Research Topics
Genomes and GenesSpecies | Nicola AbateSummaryAffiliation: University of Texas Southwestern Medical Center Country: USA Publications
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Publications
Other than potency, are all statins the same?Nicola Abate
Department of Internal Medicine, UT Southwestern Medical Center, 6011 Harry Hines Boulevard, Dallas, TX 75390 9169, USA
Curr Atheroscler Rep 8:26-31. 2006..This review evaluates the available information on potential differences among statins in non-lipid effects...- Mechanisms of disease: Ectonucleotide pyrophosphatase phosphodiesterase 1 as a 'gatekeeper' of insulin receptorsNicola Abate
University of Texas Southwestern Medical Center, Dallas 75390 9169, USA
Nat Clin Pract Endocrinol Metab 2:694-701. 2006..Understanding the mechanisms that regulate E-NPP1 expression and/or function might render this protein a new target for strategies to treat and prevent type 2 diabetes and cardiovascular disease... - ENPP1/PC-1 K121Q polymorphism and genetic susceptibility to type 2 diabetesNicola Abate
Department of Medicine, Division of Endocrinology and Metabolism and The Center for Human Nutrition, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9169, USA
Diabetes 54:1207-13. 2005.... - Adipose tissue metabolites and insulin resistance in nondiabetic Asian Indian menNicola Abate
Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
J Clin Endocrinol Metab 89:2750-5. 2004..These differences may contribute to the excessive prevalence of type 2 diabetes and cardiovascular disease in nonobese Asian Indians... - The metabolic syndrome and uric acid nephrolithiasis: novel features of renal manifestation of insulin resistanceNicola Abate
Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9169, USA
Kidney Int 65:386-92. 2004.... - Genetic polymorphism PC-1 K121Q and ethnic susceptibility to insulin resistanceNicola Abate
Center for Human Nutrition and the Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
J Clin Endocrinol Metab 88:5927-34. 2003..This finding indicates the need for expanded studies on the association between PC-1 K121Q and insulin resistance in a representative sample of the Asian Indian population... - Ethnicity, type 2 diabetes & migrant Asian IndiansNicola Abate
The Center for Human Nutrition, Department of Internal Medicine, Division of Endocrinology and Metabolism, U T Southwestern Medical Center, Dallas, Texas 75390 9169, USA
Indian J Med Res 125:251-8. 2007..This review examines epidemiological and pathophysiological aspects of the interaction between environment and ethnic predisposition to type 2 diabetes in Asian Indians migrated to the US... - The impact of ethnicity on type 2 diabetesNicola Abate
Center for Human Nutrition, UT Southwestern Medical Center at Dallas, USA
J Diabetes Complications 17:39-58. 2003..This review examines epidemiological and pathophysiological aspects of the interaction between environment and ethnic predisposition to type 2 diabetes... - Sex steroid hormones, upper body obesity, and insulin resistanceNicola Abate
Center for Human Nutrition, Department of Internal Medicine, Division of Endocrinology and Metabolism, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
J Clin Endocrinol Metab 87:4522-7. 2002..Low plasma levels of bioavailable testosterone do not independently predict excessive insulin resistance, beta-cell dysfunction, or hepatic glucose output in normogonadal men... - Should all patients with metabolic syndrome be treated with statins?Nicola Abate
Department of Internal Medicine, Center for Human Nutrition, Division of Endocrinology and Metabolism, UT Southwestern Medical Center at Dallas, 6011 Harry Hines Boulevard, Dallas, TX 75390 9169, USA
Curr Diab Rep 6:72-6. 2006..This review looks at the clinical trial evidence to support the use of statins in metabolic syndrome... - Elevated plasma high-sensitivity C-reactive protein concentrations in Asian Indians living in the United StatesManisha Chandalia
Center for Human Nutrition, Department of Internal Medicine, Division of Endocrinology and Metabolism, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390-9169, USA
J Clin Endocrinol Metab 88:3773-6. 2003.... - Ethnic differences in the frequency of ENPP1/PC1 121Q genetic variant in the Dallas Heart Study cohortManisha Chandalia
Division of Endocrinology and Metabolism and The Center for Human Nutrition, Department of Medicine, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 9169, USA
J Diabetes Complications 21:143-8. 2007..Ethnic differences in ENPP1 121Q allele frequency may contribute to the increased susceptibility to type 2 diabetes observed in US minority groups... - ENPP1/PC-1 K121Q and other predictors of posttransplant diabetesMagdalene Szuszkiewicz
The Center for Human Nutrition, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, USA
Metab Syndr Relat Disord 9:25-9. 2011..78). We conclude that black race and age are major and not modifiable risk factors for PTDM. The specific role of ENPP1 K121Q on ethnic susceptibility to PTDM deserves further investigation in larger cohorts of transplanted patients... - Insulin resistance and body fat distribution in South Asian men compared to Caucasian menManisha Chandalia
Departments of Internal Medicine, Endocrinology and Metabolism, Center for Human Nutrition, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, United States of America
PLoS ONE 2:e812. 2007..South Asians are susceptible to insulin resistance even without obesity. We examined the characteristics of body fat content, distribution and function in South Asian men and their relationships to insulin resistance compared to Caucasians... - Metabolic consequences of ENPP1 overexpression in adipose tissueWentong Pan
Department of Medicine, Division of Endocrinology, University of Texas Medical Branch at Galveston, Galveston, Texas 77555 1060, USA
Am J Physiol Endocrinol Metab 301:E901-11. 2011..Thus, our results show that, in the presence of a high-fat diet, ENPP1 overexpression in adipocytes induces fatty liver, hyperlipidemia, and dysglycemia, thus recapitulating key manifestations of the metabolic syndrome... - Ethnic difference in sex gap in high-density lipoprotein cholesterol between Asian Indians and WhitesManisha Chandalia
Department of Medicine, Division of Endocrinology and Metabolism and The Center for Human Nutrition, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 9169, USA
J Investig Med 56:574-80. 2008.... - Hyperhomocysteinemia in Asian Indians living in the United StatesManisha Chandalia
Center for Human Nutrition, Department of Internal Medicine, Division of Endocrinology and Metabolism, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9169, USA
J Clin Endocrinol Metab 88:1089-95. 2003..Lower plasma concentrations of vitamin B-12 and lower insulin sensitivity may contribute to this finding but only partially explained the ethnic-related hyperhomocysteinemia of the Asian Indians... - Diet composition and the metabolic syndrome: what is the optimal fat intake?Scott M Grundy
Center for Human Nutrition, University of Texas Southwestern Medical Center, Dallas, Texas 75235, USA
Am J Med 113:25S-29S. 2002.... - Pathophysiology of uric acid nephrolithiasisOrson W Moe
Department of Internal Medicine, Center for Mineral Metabolism and Clinical Research, Center of Human Nutrition, University of Texas Southwestern Medical Center, Department of Veteran Affairs Medical Center, Dallas, TX, USA
Endocrinol Metab Clin North Am 31:895-914. 2002..A novel renal manifestation of insulin resistance is a mild defect in ammonium excretion, which is not severe enough to disturb acid-base homeostasis, but is sufficient to set up the chemical milieu for uric acid nephrolithiasis... - Metabolic complications of obesity: inflated or inflamed?Manisha Chandalia
Department of Medicine, Division of Endocrinology and Metabolism, Dallas, TX 75390 9169, USA
J Diabetes Complications 21:128-36. 2007..Our efforts in establishing markers to identify "at risk" population and finding newer therapeutic agents must focus on adipose tissue dysfunction and not on obesity alone... - Fat distribution and insulin resistance in young adult nonobese asian Indian womenMagdalene Szuszkiewicz-Garcia
1 Department of Internal Medicine, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas
Metab Syndr Relat Disord 10:326-30. 2012..In conclusion, we demonstrate that young Asian Indian women do not have excess abdominal or intraperitoneal fat or insulin resistance for similar BMI compared to white women of European descent... - Screening and biochemical analysis of GATA4 sequence variations identified in patients with congenital heart diseaseMarie K Schluterman
Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9148, USA
Am J Med Genet A 143:817-23. 2007.... - Dose-comparison study of the combination of ezetimibe and simvastatin (Vytorin) versus atorvastatin in patients with hypercholesterolemia: the Vytorin Versus Atorvastatin (VYVA) studyChristie M Ballantyne
Department of Medicine, Baylor College of Medicine, Houston, Tex, USA
Am Heart J 149:464-73. 2005..Ezetimibe/simvastatin is a highly efficacious, well-tolerated treatment option for hypercholesterolemic patients... - Effect of ezetimibe/simvastatin versus atorvastatin or rosuvastatin on modifying lipid profiles in patients with diabetes, metabolic syndrome, or neither: Results of two subgroup analysesNicola Abate
University of Texas Southwestern Medical Center, Dallas, TX
J Clin Lipidol 2:91-105. 2008..Patients with diabetes mellitus (DM) and metabolic syndrome (MS) are at increased risk of developing coronary heart disease... - Do current body mass index criteria for obesity surgery reflect cardiovascular risk?Edward H Livingston
Division of Gastrointestinal and Endocrine Surgery, Department of Surgery, University of Texas Southwestern School of Medicine, Dallas, Texas 75390, USA
Surg Obes Relat Dis 3:577-85. 2007..We hypothesized that the inconsistencies among the studies of the obesity-cardiovascular relationship were attributable to an irregular relationship between obesity and the presence of risk factors for CVD... - The ENPP1 K121Q polymorphism is associated with type 2 diabetes in European populations: evidence from an updated meta-analysis in 42,042 subjectsJarred B McAteer
Diabetes Unit Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA 02114, USA
Diabetes 57:1125-30. 2008..We therefore conducted a new meta-analysis that includes novel unpublished data from the ENPP1 Consortium and recent negative findings from large association studies to address the contribution of K121Q to type 2 diabetes... - The Q121/Q121 genotype of ENPP1/PC-1 is associated with lower BMI in non-diabetic whitesSabrina Prudente
Unit of Diabetes and Endocrinology, Scientific Institute Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy
Obesity (Silver Spring) 15:1-4. 2007..008). These data suggest that the QQ genotype of the ENPP1/PC-1 gene is associated with lower BMI. If similar results are confirmed in prospective studies, the K121Q polymorphism may help identify people at risk for obesity... - Role of genetic polymorphism peroxisome proliferator-activated receptor-gamma2 Pro12Ala on ethnic susceptibility to diabetes in South-Asian and Caucasian subjects: Evidence for heterogeneityVenkatesan Radha
Department of Molecular Genetics, Madras Diabetes Research Foundation, Dr Mohan s Diabetes Specialties Centre, No 4, Conran Smith Road, Gopalapuram, Chennai 86, India
Diabetes Care 29:1046-51. 2006..To determine whether the peroxisome proliferator-activated receptor (PPAR)-gamma Pro12ala polymorphism modulates susceptibility to diabetes in South Asians... - Therapy and clinical trialsNicola Abate
Curr Opin Lipidol 13:457-60. 2002