Tarek Abbas

Summary

Affiliation: University of Virginia
Country: USA

Publications

  1. ncbi p21 in cancer: intricate networks and multiple activities
    Tarek Abbas
    Department of Biochemistry and Molecular Genetics, University of Virginia, School of Medicine, 1340 Jefferson Park Avenue, Charlottesville, VA 22908, USA
    Nat Rev Cancer 9:400-14. 2009
  2. ncbi CRL4(Cdt2) regulates cell proliferation and histone gene expression by targeting PR-Set7/Set8 for degradation
    Tarek Abbas
    Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, VA 22908, USA
    Mol Cell 40:9-21. 2010
  3. ncbi Selective ubiquitylation of p21 and Cdt1 by UBCH8 and UBE2G ubiquitin-conjugating enzymes via the CRL4Cdt2 ubiquitin ligase complex
    Etsuko Shibata
    Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, Virginia 22908, USA
    Mol Cell Biol 31:3136-45. 2011
  4. ncbi CRL4Cdt2: master coordinator of cell cycle progression and genome stability
    Tarek Abbas
    Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, VA, USA
    Cell Cycle 10:241-9. 2011
  5. ncbi CRL4(Cdt2) E3 ubiquitin ligase monoubiquitinates PCNA to promote translesion DNA synthesis
    Kenta Terai
    Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, VA 22908, USA
    Mol Cell 37:143-9. 2010
  6. ncbi Autocatalytic phosphorylation of CDK2 at the activating Thr160
    Tarek Abbas
    Department of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA
    Cell Cycle 6:843-52. 2007
  7. ncbi PCNA-dependent regulation of p21 ubiquitylation and degradation via the CRL4Cdt2 ubiquitin ligase complex
    Tarek Abbas
    Department of Biochemistry and Molecular Genetics, University of Virginia, School of Medicine, Charlottesville, Virginia 22908, USA
    Genes Dev 22:2496-506. 2008
  8. ncbi Differential efficacy of 3-hydroxy-3-methylglutaryl CoA reductase inhibitors on the cell cycle of prostate cancer cells
    Umasundari Sivaprasad
    Department of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
    Mol Cancer Ther 5:2310-6. 2006
  9. ncbi DNA replication and genomic instability
    Wenge Zhu
    Department of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
    Adv Exp Med Biol 570:249-79. 2005

Collaborators

Detail Information

Publications9

  1. ncbi p21 in cancer: intricate networks and multiple activities
    Tarek Abbas
    Department of Biochemistry and Molecular Genetics, University of Virginia, School of Medicine, 1340 Jefferson Park Avenue, Charlottesville, VA 22908, USA
    Nat Rev Cancer 9:400-14. 2009
    ....
  2. ncbi CRL4(Cdt2) regulates cell proliferation and histone gene expression by targeting PR-Set7/Set8 for degradation
    Tarek Abbas
    Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, VA 22908, USA
    Mol Cell 40:9-21. 2010
    ..These results demonstrate a central role of CRL4(Cdt2)-dependent cell-cycle regulation of Set8 for the maintenance of a stable epigenetic state essential for cell viability...
  3. ncbi Selective ubiquitylation of p21 and Cdt1 by UBCH8 and UBE2G ubiquitin-conjugating enzymes via the CRL4Cdt2 ubiquitin ligase complex
    Etsuko Shibata
    Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, Virginia 22908, USA
    Mol Cell Biol 31:3136-45. 2011
    ..These findings identify the UBCs required for the activity of CRL4(Cdt2) on multiple substrates and demonstrate that different UBCs are involved in the selective ubiquitylation of different substrates by the same E3 complex...
  4. ncbi CRL4Cdt2: master coordinator of cell cycle progression and genome stability
    Tarek Abbas
    Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, VA, USA
    Cell Cycle 10:241-9. 2011
    ....
  5. ncbi CRL4(Cdt2) E3 ubiquitin ligase monoubiquitinates PCNA to promote translesion DNA synthesis
    Kenta Terai
    Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, VA 22908, USA
    Mol Cell 37:143-9. 2010
    ..We propose that CRL4(Cdt2) regulates PCNA-dependent TLS associated with stresses accompanying DNA replication...
  6. ncbi Autocatalytic phosphorylation of CDK2 at the activating Thr160
    Tarek Abbas
    Department of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA
    Cell Cycle 6:843-52. 2007
    ..Our results demonstrate that CDK2 is capable of autophosphorylation at Thr160...
  7. ncbi PCNA-dependent regulation of p21 ubiquitylation and degradation via the CRL4Cdt2 ubiquitin ligase complex
    Tarek Abbas
    Department of Biochemistry and Molecular Genetics, University of Virginia, School of Medicine, Charlottesville, Virginia 22908, USA
    Genes Dev 22:2496-506. 2008
    ..Finally, we show that the CRL4(Cdt2) and the SCF(Skp2) ubiquitin ligases are redundant with each other in promoting the degradation of p21 during an unperturbed S phase of the cell cycle...
  8. ncbi Differential efficacy of 3-hydroxy-3-methylglutaryl CoA reductase inhibitors on the cell cycle of prostate cancer cells
    Umasundari Sivaprasad
    Department of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
    Mol Cancer Ther 5:2310-6. 2006
    ....
  9. ncbi DNA replication and genomic instability
    Wenge Zhu
    Department of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
    Adv Exp Med Biol 570:249-79. 2005