Research Topics
Genomes and Genes
| Amy N AbellSummaryAffiliation: University of North Carolina Country: USA Publications
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Detail Information
Publications
MEKK4 stimulation of p38 and JNK activity is negatively regulated by GSK3betaAmy N Abell
Department of Pharmacology and the Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599 7365, USA
J Biol Chem 282:30476-84. 2007..Thus, control of MEKK4 dimerization is regulated both positively and negatively by its interaction with specific proteins...
MAP3K4/CBP-regulated H2B acetylation controls epithelial-mesenchymal transition in trophoblast stem cellsAmy N Abell
Department of Pharmacology, University of North Carolina School of Medicine, Chapel Hill, NC 27599 7365, USA
Cell Stem Cell 8:525-37. 2011..Taken together, our data define an epigenetic switch that maintains the epithelial phenotype in TS cells and reveals previously unrecognized genes potentially contributing to breast cancer...- Trophoblast stem cell maintenance by fibroblast growth factor 4 requires MEKK4 activation of Jun N-terminal kinaseAmy N Abell
Department of Pharmacology and Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599 7365, USA
Mol Cell Biol 29:2748-61. 2009..Our results define MEKK4 as a signaling hub for FGF4 activation of JNK that is required for maintenance of TS cells in an undifferentiated state... - MEKK4 is an effector of the embryonic TRAF4 for JNK activationAmy N Abell
Department of Pharmacology and Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599 7365, USA
J Biol Chem 280:35793-6. 2005..The findings identify MEKK4 as the MAPK kinase kinase for TRAF4 regulation of the JNK pathway... - Ablation of MEKK4 kinase activity causes neurulation and skeletal patterning defects in the mouse embryoAmy N Abell
Department of Pharmacology, University of North Carolina, Chapel Hill, 27599 7365, USA
Mol Cell Biol 25:8948-59. 2005..Together, these data demonstrate MEKK4 regulation of p38 and that substrates downstream of p38 control cellular homeostasis. The findings are the first demonstration that MEKK4-regulated p38 activity is critical for neurulation... - Tracking the intermediate stages of epithelial-mesenchymal transition in epithelial stem cells and cancerNicole Vincent Jordan
Department of Pharmacology and Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, NC, USA
Cell Cycle 10:2865-73. 2011..This intersection between EMT and stemness in TS cells and claudin-low metastatic breast cancer demonstrates the usefulness of developmental EMT systems to understand EMT in cancer... - Rac2D57N, a dominant inhibitory Rac2 mutant that inhibits p38 kinase signaling and prevents surface ruffling in bone-marrow-derived macrophagesAmy N Abell
Department of Pharmacology, University of Colorado Health Sciences Center, 4200 East Ninth Ave, Denver, CO 80262, USA
J Cell Sci 117:243-55. 2004..Enhanced binding of Rac2D57N to its upstream regulators would inhibit Rac-dependent effects on actin cytoskeletal dynamics and p38 kinase signaling... - Dynamic reprogramming of the kinome in response to targeted MEK inhibition in triple-negative breast cancerJames S Duncan
Department of Pharmacology, Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA
Cell 149:307-21. 2012..This approach defines mechanisms of drug resistance, allowing rational design of combination therapies for cancer... - Wiring diagrams of MAPK regulation by MEKK1, 2, and 3Mark T Uhlik
Department of Pharmacology, University of North Carolina School of Medicine, 1108 Mary Ellen Jones Building, CB# 7365, Chapel Hill, NC 27599, USA
Biochem Cell Biol 82:658-63. 2004..We propose that signal transduction network wiring diagrams are valuable tools for hypothesis building and filtering physiologically relevant phenotypic responses from less connected protein relations in the regulation of MAPK pathways... - Rac-MEKK3-MKK3 scaffolding for p38 MAPK activation during hyperosmotic shockMark T Uhlik
Department of Pharmacology and the Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine Chapel Hill, NC 27599 7365, USA
Nat Cell Biol 5:1104-10. 2003..The Rac-OSM-MEKK3-MKK3 complex is the mammalian counterpart of the CDC42-STE50-STE11-Pbs2 complex in Saccharomyces cerevisiae that is required for the regulation of p38 activity... - Rho kinase inhibition rescues the endothelial cell cerebral cavernous malformation phenotypeAsya L Borikova
Department of Pharmacology and Lineberger Comprehensive Cancer Center, School of Dentistry, University of North Carolina, Chapel Hill, North Carolina 27599, USA
J Biol Chem 285:11760-4. 2010..The results define Rho kinase as a therapeutic target to rescue endothelial cells from loss of CCM protein function... - Efficiently identifying genome-wide changes with next-generation sequencing dataWeichun Huang
Biostatistics Branch, National Institute of Environmental Health Sciences, RTP, NC 27709, USA
Nucleic Acids Res 39:e130. 2011..In particular, we show that our novel and robust 'parsimony' normalization method is superior to the widely-used 'tagRatio' method. Our software EpiCenter is freely available to the public... - MEKK1 regulates calpain-dependent proteolysis of focal adhesion proteins for rear-end detachment of migrating fibroblastsBruce D Cuevas
Department of Pharmacology, Craniofacial Biology, University of Colorado Health Sciences Center, Denver, CO 80262, USA
EMBO J 22:3346-55. 2003..Inhibition of ERK1/2 or calpain, but not of JNK, mimics MEKK1 deficiency. Therefore, MEKK1 regulates calpain-mediated substratum release of migrating fibroblasts...