Research Topics
Genomes and Genes | Sarki A AbdulkadirSummaryAffiliation: University of Alabama at Birmingham Country: USA Publications
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Publications
Conditional loss of Nkx3.1 in adult mice induces prostatic intraepithelial neoplasiaSarki A Abdulkadir
Department of Pathology, University of Alabama at Birmingham School of Medicine, Birmingham, Alabama 35294, USA
Mol Cell Biol 22:1495-503. 2002..1 allele lose expression of the wild-type allele. Our results support the role of NKX3.1 as a prostate tumor suppressor and indicate a role for this gene in tumor initiation...
Genetically engineered murine models of prostate cancer: insights into mechanisms of tumorigenesis and potential utilitySarki A Abdulkadir
The University of Alabama at Birmingham, Department of Pathology, 701 19th Street South, 533 LHRB, Birmingham, AL 35294, USA
Future Oncol 1:351-60. 2005..This review will summarize some of these models and their utility, as well as propose future challenges for developing improved models...- Pim1 promotes human prostate cancer cell tumorigenicity and c-MYC transcriptional activityJongchan Kim
Department of Pathology, Vanderbilt University Medical Center, Nashville, TN, USA
BMC Cancer 10:248. 2010..In mouse models, Pim1 is known to cooperate with c-Myc to promote tumorigenicity. However, there has been limited analysis of the tumorigenic potential of Pim1 overexpression in benign and malignant human prostate cancer cells in vivo... - Haploinsufficient prostate tumor suppression by Nkx3.1: a role for chromatin accessibility in dosage-sensitive gene regulationAshish P Mogal
Department of Pathology, Vanderbilt University Medical Center, Nashville 37232, USA
J Biol Chem 282:25790-800. 2007..Our results reveal how the interplay between transcription factor dosage and chromatin affects target gene expression in tumor initiation... - Antioxidant treatment promotes prostate epithelial proliferation in Nkx3.1 mutant miceErin E Martinez
Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, USA
PLoS ONE 7:e46792. 2012..Our findings provide new insight that may help explain the increased prostate cancer risk observed with vitamin E treatment in the SELECT trial and emphasize the need for preclinical studies using accurate models of cancer... - Nkx3.1 and Myc crossregulate shared target genes in mouse and human prostate tumorigenesisPhilip D Anderson
Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
J Clin Invest 122:1907-19. 2012..We propose that coregulation of target gene expression by oncogenic/tumor suppressor transcription factors may represent a general mechanism underlying the cooperativity of oncogenic mutations during tumorigenesis... - Interaction of Nkx3.1 and p27kip1 in prostate tumor initiationBernard Gary
Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35294 0007, USA
Am J Pathol 164:1607-14. 2004..Thus Nkx3.1 and p27kip1 regulate prostatic epithelial cell proliferation and tumor initiation by affecting both haploinsufficient and nonhaploinsufficient pathways... - Chromosomal instability induced by Pim-1 is passage-dependent and associated with dysregulation of cyclin B1Meejeon Roh
Department of Pathology, The University of Alabama at Birmingham, School of Medicine, Birmingham, Alabama 35294, USA
J Biol Chem 280:40568-77. 2005..These results indicated that chronic Pim-1 overexpression dysregulates cyclin B1 protein expression, which contributes to the development of polyploidy by delaying cytokinesis... - Interactions between cells with distinct mutations in c-MYC and Pten in prostate cancerJongchan Kim
Department of Pathology, Vanderbilt University Medical Center, Nashville, TN, USA
PLoS Genet 5:e1000542. 2009..Our results highlight the utility of inducing mutations focally to model the competitive interactions between cell populations with distinct genetic alterations during tumorigenesis... - Haploinsufficiency at the Nkx3.1 locus. A paradigm for stochastic, dosage-sensitive gene regulation during tumor initiationJeffrey A Magee
Department of Pathology, Division of Laboratory Medicine, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
Cancer Cell 3:273-83. 2003..Thus, loss of a single Nkx3.1 allele likely results in hyperplasia and PIN by increasing the probability of completely inactivating select Nkx3.1-regulated pathways within a subset of affected cells... - Enhanced EGR1 activity promotes the growth of prostate cancer cells in an androgen-depleted environmentShan Zhong Yang
Department of Pathology, University of Alabama at Birmingham School of Medicine, Birmingham, Alabama 35294, USA
J Cell Biochem 97:1292-9. 2006..These findings support a role for enhanced EGR1 activity in regulating the transition from androgen-dependent to androgen-independent prostate cancer... - Transgenic mice for Cre-inducible overexpression of the oncogenes c-MYC and Pim-1 in multiple tissuesMeejeon Roh
Department of Pathology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
Genesis 44:447-53. 2006..In vivo recombination was confirmed for all lines by breeding to Cre transgenic mice. These mice provide a valuable resource for investigating the significance of MYC and Pim-1 overexpression in various tissues... - Mechanisms of prostate tumorigenesis: roles for transcription factors Nkx3.1 and Egr1Sarki A Abdulkadir
Department of Pathology, The University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
Ann N Y Acad Sci 1059:33-40. 2005..Specifically, Egr1 deficiency impairs the transition from PIN to invasive carcinoma. Thus, Nkx3.1 and Egr1 regulate gene programs involved in distinct aspects of prostate tumorigenesis... - Tumorigenic polyploid cells contain elevated ROS and ARE selectively targeted by antioxidant treatmentMeejeon Roh
Department of Pathology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
J Cell Physiol 227:801-12. 2012.... - Effects of Histone Deacetylase Inhibitor (HDACi); Trichostatin-A (TSA) on the expression of housekeeping genesAshish Mogal
Department of Pathology, Vanderbilt University, School of Medicine, Nashville, TN 37232, USA
Mol Cell Probes 20:81-6. 2006..However, RPL13A mRNA levels remained constant in all the conditions tested. Therefore, we recommend use of RPL13A as a standard for normalization during TSA treatment... - Notch signaling and ERK activation are important for the osteomimetic properties of prostate cancer bone metastatic cell linesMajd Zayzafoon
Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35233, USA
J Biol Chem 279:3662-70. 2004..These studies demonstrate that prostate cancer bone metastatic cell lines acquire osteoblastic properties through independent activation of ERK and Notch signaling; presumably, both pathways are activated in the bone microenvironment... - Overexpression of the oncogenic kinase Pim-1 leads to genomic instabilityMeejeon Roh
Department of Pathology, University of Alabama at Birmingham School of Medicine, Birmingham, Alabama 35294-0007, USA
Cancer Res 63:8079-84. 2003..Polyploidy and aneuploidy ensue due to a delay in completing cytokinesis. These results define a novel role for elevated Pim-1 expression in promoting genomic instability in human prostate tumors... - Early growth response gene 1 modulates androgen receptor signaling in prostate carcinoma cellsShan Zhong Yang
Department of Pathology, University of Alabama at Birmingham School of Medicine, Birmingham, Alabama 35294, USA
J Biol Chem 278:39906-11. 2003..These results indicate that EGR1 may promote prostate cancer development by modulating the androgen receptor signaling pathway... - A role for polyploidy in the tumorigenicity of Pim-1-expressing human prostate and mammary epithelial cellsMeejeon Roh
Department of Pathology, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America
PLoS ONE 3:e2572. 2008..In this study, we investigated whether polyploidy per se induced by a relevant oncogene can promote genomic instability and tumorigenicity in human epithelial cells...