Research Topics
Species | J L AbelsonSummaryAffiliation: University of Michigan Country: USA Publications
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Publications
Effects of perceived control and cognitive coping on endocrine stress responses to pharmacological activationJames L Abelson
Department of Psychiatry, Trauma, Stress and Anxiety Research Group, Molecular and Behavioral Neuroscience Institute, University of Michigan, Ann Arbor, Michigan, USA
Biol Psychiatry 64:701-7. 2008..This study attempted to identify the core factors that modulate HPA axis activity in this model...- Respiratory irregularity and stress hormones in panic disorder: exploring potential linkagesJames L Abelson
Department of Psychiatry, Trauma, Stress and Anxiety Research Group, Drive, University of Michigan, Ann Arbor, Michigan, USA
Depress Anxiety 25:885-7. 2008..Follow-up work is needed to directly test this hypothesis... - HPA axis activity in patients with panic disorder: review and synthesis of four studiesJames L Abelson
Department of Psychiatry and Molecular and Behavioral Neuroscience Institute, Trauma, Stress and Anxiety Research Group, University of Michigan, Ann Arbor, Michigan 48109 0118, USA
Depress Anxiety 24:66-76. 2007..Most of the published panic/HPA literature is consistent with the hypothesis that HPA axis dysregulation in panic is due to hypersensitivity to contextual cues. This hypothesis requires experimental testing... - Cognitive modulation of endocrine responses to CRH stimulation in healthy subjectsJames L Abelson
University of Michigan Department of Psychiatry, Trauma, Stress and Anxiety Research Group, Molecular and Behavioral Neuroscience Institute, United States
Psychoneuroendocrinology 35:451-9. 2010.... - Cognitive modulation of the endocrine stress response to a pharmacological challenge in normal and panic disorder subjectsJames L Abelson
Department of Psychiatry and Mental Health Research Institute, Trauma, Stress and Anxiety Research Group, University of Michigan, Ann Arbor 48109 0118, USA
Arch Gen Psychiatry 62:668-75. 2005..Scientific study of how such factors moderate human HPA axis activity has been limited. Their relevance to HPA axis disturbances in psychiatric patients is largely unexplored... - Deep brain stimulation for refractory obsessive-compulsive disorderJames L Abelson
Department of Psychiatry, University of Michigan, Trauma, Stress and Anxiety Research Group, Ann Arbor, Michigan, USA
Biol Psychiatry 57:510-6. 2005..Nondestructive, electrical stimulation (deep brain stimulation; DBS) has proven an effective alternative to ablative surgery for neurological indications, suggesting potential utility in place of capsulotomy for OCD... - Acute HPA axis response to naltrexone differs in female vs. male smokersDaniel J O Roche
Committee on Neurobiology, University of Chicago, 947 E 58th St, Chicago, IL 60637, United States
Psychoneuroendocrinology 35:596-606. 2010..Additionally, exploratory analyses compared the combined effects of naltrexone and cigarette smoking on hormonal responsivity between the sexes... - Twenty-four hour growth hormone secretion in patients with panic disorderJames L Abelson
Department of Psychiatry, University of Michigan, Anxiety and Stress Disorders Program, 1500 E Medical Center Drive, Ann Arbor, MI 48109 0118, USA
Psychoneuroendocrinology 30:72-9. 2005..However, basal levels of GH release over a full circadian cycle have not been examined in panic. Reduced basal GH release would suggest an overall hypo-active GH system rather than a specific alpha-adrenergic abnormality... - HPA axis, respiration and the airways in stress--a review in search of intersectionsJames L Abelson
Stress and Anxiety Research Group, Department of Psychiatry Trauma, University of Michigan, Ann Arbor, MI 48109, USA
Biol Psychol 84:57-65. 2010..Given the importance of both systems to an organism's ability to survive and adapt in challenging and changing environments, further study of their interactions is needed... - Hypothalamic-pituitary adrenal response to cholecystokinin-B receptor agonism is resistant to cortisol feedback inhibitionJ L Abelson
Department of Psychiatry, Anxiety Disorders Program, Mental Health Research Institute, University of Michigan, Ann Arbor, MI 48109, USA
Psychoneuroendocrinology 28:169-80. 2003.... - Respiratory psychophysiology and anxiety: cognitive intervention in the doxapram model of panicJ L Abelson
Department of Psychiatry, University of Michigan, Ann Arbor, USA
Psychosom Med 58:302-13. 1996.... - Neuroendocrine responses to laboratory panic: cognitive intervention in the doxapram modelJ L Abelson
University of Michigan Department of Psychiatry, Anxiety Disorders Program, Ann Arbor 48109 0840, USA
Psychoneuroendocrinology 21:375-90. 1996.... - Dose response of adrenocorticotropin and cortisol to the CCK-B agonist pentagastrinJ L Abelson
University of Michigan, Department of Psychiatry, Ann Arbor, USA
Neuropsychopharmacology 21:485-94. 1999..Further work is needed to determine the mechanisms and the physiological significance of CCK-mediated modulation of the human neuroendocrine stress axis... - Effect of comorbid anxiety disorders on the hypothalamic-pituitary-adrenal axis response to a social stressor in major depressionElizabeth A Young
Department of Psychiatry and Mental Health Research Institute, University of Michigan, Ann Arbor, Michigan 48109-0720, USA
Biol Psychiatry 56:113-20. 2004..All patient groups showed similar levels of TSST-induced anxiety. CONCLUSIONS: Comorbid anxiety disorders might play a role in the increased activation of the HPA axis observed in patients with major depression... - Effects of propranolol on symptom and endocrine responses to pentagastrinSamir Khan
Trauma, Stress and Anxiety Research Center, Department of Psychiatry, University of Michigan, 1500 E. Medical Center Drive, Ann Arbor, MI 48109-0118, USA
Psychoneuroendocrinology 29:1163-71. 2004..They support the hypothesis that the HPA response to pentagastrin is not secondary to the psychological stress of its side effects... - Medial prefrontal cortex and right insula activity predict plasma ACTH response to trauma recallAnthony P King
Psychiatry, University of Michigan, Ann Arbor, MI, USA
Neuroimage 47:872-80. 2009..These results support the hypotheses that right insula is involved in psychological activation of the LHPA axis and that rostral mPFC may negatively modulate LHPA axis responses... - CRH-stimulated cortisol release and food intake in healthy, non-obese adultsSophie A George
Department of Psychiatry, University of Michigan, Trauma, Stress and Anxiety Research Group, 4250 Plymouth Rd Box 5765, Ann Arbor, MI 48109 2700, United States
Psychoneuroendocrinology 35:607-12. 2010..Cortisol responses to laboratory stressors predict consumption but it is unclear whether such responses mark a vulnerability to stress-related eating or whether cortisol directly stimulates eating in humans... - Effect of repeat exposure on neuroendocrine and symptom responses to pentagastrinSamir Khan
Trauma, Stress and Anxiety Research Group, Department of Psychiatry, University of Michigan, UH 9D/0118, 1500 E. Medical Center Drive, Ann Arbor, MI 4810-0118, USA
Psychiatry Res 126:189-95. 2004..Novelty, per se, is not likely the primary mediator of the HPA response. This model may be useful for further study of cognitive-emotional modulators of HPA axis activity... - Error-related hyperactivity of the anterior cingulate cortex in obsessive-compulsive disorderKate Dimond Fitzgerald
Department of Psychiatry, University of Michigan, Ann Arbor, Michigan, 48109-0118, USA
Biol Psychiatry 57:287-94. 2005..Activity in this region was positively correlated with symptom severity in the patients. CONCLUSIONS: Error-processing abnormalities within the rostral anterior cingulate occur in the absence of symptom expression in patients with OCD... - Impact of social anxiety disorder on employment among women receiving welfare benefitsRichard M Tolman
University of Michigan School of Social Work, 1080 S University Ave, Ann Arbor, MI 48104, USA
Psychiatr Serv 60:61-6. 2009..The hypothesis that social anxiety disorder would predict reduced work attainment was examined... - Obsessive-compulsive disorder among African Americans and blacks of Caribbean descent: results from the National Survey of American LifeJoseph A Himle
Department of Psychiatry, University of Michigan, Ann Arbor, Michigan 48109 5763, USA
Depress Anxiety 25:993-1005. 2008..This is the first comprehensive examination of OCD among African Americans and blacks of Caribbean descent... - Chronic medication does not affect hyperactive error responses in obsessive-compulsive disorderEmily R Stern
Department of Psychiatry, University of Michigan, Ann Arbor, Michigan 48106, USA
Psychophysiology 47:913-20. 2010..The absence in patients of a relationship between ERN amplitude and anxiety/depression, as was found in controls, suggests that elevated error signals in OCD may be disorder-specific... - Severity of anxiety and work-related outcomes of patients with anxiety disordersSteven R Erickson
College of Pharmacy, University of Michigan, Michigan 48109 1065, USA
Depress Anxiety 26:1165-71. 2009..Four validated instruments were used to also allow examination of their psychometric properties, with the goal of improving measurement of work-related quality of life in this population... - Naturalistic stress and cortisol response to awakening: adaptation to seafaringJonathan Liberzon
University of Michigan School of Natural Resources, Department of Psychiatry, Ann Arbor, MI 48103, USA
Psychoneuroendocrinology 33:1023-6. 2008.... - The impact of panic disorder on interoception and dyspnea reports in chronic obstructive pulmonary diseaseNicholas D Giardino
Mental Health Service, VA Ann Arbor Healthcare System, Ann Arbor, MI, USA
Biol Psychol 84:142-6. 2010..Emotional responses to dyspneic sensations may account for higher dyspnea ratings in patients with PD and COPD... - Paralimbic and medial prefrontal cortical involvement in neuroendocrine responses to traumatic stimuliIsrael Liberzon
Department of Psychiatry, University of Michigan Medical School, Ann Arbor, MI, USA
Am J Psychiatry 164:1250-8. 2007..The authors used [(15)O]H(2)O positron emission tomography (PET) on subjects with posttraumatic stress disorder (PTSD) to study these circuits... - Anxious and depressive disorders and their comorbidity: effect on central nervous system noradrenergic functionOliver G Cameron
Department of Psychiatry, University of Michigan Medical Center, Ann Arbor, Michigan, USA
Biol Psychiatry 56:875-83. 2004.... - Interaction of brain noradrenergic system and the hypothalamic-pituitary-adrenal (HPA) axis in manElizabeth A Young
Department of Psychiatry, University of Michigan, Ann Arbor, 48109 0720, USA
Psychoneuroendocrinology 30:807-14. 2005..This relationship is less well characterized in humans and little is known about the influence of psychiatric disorders, which disturb one of these systems, on this relationship... - The development of persistent pain and psychological morbidity after motor vehicle collision: integrating the potential role of stress response systems into a biopsychosocial modelSamuel A McLean
Department of Emergency Medicine, University of Michigan Medical Center, Ann Arbor, Michigan, USA
Psychosom Med 67:783-90. 2005.... - Videoconferencing-based cognitive-behavioral therapy for obsessive-compulsive disorderJoseph A Himle
The University of Michigan Department of Psychiatry, 2101 Commonwealth Ave, Ann Arbor, MI 48105, USA
Behav Res Ther 44:1821-9. 2006..This pilot study suggests that videoconferencing-based CBT is a promising method to bring appropriate treatment to thousands who live far distances from well-trained therapists... - Medial frontal cortex activity and loss-related responses to errorsStephan F Taylor
Department of Psychiatry, University of Michigan, Ann Arbor, Michigan 48109, USA
J Neurosci 26:4063-70. 2006..The findings support the hypothesis that the rostral extent of the MFC (rACC) processes loss-related responses to errors, and individual differences may account for some of the reported variation of error-related foci in the MFC... - Increased psychiatric morbidity after abdominal aortic surgery: risk factors for stress-related disordersIsrael Liberzon
Department of Psychiatry, University of Michigan, Ann Arbor, Michigan, USA
J Vasc Surg 43:929-34. 2006..These complications are also expected after abdominal aortic surgery, but their incidence and relevant risk factors in this population have not been documented... - Trait anxiety modulates anterior cingulate activation to threat interferenceHeide Klumpp
Department of Psychiatry, University of Michigan Ann Arbor, 4250 Plymouth Road, Ann Arbor, MI 48109, USA
Depress Anxiety 28:194-201. 2011..anterior cingulate cortex, "ACC") might play a role. In this study, we explored the hypothesis that trait anxiety would be associated with ACC activity in an attentional control task with varying levels of threat interference... - Hyperactive error responses and altered connectivity in ventromedial and frontoinsular cortices in obsessive-compulsive disorderEmily R Stern
Department of Psychiatry, University of Michigan, Ann Arbor, Michigan 48109, USA
Biol Psychiatry 69:583-91. 2011..While OCD has been associated with an increased neural response to errors, the influence of motivational factors on this effect remains poorly understood... - Persistent respiratory irregularity in patients with panic disorderJ L Abelson
Anxiety Disorders Program, Department of Psychiatry, University of Michigan, Ann Arbor, Michigan 48109 0840, USA
Biol Psychiatry 49:588-95. 2001..However, respiratory abnormalities persisted, including a striking irregularity in breathing patterns... - Defense mechanism changes in successfully treated patients with obsessive-compulsive disorderR C Albucher
Department of Psychiatry, University of Michigan Medical Center, Ann Arbor 48109 0840, USA
Am J Psychiatry 155:558-9. 1998..Changes in defense mechanisms after treatment of patients with obsessive-compulsive disorder (OCD) were measured by using an established rating scale... - The buffering effects of active coping on the relationship between SES and cortisol among African American young adultsKaren H Schmeelk-Cone
University of Michigan School of Public Health, USA
Behav Med 29:85-94. 2003..The authors suggest that coping style may play an adaptive role regarding salivary cortisol measures in young adults when they are students or unemployed. Active coping may help protect against stress among young African American adults... - Salivary cortisol response during exposure treatment in driving phobicsGeorg W Alpers
Stanford University School of Medicine, and VAPA Health Care System, Palo Alto, California, USA
Psychosom Med 65:679-87. 2003..We addressed this issue by measuring cortisol in situational phobics during exposure treatment...
Research Grants
- Cognitive Modulation of Human Neuroendocrine Stress AxisJames Abelson; Fiscal Year: 2005..Existing animal data will be used to identify factors within the cognitive intervention which likely account for its potency and dismantling studies will be done to examine the separable effects of these factors. ..
- Effects of comorbid anxiety disorders on the HPA axis profile of depressionJames L Abelson; Fiscal Year: 2010..We will also explore if timing of trauma changes the stress hormone response to a public speaking challenge. ..
- Psychological Modulation of the Human HPA Stress AxisJames L Abelson; Fiscal Year: 2010..Ultimately, these efforts will help us better understand the role of stress in disease and develop improved methods for modulating its negative effects. ..
- Psychological Modulation of the Human HPA Stress AxisJames Abelson; Fiscal Year: 2007..Ultimately, these efforts will help us better understand the role of stress in disease and develop improved methods for modulating its negative effects. ..