric Heart Lung Center, Section of Neonatology, University of Colorado School of Medicine, Denver, Colorado, USA
    Am J Respir Crit Care Med 172:745-9. 2005
    ....
  70. ncbi request reprint Pulmonary vasodilator therapy in congenital diaphragmatic hernia: acute, late, and chronic pulmonary hypertension
    John P Kinsella
    Department of Pediatrics, Division of Neonatology, The Children s Hospital and the University of Colorado School of Medicine, Denver, CO 80218 1088, USA
    Semin Perinatol 29:123-8. 2005
    ..We will also review the role of currently available pulmonary vasoactive drugs in the management of pulmonary hypertension in this population...
  71. ncbi request reprint Inhaled NO restores lung structure in eNOS-deficient mice recovering from neonatal hypoxia
    Vivek Balasubramaniam
    Pediatric Heart Lung Center, Dept of Pediatrics, UCHSC at Fitzsimmons, Pediatrics 8317, PO Box 6511, Aurora, CO 80045, USA
    Am J Physiol Lung Cell Mol Physiol 291:L119-27. 2006
    ..01). We conclude that deficiency of eNOS leads to a persistent failure of lung growth during recovery from neonatal hypoxia and that, after hypoxia, inhaled NO stimulates alveolar and vascular growth in eNOS-/- mice...
  72. ncbi request reprint Nitric oxide augments fetal pulmonary artery endothelial cell angiogenesis in vitro
    Vivek Balasubramaniam
    Pediatric Heart Lung Center, Department of Pediatrics, University of Colorado School of Medicine, Denver, CO, USA
    Am J Physiol Lung Cell Mol Physiol 290:L1111-6. 2006
    ....
  73. ncbi request reprint Vascular endothelial growth factor improves pulmonary vascular reactivity and structure in an experimental model of chronic pulmonary hypertension in fetal sheep
    Theresa R Grover
    Pediatric Heart Lung Center, University of Colorado Health Sciences Center, Perinatal Research Facility, Aurora, CO 80045, USA
    Chest 128:614S. 2005
  74. ncbi request reprint Endothelin B receptor blockade attenuates pulmonary vasodilation in oxygen-ventilated fetal lambs
    D Dunbar Ivy
    Pediatric Heart Lung Center, Section of Cardiology, University of Colorado School of Medicine and The Children s Hospital, Denver, CO 80218, USA
    Biol Neonate 86:155-9. 2004
    ..However, whether activation of ETB receptors contributes to the fall in pulmonary vascular tone at birth is unknown...
  75. ncbi request reprint Inhaled nitric oxide therapy in children
    John P Kinsella
    Department of Pediatrics, The Children s Hospital and the University of Colorado School of Medicine, Pediatric Heart Lung Center, Section of Neonatology, Box B 070, 1056 E 19th Ave, Denver, CO 80218 1088, USA
    Paediatr Respir Rev 6:190-8. 2005
    ..In this review, we summarise the current status of iNO therapy in the newborn and the potential role of iNO in other paediatric populations...
  76. ncbi request reprint Ontogeny of endothelin-converting enzyme gene expression and protein content in the ovine fetal lung
    Dunbar Ivy
    Pediatric Heart Lung Center, Section of Pediatric Cardiology, University of Colorado School of Medicine and Children s Hospital, Denver, CO 80218, USA
    Biol Neonate 81:139-44. 2002
    ..We speculate that alterations in ECE-1 contribute to the changes in ET-1 levels during the perinatal period and that the majority of ET-1 produced in the fetal lamb pulmonary vasculature is produced by the vascular endothelium...
  77. ncbi request reprint Use of inhaled nitric oxide during interhospital transport of newborns with hypoxemic respiratory failure
    John P Kinsella
    Division of Neonatology, Department of Pediatrics, Children s Hospital and University of Colorado School of Medicine Denver, CO 80218, USA
    Pediatrics 109:158-61. 2002
  78. ncbi request reprint ABCA3 deficiency presenting as persistent pulmonary hypertension of the newborn
    Anette M Kunig
    Pediatric Heart Lung Center, Department of Pediatrics, University of Colorado Health Sciences Center, Denver, CO, USA
    J Pediatr 151:322-4. 2007
    ..When PH is prolonged and does not respond to standard therapies, genetic causes of surfactant abnormalities should be considered in the differential diagnosis...
  79. ncbi request reprint Interactive effects of high-frequency oscillatory ventilation and inhaled nitric oxide in acute hypoxemic respiratory failure in pediatrics
    Emily L Dobyns
    Department of Pediatrics at the Children s Hospital University of Colorado School of Medicine, Denver, USA
    Crit Care Med 30:2425-9. 2002
    ....
  80. ncbi request reprint Cotyledon and binucleate cell nitric oxide synthase expression in an ovine model of fetal growth restriction
    H L Galan
    Department of Obstetrics and Gynecology, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    J Appl Physiol 90:2420-6. 2001
    ..We speculate that disruption of normal vascular development and BNC eNOS production and function leads to abnormal placental vascular tone and blood flow in this model of PI-IUGR...
  81. pmc Left ventricular diastolic dysfunction in bronchopulmonary dysplasia
    Peter M Mourani
    Division of Critical Care, The Pediatric Heart Lung Center, Department of Pediatrics, The Children s Hospital and University of Colorado Denver, School of Medicine, Aurora, Colorado, USA
    J Pediatr 152:291-3. 2008
    ..We speculate that close monitoring for left ventricular diastolic dysfunction may assist with clinical management and improve outcomes of infants with severe bronchopulmonary dysplasia...
  82. ncbi request reprint Reversal of pulmonary hypertension associated with plexiform lesions in congenital heart disease: a case report
    C L Epting
    Section of Pediatric Cardiology, The Pediatric Heart Lung Center, B100 The Children s Hospital, 1056 E, 19th Avenue, Denver, CO 80218, USA
    Pediatr Cardiol 23:182-5. 2002
    ....
  83. ncbi request reprint Effects of sildenafil on pulmonary hypertension and exercise tolerance in severe cystic fibrosis-related lung disease
    Gregory S Montgomery
    Division of Pediatric Pulmonology, Department of Pediatrics, Indiana University Medical Center, Indianapolis, Indiana, USA
    Pediatr Pulmonol 41:383-5. 2006
    ..We report on a patient with severe CF lung disease who experienced clinically significant improvements in exercise tolerance and pulmonary hypertension without changing lung function during sildenafil therapy...
  84. ncbi request reprint NO pathway in CF and non-CF children
    Jamie L Wooldridge
    Department of Pediatrics, University of Colorado Health Sciences Center, Denver, Colorado, USA
    Pediatr Pulmonol 37:338-50. 2004
    ..We conclude that lower airway NO, nitrate levels, and NOS II expression are not different in young children with CF and disease control patients, but that NOS II expression decreases in CF as airway inflammation increases...
  85. doi request reprint The dysmorphic pulmonary circulation in bronchopulmonary dysplasia: a growing story
    Steven H Abman
    Am J Respir Crit Care Med 178:114-5. 2008
  86. ncbi request reprint Prognosis of pulmonary arterial hypertension: ACCP evidence-based clinical practice guidelines
    Vallerie V McLaughlin
    University of Michigan, 1500 East Medical Center Dr, Women s Hospital Room L3119, Ann Arbor, MI 48109 0273, USA
    Chest 126:78S-92S. 2004
    ..Assessment of prognosis of such patients is important, as it influences both medical therapy and referral for transplantation. This chapter will provide evidence based recommendations to assess the prognosis of patients with PAH...
  87. ncbi request reprint Inhaled nitric oxide enhances distal lung growth after exposure to hyperoxia in neonatal rats
    Yuh Jyh Lin
    Department of Pediatrics, National Cheng Kung University, Tainan, Taiwan 704
    Pediatr Res 58:22-9. 2005
    ..We conclude that neonatal hyperoxia reduced lung VEGF expression, which persisted during recovery in room air, and that inhaled NO restored distal lung growth in infant rats after neonatal hyperoxia...
  88. ncbi request reprint Effects of long-term bosentan in children with pulmonary arterial hypertension
    Erika Berman Rosenzweig
    Division of Pediatric Cardiology, New York Presbyterian Hospital, New York, New York 10032, USA
    J Am Coll Cardiol 46:697-704. 2005
    ..This study investigated the long-term outcome of children with pulmonary arterial hypertension (PAH) treated with bosentan therapy, with or without concomitant prostanoid therapy...
  89. pmc Bronchopulmonary dysplasia: where have all the vessels gone? Roles of angiogenic growth factors in chronic lung disease
    Bernard Thebaud
    Department of Pediatrics, Division of Neonatology, Vascular Biology Group, University of Alberta, HMRC 407, Edmonton, AB, T6G 2S2, Canada
    Am J Respir Crit Care Med 175:978-85. 2007
    ....
  90. ncbi request reprint Chronic hypertension impairs flow-induced vasodilation and augments the myogenic response in fetal lung
    Laurent Storme
    Department of Neonatology, CHRU de Lille, France
    Am J Physiol Lung Cell Mol Physiol 282:L56-66. 2002
    ..We conclude that chronic PH impairs flow-induced vasodilation and increases the myogenic response in fetal lung. We speculate that decreased NO signaling and an augmented myogenic response contributes to abnormal vasoreactivity in PH...
  91. ncbi request reprint Pulmonary artery hypertension and sleep-disordered breathing: ACCP evidence-based clinical practice guidelines
    Charles W Atwood
    Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Pittsburgh Medical Center and the VA Pittsburgh Healthcare System, Pittsburgh, PA 15213, USA
    Chest 126:72S-77S. 2004
    ..The limited data available also suggest that SDB is uncommon in patients with IPAH. Treatment of SDB with continuous positive airway pressure may lower pulmonary artery pressures when the degree of PH is mild...
  92. ncbi request reprint Inhaled ethyl nitrite gas for persistent pulmonary hypertension in infants
    Steven H Abman
    Lancet 360:2076-7; author reply 2077. 2002