Tarek Abbas

Summary

Affiliation: University of Virginia
Country: USA

Publications

  1. pmc p21 in cancer: intricate networks and multiple activities
    Tarek Abbas
    Department of Biochemistry and Molecular Genetics, University of Virginia, School of Medicine, 1340 Jefferson Park Avenue, Charlottesville, VA 22908, USA
    Nat Rev Cancer 9:400-14. 2009
  2. pmc Regulation of TGF-β signaling, exit from the cell cycle, and cellular migration through cullin cross-regulation: SCF-FBXO11 turns off CRL4-Cdt2
    Tarek Abbas
    Department of Radiation Oncology School of Medicine, University of Virginia, Charlottesville, VA, USA
    Cell Cycle 12:2175-82. 2013
  3. pmc CRL4(Cdt2) regulates cell proliferation and histone gene expression by targeting PR-Set7/Set8 for degradation
    Tarek Abbas
    Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, VA 22908, USA
    Mol Cell 40:9-21. 2010
  4. pmc CRL1-FBXO11 promotes Cdt2 ubiquitylation and degradation and regulates Pr-Set7/Set8-mediated cellular migration
    Tarek Abbas
    Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, VA 22908, USA
    Mol Cell 49:1147-58. 2013
  5. pmc Selective ubiquitylation of p21 and Cdt1 by UBCH8 and UBE2G ubiquitin-conjugating enzymes via the CRL4Cdt2 ubiquitin ligase complex
    Etsuko Shibata
    Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, Virginia 22908, USA
    Mol Cell Biol 31:3136-45. 2011
  6. pmc CRL4(Cdt2) E3 ubiquitin ligase monoubiquitinates PCNA to promote translesion DNA synthesis
    Kenta Terai
    Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, VA 22908, USA
    Mol Cell 37:143-9. 2010
  7. pmc Degradation of p12 subunit by CRL4Cdt2 E3 ligase inhibits fork progression after DNA damage
    Kenta Terai
    From the Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, Virginia 22908
    J Biol Chem 288:30509-14. 2013
  8. pmc Genomic instability in cancer
    Tarek Abbas
    Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, Virginia 22908, USA
    Cold Spring Harb Perspect Biol 5:a012914. 2013
  9. pmc The MCM8-MCM9 complex promotes RAD51 recruitment at DNA damage sites to facilitate homologous recombination
    Jonghoon Park
    Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, Virginia, USA
    Mol Cell Biol 33:1632-44. 2013
  10. pmc CRL4Cdt2: master coordinator of cell cycle progression and genome stability
    Tarek Abbas
    Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, VA, USA
    Cell Cycle 10:241-9. 2011

Collaborators

Detail Information

Publications14

  1. pmc p21 in cancer: intricate networks and multiple activities
    Tarek Abbas
    Department of Biochemistry and Molecular Genetics, University of Virginia, School of Medicine, 1340 Jefferson Park Avenue, Charlottesville, VA 22908, USA
    Nat Rev Cancer 9:400-14. 2009
    ....
  2. pmc Regulation of TGF-β signaling, exit from the cell cycle, and cellular migration through cullin cross-regulation: SCF-FBXO11 turns off CRL4-Cdt2
    Tarek Abbas
    Department of Radiation Oncology School of Medicine, University of Virginia, Charlottesville, VA, USA
    Cell Cycle 12:2175-82. 2013
    ..We discuss how this new method of regulating the abundance of Cdt2 participates in various cellular activities...
  3. pmc CRL4(Cdt2) regulates cell proliferation and histone gene expression by targeting PR-Set7/Set8 for degradation
    Tarek Abbas
    Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, VA 22908, USA
    Mol Cell 40:9-21. 2010
    ..These results demonstrate a central role of CRL4(Cdt2)-dependent cell-cycle regulation of Set8 for the maintenance of a stable epigenetic state essential for cell viability...
  4. pmc CRL1-FBXO11 promotes Cdt2 ubiquitylation and degradation and regulates Pr-Set7/Set8-mediated cellular migration
    Tarek Abbas
    Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, VA 22908, USA
    Mol Cell 49:1147-58. 2013
    ..This is an interesting example of cross-regulation between specific Cullin 4 and Cullin 1 E3 ubiquitin ligases and highlights the role of ubiquitylation in regulating cellular responses to TGF-β and the migration of epithelial cells...
  5. pmc Selective ubiquitylation of p21 and Cdt1 by UBCH8 and UBE2G ubiquitin-conjugating enzymes via the CRL4Cdt2 ubiquitin ligase complex
    Etsuko Shibata
    Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, Virginia 22908, USA
    Mol Cell Biol 31:3136-45. 2011
    ..These findings identify the UBCs required for the activity of CRL4(Cdt2) on multiple substrates and demonstrate that different UBCs are involved in the selective ubiquitylation of different substrates by the same E3 complex...
  6. pmc CRL4(Cdt2) E3 ubiquitin ligase monoubiquitinates PCNA to promote translesion DNA synthesis
    Kenta Terai
    Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, VA 22908, USA
    Mol Cell 37:143-9. 2010
    ..We propose that CRL4(Cdt2) regulates PCNA-dependent TLS associated with stresses accompanying DNA replication...
  7. pmc Degradation of p12 subunit by CRL4Cdt2 E3 ligase inhibits fork progression after DNA damage
    Kenta Terai
    From the Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, Virginia 22908
    J Biol Chem 288:30509-14. 2013
    ..These results suggest that ubiquitination of p12 through CRL4(Cdt2) and subsequent degradation form one mechanism by which a cell responds to DNA damage to inhibit fork progression. ..
  8. pmc Genomic instability in cancer
    Tarek Abbas
    Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, Virginia 22908, USA
    Cold Spring Harb Perspect Biol 5:a012914. 2013
    ..In this article, we summarize our current knowledge of how genomic instability arises, with a particular emphasis on how the DNA replication process can give rise to such instability...
  9. pmc The MCM8-MCM9 complex promotes RAD51 recruitment at DNA damage sites to facilitate homologous recombination
    Jonghoon Park
    Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, Virginia, USA
    Mol Cell Biol 33:1632-44. 2013
    ..Thus, these two metazoan-specific MCM homologs are new components of HR and may represent novel targets for treating cancer in combination with DNA cross-linking agents...
  10. pmc CRL4Cdt2: master coordinator of cell cycle progression and genome stability
    Tarek Abbas
    Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, VA, USA
    Cell Cycle 10:241-9. 2011
    ....
  11. pmc PCNA-dependent regulation of p21 ubiquitylation and degradation via the CRL4Cdt2 ubiquitin ligase complex
    Tarek Abbas
    Department of Biochemistry and Molecular Genetics, University of Virginia, School of Medicine, Charlottesville, Virginia 22908, USA
    Genes Dev 22:2496-506. 2008
    ..Finally, we show that the CRL4(Cdt2) and the SCF(Skp2) ubiquitin ligases are redundant with each other in promoting the degradation of p21 during an unperturbed S phase of the cell cycle...
  12. doi request reprint DNA replication and genomic instability
    Wenge Zhu
    Department of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
    Adv Exp Med Biol 570:249-79. 2005
  13. ncbi request reprint Autocatalytic phosphorylation of CDK2 at the activating Thr160
    Tarek Abbas
    Department of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA
    Cell Cycle 6:843-52. 2007
    ..Our results demonstrate that CDK2 is capable of autophosphorylation at Thr160...
  14. ncbi request reprint Differential efficacy of 3-hydroxy-3-methylglutaryl CoA reductase inhibitors on the cell cycle of prostate cancer cells
    Umasundari Sivaprasad
    Department of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
    Mol Cancer Ther 5:2310-6. 2006
    ....