Research Topics
Genomes and Genes | Ted AbelSummaryAffiliation: University of Pennsylvania Country: USA Publications
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Publications
Enhancement of presynaptic glutamate release and persistent inflammatory pain by increasing neuronal cAMP in the anterior cingulate cortexLong Jun Wu
Department of Physiology, Faculty of Medicine, University of Toronto Centre for Study of Pain, University of Toronto, 1 King s College Circle, Toronto, Ontario M5S 1A8, Canada
Mol Pain 4:40. 2008..The present study provides the first evidence linking enhanced presynaptic glutamate release in the ACC to behavioral sensitization caused by peripheral inflammation...
Molecular mechanisms of memory acquisition, consolidation and retrievalT Abel
Department of Biology, University of Pennsylvania, 3740 Hamilton Walk, Philadelphia, PA 19104, USA
Curr Opin Neurobiol 11:180-7. 2001....- Epigenetic targets of HDAC inhibition in neurodegenerative and psychiatric disordersTed Abel
Department of Biology, University of Pennsylvania, 204G Lynch Laboratories, 433 South University Avenue, Philadelphia, PA 19104 6018, USA
Curr Opin Pharmacol 8:57-64. 2008..These agents may prove useful in the clinic for the treatment of the cognitive impairments that are central elements of many neurodevelopmental, neurological, and psychiatric disorders... - Genetic approaches to the study of synaptic plasticity and memory storageMichael P Kaplan
Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6018, USA
CNS Spectr 8:597-610. 2003.... - Transgenic mice expressing an inhibitory truncated form of p300 exhibit long-term memory deficitsAna M M Oliveira
Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Learn Mem 14:564-72. 2007..Thus, our study demonstrates that p300 is required for certain forms of memory and that the HAT and carboxy-terminal domains play a critical role... - Constitutive activation of the G-protein subunit Galphas within forebrain neurons causes PKA-dependent alterations in fear conditioning and cortical Arc mRNA expressionMichele P Kelly
Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Learn Mem 15:75-83. 2008..Our results imply that chronically stimulating targets upstream of cAMP may detrimentally affect cognition... - Constitutive activation of Galphas within forebrain neurons causes deficits in sensorimotor gating because of PKA-dependent decreases in cAMPMichele P Kelly
Department of Biology, University of Pennsylvania, Philadelphia, PA 19104, USA
Neuropsychopharmacology 32:577-88. 2007..We conclude that expression of Galphas(*) within forebrain neurons causes PPI deficits because of a PKA-dependent decrease in cAMP and suggest that cAMP PDE inhibitors may exhibit antipsychotic-like therapeutic effects... - A novel conditional genetic system reveals that increasing neuronal cAMP enhances memory and retrievalCarolina Isiegas
Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
J Neurosci 28:6220-30. 2008.... - Astrocyte-derived adenosine and A1 receptor activity contribute to sleep loss-induced deficits in hippocampal synaptic plasticity and memory in miceCedrick Florian
Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
J Neurosci 31:6956-62. 2011.... - Exchange protein activated by cAMP enhances long-term memory formation independent of protein kinase ANan Ma
University of Pennsylvania, Department of Biology, Philadelphia, Pennsylvania 19104, USA
Learn Mem 16:367-70. 2009.... - Genomic analysis of sleep deprivation reveals translational regulation in the hippocampusChristopher G Vecsey
Department of Biology, Brandeis University, Waltham, Massachusetts, USA
Physiol Genomics 44:981-91. 2012..Because protein synthesis and mTOR activation are required for long-term memory formation, our study improves our understanding of the molecular mechanisms underlying the memory impairments induced by sleep deprivation... - Histone deacetylase inhibitors enhance memory and synaptic plasticity via CREB:CBP-dependent transcriptional activationChristopher G Vecsey
Neuroscience Graduate Group, University of Pennsylvania, 19104, USA
J Neurosci 27:6128-40. 2007..Our results suggest that HDAC inhibitors enhance memory processes by the activation of key genes regulated by the CREB:CBP transcriptional complex... - Chronic ketamine impairs fear conditioning and produces long-lasting reductions in auditory evoked potentialsLaura C Amann
SMRI Laboratory for Experimental Therapeutics in Psychiatry, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
Neurobiol Dis 35:311-7. 2009..Though no interactions were found involving test week, stimulus and treatment condition, these results suggest that repeated ketamine administration impairs fear memory and has lasting effects on encoding of sensory stimuli... - Involvement of hippocampal jun-N terminal kinase pathway in the enhancement of learning and memory by nicotineJustin W Kenney
Department of Psychology, Temple University, Philadelphia, PA 19122, USA
Neuropsychopharmacology 35:483-92. 2010..These data suggest that nicotine and learning interact to alter hippocampal JNK1 gene expression and related signaling processes, thus resulting in strengthened contextual memories... - Effects of chronic olanzapine and haloperidol differ on the mouse N1 auditory evoked potentialChristina R Maxwell
Division of Neuropsychiatry, Department of Psychiatry, Stanley Center for Experimental Therapeutics in Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
Neuropsychopharmacology 29:739-46. 2004..This study suggests that olanzapine may help improve N100 impairments seen in schizophrenia, while haloperidol does not... - NR4A nuclear receptors support memory enhancement by histone deacetylase inhibitorsJoshua D Hawk
Neuroscience Graduate Group and Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
J Clin Invest 122:3593-602. 2012..Blocking NR4A signaling interfered with the ability of HDAC inhibitors to enhance memory. These results demonstrate that the Nr4a gene family contributes to memory formation and is a promising target for improving cognitive function... - Transgenic mice expressing a truncated form of CREB-binding protein (CBP) exhibit deficits in hippocampal synaptic plasticity and memory storageMarcelo A Wood
Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Learn Mem 12:111-9. 2005..Together, these results demonstrate that CBP is involved in specific forms of hippocampal synaptic plasticity and hippocampus-dependent long-term memory formation... - Neuregulin 1 transgenic mice display reduced mismatch negativity, contextual fear conditioning and social interactionsRichard S Ehrlichman
Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA
Brain Res 1294:116-27. 2009..Event-related potentials (ERPs) were recorded to assess auditory gating and novel stimulus detection... - Fear conditioning increases NREM sleepKevin Hellman
Neuroscience Graduate Group, University of Pennsylvania, Philadelphia, PA 19104 6084, USA
Behav Neurosci 121:310-23. 2007.... - Sleep deprivation impairs cAMP signalling in the hippocampusChristopher G Vecsey
Neuroscience Graduate Group, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Nature 461:1122-5. 2009..Thus, drugs that enhance cAMP signalling may provide a new therapeutic approach to counteract the cognitive effects of sleep deprivation... - Genetic disruption of protein kinase A anchoring reveals a role for compartmentalized kinase signaling in theta-burst long-term potentiation and spatial memoryTing Nie
Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
J Neurosci 27:10278-88. 2007..In addition, a pool of anchored PKA in hippocampal area CA3 is required for spatial memory. These findings reveal a novel and significant role for anchored PKA signaling in cellular mechanisms underlying memory storage... - Transgenic inhibition of neuronal protein kinase A activity facilitates fear extinctionCarolina Isiegas
Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
J Neurosci 26:12700-7. 2006..Further, these experiments represent the first genetic evidence that protein kinases may be constraints for the extinction of fear... - Differential transcriptional response to nonassociative and associative components of classical fear conditioning in the amygdala and hippocampusMichael B Keeley
Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Learn Mem 13:135-42. 2006.... - Behavioral and neurochemical alterations in mice lacking the RNA-binding protein translinJoel M Stein
Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
J Neurosci 26:2184-96. 2006..Our results in mice indicate that mutations in translin may contribute to fragile X-like syndromes, mental retardation, attention deficit hyperactivity disorder, epilepsy, and autism spectrum disorders in humans... - The effects of ketamine vary among inbred mouse strains and mimic schizophrenia for the P80, but not P20 or N40 auditory ERP componentsPatrick M Connolly
Stanley Center for Experimental Therapeutics, Division of Neuropsychiatry, Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Neurochem Res 29:1179-88. 2004..Future studies could use transcription profiling to clarify such interactions between genetic background, specific neuronal circuits, and transmitter systems... - Ubiquitin C-terminal hydrolase L3 (Uchl3) is involved in working memoryMarcelo A Wood
Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Hippocampus 15:610-21. 2005..Our results suggest a novel role for ubiquitin C-terminal hydrolase enzymes in mammals in spatial learning and working memory... - The impact of sleep deprivation on neuronal and glial signaling pathways important for memory and synaptic plasticityRobbert Havekes
Department of Biology, University of Pennsylvania, Philadelphia, PA 19104, USA
Cell Signal 24:1251-60. 2012..Future research building on these studies promises to contribute to the development of novel strategies to ameliorate the effects of sleep loss on cognition... - Sociability and brain development in BALB/cJ and C57BL/6J miceAndrew H Fairless
Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania School of Medicine, Translational Research Laboratory, 125 South 31st Street, Philadelphia, PA 19104 3403, USA
Behav Brain Res 228:299-310. 2012..The associations reported here will provide directions for future mechanistic studies of sociability development... - Targeting amyloid-beta peptide (Abeta) oligomers by passive immunization with a conformation-selective monoclonal antibody improves learning and memory in Abeta precursor protein (APP) transgenic miceEdward B Lee
Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, 19104, USA
J Biol Chem 281:4292-9. 2006..These data implicated Abeta oligomers as a pathologic substrate for cognitive decline in Alzheimer disease... - Differential role for CBP and p300 CREB-binding domain in motor skill learningAna M M Oliveira
Department of Biology, University of Pennsylvania, Philadelphia, PA, USA
Behav Neurosci 120:724-9. 2006..These results suggest that the CREB-CBP interaction is more limiting or critical than the CREB-p300 interaction for motor skill learning. Thus, CBP and p300 are genetically distinct at the behavioral level... - Post-training intrahippocampal inhibition of class I histone deacetylases enhances long-term object-location memoryJoshua D Hawk
Neuroscience Graduate Group, Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Learn Mem 18:367-70. 2011.... - Post-training reversible inactivation of the hippocampus enhances novel object recognition memoryAna M M Oliveira
Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Learn Mem 17:155-60. 2010.... - Chronic Galphas signaling in the striatum increases anxiety-related behaviors independent of developmental effectsChristopher Favilla
Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
J Neurosci 28:13952-6. 2008.... - Gravin orchestrates protein kinase A and β2-adrenergic receptor signaling critical for synaptic plasticity and memoryRobbert Havekes
Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6018, USA
J Neurosci 32:18137-49. 2012.... - Gadd45b knockout mice exhibit selective deficits in hippocampus-dependent long-term memoryPrescott T Leach
Department of Psychology, Neuroscience Program, Temple University, Philadelphia, Pennsylvania 19122, USA
Learn Mem 19:319-24. 2012..Therefore, Gadd45b may be a novel therapeutic target for the cognitive deficits associated with many neurodevelopmental, neurological, and psychiatric disorders... - Behavioral impairments caused by injections of the protein synthesis inhibitor anisomycin after contextual retrieval reverse with timeK Matthew Lattal
Department of Biology, University of Pennsylvania, Philadelphia, PA 19104, USA
Proc Natl Acad Sci U S A 101:4667-72. 2004..These results suggest that anisomycin injections after retrieval do not retroactively affect the memory from conditioning... - Sensorimotor gating deficits in transgenic mice expressing a constitutively active form of Gs alphaThomas J Gould
Department of Psychology, Temple University, Weiss Hall, Philadelphia, PA, USA
Neuropsychopharmacology 29:494-501. 2004.... - Corticosterone modulates auditory gating in mouseChristina R Maxwell
Division of Neuropsychiatry, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
Neuropsychopharmacology 31:897-903. 2006..These data highlight the need to consider serum glucocorticoid levels when assessing human disease states associated with aberrations of information processing such as schizophrenia and depression... - Longitudinal in-vivo diffusion tensor imaging for assessing brain developmental changes in BALB/cJ mice, a model of reduced sociability relevant to autismManoj Kumar
Department of Radiology, Perelman School of Medicine at the University of Pennsylvania, B6 Blockley Hall, 423 Guardian Drive, Philadelphia, PA 19104, USA
Brain Res 1455:56-67. 2012..These results indicate that DTI may be used as an in-vivo, non-invasive imaging method to assess developmental trajectories of brain connectivity in mouse models of neurodevelopmental and behavioral disorders... - The cholinergic system and neostriatal memory functionsRobbert Havekes
Department of Biology, University of Pennsylvania, 433 S University Avenue, Philadelphia, PA 19104, USA
Behav Brain Res 221:412-23. 2011..Together, these data indicate that the cholinergic system in the striatum is involved in a diverse set of cognitive functions through interactions with other neurotransmitter systems including the dopaminergic and GABAergic systems... - Compartmentalized PKA signaling events are required for synaptic tagging and capture during hippocampal late-phase long-term potentiationTed Huang
Department of Neuroscience, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Eur J Cell Biol 85:635-42. 2006..Thus our data highlight the idea that PKA anchoring may allow for specific populations of synapses to change in synaptic strength in the face of plasticity-related transcription that is cell-wide... - Astrocytic modulation of sleep homeostasis and cognitive consequences of sleep lossMichael M Halassa
Department of Neuroscience, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Neuron 61:213-9. 2009.... 
Association between sociability and diffusion tensor imaging in BALB/cJ miceSungheon Kim
Department of Radiology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
NMR Biomed 25:104-12. 2012..This study demonstrates the feasibility of using DTI to detect brain regions associated with sociability in a mouse model system...- The role of protein synthesis in memory consolidation: progress amid decades of debatePepe J Hernandez
Department of Biology, University of Pennsylvania, 433 S University Avenue, Philadelphia, PA 19104, USA
Neurobiol Learn Mem 89:293-311. 2008..We conclude by presenting avenues of research we believe will best provide answers to both long-standing and more recent questions facing field of learning and memory... - Regulation of hippocampus-dependent memory by cyclic AMP-dependent protein kinaseTed Abel
University of Pennsylvania, Department of Biology, Biological Basis of Behavior Program, Philadelphia, PA 19104, USA
Prog Brain Res 169:97-115. 2008..Future directions and open questions regarding the role of PKA in memory storage are also described... - Sleep deprivation selectively impairs memory consolidation for contextual fear conditioningLaurel A Graves
Neuroscience Graduate Group, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
Learn Mem 10:168-76. 2003.... - Myristoylated alanine rich C kinase substrate (MARCKS) heterozygous mutant mice exhibit deficits in hippocampal mossy fiber-CA3 long-term potentiationRifat J Hussain
Department of Psychiatry, University of Pennsylvania School of Medicine, Clinical Research Building, Philadelphia, Pennsylvania, USA
Hippocampus 16:495-503. 2006..The implications of these findings for the role of the mossy fiber-CA3 pathway in hippocampus-dependent learning processes are discussed... - Adrenergic signaling plays a critical role in the maintenance of waking and in the regulation of REM sleepMing Ouyang
Dept. of Pharmacology, University of Pennsylvania, 103 John Morgan Bldg, 3620 Hamilton Walk, Philadelphia, PA 19104-6084, USA
J Neurophysiol 92:2071-82. 2004..These results provide genetic evidence that adrenergic signaling acts to maintain waking and is important for the regulation of REM sleep and possibly sleep homeostasis... - Effects of post-session injections of anisomycin on the extinction of a spatial preference and on the acquisition of a spatial reversal preferenceK Matthew Lattal
Department of Biology, University of Pennsylvania, 3740 Hamilton Walk, Philadelphia, PA 19104, USA
Behav Brain Res 153:327-39. 2004..These findings suggest that acquisition and extinction may involve different molecular processes, and they do not support the idea that brief extinction trials induce a protein synthesis-dependent reconsolidation phase of spatial memory... - Aging impairs hippocampus-dependent long-term memory for object location in miceMathieu E Wimmer
Neuroscience Graduate Group, University of Pennsylvania, Philadelphia, PA 19104, USA
Neurobiol Aging 33:2220-4. 2012..Aged animals performed similarly to young adult mice on an object recognition task that does not rely on hippocampal function... - Development of home cage social behaviors in BALB/cJ vs. C57BL/6J miceAndrew H Fairless
Center for Neurobiology and Behavior, Department of Psychiatry, Perelman School of Medicine at University of Pennsylvania, Translational Research Laboratory, 125 South 31st Street, Room 2220, Philadelphia, PA 19104 3403, USA
Behav Brain Res 237:338-47. 2013.... - The role of NR4A transcription factors in memory formationJosh D Hawk
University of Pennsylvania, Neuroscience Graduate Group, Philadelphia, PA, United States
Brain Res Bull 85:21-9. 2011..In this article, we review insights gained in other physiological contexts regarding Nr4a function and regulation, and highlight how these lessons can be applied to the study of memory formation... - Subregion-specific p300 conditional knock-out mice exhibit long-term memory impairmentsAna M M Oliveira
Department of Biology, University of Pennsylvania, Philadelphia, PA 19104, USA
Learn Mem 18:161-9. 2011..We found that p300 is required for the formation of long-term recognition memory and long-term contextual fear memory in the CA1 area of the hippocampus and cortical areas... - Low sociability is associated with reduced size of the corpus callosum in the BALB/cJ inbred mouse strainAndrew H Fairless
Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania School of Medicine, Translational Research Laboratory, 125 South 31st Street, Room 2220, Philadelphia, PA 19104 3403, USA
Brain Res 1230:211-7. 2008..Additional studies are warranted to elucidate the relationship between brain connectivity and sociability in this model system... - Impaired rapid eye movement sleep in the Tg2576 APP murine model of Alzheimer's disease with injury to pedunculopontine cholinergic neuronsBin Zhang
Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Maloney 3, HUP, 3600 Spruce St, Philadelphia, PA 19104-4283, USA
Am J Pathol 167:1361-9. 2005..The differential vulnerability of these cholinergic neurons to Abeta injury provides an invaluable tool with which to understand mechanisms of sleep/wake perturbations in Alzheimer's disease... - Embryo culture does not affect the longevity of offspring in miceJoshua Sommovilla
Department of Biology, University of Pennsylvania, Philadelphia, PA 19104, USA
Reproduction 130:599-601. 2005..2004). Here we monitored the mice generated in our previous study and found no difference in their longevity... - Long-term effects of culture of preimplantation mouse embryos on behaviorDavid J Ecker
Department of Biology, University of Pennsylvania, 415 South University Avenue, Philadelphia, PA 19104, USA
Proc Natl Acad Sci U S A 101:1595-600. 2004.... - Protein synthesis is required for the enhancement of long-term potentiation and long-term memory by spaced trainingMatthew T Scharf
Department of Biology, University of Pennsylvania, Philadelphia, PA 19104-6018, USA
J Neurophysiol 87:2770-7. 2002.... - Mice deficient for testis-brain RNA-binding protein exhibit a coordinate loss of TRAX, reduced fertility, altered gene expression in the brain, and behavioral changesVargheese Chennathukuzhi
Center for Research on Reproduction and Women s Health, School of Medicine, Department of Biology, University of Pennsylvania, 1310 Biomedical Research Building II III, 421 Curie Boulevard, Philadelphia, PA 19104 6142, USA
Mol Cell Biol 23:6419-34. 2003..Behavioral abnormalities were also seen. Compared to littermates, the TB-RBP-null mice appeared docile and exhibited reduced Rota-Rod performance... - Genetic evidence for a role of CREB in sustained cortical arousalLaurel A Graves
Neuroscience Graduate Group, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
J Neurophysiol 90:1152-9. 2003.... - Extinction, renewal, and spontaneous recovery of a spatial preference in the water mazeK Matthew Lattal
Department of Biology, University of Pennsylvania, 3740 Hamilton Walk, Philadelphia, PA 19104, USA
Behav Neurosci 117:1017-28. 2003..Implications of these findings for theories of spatial learning and hippocampal function are discussed... - The mouse: genetics meets behaviourMaja Bucan
Center for Neurobiology and Behavior, Clinical Research Building, Room 111A, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Nat Rev Genet 3:114-23. 2002.... - Quantification of brain maturation and growth patterns in C57BL/6J mice via computational neuroanatomy of diffusion tensor imagesSajjad Baloch
Department of Radiology, University of Pennsylvania, PA 19104, USA
Cereb Cortex 19:675-87. 2009..Fiber maturation reaches steady state in about 10 days for the cortex, to 30-40 days for the corpus callosum, the hippocampus, and the internal and external capsules... - TetR hybrid transcription factors report cell signaling and are inhibited by doxycyclineMichael B Keeley
University of Pennsylvania, Philadelphia, PA 19104, USA
Biotechniques 39:529-36. 2005..This system may be useful in creating temporally restricted windows of response to cell signaling and may be of value in the advancement of methods used to study signal transduction... - Inhibition of auditory evoked potentials and prepulse inhibition of startle in DBA/2J and DBA/2Hsd inbred mouse substrainsPatrick M Connolly
Stanley Center for Experimental Therapeutics in Psychiatry, Division of Neuropsychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
Brain Res 992:85-95. 2003..Future studies will attempt to determine the cause of these differences in sensory and sensorimotor processing between these two closely related inbred mouse strains... - Genetic dissection of neural circuits and behavior in Mus musculusRobbert Havekes
Department of Biology, University of Pennsylvania, Philadelphia, PA, USA
Adv Genet 65:1-38. 2009..In this chapter, we will give an overview of several state of the art genetic approaches to study gene function in the mouse brain in a spatially and temporally restricted fashion...
Research Grants
- TRAINING PROGRAM IN BEHAVIORAL/COGNITIVE NEUROSCIENCEEDWIN TED ABEL; Fiscal Year: 2007..In view of the continued expansion of Behavioral and Cognitive Neuroscience faculty at Penn, and the number of highly qualified trainees, we are requesting support for eight trainees per year for the next five years. ..
- Molecular Mechanisms of Long-Term Memory StorageEDWIN TED G ABEL; Fiscal Year: 2010..With the combination of genetic, biochemical, molecular, and pharmacological studies outlined in this grant proposal, we hope to define the role of CBP and histone acetylation in memory storage and synaptic plasticity. ..
- Epigenetic Mechanisms of Memory StorageEDWIN TED G ABEL; Fiscal Year: 2010..Knowledge of the molecular mechanisms and targets of epigenetic modifications during memory storage promises to lead to the development of novel therapeutic approaches for schizophrenia, bipolar disorder, and depression. ..
- Molecular Mechanisms of Long-Term Memory StorageEDWIN ABEL; Fiscal Year: 2007..With the combination of genetic, biochemical, molecular, and pharmacological studies outlined in this grant proposal, we hope to define the role of CBP and histone acetylation in memory storage and synaptic plasticity. ..
- MOLECULAR BASIS OF LONG-TERM MEMORY STORAGEEDWIN TED ABEL; Fiscal Year: 2004..abstract_text> ..
- SLEEP MEMORY: A MOLECULAR AND GENETIC ANALYSISEDWIN ABEL; Fiscal Year: 2002..abstract_text> ..
- Tools to conditionally regulate intracellular signaling pathways in vivoEDWIN TED G ABEL; Fiscal Year: 2010..Knowledge of these molecular mechanisms promises to lead to the development of novel therapeutic approaches to treat cognitive deficits. ..