Nicola Abate

Summary

Affiliation: University of Texas Southwestern Medical Center
Country: USA

Publications

  1. ncbi Ethnicity, type 2 diabetes & migrant Asian Indians
    Nicola Abate
    The Center for Human Nutrition, Department of Internal Medicine, Division of Endocrinology and Metabolism, U T Southwestern Medical Center, Dallas, Texas 75390 9169, USA
    Indian J Med Res 125:251-8. 2007
  2. ncbi Other than potency, are all statins the same?
    Nicola Abate
    Department of Internal Medicine, UT Southwestern Medical Center, 6011 Harry Hines Boulevard, Dallas, TX 75390 9169, USA
    Curr Atheroscler Rep 8:26-31. 2006
  3. ncbi Mechanisms of disease: Ectonucleotide pyrophosphatase phosphodiesterase 1 as a 'gatekeeper' of insulin receptors
    Nicola Abate
    University of Texas Southwestern Medical Center, Dallas 75390 9169, USA
    Nat Clin Pract Endocrinol Metab 2:694-701. 2006
  4. ncbi Should all patients with metabolic syndrome be treated with statins?
    Nicola Abate
    Department of Internal Medicine, Center for Human Nutrition, Division of Endocrinology and Metabolism, UT Southwestern Medical Center at Dallas, 6011 Harry Hines Boulevard, Dallas, TX 75390 9169, USA
    Curr Diab Rep 6:72-6. 2006
  5. ncbi ENPP1/PC-1 K121Q polymorphism and genetic susceptibility to type 2 diabetes
    Nicola Abate
    Department of Medicine, Division of Endocrinology and Metabolism and The Center for Human Nutrition, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9169, USA
    Diabetes 54:1207-13. 2005
  6. ncbi Adipose tissue metabolites and insulin resistance in nondiabetic Asian Indian men
    Nicola Abate
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    J Clin Endocrinol Metab 89:2750-5. 2004
  7. ncbi The metabolic syndrome and uric acid nephrolithiasis: novel features of renal manifestation of insulin resistance
    Nicola Abate
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9169, USA
    Kidney Int 65:386-92. 2004
  8. ncbi Genetic polymorphism PC-1 K121Q and ethnic susceptibility to insulin resistance
    Nicola Abate
    Center for Human Nutrition and the Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Clin Endocrinol Metab 88:5927-34. 2003
  9. ncbi The impact of ethnicity on type 2 diabetes
    Nicola Abate
    Center for Human Nutrition, UT Southwestern Medical Center at Dallas, USA
    J Diabetes Complications 17:39-58. 2003
  10. ncbi Sex steroid hormones, upper body obesity, and insulin resistance
    Nicola Abate
    Center for Human Nutrition, Department of Internal Medicine, Division of Endocrinology and Metabolism, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Clin Endocrinol Metab 87:4522-7. 2002

Collaborators

Detail Information

Publications34

  1. ncbi Ethnicity, type 2 diabetes & migrant Asian Indians
    Nicola Abate
    The Center for Human Nutrition, Department of Internal Medicine, Division of Endocrinology and Metabolism, U T Southwestern Medical Center, Dallas, Texas 75390 9169, USA
    Indian J Med Res 125:251-8. 2007
    ..This review examines epidemiological and pathophysiological aspects of the interaction between environment and ethnic predisposition to type 2 diabetes in Asian Indians migrated to the US...
  2. ncbi Other than potency, are all statins the same?
    Nicola Abate
    Department of Internal Medicine, UT Southwestern Medical Center, 6011 Harry Hines Boulevard, Dallas, TX 75390 9169, USA
    Curr Atheroscler Rep 8:26-31. 2006
    ..This review evaluates the available information on potential differences among statins in non-lipid effects...
  3. ncbi Mechanisms of disease: Ectonucleotide pyrophosphatase phosphodiesterase 1 as a 'gatekeeper' of insulin receptors
    Nicola Abate
    University of Texas Southwestern Medical Center, Dallas 75390 9169, USA
    Nat Clin Pract Endocrinol Metab 2:694-701. 2006
    ..Understanding the mechanisms that regulate E-NPP1 expression and/or function might render this protein a new target for strategies to treat and prevent type 2 diabetes and cardiovascular disease...
  4. ncbi Should all patients with metabolic syndrome be treated with statins?
    Nicola Abate
    Department of Internal Medicine, Center for Human Nutrition, Division of Endocrinology and Metabolism, UT Southwestern Medical Center at Dallas, 6011 Harry Hines Boulevard, Dallas, TX 75390 9169, USA
    Curr Diab Rep 6:72-6. 2006
    ..This review looks at the clinical trial evidence to support the use of statins in metabolic syndrome...
  5. ncbi ENPP1/PC-1 K121Q polymorphism and genetic susceptibility to type 2 diabetes
    Nicola Abate
    Department of Medicine, Division of Endocrinology and Metabolism and The Center for Human Nutrition, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9169, USA
    Diabetes 54:1207-13. 2005
    ....
  6. ncbi Adipose tissue metabolites and insulin resistance in nondiabetic Asian Indian men
    Nicola Abate
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    J Clin Endocrinol Metab 89:2750-5. 2004
    ..These differences may contribute to the excessive prevalence of type 2 diabetes and cardiovascular disease in nonobese Asian Indians...
  7. ncbi The metabolic syndrome and uric acid nephrolithiasis: novel features of renal manifestation of insulin resistance
    Nicola Abate
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9169, USA
    Kidney Int 65:386-92. 2004
    ....
  8. ncbi Genetic polymorphism PC-1 K121Q and ethnic susceptibility to insulin resistance
    Nicola Abate
    Center for Human Nutrition and the Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Clin Endocrinol Metab 88:5927-34. 2003
    ..This finding indicates the need for expanded studies on the association between PC-1 K121Q and insulin resistance in a representative sample of the Asian Indian population...
  9. ncbi The impact of ethnicity on type 2 diabetes
    Nicola Abate
    Center for Human Nutrition, UT Southwestern Medical Center at Dallas, USA
    J Diabetes Complications 17:39-58. 2003
    ..This review examines epidemiological and pathophysiological aspects of the interaction between environment and ethnic predisposition to type 2 diabetes...
  10. ncbi Sex steroid hormones, upper body obesity, and insulin resistance
    Nicola Abate
    Center for Human Nutrition, Department of Internal Medicine, Division of Endocrinology and Metabolism, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Clin Endocrinol Metab 87:4522-7. 2002
    ..Low plasma levels of bioavailable testosterone do not independently predict excessive insulin resistance, beta-cell dysfunction, or hepatic glucose output in normogonadal men...
  11. ncbi Elevated plasma high-sensitivity C-reactive protein concentrations in Asian Indians living in the United States
    Manisha Chandalia
    Center for Human Nutrition, Department of Internal Medicine, Division of Endocrinology and Metabolism, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9169, USA
    J Clin Endocrinol Metab 88:3773-6. 2003
    ....
  12. pmc Adipose tissue dysfunction in humans: a potential role for the transmembrane protein ENPP1
    Manisha Chandalia
    Department of Medicine, Division of Endocrinology, University of Texas Medical Branch at Galveston, Texas 77555 1060, USA
    J Clin Endocrinol Metab 97:4663-72. 2012
    ....
  13. ncbi Ethnic differences in the frequency of ENPP1/PC1 121Q genetic variant in the Dallas Heart Study cohort
    Manisha Chandalia
    Division of Endocrinology and Metabolism and The Center for Human Nutrition, Department of Medicine, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 9169, USA
    J Diabetes Complications 21:143-8. 2007
    ..Ethnic differences in ENPP1 121Q allele frequency may contribute to the increased susceptibility to type 2 diabetes observed in US minority groups...
  14. pmc ENPP1/PC-1 K121Q and other predictors of posttransplant diabetes
    Magdalene Szuszkiewicz
    The Center for Human Nutrition, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, USA
    Metab Syndr Relat Disord 9:25-9. 2011
    ..78). We conclude that black race and age are major and not modifiable risk factors for PTDM. The specific role of ENPP1 K121Q on ethnic susceptibility to PTDM deserves further investigation in larger cohorts of transplanted patients...
  15. pmc Insulin resistance and body fat distribution in South Asian men compared to Caucasian men
    Manisha Chandalia
    Departments of Internal Medicine, Endocrinology and Metabolism, Center for Human Nutrition, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, United States of America
    PLoS ONE 2:e812. 2007
    ..South Asians are susceptible to insulin resistance even without obesity. We examined the characteristics of body fat content, distribution and function in South Asian men and their relationships to insulin resistance compared to Caucasians...
  16. pmc Fat distribution and insulin resistance in young adult nonobese Asian Indian women
    Magdalene Szuszkiewicz-Garcia
    Department of Internal Medicine, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, USA
    Metab Syndr Relat Disord 10:326-30. 2012
    ..In conclusion, we demonstrate that young Asian Indian women do not have excess abdominal or intraperitoneal fat or insulin resistance for similar BMI compared to white women of European descent...
  17. pmc Metabolic consequences of ENPP1 overexpression in adipose tissue
    Wentong Pan
    Department of Medicine, Division of Endocrinology, University of Texas Medical Branch at Galveston, Galveston, Texas 77555 1060, USA
    Am J Physiol Endocrinol Metab 301:E901-11. 2011
    ..Thus, our results show that, in the presence of a high-fat diet, ENPP1 overexpression in adipocytes induces fatty liver, hyperlipidemia, and dysglycemia, thus recapitulating key manifestations of the metabolic syndrome...
  18. doi Ethnic difference in sex gap in high-density lipoprotein cholesterol between Asian Indians and Whites
    Manisha Chandalia
    Department of Medicine, Division of Endocrinology and Metabolism and The Center for Human Nutrition, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 9169, USA
    J Investig Med 56:574-80. 2008
    ....
  19. ncbi Hyperhomocysteinemia in Asian Indians living in the United States
    Manisha Chandalia
    Center for Human Nutrition, Department of Internal Medicine, Division of Endocrinology and Metabolism, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9169, USA
    J Clin Endocrinol Metab 88:1089-95. 2003
    ..Lower plasma concentrations of vitamin B-12 and lower insulin sensitivity may contribute to this finding but only partially explained the ethnic-related hyperhomocysteinemia of the Asian Indians...
  20. pmc Body fat distribution and insulin resistance
    Pavankumar Patel
    Division of Endocrinology, Department of Internal Medicine, University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555, USA
    Nutrients 5:2019-27. 2013
    ..Therapeutic lifestyle change continues to be the most important intervention in clinical practice to improve adipose tissue function and avoid development of insulin resistance and related cardio-metabolic complications...
  21. ncbi Diet composition and the metabolic syndrome: what is the optimal fat intake?
    Scott M Grundy
    Center for Human Nutrition, University of Texas Southwestern Medical Center, Dallas, Texas 75235, USA
    Am J Med 113:25S-29S. 2002
    ....
  22. pmc Role of subcutaneous adipose tissue in the pathogenesis of insulin resistance
    Pavankumar Patel
    Department of Medicine, Division of Endocrinology and Institute for Translational Science ITS, University of Texas Medical Branch at Galveston, Galveston, TX 77555 1060, USA
    J Obes 2013:489187. 2013
    ....
  23. pmc Adipose tissue collagen and inflammation in nonobese Asian Indian men
    Alejandro Munoz
    Division of Endocrinology and Metabolism, Department of Medicine, University of Texas Medical Branch, Galveston, Texas 77555 1060, USA
    J Clin Endocrinol Metab 98:E1360-3. 2013
    ..The objective of this study was to determine whether these AT abnormalities can be found independent of obesity in the presence of systemic insulin resistance...
  24. ncbi Pathophysiology of uric acid nephrolithiasis
    Orson W Moe
    Department of Internal Medicine, Center for Mineral Metabolism and Clinical Research, Center of Human Nutrition, University of Texas Southwestern Medical Center, Department of Veteran Affairs Medical Center, Dallas, TX, USA
    Endocrinol Metab Clin North Am 31:895-914. 2002
    ..A novel renal manifestation of insulin resistance is a mild defect in ammonium excretion, which is not severe enough to disturb acid-base homeostasis, but is sufficient to set up the chemical milieu for uric acid nephrolithiasis...
  25. pmc Dietary obesity-induced Egr-1 in adipocytes facilitates energy storage via suppression of FOXC2
    Jifeng Zhang
    Cardiovascular Center, Department of Internal Medicine, University of Michigan Medical Center, MSRB III 7301E, 1150 W Medical Center Drive, Ann Arbor, MI 48109, USA
    Sci Rep 3:1476. 2013
    ..Altogether, these studies suggest an important role for Egr-1, which, by repressing FOXC2 expression, promotes energy storage in WAT and favored the development of obesity under high energy intake...
  26. ncbi Metabolic complications of obesity: inflated or inflamed?
    Manisha Chandalia
    Department of Medicine, Division of Endocrinology and Metabolism, Dallas, TX 75390 9169, USA
    J Diabetes Complications 21:128-36. 2007
    ..Our efforts in establishing markers to identify "at risk" population and finding newer therapeutic agents must focus on adipose tissue dysfunction and not on obesity alone...
  27. ncbi Effect of ezetimibe/simvastatin versus atorvastatin or rosuvastatin on modifying lipid profiles in patients with diabetes, metabolic syndrome, or neither: Results of two subgroup analyses
    Nicola Abate
    University of Texas Southwestern Medical Center, Dallas, TX
    J Clin Lipidol 2:91-105. 2008
    ..Patients with diabetes mellitus (DM) and metabolic syndrome (MS) are at increased risk of developing coronary heart disease...
  28. ncbi Do current body mass index criteria for obesity surgery reflect cardiovascular risk?
    Edward H Livingston
    Division of Gastrointestinal and Endocrine Surgery, Department of Surgery, University of Texas Southwestern School of Medicine, Dallas, Texas 75390, USA
    Surg Obes Relat Dis 3:577-85. 2007
    ..We hypothesized that the inconsistencies among the studies of the obesity-cardiovascular relationship were attributable to an irregular relationship between obesity and the presence of risk factors for CVD...
  29. ncbi Screening and biochemical analysis of GATA4 sequence variations identified in patients with congenital heart disease
    Marie K Schluterman
    Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9148, USA
    Am J Med Genet A 143:817-23. 2007
    ....
  30. ncbi Dose-comparison study of the combination of ezetimibe and simvastatin (Vytorin) versus atorvastatin in patients with hypercholesterolemia: the Vytorin Versus Atorvastatin (VYVA) study
    Christie M Ballantyne
    Department of Medicine, Baylor College of Medicine, Houston, Tex, USA
    Am Heart J 149:464-73. 2005
    ..This study tested the hypothesis that ezetimibe/simvastatin, a lipid-lowering agent that inhibits both intestinal cholesterol absorption and cholesterol synthesis, provides greater LDL-C reductions than atorvastatin across dose ranges...
  31. ncbi The ENPP1 K121Q polymorphism is associated with type 2 diabetes in European populations: evidence from an updated meta-analysis in 42,042 subjects
    Jarred B McAteer
    Diabetes Unit Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA 02114, USA
    Diabetes 57:1125-30. 2008
    ..We therefore conducted a new meta-analysis that includes novel unpublished data from the ENPP1 Consortium and recent negative findings from large association studies to address the contribution of K121Q to type 2 diabetes...
  32. ncbi The Q121/Q121 genotype of ENPP1/PC-1 is associated with lower BMI in non-diabetic whites
    Sabrina Prudente
    Unit of Diabetes and Endocrinology, Scientific Institute Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy
    Obesity (Silver Spring) 15:1-4. 2007
    ..008). These data suggest that the QQ genotype of the ENPP1/PC-1 gene is associated with lower BMI. If similar results are confirmed in prospective studies, the K121Q polymorphism may help identify people at risk for obesity...
  33. ncbi Role of genetic polymorphism peroxisome proliferator-activated receptor-gamma2 Pro12Ala on ethnic susceptibility to diabetes in South-Asian and Caucasian subjects: Evidence for heterogeneity
    Venkatesan Radha
    Department of Molecular Genetics, Madras Diabetes Research Foundation, Dr Mohan s Diabetes Specialties Centre, No 4, Conran Smith Road, Gopalapuram, Chennai 86, India
    Diabetes Care 29:1046-51. 2006
    ..To determine whether the peroxisome proliferator-activated receptor (PPAR)-gamma Pro12ala polymorphism modulates susceptibility to diabetes in South Asians...
  34. ncbi Therapy and clinical trials
    Nicola Abate
    Curr Opin Lipidol 13:457-60. 2002