Sarki A Abdulkadir

Summary

Affiliation: University of Alabama at Birmingham
Country: USA

Publications

  1. pmc Conditional loss of Nkx3.1 in adult mice induces prostatic intraepithelial neoplasia
    Sarki A Abdulkadir
    Department of Pathology, University of Alabama at Birmingham School of Medicine, Birmingham, Alabama 35294, USA
    Mol Cell Biol 22:1495-503. 2002
  2. ncbi request reprint Genetically engineered murine models of prostate cancer: insights into mechanisms of tumorigenesis and potential utility
    Sarki A Abdulkadir
    The University of Alabama at Birmingham, Department of Pathology, 701 19th Street South, 533 LHRB, Birmingham, AL 35294, USA
    Future Oncol 1:351-60. 2005
  3. pmc Antioxidant treatment promotes prostate epithelial proliferation in Nkx3.1 mutant mice
    Erin E Martinez
    Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, USA
    PLoS ONE 7:e46792. 2012
  4. pmc Pim1 promotes human prostate cancer cell tumorigenicity and c-MYC transcriptional activity
    Jongchan Kim
    Department of Pathology, Vanderbilt University Medical Center, Nashville, TN, USA
    BMC Cancer 10:248. 2010
  5. ncbi request reprint Haploinsufficient prostate tumor suppression by Nkx3.1: a role for chromatin accessibility in dosage-sensitive gene regulation
    Ashish P Mogal
    Department of Pathology, Vanderbilt University Medical Center, Nashville 37232, USA
    J Biol Chem 282:25790-800. 2007
  6. pmc Nkx3.1 and Myc crossregulate shared target genes in mouse and human prostate tumorigenesis
    Philip D Anderson
    Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    J Clin Invest 122:1907-19. 2012
  7. pmc Interaction of Nkx3.1 and p27kip1 in prostate tumor initiation
    Bernard Gary
    Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35294 0007, USA
    Am J Pathol 164:1607-14. 2004
  8. ncbi request reprint Chromosomal instability induced by Pim-1 is passage-dependent and associated with dysregulation of cyclin B1
    Meejeon Roh
    Department of Pathology, The University of Alabama at Birmingham, School of Medicine, Birmingham, Alabama 35294, USA
    J Biol Chem 280:40568-77. 2005
  9. pmc Interactions between cells with distinct mutations in c-MYC and Pten in prostate cancer
    Jongchan Kim
    Department of Pathology, Vanderbilt University Medical Center, Nashville, TN, USA
    PLoS Genet 5:e1000542. 2009
  10. ncbi request reprint Transgenic mice for Cre-inducible overexpression of the oncogenes c-MYC and Pim-1 in multiple tissues
    Meejeon Roh
    Department of Pathology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Genesis 44:447-53. 2006

Collaborators

Detail Information

Publications19

  1. pmc Conditional loss of Nkx3.1 in adult mice induces prostatic intraepithelial neoplasia
    Sarki A Abdulkadir
    Department of Pathology, University of Alabama at Birmingham School of Medicine, Birmingham, Alabama 35294, USA
    Mol Cell Biol 22:1495-503. 2002
    ..1 allele lose expression of the wild-type allele. Our results support the role of NKX3.1 as a prostate tumor suppressor and indicate a role for this gene in tumor initiation...
  2. ncbi request reprint Genetically engineered murine models of prostate cancer: insights into mechanisms of tumorigenesis and potential utility
    Sarki A Abdulkadir
    The University of Alabama at Birmingham, Department of Pathology, 701 19th Street South, 533 LHRB, Birmingham, AL 35294, USA
    Future Oncol 1:351-60. 2005
    ..This review will summarize some of these models and their utility, as well as propose future challenges for developing improved models...
  3. pmc Antioxidant treatment promotes prostate epithelial proliferation in Nkx3.1 mutant mice
    Erin E Martinez
    Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, USA
    PLoS ONE 7:e46792. 2012
    ..Our findings provide new insight that may help explain the increased prostate cancer risk observed with vitamin E treatment in the SELECT trial and emphasize the need for preclinical studies using accurate models of cancer...
  4. pmc Pim1 promotes human prostate cancer cell tumorigenicity and c-MYC transcriptional activity
    Jongchan Kim
    Department of Pathology, Vanderbilt University Medical Center, Nashville, TN, USA
    BMC Cancer 10:248. 2010
    ..In mouse models, Pim1 is known to cooperate with c-Myc to promote tumorigenicity. However, there has been limited analysis of the tumorigenic potential of Pim1 overexpression in benign and malignant human prostate cancer cells in vivo...
  5. ncbi request reprint Haploinsufficient prostate tumor suppression by Nkx3.1: a role for chromatin accessibility in dosage-sensitive gene regulation
    Ashish P Mogal
    Department of Pathology, Vanderbilt University Medical Center, Nashville 37232, USA
    J Biol Chem 282:25790-800. 2007
    ..Our results reveal how the interplay between transcription factor dosage and chromatin affects target gene expression in tumor initiation...
  6. pmc Nkx3.1 and Myc crossregulate shared target genes in mouse and human prostate tumorigenesis
    Philip D Anderson
    Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    J Clin Invest 122:1907-19. 2012
    ..We propose that coregulation of target gene expression by oncogenic/tumor suppressor transcription factors may represent a general mechanism underlying the cooperativity of oncogenic mutations during tumorigenesis...
  7. pmc Interaction of Nkx3.1 and p27kip1 in prostate tumor initiation
    Bernard Gary
    Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35294 0007, USA
    Am J Pathol 164:1607-14. 2004
    ..Thus Nkx3.1 and p27kip1 regulate prostatic epithelial cell proliferation and tumor initiation by affecting both haploinsufficient and nonhaploinsufficient pathways...
  8. ncbi request reprint Chromosomal instability induced by Pim-1 is passage-dependent and associated with dysregulation of cyclin B1
    Meejeon Roh
    Department of Pathology, The University of Alabama at Birmingham, School of Medicine, Birmingham, Alabama 35294, USA
    J Biol Chem 280:40568-77. 2005
    ..These results indicated that chronic Pim-1 overexpression dysregulates cyclin B1 protein expression, which contributes to the development of polyploidy by delaying cytokinesis...
  9. pmc Interactions between cells with distinct mutations in c-MYC and Pten in prostate cancer
    Jongchan Kim
    Department of Pathology, Vanderbilt University Medical Center, Nashville, TN, USA
    PLoS Genet 5:e1000542. 2009
    ..Our results highlight the utility of inducing mutations focally to model the competitive interactions between cell populations with distinct genetic alterations during tumorigenesis...
  10. ncbi request reprint Transgenic mice for Cre-inducible overexpression of the oncogenes c-MYC and Pim-1 in multiple tissues
    Meejeon Roh
    Department of Pathology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Genesis 44:447-53. 2006
    ..In vivo recombination was confirmed for all lines by breeding to Cre transgenic mice. These mice provide a valuable resource for investigating the significance of MYC and Pim-1 overexpression in various tissues...
  11. ncbi request reprint Mechanisms of prostate tumorigenesis: roles for transcription factors Nkx3.1 and Egr1
    Sarki A Abdulkadir
    Department of Pathology, The University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Ann N Y Acad Sci 1059:33-40. 2005
    ..Specifically, Egr1 deficiency impairs the transition from PIN to invasive carcinoma. Thus, Nkx3.1 and Egr1 regulate gene programs involved in distinct aspects of prostate tumorigenesis...
  12. ncbi request reprint Haploinsufficiency at the Nkx3.1 locus. A paradigm for stochastic, dosage-sensitive gene regulation during tumor initiation
    Jeffrey A Magee
    Department of Pathology, Division of Laboratory Medicine, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Cancer Cell 3:273-83. 2003
    ..Thus, loss of a single Nkx3.1 allele likely results in hyperplasia and PIN by increasing the probability of completely inactivating select Nkx3.1-regulated pathways within a subset of affected cells...
  13. ncbi request reprint Enhanced EGR1 activity promotes the growth of prostate cancer cells in an androgen-depleted environment
    Shan Zhong Yang
    Department of Pathology, University of Alabama at Birmingham School of Medicine, Birmingham, Alabama 35294, USA
    J Cell Biochem 97:1292-9. 2006
    ..These findings support a role for enhanced EGR1 activity in regulating the transition from androgen-dependent to androgen-independent prostate cancer...
  14. pmc Tumorigenic polyploid cells contain elevated ROS and ARE selectively targeted by antioxidant treatment
    Meejeon Roh
    Department of Pathology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    J Cell Physiol 227:801-12. 2012
    ....
  15. ncbi request reprint Effects of Histone Deacetylase Inhibitor (HDACi); Trichostatin-A (TSA) on the expression of housekeeping genes
    Ashish Mogal
    Department of Pathology, Vanderbilt University, School of Medicine, Nashville, TN 37232, USA
    Mol Cell Probes 20:81-6. 2006
    ..However, RPL13A mRNA levels remained constant in all the conditions tested. Therefore, we recommend use of RPL13A as a standard for normalization during TSA treatment...
  16. ncbi request reprint Notch signaling and ERK activation are important for the osteomimetic properties of prostate cancer bone metastatic cell lines
    Majd Zayzafoon
    Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35233, USA
    J Biol Chem 279:3662-70. 2004
    ..These studies demonstrate that prostate cancer bone metastatic cell lines acquire osteoblastic properties through independent activation of ERK and Notch signaling; presumably, both pathways are activated in the bone microenvironment...
  17. ncbi request reprint Overexpression of the oncogenic kinase Pim-1 leads to genomic instability
    Meejeon Roh
    Department of Pathology, University of Alabama at Birmingham School of Medicine, Birmingham, Alabama 35294 0007, USA
    Cancer Res 63:8079-84. 2003
    ..Polyploidy and aneuploidy ensue due to a delay in completing cytokinesis. These results define a novel role for elevated Pim-1 expression in promoting genomic instability in human prostate tumors...
  18. ncbi request reprint Early growth response gene 1 modulates androgen receptor signaling in prostate carcinoma cells
    Shan Zhong Yang
    Department of Pathology, University of Alabama at Birmingham School of Medicine, Birmingham, Alabama 35294, USA
    J Biol Chem 278:39906-11. 2003
    ..These results indicate that EGR1 may promote prostate cancer development by modulating the androgen receptor signaling pathway...
  19. pmc A role for polyploidy in the tumorigenicity of Pim-1-expressing human prostate and mammary epithelial cells
    Meejeon Roh
    Department of Pathology, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America
    PLoS ONE 3:e2572. 2008
    ..In this study, we investigated whether polyploidy per se induced by a relevant oncogene can promote genomic instability and tumorigenicity in human epithelial cells...