Sherif Z Abdel Rahman
Affiliation: University of Texas Medical Branch
Speidel J, Xu M, Abdel Rahman S. Bisphenol A (BPA) and bisphenol S (BPS) alter the promoter activity of the ABCB1 gene encoding P-glycoprotein in the human placenta in a haplotype-dependent manner. Toxicol Appl Pharmacol. 2018;359:47-54 pubmed publisher
..Such alteration could significantly impact placental P-gp levels and alter fetal exposure to many therapeutic and environmental xenobiotics. ..
Xu M, Cross C, Speidel J, Abdel Rahman S. MGMT DNA repair gene promoter/enhancer haplotypes alter transcription factor binding and gene expression. Cell Oncol (Dordr). 2016;39:435-447 pubmed
..The data generated support our hypothesis that promoter haplotypes alter the binding of TFs to the MGMT P/E and, subsequently, affect their regulatory function on MGMT promoter activity and expression level. ..
Abdel Rahman S, Ammenheuser M, Omiecinski C, Wickliffe J, Rosenblatt J, Ward J. Variability in human sensitivity to 1,3-butadiene: influence of polymorphisms in the 5'-flanking region of the microsomal epoxide hydrolase gene (EPHX1). Toxicol Sci. 2005;85:624-31 pubmed
..89 +/- 2.16 (95% CI = 6.56-15.20; p = 0.0027) above baseline. These new data confirm and extend our previous findings that sensitivity to the genotoxic effects of BD is inversely correlated with predicted mEH activity. ..
Mostafa A, Hamdy N, El Mesallamy H, Abdel Rahman S. Glucagon-like peptide 1 (GLP-1)-based therapy upregulates LXR-ABCA1/ABCG1 cascade in adipocytes. Biochem Biophys Res Commun. 2015;468:900-5 pubmed publisher
..05). Our data suggest that GLP-1-based therapy modulate ABCA1/ABCG1 expression in adipocytes potentially through an LXR-Î± mediated process. ..