Amy N Abell

Summary

Affiliation: University of North Carolina
Country: USA

Publications

  1. pmc Trophoblast stem cell maintenance by fibroblast growth factor 4 requires MEKK4 activation of Jun N-terminal kinase
    Amy N Abell
    Department of Pharmacology and Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599 7365, USA
    Mol Cell Biol 29:2748-61. 2009
  2. pmc MAP3K4/CBP-regulated H2B acetylation controls epithelial-mesenchymal transition in trophoblast stem cells
    Amy N Abell
    Department of Pharmacology, University of North Carolina School of Medicine, Chapel Hill, NC 27599 7365, USA
    Cell Stem Cell 8:525-37. 2011
  3. ncbi MEKK4 stimulation of p38 and JNK activity is negatively regulated by GSK3beta
    Amy N Abell
    Department of Pharmacology and the Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599 7365, USA
    J Biol Chem 282:30476-84. 2007
  4. ncbi MEKK4 is an effector of the embryonic TRAF4 for JNK activation
    Amy N Abell
    Department of Pharmacology and Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599 7365, USA
    J Biol Chem 280:35793-6. 2005
  5. pmc Ablation of MEKK4 kinase activity causes neurulation and skeletal patterning defects in the mouse embryo
    Amy N Abell
    Department of Pharmacology, University of North Carolina, Chapel Hill, 27599 7365, USA
    Mol Cell Biol 25:8948-59. 2005
  6. pmc SWI/SNF chromatin-remodeling factor Smarcd3/Baf60c controls epithelial-mesenchymal transition by inducing Wnt5a signaling
    Nicole Vincent Jordan
    Department of Pharmacology and Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, NC, USA
    Mol Cell Biol 33:3011-25. 2013
  7. pmc Tracking the intermediate stages of epithelial-mesenchymal transition in epithelial stem cells and cancer
    Nicole Vincent Jordan
    Department of Pharmacology and Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, NC, USA
    Cell Cycle 10:2865-73. 2011
  8. ncbi Rac2D57N, a dominant inhibitory Rac2 mutant that inhibits p38 kinase signaling and prevents surface ruffling in bone-marrow-derived macrophages
    Amy N Abell
    Department of Pharmacology, University of Colorado Health Sciences Center, 4200 East Ninth Ave, Denver, CO 80262, USA
    J Cell Sci 117:243-55. 2004
  9. pmc Dynamic reprogramming of the kinome in response to targeted MEK inhibition in triple-negative breast cancer
    James S Duncan
    Department of Pharmacology, Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA
    Cell 149:307-21. 2012
  10. ncbi Wiring diagrams of MAPK regulation by MEKK1, 2, and 3
    Mark T Uhlik
    Department of Pharmacology, University of North Carolina School of Medicine, 1108 Mary Ellen Jones Building, CB 7365, Chapel Hill, NC 27599, USA
    Biochem Cell Biol 82:658-63. 2004

Collaborators

Detail Information

Publications14

  1. pmc Trophoblast stem cell maintenance by fibroblast growth factor 4 requires MEKK4 activation of Jun N-terminal kinase
    Amy N Abell
    Department of Pharmacology and Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599 7365, USA
    Mol Cell Biol 29:2748-61. 2009
    ..Our results define MEKK4 as a signaling hub for FGF4 activation of JNK that is required for maintenance of TS cells in an undifferentiated state...
  2. pmc MAP3K4/CBP-regulated H2B acetylation controls epithelial-mesenchymal transition in trophoblast stem cells
    Amy N Abell
    Department of Pharmacology, University of North Carolina School of Medicine, Chapel Hill, NC 27599 7365, USA
    Cell Stem Cell 8:525-37. 2011
    ..Taken together, our data define an epigenetic switch that maintains the epithelial phenotype in TS cells and reveals previously unrecognized genes potentially contributing to breast cancer...
  3. ncbi MEKK4 stimulation of p38 and JNK activity is negatively regulated by GSK3beta
    Amy N Abell
    Department of Pharmacology and the Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599 7365, USA
    J Biol Chem 282:30476-84. 2007
    ..Thus, control of MEKK4 dimerization is regulated both positively and negatively by its interaction with specific proteins...
  4. ncbi MEKK4 is an effector of the embryonic TRAF4 for JNK activation
    Amy N Abell
    Department of Pharmacology and Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599 7365, USA
    J Biol Chem 280:35793-6. 2005
    ..The findings identify MEKK4 as the MAPK kinase kinase for TRAF4 regulation of the JNK pathway...
  5. pmc Ablation of MEKK4 kinase activity causes neurulation and skeletal patterning defects in the mouse embryo
    Amy N Abell
    Department of Pharmacology, University of North Carolina, Chapel Hill, 27599 7365, USA
    Mol Cell Biol 25:8948-59. 2005
    ..Together, these data demonstrate MEKK4 regulation of p38 and that substrates downstream of p38 control cellular homeostasis. The findings are the first demonstration that MEKK4-regulated p38 activity is critical for neurulation...
  6. pmc SWI/SNF chromatin-remodeling factor Smarcd3/Baf60c controls epithelial-mesenchymal transition by inducing Wnt5a signaling
    Nicole Vincent Jordan
    Department of Pharmacology and Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, NC, USA
    Mol Cell Biol 33:3011-25. 2013
    ..Inhibition of Wnt5a by either RNAi knockdown or blocking antibody reversed Smarcd3/Baf60c-induced EMT. Thus, Smarcd3/Baf60c epigenetically regulates EMT by activating WNT signaling pathways...
  7. pmc Tracking the intermediate stages of epithelial-mesenchymal transition in epithelial stem cells and cancer
    Nicole Vincent Jordan
    Department of Pharmacology and Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, NC, USA
    Cell Cycle 10:2865-73. 2011
    ..This intersection between EMT and stemness in TS cells and claudin-low metastatic breast cancer demonstrates the usefulness of developmental EMT systems to understand EMT in cancer...
  8. ncbi Rac2D57N, a dominant inhibitory Rac2 mutant that inhibits p38 kinase signaling and prevents surface ruffling in bone-marrow-derived macrophages
    Amy N Abell
    Department of Pharmacology, University of Colorado Health Sciences Center, 4200 East Ninth Ave, Denver, CO 80262, USA
    J Cell Sci 117:243-55. 2004
    ..Enhanced binding of Rac2D57N to its upstream regulators would inhibit Rac-dependent effects on actin cytoskeletal dynamics and p38 kinase signaling...
  9. pmc Dynamic reprogramming of the kinome in response to targeted MEK inhibition in triple-negative breast cancer
    James S Duncan
    Department of Pharmacology, Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA
    Cell 149:307-21. 2012
    ..This approach defines mechanisms of drug resistance, allowing rational design of combination therapies for cancer...
  10. ncbi Wiring diagrams of MAPK regulation by MEKK1, 2, and 3
    Mark T Uhlik
    Department of Pharmacology, University of North Carolina School of Medicine, 1108 Mary Ellen Jones Building, CB 7365, Chapel Hill, NC 27599, USA
    Biochem Cell Biol 82:658-63. 2004
    ..We propose that signal transduction network wiring diagrams are valuable tools for hypothesis building and filtering physiologically relevant phenotypic responses from less connected protein relations in the regulation of MAPK pathways...
  11. ncbi Rac-MEKK3-MKK3 scaffolding for p38 MAPK activation during hyperosmotic shock
    Mark T Uhlik
    Department of Pharmacology and the Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine Chapel Hill, NC 27599 7365, USA
    Nat Cell Biol 5:1104-10. 2003
    ..The Rac-OSM-MEKK3-MKK3 complex is the mammalian counterpart of the CDC42-STE50-STE11-Pbs2 complex in Saccharomyces cerevisiae that is required for the regulation of p38 activity...
  12. pmc Rho kinase inhibition rescues the endothelial cell cerebral cavernous malformation phenotype
    Asya L Borikova
    Department of Pharmacology and Lineberger Comprehensive Cancer Center, School of Dentistry, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    J Biol Chem 285:11760-4. 2010
    ..The results define Rho kinase as a therapeutic target to rescue endothelial cells from loss of CCM protein function...
  13. pmc Efficiently identifying genome-wide changes with next-generation sequencing data
    Weichun Huang
    Biostatistics Branch, National Institute of Environmental Health Sciences, RTP, NC 27709, USA
    Nucleic Acids Res 39:e130. 2011
    ..In particular, we show that our novel and robust 'parsimony' normalization method is superior to the widely-used 'tagRatio' method. Our software EpiCenter is freely available to the public...
  14. pmc MEKK1 regulates calpain-dependent proteolysis of focal adhesion proteins for rear-end detachment of migrating fibroblasts
    Bruce D Cuevas
    Department of Pharmacology, Craniofacial Biology, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    EMBO J 22:3346-55. 2003
    ..Inhibition of ERK1/2 or calpain, but not of JNK, mimics MEKK1 deficiency. Therefore, MEKK1 regulates calpain-mediated substratum release of migrating fibroblasts...