Zalfa A Abdel-Malek

Summary

Affiliation: University of Cincinnati
Country: USA

Publications

  1. ncbi The melanocortin-1 receptor and human pigmentation
    Z Abdel-Malek
    Department of Dermatology, University of Cincinnati, Ohio 45267, USA
    Ann N Y Acad Sci 885:117-33. 1999
  2. ncbi The melanocortin-1 receptor is a key regulator of human cutaneous pigmentation
    Z Abdel-Malek
    University of Cincinnati, Ohio, 45267 592, USA
    Pigment Cell Res 13:156-62. 2000
  3. ncbi The melanocortin 1 receptor is the principal mediator of the effects of agouti signaling protein on mammalian melanocytes
    Z A Abdel-Malek
    Department of Dermatology, University of Cincinnati College of Medicine, Cincinnati, OH, USA
    J Cell Sci 114:1019-24. 2001
  4. ncbi Melanocortin receptors: their functions and regulation by physiological agonists and antagonists
    Z A Abdel-Malek
    Department of Dermatology, University of Cincinnati, Ohio 45267 0592, USA
    Cell Mol Life Sci 58:434-41. 2001
  5. doi Development of α-melanocortin analogs for melanoma prevention and targeting
    Zalfa A Abdel-Malek
    Department of Dermatology, University of Cincinnati, Cincinnati, OH 45267, USA
    Adv Exp Med Biol 681:126-32. 2010
  6. doi beta-Defensin 3: a novel and unexpected key that unlocks the melanocortin 1 receptor
    Zalfa A Abdel-Malek
    Pigment Cell Melanoma Res 21:7-8. 2008
  7. ncbi Melanoma prevention strategy based on using tetrapeptide alpha-MSH analogs that protect human melanocytes from UV-induced DNA damage and cytotoxicity
    Zalfa A Abdel-Malek
    Department of Dermatology, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, Ohio 45267 0592, USA
    FASEB J 20:1561-3. 2006
  8. doi The melanocortin 1 receptor and the UV response of human melanocytes--a shift in paradigm
    Zalfa A Abdel-Malek
    Department of Dermatology, University of Cincinnati College of Medicine, Cincinnati, OH, USA
    Photochem Photobiol 84:501-8. 2008
  9. ncbi Human melanocortin 1 receptor variants, receptor function and melanocyte response to UV radiation
    M Cathy Scott
    Department of Dermatology, University of Cincinnati College of Medicine, PO Box 670592, Cincinnati, Ohio 45267 0592, USA
    J Cell Sci 115:2349-55. 2002
  10. ncbi Melanin content and MC1R function independently affect UVR-induced DNA damage in cultured human melanocytes
    Jennifer E Hauser
    Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, OH, USA
    Pigment Cell Res 19:303-14. 2006

Research Grants

  1. 19th International Pigment Cell Conference - 2005
    Zalfa Abdel Malek; Fiscal Year: 2005
  2. Discovery of Alpha-MSH Analogs for Skin Cancer Prevention
    Zalfa Abdel Malek; Fiscal Year: 2006

Collaborators

Detail Information

Publications26

  1. ncbi The melanocortin-1 receptor and human pigmentation
    Z Abdel-Malek
    Department of Dermatology, University of Cincinnati, Ohio 45267, USA
    Ann N Y Acad Sci 885:117-33. 1999
    ....
  2. ncbi The melanocortin-1 receptor is a key regulator of human cutaneous pigmentation
    Z Abdel-Malek
    University of Cincinnati, Ohio, 45267 592, USA
    Pigment Cell Res 13:156-62. 2000
    ..These results begin to elucidate the significance of MC1R variants in the function of the receptor. Our data emphasize the significance of a normally functioning MC1R in the response of melanocytes to melanocortins, ASP, and UVR...
  3. ncbi The melanocortin 1 receptor is the principal mediator of the effects of agouti signaling protein on mammalian melanocytes
    Z A Abdel-Malek
    Department of Dermatology, University of Cincinnati College of Medicine, Cincinnati, OH, USA
    J Cell Sci 114:1019-24. 2001
    ..These results indicate that a functional melanocortin 1 receptor is obligatory for the response of mammalian melanocytes to agouti signaling protein...
  4. ncbi Melanocortin receptors: their functions and regulation by physiological agonists and antagonists
    Z A Abdel-Malek
    Department of Dermatology, University of Cincinnati, Ohio 45267 0592, USA
    Cell Mol Life Sci 58:434-41. 2001
    ..These advances have opened new horizons for exploring the significance of melanocortins, their antagonists, and their receptors in a variety of important physiological functions...
  5. doi Development of α-melanocortin analogs for melanoma prevention and targeting
    Zalfa A Abdel-Malek
    Department of Dermatology, University of Cincinnati, Cincinnati, OH 45267, USA
    Adv Exp Med Biol 681:126-32. 2010
    ..The main challenge is to develop specific MC1R agonists that will target melanocytes for skin cancer prevention, or for localization and treatment of metastatic melanoma...
  6. doi beta-Defensin 3: a novel and unexpected key that unlocks the melanocortin 1 receptor
    Zalfa A Abdel-Malek
    Pigment Cell Melanoma Res 21:7-8. 2008
  7. ncbi Melanoma prevention strategy based on using tetrapeptide alpha-MSH analogs that protect human melanocytes from UV-induced DNA damage and cytotoxicity
    Zalfa A Abdel-Malek
    Department of Dermatology, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, Ohio 45267 0592, USA
    FASEB J 20:1561-3. 2006
    ..Analogs, such as 4-Phenylbutyryl-His-D-Phe-Arg-Trp-NH2 with prolonged and reversible effects, can potentially be developed into topical agents to prevent skin photocarcinogenesis, particularly melanoma...
  8. doi The melanocortin 1 receptor and the UV response of human melanocytes--a shift in paradigm
    Zalfa A Abdel-Malek
    Department of Dermatology, University of Cincinnati College of Medicine, Cincinnati, OH, USA
    Photochem Photobiol 84:501-8. 2008
    ....
  9. ncbi Human melanocortin 1 receptor variants, receptor function and melanocyte response to UV radiation
    M Cathy Scott
    Department of Dermatology, University of Cincinnati College of Medicine, PO Box 670592, Cincinnati, Ohio 45267 0592, USA
    J Cell Sci 115:2349-55. 2002
    ..We conclude that loss-of-function mutations in the MC1R gene sensitize human melanocytes to the DNA damaging effects of UV radiation, which may increase skin cancer risk...
  10. ncbi Melanin content and MC1R function independently affect UVR-induced DNA damage in cultured human melanocytes
    Jennifer E Hauser
    Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, OH, USA
    Pigment Cell Res 19:303-14. 2006
    ..Therefore, MC, mainly EC, and MC1R function are independent determinants of UVR-induced DNA damage in melanocytes...
  11. ncbi Significance of the melanocortin 1 receptor in regulating human melanocyte pigmentation, proliferation, and survival
    Ana Luisa Kadekaro
    Department of Dermatology, University of Cincinnati, Cincinnati, Ohio 45267, USA
    Ann N Y Acad Sci 994:359-65. 2003
    ..This effect was absent in human melanocytes with loss of function MC1R mutations. We predict that the survival effect of alpha-MSH is caused by reduction of UV-induced DNA damage and contributes to the prevention of melanoma...
  12. ncbi Cutaneous photoprotection and melanoma susceptibility: reaching beyond melanin content to the frontiers of DNA repair
    Ana Luisa Kadekaro
    Department of Dermatology, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    Front Biosci 11:2157-73. 2006
    ....
  13. pmc Melanocortin 1 receptor genotype: an important determinant of the damage response of melanocytes to ultraviolet radiation
    Ana Luisa Kadekaro
    Department of Dermatology, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267 0592, USA
    FASEB J 24:3850-60. 2010
    ..Our findings highlight the molecular mechanisms by which the melanocortin 1 receptor genotype controls genomic stability of and the mutagenic effect of ultraviolet radiation on human melanocytes...
  14. doi alpha-MSH tripeptide analogs activate the melanocortin 1 receptor and reduce UV-induced DNA damage in human melanocytes
    Zalfa A Abdel-Malek
    Department of Dermatology, University of Cincinnati, Cincinnati, OH, USA
    Pigment Cell Melanoma Res 22:635-44. 2009
    ..These results demonstrate activation of the MC1R by tripeptide melanocortin analogs. Designing small analogs for topical delivery should prove practical and efficacious for skin cancer prevention...
  15. doi Stepping up melanocytes to the challenge of UV exposure
    Zalfa A Abdel-Malek
    Department of Dermatology, University of Cincinnati Collage of Medicine, Cincinnati, OH, USA
    Pigment Cell Melanoma Res 23:171-86. 2010
    ..Unraveling these mechanisms might lead to strategies to prevent melanoma, as well as non-melanoma skin cancer...
  16. pmc Defining MC1R regulation in human melanocytes by its agonist α-melanocortin and antagonists agouti signaling protein and β-defensin 3
    Viki B Swope
    Department of Dermatology, University of Cincinnati, Cincinnati, Ohio 45267 0592, USA
    J Invest Dermatol 132:2255-62. 2012
    ..Therefore, in addition to the MC1R genotype, regulation of MC1R expression and activity is expected to affect human pigmentation and the responses to UV...
  17. ncbi Cutaneous photobiology. The melanocyte vs. the sun: who will win the final round?
    Ana Luisa Kadekaro
    Department of Dermatology, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0592, USA
    Pigment Cell Res 16:434-47. 2003
    ....
  18. ncbi Regulation of the human melanocortin 1 receptor expression in epidermal melanocytes by paracrine and endocrine factors and by ultraviolet radiation
    M Cathy Scott
    Department of Dermatology, University of Cincinnati, Cincinnati, Ohio 45267 592, USA
    Pigment Cell Res 15:433-9. 2002
    ..Differences in the responses of NHM to some of these factors suggest differential regulation of MC1R gene expression, which may contribute to the variation in constitutive and UV-induced cutaneous pigmentation in humans...
  19. ncbi alpha-Melanocortin and endothelin-1 activate antiapoptotic pathways and reduce DNA damage in human melanocytes
    Ana Luisa Kadekaro
    Department of Dermatology, University of Cincinnati College of Medicine and Shriners Burns Institute, Cincinnati, Ohio 45267 0592, USA
    Cancer Res 65:4292-9. 2005
    ..These effects are expected to reduce genomic instability and mutagenesis...
  20. ncbi Walking in the footsteps of giants: melanocortins and human pigmentation, a historical perspective
    Ana Luisa Kadekaro
    Department of Dermatology, University of Cincinnati, Cincinnati, OH 45267, USA
    Pigment Cell Res 20:150-2. 2007
  21. ncbi Significance of the melanocortin 1 receptor in the DNA damage response of human melanocytes to ultraviolet radiation
    Viki Swope
    Department of Dermatology, University of Cincinnati, Cincinnati, OH, USA
    Pigment Cell Melanoma Res 27:601-10. 2014
    ..We propose that α-MSH increases UV-induced γH2AX to facilitate formation of DNA repair complexes and repair of DNA photoproducts, and LOF of MC1R compromises the DDR and genomic stability of melanocytes. ..
  22. ncbi Regulation of constitutive and UVR-induced skin pigmentation by melanocortin 1 receptor isoforms
    Francois Rouzaud
    Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
    FASEB J 20:1927-9. 2006
    ....
  23. pmc Mesenchymal-epithelial interactions in the skin: increased expression of dickkopf1 by palmoplantar fibroblasts inhibits melanocyte growth and differentiation
    Yuji Yamaguchi
    Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bldg 37, Rm 1B25, Bethesda, MD 20892 4254, USA
    J Cell Biol 165:275-85. 2004
    ....
  24. ncbi Influence of alpha-melanocyte-stimulating hormone and ultraviolet radiation on the transfer of melanosomes to keratinocytes
    Victoria M Virador
    Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health NIH, Bethesda, Maryland, 20892, USA
    FASEB J 16:105-7. 2002
    ....
  25. ncbi MC1R and the response of melanocytes to ultraviolet radiation
    Francois Rouzaud
    Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Building 37, Room 2132, Bethesda, MD 20892, USA
    Mutat Res 571:133-52. 2005
    ..The MC1R gene is considered a melanoma susceptibility gene, and its significance in determining the risk for skin cancer is of tremendous interest...
  26. ncbi Mitogen- and ultraviolet-B-induced signaling pathways in normal human melanocytes
    Akihiro Tada
    POLA Laboratories, Yokohama, Japan
    J Invest Dermatol 118:316-22. 2002
    ..Therefore, in human melanocytes, CREB is a common downstream target for distinct effectors that are involved in either mitogenic signaling or stress signaling initiated by ultraviolet radiation B...

Research Grants2

  1. 19th International Pigment Cell Conference - 2005
    Zalfa Abdel Malek; Fiscal Year: 2005
    ..abstract_text> ..
  2. Discovery of Alpha-MSH Analogs for Skin Cancer Prevention
    Zalfa Abdel Malek; Fiscal Year: 2006
    ....