Hany Abdel-Hafiz

Summary

Affiliation: University of Colorado Denver
Country: USA

Publications

  1. pmc Mechanisms underlying the control of progesterone receptor transcriptional activity by SUMOylation
    Hany Abdel-Hafiz
    Department of Medicine, Division of Endocrinology, University of Colorado Denver, Anschutz Medical Campus, Aurora, Colorado 80045, USA
    J Biol Chem 284:9099-108. 2009
  2. doi request reprint Post-translational modifications of the progesterone receptors
    Hany A Abdel-Hafiz
    Division of Endocrinology, Department of Medicine, Anschutz Medical Campus, University of Colorado Denver, Aurora, CO 80045, USA Electronic address
    J Steroid Biochem Mol Biol 140:80-9. 2014
  3. pmc Control of progesterone receptor transcriptional synergy by SUMOylation and deSUMOylation
    Hany A Abdel-Hafiz
    Division of Endocrinology, Department of Medicine, Anschutz Medical Campus, University of Colorado, Aurora, CO 80045, USA
    BMC Mol Biol 13:10. 2012
  4. pmc Hepatitis B virus X protein impedes the DNA repair via its association with transcription factor, TFIIH
    Ishtiaq Qadri
    NUST Center of Virology and Immunology, National University of Science and Technology, Academic Block, Kashmir Highway, H 12 Islamabad, Pakistan
    BMC Microbiol 11:48. 2011
  5. ncbi request reprint Functional properties of the N-terminal region of progesterone receptors and their mechanistic relationship to structure
    Glenn S Takimoto
    Department of Medicine, Molecular Biology Program, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    J Steroid Biochem Mol Biol 85:209-19. 2003
  6. ncbi request reprint Progesterone receptors (PR)-B and -A regulate transcription by different mechanisms: AF-3 exerts regulatory control over coactivator binding to PR-B
    Lin Tung
    Department of Medicine, RC1 South, 12801 East 17th Avenue, P O Box 6511, Aurora, Colorado 80045, USA
    Mol Endocrinol 20:2656-70. 2006
  7. ncbi request reprint The inhibitory function in human progesterone receptor N termini binds SUMO-1 protein to regulate autoinhibition and transrepression
    Hany Abdel-Hafiz
    Department of Medicine, Molecular Biology Program, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, Denver, CO 80262, USA
    J Biol Chem 277:33950-6. 2002
  8. ncbi request reprint Progesterone receptor action: translating studies in breast cancer models to clinical insights
    Carol A Lange
    Department of Medicine, Division of Hematology, Oncology and Transplant, University of Minnesota Cancer Center, Minneapolis, Minnesota 55455, USA
    Adv Exp Med Biol 630:94-111. 2008

Collaborators

Detail Information

Publications8

  1. pmc Mechanisms underlying the control of progesterone receptor transcriptional activity by SUMOylation
    Hany Abdel-Hafiz
    Department of Medicine, Division of Endocrinology, University of Colorado Denver, Anschutz Medical Campus, Aurora, Colorado 80045, USA
    J Biol Chem 284:9099-108. 2009
    ..In summary, SUMOylation tightly regulates the transcriptional activity of PR by repressing the receptors directly while activating them indirectly through augmented SRC-1 coactivation...
  2. doi request reprint Post-translational modifications of the progesterone receptors
    Hany A Abdel-Hafiz
    Division of Endocrinology, Department of Medicine, Anschutz Medical Campus, University of Colorado Denver, Aurora, CO 80045, USA Electronic address
    J Steroid Biochem Mol Biol 140:80-9. 2014
    ..There is much left to be learned. However, our understanding of this may help to identify therapeutic agents that target PR activity in tissue-specific, even gene-specific ways. ..
  3. pmc Control of progesterone receptor transcriptional synergy by SUMOylation and deSUMOylation
    Hany A Abdel-Hafiz
    Division of Endocrinology, Department of Medicine, Anschutz Medical Campus, University of Colorado, Aurora, CO 80045, USA
    BMC Mol Biol 13:10. 2012
    ..SUMO conjugation of progesterone receptors (PRs) at the N-terminal lysine (K) 388 residue of PR-B is hormone-dependent and suppresses PR-dependent transcription. Mutation of the SUMOylation motif promotes transcriptional synergy...
  4. pmc Hepatitis B virus X protein impedes the DNA repair via its association with transcription factor, TFIIH
    Ishtiaq Qadri
    NUST Center of Virology and Immunology, National University of Science and Technology, Academic Block, Kashmir Highway, H 12 Islamabad, Pakistan
    BMC Microbiol 11:48. 2011
    ..HBx is known to interact with DNA helicase components of TFIIH, a basal transcriptional factor and an integral component of DNA excision repair...
  5. ncbi request reprint Functional properties of the N-terminal region of progesterone receptors and their mechanistic relationship to structure
    Glenn S Takimoto
    Department of Medicine, Molecular Biology Program, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    J Steroid Biochem Mol Biol 85:209-19. 2003
    ..This would explain why PR-B are stronger transactivators than PR-A...
  6. ncbi request reprint Progesterone receptors (PR)-B and -A regulate transcription by different mechanisms: AF-3 exerts regulatory control over coactivator binding to PR-B
    Lin Tung
    Department of Medicine, RC1 South, 12801 East 17th Avenue, P O Box 6511, Aurora, Colorado 80045, USA
    Mol Endocrinol 20:2656-70. 2006
    ..In sum, AF3 in BUS plays a critical modulatory role in PR-B, and in doing so, defines a mechanism for PR-B function that is fundamentally distinct from that of PR-A...
  7. ncbi request reprint The inhibitory function in human progesterone receptor N termini binds SUMO-1 protein to regulate autoinhibition and transrepression
    Hany Abdel-Hafiz
    Department of Medicine, Molecular Biology Program, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, Denver, CO 80262, USA
    J Biol Chem 277:33950-6. 2002
    ..We conclude that autoinhibition and transrepression involve N-terminal sumoylation combined with intramolecular N/C-terminal communication...
  8. ncbi request reprint Progesterone receptor action: translating studies in breast cancer models to clinical insights
    Carol A Lange
    Department of Medicine, Division of Hematology, Oncology and Transplant, University of Minnesota Cancer Center, Minneapolis, Minnesota 55455, USA
    Adv Exp Med Biol 630:94-111. 2008
    ....