Ted Abel

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. pmc Sleep deprivation impairs cAMP signalling in the hippocampus
    Christopher G Vecsey
    Neuroscience Graduate Group, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Nature 461:1122-5. 2009
  2. pmc Aging in mice reduces the ability to sustain sleep/wake states
    Mathieu E Wimmer
    Neuroscience Graduate Group, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 8:e81880. 2013
  3. doi request reprint Sleep, plasticity and memory from molecules to whole-brain networks
    Ted Abel
    Department of Biology, School of Arts and Sciences, University of Pennsylvania, Philadelphia, PA, USA Electronic address
    Curr Biol 23:R774-88. 2013
  4. pmc Enhancement of presynaptic glutamate release and persistent inflammatory pain by increasing neuronal cAMP in the anterior cingulate cortex
    Long Jun Wu
    Department of Physiology, Faculty of Medicine, University of Toronto Centre for Study of Pain, University of Toronto, 1 King s College Circle, Toronto, Ontario M5S 1A8, Canada
    Mol Pain 4:40. 2008
  5. ncbi request reprint Molecular mechanisms of memory acquisition, consolidation and retrieval
    T Abel
    Department of Biology, University of Pennsylvania, 3740 Hamilton Walk, Philadelphia, PA 19104, USA
    Curr Opin Neurobiol 11:180-7. 2001
  6. ncbi request reprint Genetic approaches to the study of synaptic plasticity and memory storage
    Michael P Kaplan
    Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6018, USA
    CNS Spectr 8:597-610. 2003
  7. pmc Epigenetic targets of HDAC inhibition in neurodegenerative and psychiatric disorders
    Ted Abel
    Department of Biology, University of Pennsylvania, 204G Lynch Laboratories, 433 South University Avenue, Philadelphia, PA 19104 6018, USA
    Curr Opin Pharmacol 8:57-64. 2008
  8. pmc Transgenic mice expressing an inhibitory truncated form of p300 exhibit long-term memory deficits
    Ana M M Oliveira
    Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Learn Mem 14:564-72. 2007
  9. pmc Constitutive activation of the G-protein subunit Galphas within forebrain neurons causes PKA-dependent alterations in fear conditioning and cortical Arc mRNA expression
    Michele P Kelly
    Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Learn Mem 15:75-83. 2008
  10. pmc A novel conditional genetic system reveals that increasing neuronal cAMP enhances memory and retrieval
    Carolina Isiegas
    Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Neurosci 28:6220-30. 2008

Research Grants

Detail Information

Publications72

  1. pmc Sleep deprivation impairs cAMP signalling in the hippocampus
    Christopher G Vecsey
    Neuroscience Graduate Group, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Nature 461:1122-5. 2009
    ..Thus, drugs that enhance cAMP signalling may provide a new therapeutic approach to counteract the cognitive effects of sleep deprivation...
  2. pmc Aging in mice reduces the ability to sustain sleep/wake states
    Mathieu E Wimmer
    Neuroscience Graduate Group, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 8:e81880. 2013
    ..These combined analyses provide a window into the mechanisms underlying the destabilization of long periods of sleep and wake and reduced vigilance that develop with aging. ..
  3. doi request reprint Sleep, plasticity and memory from molecules to whole-brain networks
    Ted Abel
    Department of Biology, School of Arts and Sciences, University of Pennsylvania, Philadelphia, PA, USA Electronic address
    Curr Biol 23:R774-88. 2013
    ....
  4. pmc Enhancement of presynaptic glutamate release and persistent inflammatory pain by increasing neuronal cAMP in the anterior cingulate cortex
    Long Jun Wu
    Department of Physiology, Faculty of Medicine, University of Toronto Centre for Study of Pain, University of Toronto, 1 King s College Circle, Toronto, Ontario M5S 1A8, Canada
    Mol Pain 4:40. 2008
    ..The present study provides the first evidence linking enhanced presynaptic glutamate release in the ACC to behavioral sensitization caused by peripheral inflammation...
  5. ncbi request reprint Molecular mechanisms of memory acquisition, consolidation and retrieval
    T Abel
    Department of Biology, University of Pennsylvania, 3740 Hamilton Walk, Philadelphia, PA 19104, USA
    Curr Opin Neurobiol 11:180-7. 2001
    ....
  6. ncbi request reprint Genetic approaches to the study of synaptic plasticity and memory storage
    Michael P Kaplan
    Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6018, USA
    CNS Spectr 8:597-610. 2003
    ....
  7. pmc Epigenetic targets of HDAC inhibition in neurodegenerative and psychiatric disorders
    Ted Abel
    Department of Biology, University of Pennsylvania, 204G Lynch Laboratories, 433 South University Avenue, Philadelphia, PA 19104 6018, USA
    Curr Opin Pharmacol 8:57-64. 2008
    ..These agents may prove useful in the clinic for the treatment of the cognitive impairments that are central elements of many neurodevelopmental, neurological, and psychiatric disorders...
  8. pmc Transgenic mice expressing an inhibitory truncated form of p300 exhibit long-term memory deficits
    Ana M M Oliveira
    Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Learn Mem 14:564-72. 2007
    ..Thus, our study demonstrates that p300 is required for certain forms of memory and that the HAT and carboxy-terminal domains play a critical role...
  9. pmc Constitutive activation of the G-protein subunit Galphas within forebrain neurons causes PKA-dependent alterations in fear conditioning and cortical Arc mRNA expression
    Michele P Kelly
    Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Learn Mem 15:75-83. 2008
    ..Our results imply that chronically stimulating targets upstream of cAMP may detrimentally affect cognition...
  10. pmc A novel conditional genetic system reveals that increasing neuronal cAMP enhances memory and retrieval
    Carolina Isiegas
    Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Neurosci 28:6220-30. 2008
    ....
  11. pmc Constitutive activation of Galphas within forebrain neurons causes deficits in sensorimotor gating because of PKA-dependent decreases in cAMP
    Michele P Kelly
    Department of Biology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Neuropsychopharmacology 32:577-88. 2007
    ..We conclude that expression of Galphas(*) within forebrain neurons causes PPI deficits because of a PKA-dependent decrease in cAMP and suggest that cAMP PDE inhibitors may exhibit antipsychotic-like therapeutic effects...
  12. pmc Histone deacetylase inhibitors enhance memory and synaptic plasticity via CREB:CBP-dependent transcriptional activation
    Christopher G Vecsey
    Neuroscience Graduate Group, University of Pennsylvania, 19104, USA
    J Neurosci 27:6128-40. 2007
    ..Our results suggest that HDAC inhibitors enhance memory processes by the activation of key genes regulated by the CREB:CBP transcriptional complex...
  13. pmc Astrocyte-derived adenosine and A1 receptor activity contribute to sleep loss-induced deficits in hippocampal synaptic plasticity and memory in mice
    Cedrick Florian
    Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Neurosci 31:6956-62. 2011
    ....
  14. pmc Exchange protein activated by cAMP enhances long-term memory formation independent of protein kinase A
    Nan Ma
    University of Pennsylvania, Department of Biology, Philadelphia, Pennsylvania 19104, USA
    Learn Mem 16:367-70. 2009
    ....
  15. pmc Genomic analysis of sleep deprivation reveals translational regulation in the hippocampus
    Christopher G Vecsey
    Department of Biology, Brandeis University, Waltham, Massachusetts, USA
    Physiol Genomics 44:981-91. 2012
    ..Because protein synthesis and mTOR activation are required for long-term memory formation, our study improves our understanding of the molecular mechanisms underlying the memory impairments induced by sleep deprivation...
  16. ncbi request reprint Effects of chronic olanzapine and haloperidol differ on the mouse N1 auditory evoked potential
    Christina R Maxwell
    Division of Neuropsychiatry, Department of Psychiatry, Stanley Center for Experimental Therapeutics in Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Neuropsychopharmacology 29:739-46. 2004
    ..This study suggests that olanzapine may help improve N100 impairments seen in schizophrenia, while haloperidol does not...
  17. pmc Chronic ketamine impairs fear conditioning and produces long-lasting reductions in auditory evoked potentials
    Laura C Amann
    SMRI Laboratory for Experimental Therapeutics in Psychiatry, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Neurobiol Dis 35:311-7. 2009
    ..Though no interactions were found involving test week, stimulus and treatment condition, these results suggest that repeated ketamine administration impairs fear memory and has lasting effects on encoding of sensory stimuli...
  18. pmc Involvement of hippocampal jun-N terminal kinase pathway in the enhancement of learning and memory by nicotine
    Justin W Kenney
    Department of Psychology, Temple University, Philadelphia, PA 19122, USA
    Neuropsychopharmacology 35:483-92. 2010
    ..These data suggest that nicotine and learning interact to alter hippocampal JNK1 gene expression and related signaling processes, thus resulting in strengthened contextual memories...
  19. pmc NR4A nuclear receptors support memory enhancement by histone deacetylase inhibitors
    Joshua D Hawk
    Neuroscience Graduate Group and Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Clin Invest 122:3593-602. 2012
    ..Blocking NR4A signaling interfered with the ability of HDAC inhibitors to enhance memory. These results demonstrate that the Nr4a gene family contributes to memory formation and is a promising target for improving cognitive function...
  20. pmc Fear conditioning increases NREM sleep
    Kevin Hellman
    Neuroscience Graduate Group, University of Pennsylvania, Philadelphia, PA 19104 6084, USA
    Behav Neurosci 121:310-23. 2007
    ....
  21. pmc Transgenic mice expressing a truncated form of CREB-binding protein (CBP) exhibit deficits in hippocampal synaptic plasticity and memory storage
    Marcelo A Wood
    Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Learn Mem 12:111-9. 2005
    ..Together, these results demonstrate that CBP is involved in specific forms of hippocampal synaptic plasticity and hippocampus-dependent long-term memory formation...
  22. pmc Neuregulin 1 transgenic mice display reduced mismatch negativity, contextual fear conditioning and social interactions
    Richard S Ehrlichman
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA
    Brain Res 1294:116-27. 2009
    ..Using mutant mice heterozygous for Nrg1 (Nrg1(+/-)) we studied the effects of Nrg1 signaling on behavioral and electrophysiological measures relevant to schizophrenia...
  23. pmc Chronic Galphas signaling in the striatum increases anxiety-related behaviors independent of developmental effects
    Christopher Favilla
    Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Neurosci 28:13952-6. 2008
    ....
  24. pmc Daily acclimation handling does not affect hippocampal long-term potentiation or cause chronic sleep deprivation in mice
    Christopher G Vecsey
    Department of Biology, School of Arts and Sciences, University of Pennsylvania, Philadelphia, PA 19104, USA
    Sleep 36:601-7. 2013
    ..Here, we examine whether acclimation handling, performed as in our sleep deprivation studies, alters sleep/wake behavior, stress, or forms of hippocampal synaptic plasticity that are impaired by sleep deprivation...
  25. pmc Differential transcriptional response to nonassociative and associative components of classical fear conditioning in the amygdala and hippocampus
    Michael B Keeley
    Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Learn Mem 13:135-42. 2006
    ....
  26. ncbi request reprint Ubiquitin C-terminal hydrolase L3 (Uchl3) is involved in working memory
    Marcelo A Wood
    Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Hippocampus 15:610-21. 2005
    ..Our results suggest a novel role for ubiquitin C-terminal hydrolase enzymes in mammals in spatial learning and working memory...
  27. ncbi request reprint Behavioral and neurochemical alterations in mice lacking the RNA-binding protein translin
    Joel M Stein
    Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Neurosci 26:2184-96. 2006
    ..Our results in mice indicate that mutations in translin may contribute to fragile X-like syndromes, mental retardation, attention deficit hyperactivity disorder, epilepsy, and autism spectrum disorders in humans...
  28. pmc Genetic disruption of protein kinase A anchoring reveals a role for compartmentalized kinase signaling in theta-burst long-term potentiation and spatial memory
    Ting Nie
    Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Neurosci 27:10278-88. 2007
    ..In addition, a pool of anchored PKA in hippocampal area CA3 is required for spatial memory. These findings reveal a novel and significant role for anchored PKA signaling in cellular mechanisms underlying memory storage...
  29. pmc Transgenic inhibition of neuronal protein kinase A activity facilitates fear extinction
    Carolina Isiegas
    Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Neurosci 26:12700-7. 2006
    ..Further, these experiments represent the first genetic evidence that protein kinases may be constraints for the extinction of fear...
  30. ncbi request reprint The effects of ketamine vary among inbred mouse strains and mimic schizophrenia for the P80, but not P20 or N40 auditory ERP components
    Patrick M Connolly
    Stanley Center for Experimental Therapeutics, Division of Neuropsychiatry, Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Neurochem Res 29:1179-88. 2004
    ..Future studies could use transcription profiling to clarify such interactions between genetic background, specific neuronal circuits, and transmitter systems...
  31. pmc Development of home cage social behaviors in BALB/cJ vs. C57BL/6J mice
    Andrew H Fairless
    Center for Neurobiology and Behavior, Department of Psychiatry, Perelman School of Medicine at University of Pennsylvania, Translational Research Laboratory, 125 South 31st Street, Room 2220, Philadelphia, PA 19104 3403, USA
    Behav Brain Res 237:338-47. 2013
    ....
  32. pmc The impact of sleep deprivation on neuronal and glial signaling pathways important for memory and synaptic plasticity
    Robbert Havekes
    Department of Biology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Cell Signal 24:1251-60. 2012
    ..Future research building on these studies promises to contribute to the development of novel strategies to ameliorate the effects of sleep loss on cognition...
  33. pmc Sociability and brain development in BALB/cJ and C57BL/6J mice
    Andrew H Fairless
    Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania School of Medicine, Translational Research Laboratory, 125 South 31st Street, Philadelphia, PA 19104 3403, USA
    Behav Brain Res 228:299-310. 2012
    ..The associations reported here will provide directions for future mechanistic studies of sociability development...
  34. ncbi request reprint Differential role for CBP and p300 CREB-binding domain in motor skill learning
    Ana M M Oliveira
    Department of Biology, University of Pennsylvania, Philadelphia, PA, USA
    Behav Neurosci 120:724-9. 2006
    ..These results suggest that the CREB-CBP interaction is more limiting or critical than the CREB-p300 interaction for motor skill learning. Thus, CBP and p300 are genetically distinct at the behavioral level...
  35. ncbi request reprint Targeting amyloid-beta peptide (Abeta) oligomers by passive immunization with a conformation-selective monoclonal antibody improves learning and memory in Abeta precursor protein (APP) transgenic mice
    Edward B Lee
    Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, 19104, USA
    J Biol Chem 281:4292-9. 2006
    ..These data implicated Abeta oligomers as a pathologic substrate for cognitive decline in Alzheimer disease...
  36. pmc Post-training reversible inactivation of the hippocampus enhances novel object recognition memory
    Ana M M Oliveira
    Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Learn Mem 17:155-60. 2010
    ....
  37. pmc Post-training intrahippocampal inhibition of class I histone deacetylases enhances long-term object-location memory
    Joshua D Hawk
    Neuroscience Graduate Group, Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Learn Mem 18:367-70. 2011
    ....
  38. pmc Compartmentalized PKA signaling events are required for synaptic tagging and capture during hippocampal late-phase long-term potentiation
    Ted Huang
    Department of Neuroscience, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Eur J Cell Biol 85:635-42. 2006
    ..Thus our data highlight the idea that PKA anchoring may allow for specific populations of synapses to change in synaptic strength in the face of plasticity-related transcription that is cell-wide...
  39. pmc Gravin orchestrates protein kinase A and β2-adrenergic receptor signaling critical for synaptic plasticity and memory
    Robbert Havekes
    Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6018, USA
    J Neurosci 32:18137-49. 2012
    ....
  40. pmc Gadd45b knockout mice exhibit selective deficits in hippocampus-dependent long-term memory
    Prescott T Leach
    Department of Psychology, Neuroscience Program, Temple University, Philadelphia, Pennsylvania 19122, USA
    Learn Mem 19:319-24. 2012
    ..Therefore, Gadd45b may be a novel therapeutic target for the cognitive deficits associated with many neurodevelopmental, neurological, and psychiatric disorders...
  41. ncbi request reprint Corticosterone modulates auditory gating in mouse
    Christina R Maxwell
    Division of Neuropsychiatry, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Neuropsychopharmacology 31:897-903. 2006
    ..These data highlight the need to consider serum glucocorticoid levels when assessing human disease states associated with aberrations of information processing such as schizophrenia and depression...
  42. pmc Behavioral impairments caused by injections of the protein synthesis inhibitor anisomycin after contextual retrieval reverse with time
    K Matthew Lattal
    Department of Biology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 101:4667-72. 2004
    ..These results suggest that anisomycin injections after retrieval do not retroactively affect the memory from conditioning...
  43. pmc Sensorimotor gating deficits in transgenic mice expressing a constitutively active form of Gs alpha
    Thomas J Gould
    Department of Psychology, Temple University, Weiss Hall, Philadelphia, PA, USA
    Neuropsychopharmacology 29:494-501. 2004
    ....
  44. pmc Longitudinal in-vivo diffusion tensor imaging for assessing brain developmental changes in BALB/cJ mice, a model of reduced sociability relevant to autism
    Manoj Kumar
    Department of Radiology, Perelman School of Medicine at the University of Pennsylvania, B6 Blockley Hall, 423 Guardian Drive, Philadelphia, PA 19104, USA
    Brain Res 1455:56-67. 2012
    ..These results indicate that DTI may be used as an in-vivo, non-invasive imaging method to assess developmental trajectories of brain connectivity in mouse models of neurodevelopmental and behavioral disorders...
  45. pmc Astrocytic modulation of sleep homeostasis and cognitive consequences of sleep loss
    Michael M Halassa
    Department of Neuroscience, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Neuron 61:213-9. 2009
    ....
  46. pmc The cholinergic system and neostriatal memory functions
    Robbert Havekes
    Department of Biology, University of Pennsylvania, 433 S University Avenue, Philadelphia, PA 19104, USA
    Behav Brain Res 221:412-23. 2011
    ..Together, these data indicate that the cholinergic system in the striatum is involved in a diverse set of cognitive functions through interactions with other neurotransmitter systems including the dopaminergic and GABAergic systems...
  47. pmc Aging impairs hippocampus-dependent long-term memory for object location in mice
    Mathieu E Wimmer
    Neuroscience Graduate Group, University of Pennsylvania, Philadelphia, PA 19104, USA
    Neurobiol Aging 33:2220-4. 2012
    ..Aged animals performed similarly to young adult mice on an object recognition task that does not rely on hippocampal function...
  48. doi request reprint Association between sociability and diffusion tensor imaging in BALB/cJ mice
    Sungheon Kim
    Department of Radiology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    NMR Biomed 25:104-12. 2012
    ..This study demonstrates the feasibility of using DTI to detect brain regions associated with sociability in a mouse model system...
  49. pmc Myristoylated alanine rich C kinase substrate (MARCKS) heterozygous mutant mice exhibit deficits in hippocampal mossy fiber-CA3 long-term potentiation
    Rifat J Hussain
    Department of Psychiatry, University of Pennsylvania School of Medicine, Clinical Research Building, Philadelphia, Pennsylvania, USA
    Hippocampus 16:495-503. 2006
    ..The implications of these findings for the role of the mossy fiber-CA3 pathway in hippocampus-dependent learning processes are discussed...
  50. pmc Sleep deprivation selectively impairs memory consolidation for contextual fear conditioning
    Laurel A Graves
    Neuroscience Graduate Group, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Learn Mem 10:168-76. 2003
    ....
  51. pmc The role of protein synthesis in memory consolidation: progress amid decades of debate
    Pepe J Hernandez
    Department of Biology, University of Pennsylvania, 433 S University Avenue, Philadelphia, PA 19104, USA
    Neurobiol Learn Mem 89:293-311. 2008
    ..We conclude by presenting avenues of research we believe will best provide answers to both long-standing and more recent questions facing field of learning and memory...
  52. pmc Regulation of hippocampus-dependent memory by cyclic AMP-dependent protein kinase
    Ted Abel
    University of Pennsylvania, Department of Biology, Biological Basis of Behavior Program, Philadelphia, PA 19104, USA
    Prog Brain Res 169:97-115. 2008
    ..Future directions and open questions regarding the role of PKA in memory storage are also described...
  53. ncbi request reprint Effects of post-session injections of anisomycin on the extinction of a spatial preference and on the acquisition of a spatial reversal preference
    K Matthew Lattal
    Department of Biology, University of Pennsylvania, 3740 Hamilton Walk, Philadelphia, PA 19104, USA
    Behav Brain Res 153:327-39. 2004
    ..These findings suggest that acquisition and extinction may involve different molecular processes, and they do not support the idea that brief extinction trials induce a protein synthesis-dependent reconsolidation phase of spatial memory...
  54. ncbi request reprint Adrenergic signaling plays a critical role in the maintenance of waking and in the regulation of REM sleep
    Ming Ouyang
    Dept of Pharmacology, University of Pennsylvania, 103 John Morgan Bldg, 3620 Hamilton Walk, Philadelphia, PA 19104 6084, USA
    J Neurophysiol 92:2071-82. 2004
    ..These results provide genetic evidence that adrenergic signaling acts to maintain waking and is important for the regulation of REM sleep and possibly sleep homeostasis...
  55. pmc Suppression of InsP3 receptor-mediated Ca2+ signaling alleviates mutant presenilin-linked familial Alzheimer's disease pathogenesis
    Dustin Shilling
    Department of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104
    J Neurosci 34:6910-23. 2014
    ..Targeting the InsP3 signaling pathway could be considered a potential therapeutic strategy for patients harboring mutations in PS linked to AD. ..
  56. ncbi request reprint Genetic evidence for a role of CREB in sustained cortical arousal
    Laurel A Graves
    Neuroscience Graduate Group, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Neurophysiol 90:1152-9. 2003
    ....
  57. pmc The role of histone acetylation in memory formation and cognitive impairments
    Lucia Peixoto
    Department of Biology, School of Arts and Sciences, University of Pennsylvania, Philadelphia, PA, USA
    Neuropsychopharmacology 38:62-76. 2013
    ....
  58. pmc Subregion-specific p300 conditional knock-out mice exhibit long-term memory impairments
    Ana M M Oliveira
    Department of Biology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Learn Mem 18:161-9. 2011
    ..We found that p300 is required for the formation of long-term recognition memory and long-term contextual fear memory in the CA1 area of the hippocampus and cortical areas...
  59. pmc The role of NR4A transcription factors in memory formation
    Josh D Hawk
    University of Pennsylvania, Neuroscience Graduate Group, Philadelphia, PA, United States
    Brain Res Bull 85:21-9. 2011
    ..In this article, we review insights gained in other physiological contexts regarding Nr4a function and regulation, and highlight how these lessons can be applied to the study of memory formation...
  60. ncbi request reprint Protein synthesis is required for the enhancement of long-term potentiation and long-term memory by spaced training
    Matthew T Scharf
    Department of Biology, University of Pennsylvania, Philadelphia, PA 19104 6018, USA
    J Neurophysiol 87:2770-7. 2002
    ....
  61. pmc Low sociability is associated with reduced size of the corpus callosum in the BALB/cJ inbred mouse strain
    Andrew H Fairless
    Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania School of Medicine, Translational Research Laboratory, 125 South 31st Street, Room 2220, Philadelphia, PA 19104 3403, USA
    Brain Res 1230:211-7. 2008
    ..Additional studies are warranted to elucidate the relationship between brain connectivity and sociability in this model system...
  62. ncbi request reprint Embryo culture does not affect the longevity of offspring in mice
    Joshua Sommovilla
    Department of Biology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Reproduction 130:599-601. 2005
    ..2004). Here we monitored the mice generated in our previous study and found no difference in their longevity...
  63. pmc Impaired rapid eye movement sleep in the Tg2576 APP murine model of Alzheimer's disease with injury to pedunculopontine cholinergic neurons
    Bin Zhang
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Maloney 3, HUP, 3600 Spruce St, Philadelphia, PA 19104 4283, USA
    Am J Pathol 167:1361-9. 2005
    ..The differential vulnerability of these cholinergic neurons to Abeta injury provides an invaluable tool with which to understand mechanisms of sleep/wake perturbations in Alzheimer's disease...
  64. pmc Sleep deprivation during a specific 3-hour time window post-training impairs hippocampal synaptic plasticity and memory
    Toni Moi Prince
    Neuroscience Graduate Group, University of Pennsylvania, Philadelphia, PA 19104, USA
    Neurobiol Learn Mem 109:122-30. 2014
    ..Together, our findings define a specific 3-h critical period, extending from 1 to 4h after training, during which sleep deprivation impairs hippocampal function...
  65. pmc Long-term effects of culture of preimplantation mouse embryos on behavior
    David J Ecker
    Department of Biology, University of Pennsylvania, 415 South University Avenue, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 101:1595-600. 2004
    ....
  66. pmc Mice deficient for testis-brain RNA-binding protein exhibit a coordinate loss of TRAX, reduced fertility, altered gene expression in the brain, and behavioral changes
    Vargheese Chennathukuzhi
    Center for Research on Reproduction and Women s Health, School of Medicine, Department of Biology, University of Pennsylvania, 1310 Biomedical Research Building II III, 421 Curie Boulevard, Philadelphia, PA 19104 6142, USA
    Mol Cell Biol 23:6419-34. 2003
    ..Behavioral abnormalities were also seen. Compared to littermates, the TB-RBP-null mice appeared docile and exhibited reduced Rota-Rod performance...
  67. pmc Genetic dissection of neural circuits and behavior in Mus musculus
    Robbert Havekes
    Department of Biology, University of Pennsylvania, Philadelphia, PA, USA
    Adv Genet 65:1-38. 2009
    ..In this chapter, we will give an overview of several state of the art genetic approaches to study gene function in the mouse brain in a spatially and temporally restricted fashion...
  68. ncbi request reprint Extinction, renewal, and spontaneous recovery of a spatial preference in the water maze
    K Matthew Lattal
    Department of Biology, University of Pennsylvania, 3740 Hamilton Walk, Philadelphia, PA 19104, USA
    Behav Neurosci 117:1017-28. 2003
    ..Implications of these findings for theories of spatial learning and hippocampal function are discussed...
  69. ncbi request reprint TetR hybrid transcription factors report cell signaling and are inhibited by doxycycline
    Michael B Keeley
    University of Pennsylvania, Philadelphia, PA 19104, USA
    Biotechniques 39:529-36. 2005
    ..This system may be useful in creating temporally restricted windows of response to cell signaling and may be of value in the advancement of methods used to study signal transduction...
  70. ncbi request reprint The mouse: genetics meets behaviour
    Maja Bucan
    Center for Neurobiology and Behavior, Clinical Research Building, Room 111A, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Nat Rev Genet 3:114-23. 2002
    ....
  71. ncbi request reprint Inhibition of auditory evoked potentials and prepulse inhibition of startle in DBA/2J and DBA/2Hsd inbred mouse substrains
    Patrick M Connolly
    Stanley Center for Experimental Therapeutics in Psychiatry, Division of Neuropsychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Brain Res 992:85-95. 2003
    ..Future studies will attempt to determine the cause of these differences in sensory and sensorimotor processing between these two closely related inbred mouse strains...
  72. pmc Quantification of brain maturation and growth patterns in C57BL/6J mice via computational neuroanatomy of diffusion tensor images
    Sajjad Baloch
    Department of Radiology, University of Pennsylvania, PA 19104, USA
    Cereb Cortex 19:675-87. 2009
    ..Fiber maturation reaches steady state in about 10 days for the cortex, to 30-40 days for the corpus callosum, the hippocampus, and the internal and external capsules...

Research Grants21

  1. TRAINING PROGRAM IN BEHAVIORAL/COGNITIVE NEUROSCIENCE
    EDWIN TED ABEL; Fiscal Year: 2007
    ..In view of the continued expansion of Behavioral and Cognitive Neuroscience faculty at Penn, and the number of highly qualified trainees, we are requesting support for eight trainees per year for the next five years. ..
  2. SLEEP MEMORY--A MOLECULAR AND GENETIC ANALYSIS
    EDWIN ABEL; Fiscal Year: 1999
    ..abstract_text> ..
  3. Molecular Mechanisms of Long-Term Memory Storage
    EDWIN TED ABEL; Fiscal Year: 2009
    ..With the combination of genetic, biochemical, molecular, and pharmacological studies outlined in this grant proposal, we hope to define the role of CBP and histone acetylation in memory storage and synaptic plasticity. ..
  4. Tools to conditionally regulate intracellular signaling pathways in vivo
    EDWIN TED ABEL; Fiscal Year: 2009
    ..Knowledge of these molecular mechanisms promises to lead to the development of novel therapeutic approaches to treat cognitive deficits. ..
  5. Molecular Mechanisms of Long-Term Memory Storage
    EDWIN TED G ABEL; Fiscal Year: 2010
    ..With the combination of genetic, biochemical, molecular, and pharmacological studies outlined in this grant proposal, we hope to define the role of CBP and histone acetylation in memory storage and synaptic plasticity. ..
  6. Epigenetic Mechanisms of Memory Storage
    EDWIN TED G ABEL; Fiscal Year: 2010
    ..Knowledge of the molecular mechanisms and targets of epigenetic modifications during memory storage promises to lead to the development of novel therapeutic approaches for schizophrenia, bipolar disorder, and depression. ..
  7. Molecular Mechanisms of Long-Term Memory Storage
    EDWIN ABEL; Fiscal Year: 2007
    ..With the combination of genetic, biochemical, molecular, and pharmacological studies outlined in this grant proposal, we hope to define the role of CBP and histone acetylation in memory storage and synaptic plasticity. ..
  8. Molecular Mechanisms of Long-Term Memory Storage
    EDWIN ABEL; Fiscal Year: 2006
    ..With the combination of genetic, biochemical, molecular, and pharmacological studies outlined in this grant proposal, we hope to define the role of CBP and histone acetylation in memory storage and synaptic plasticity. ..
  9. MOLECULAR BASIS OF LONG-TERM MEMORY STORAGE
    EDWIN TED ABEL; Fiscal Year: 2004
    ..abstract_text> ..
  10. MOLECULAR BASIS OF LONG-TERM MEMORY STORAGE
    EDWIN ABEL; Fiscal Year: 2000
    ..abstract_text> ..
  11. SLEEP MEMORY: A MOLECULAR AND GENETIC ANALYSIS
    EDWIN ABEL; Fiscal Year: 2000
    ..abstract_text> ..
  12. SLEEP MEMORY: A MOLECULAR AND GENETIC ANALYSIS
    EDWIN ABEL; Fiscal Year: 2001
    ..abstract_text> ..
  13. MOLECULAR BASIS OF LONG-TERM MEMORY STORAGE
    EDWIN ABEL; Fiscal Year: 2001
    ..abstract_text> ..
  14. SLEEP MEMORY: A MOLECULAR AND GENETIC ANALYSIS
    EDWIN ABEL; Fiscal Year: 2001
    ..abstract_text> ..
  15. SLEEP MEMORY: A MOLECULAR AND GENETIC ANALYSIS
    EDWIN ABEL; Fiscal Year: 2002
    ..abstract_text> ..
  16. MOLECULAR BASIS OF LONG-TERM MEMORY STORAGE
    EDWIN ABEL; Fiscal Year: 2002
    ..abstract_text> ..
  17. MOLECULAR BASIS OF LONG-TERM MEMORY STORAGE
    EDWIN ABEL; Fiscal Year: 2003
    ..abstract_text> ..
  18. Tools to conditionally regulate intracellular signaling pathways in vivo
    EDWIN TED G ABEL; Fiscal Year: 2010
    ..Knowledge of these molecular mechanisms promises to lead to the development of novel therapeutic approaches to treat cognitive deficits. ..