Genomes and Genes
University of Nebraska Medical Center
Organization: University of Nebraska Medical Center
- Clinical implications of novel activating EGFR mutations in malignant peritoneal mesotheliomaJason M Foster
Department of Surgery, Creighton Cancer Center, Creighton University, Omaha, NE, USA
World J Surg Oncol 8:88. 2010..Here we present the mutant EGFR activating potential and the matured survival data of the EGFR mutant(mut+) relative to wild type EGFR(mut-) mesothelioma...
- Two cases of Norwalk virus enteritis following small bowel transplantation treated with oral human serum immunoglobulinDiana F Florescu
Section of Infectious Diseases, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE 68198 5400, USA
Pediatr Transplant 12:372-5. 2008..Protracted diarrhea is a challenging problem after small bowel transplantation. We report two patients who developed Norwalk virus enteritis after small bowel transplantation. Both received oral HSIG with resolution of diarrhea within 48 h...
- Effects of ethanol on hepatic cellular replication and cell cycle progressionDahn L Clemens
Department of Internal Medicine, University of Nebraska Medical Center and Veterans Affairs Medical Center, Omaha Nebraska 68105, USA
World J Gastroenterol 13:4955-9. 2007..It is the goal of this article to review the mechanisms by which ethanol metabolism mediates impairment of hepatic replication...
- Retransplantation for hepatitis C: results of a U.S. multicenter retransplant studyTimothy McCashland
Department of Hepatology, University of Nebraska Medical Center, Omaha, NE 68198 3285, USA
Liver Transpl 13:1246-53. 2007..MELD scores were not predictive of post-reTX survival. Survival was <50% in the non-HCV reTx group with MELD score of >30. Many patients with recurrent HCV are not considered for reTX and die from recurrent disease...
- A challenge for regenerative medicine: proper genetic programming, not cellular mimicryAngie Rizzino
Eppley Institute for Research in Cancer and Allied Diseases, Department of Pathology and Microbiology, University of Nebraska Medical Center, Nebraska Medical Center, Omaha, Nebraska 68198 6805, USA
Dev Dyn 236:3199-207. 2007..This review further argues that progress in regenerative medicine will be significantly hampered by failing to address the issue of cellular look-alikes...
- Hematopoietic stem cell transplantation for Hodgkin's disease in a patient with dysfibrinogenemia and thrombosisApar Kishor Ganti
Department of Internal Medicine, Section of Oncology Hematology, University of Nebraska Medical Center, 987680 Nebraska Medical Center, Omaha, NE 68198 7680, USA
J Thromb Thrombolysis 23:155-8. 2007..Management of patients with dysfibrinogenemia and a thrombotic tendency usually involves long-term anticoagulation...
- Pharmacological management of a teen with significant alcohol use and depressionChristopher J Kratochvil
Department of Psychiatry, University of Nebraska Medical Center, Omaha, NE 68198 5581, USA
J Am Acad Child Adolesc Psychiatry 45:1011-5. 2006
- Comparison of nanogel drug carriers and their formulations with nucleoside 5'-triphosphatesSerguei V Vinogradov
Center for Drug Delivery and Nanomedicine, and College of Pharmacy, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA
Pharm Res 23:920-30. 2006..The aim of the study is to synthesize and characterize nanogel carriers composed of amphiphilic polymers and cationic polyethylenimine for encapsulation and delivery of cytotoxic nucleoside analogs 5'-triphosphates (NTPs) into cancer cells...
- Isolated liver transplantation in infants with end-stage liver disease due to short bowel syndromeJean F Botha
Department of Surgery, Section of Organ Transplantation, University of Nebraska Medical Center, Omaha, NE 68918 3285, USA
Liver Transpl 12:1062-6. 2006..65 to 3.05). In conclusion, Isolated liver transplantation in children with liver failure as a result of SBS, who have favorable prognostic features for full enteral adaptation, is feasible with satisfactory long-term survival...
- Cognitive impairment in people diagnosed with end-stage liver disease evaluated for liver transplantationJames H Sorrell
Department of Psychiatry, University of Nebraska Medical Center, Nebraska 68198 8470, USA
Psychiatry Clin Neurosci 60:174-81. 2006..Furthermore, the presence of these cognitive impairments predicted disability independent of the severity of the underlying liver disease...
- Recruiting and enrolling pregnant adolescents for researchMargaret M Kaiser
Medical Center College of Nursing, University of Nebraska, Omaha, Nebraska 68198 5330, USA
Issues Compr Pediatr Nurs 29:45-52. 2006..Recommendations for sampling strategies for future research are offered...
- Mobius syndrome: a dental hygiene case study and review of the literatureMichelle L Sensat
Department of Dental Hygiene, College of Dentistry, University of Nebraska Medical Center, Lincoln, NB, USA
Int J Dent Hyg 1:62-7. 2003..This article reviews the case study of a 40-year-old male client with Mobius syndrome, dental hygiene diagnosis (DHDx) and intervention, and the dental hygienists' responsibility and role in care...
- Cardiac sympathetic afferent reflexes in heart failureW Wang
Department of Physiology and Biophysics, University of Nebraska College of Medicine, Omaha, NE 68198 4575, USA
Heart Fail Rev 5:57-71. 2000....
- Reflections on teaching health care ethics on the webToby L Schonfeld
Section on Humanities and Law Preventive and Societal Medicine, University of Nebraska Medical Center, Omaha 68198 6075, USA
Sci Eng Ethics 11:481-94. 2005..Building an online community is another good way to increase the interaction of students and their engagement with the material...
- A randomized, placebo-controlled trial of citalopram for the prevention of major depression during treatment for head and neck cancerWilliam M Lydiatt
Department of Otolaryngology Head and Neck Surgery, University of Nebraska Medical Center, Omaha, NE 68198 1225, USA
Arch Otolaryngol Head Neck Surg 134:528-35. 2008..To determine whether prophylactic treatment with the antidepressant citalopram hydrobromide, compared with placebo, could prevent major depressive disorder in patients undergoing therapy for head and neck cancer (HNC)...
- The effect of sodium thiosulfate administration on nephrocalcinosis in a rat modelChad A Lagrange
Division of Urology, Department of Surgery, University of Kentucky Medical Center, Lexington, Kentucky, USA
J Endourol 23:529-33. 2009..We proposed a rat model to evaluate whether STS has any possible beneficial effect on calcium nephrolithiasis or nephrocalcinosis...
- The experience of spouses as informal caregivers for recipients of hematopoietic stem cell transplantsMargaret E Wilson
College of Nursing, University of Nebraska Medical Center, Omaha, NE 68198 5330, USA
Cancer Nurs 32:E15-23. 2009..Spouses structured the uncertainty with rituals, formed a positive perspective, and envisioned the future. They described a caregiving role but also needed to balance "me and my world" with "us and our world."..
- Maintenance of activity and eating change after a clinical trial of tailored newsletters with older rural womenSusan Noble Walker
College of Nursing, University of Nebraska Medical Center, Omaha, NE 68198, USA
Nurs Res 59:311-21. 2010....
- HIV-associated neurocognitive disorders in sub-Saharan Africa: a pilot study in CameroonGeorgette D Kanmogne
Department of Pharmacology and Experimental Neurosciences, University of Nebraska Medical Center, Omaha, NE, USA
BMC Neurol 10:60. 2010..The objectives of this study were to determine whether Western neuropsychological (NP) methods are appropriate for use in Cameroon, and to evaluate cognitive function in a sample of HIV-infected adults...
- Acquisition of mands and tacts with concurrent echoic trainingTiffany Kodak
MUNROE MEYER INSTITUTE AND UNIVERSITY OF NEBRASKA MEDICAL CENTER, Omaha, Nebraska 68198, USA
J Appl Behav Anal 42:839-43. 2009..Results indicated that combining echoic training with mand or tact training increased unprompted manding and tacting...
- A quick esthetic remount cast for all-ceramic restorationsPaul A Hansen
Department of Restorative Dentistry, University of Nebraska Medical Center, College of Dentistry, Lincoln, NE 68583 0750, USA
J Prosthodont 19:494-6. 2010..The remount cast allows the laboratory technician to know the precise location of the gingival tissues and allows modification of all-ceramic restorations...
- Structural approach to the aging of phosphylated cholinesterasesPatrick Masson
Centre de Recherches du Service de Sante des Armees, Dept Toxicology, 38702 La Tronche Cedex, France
Chem Biol Interact 187:157-62. 2010..Knowledge of the molecular basis of aging will help to design reactivators of aged ChEs, molecules capable of slowing the aging process, and pseudocatalytic ChE-based bioscavengers...
- Myocardial perfusion imaging with contrast ultrasoundThomas R Porter
University of Nebraska Medical Center, Cardiology, 981165 Nebraska Medical Center, Omaha, Nebraska 68198 1165, USA
JACC Cardiovasc Imaging 3:176-87. 2010..A review of the clinical studies that have examined the clinical utility of myocardial perfusion imaging with MCE during rest and stress echocardiography is then presented. The limitations of MCE are also discussed...
- Effect of 5-S-GAD on UV-B-induced cataracts in ratsHiroyoshi Kawada
Department of Ophthalmology, Kanazawa Medical University, Ishikawa, Japan
Jpn J Ophthalmol 53:531-5. 2009..This is a report of an investigation of the effect of 5-S-GAD (eyedrops) on UVB-induced cataracts in rats...
- Rurality and other determinants of early colorectal cancer diagnosis in Nebraska: a 6-year cancer registry study, 1998-2003Jayashri Sankaranarayanan
College of Pharmacy, University of Nebraska Medical Center, Omaha, NE 68198 6045, USA
J Rural Health 25:358-65. 2009..There are no studies of rurality, and other determinants of colorectal cancer (CRC) stage at diagnosis with population-based data from the Midwest...
- The renal vascular response to diabetesPamela K Carmines
University of Nebraska College of Medicine, Omaha, Nebraska, USA
Curr Opin Nephrol Hypertens 19:85-90. 2010..This review will summarize recent advances (published January 2008 through June 2009) regarding the renal vascular and glomerular functional changes that occur during the early stage of diabetes...
- Excretion of antimicrobials used to treat methicillin-resistant Staphylococcus aureus infections during lactation: safety in breastfeeding infantsJennifer A Mitrano
Department of Pharmacy Practice, School of Pharmacy, Massachusetts College of Pharmacy and Health Sciences, Worcester, Massachusetts 01608, USA
Pharmacotherapy 29:1103-9. 2009....
- Assessment of noise exposure in a hospital kitchenChandran Achutan
Department of Environmental, Agricultural and Occupational Health, College of Public Health, Omaha, NE 68198, USA
Noise Health 11:145-50. 2009....
- Collar spine models in the genus Echinostoma (Trematoda: Echinostomatidae)Ivan Kanev
H W Manter Laboratory of Parasitology, University of Nebraska, W 529 Nebraska Hall, Lincoln, NE 68588, USA
Parasitol Res 105:921-7. 2009..Reports of even numbered spine counts in the genus Echinostoma are erroneous and probably reflect counts on worms with lost, retracted, or supernumerary spines...
- Inpatient hospital service utilization of the uninsured in Nebraska: policy implications for addressing uncompensated careLi Wu Chen
Department of Health Services Research and Administration, College of Public Health, University of Nebraska Medical Center, 984350 Nebraska Medical Center, Omaha, NE 68198 4350, USA
J Health Care Poor Underserved 20:444-57. 2009..The study may have a wide application to other states examining the same policy issues. The model used in this study can be easily created for other states, as the required data are readily available...
- MMP-12 has a role in abdominal aortic aneurysms in miceG Matthew Longo
Department of Surgery, University of Nebraska Medical Center, 8111 Dodge Street, Omaha, NE 68114, USA
Surgery 137:457-62. 2005..Matrix metalloproteinase (MMP)-12 levels are increased in the abdominal aortic aneurysm (AAA), implicating this protease in AAA pathogenesis. The purpose of this study was to assess the role of MMP-12 in aneurysm formation...
- ERK-MAP-kinases differentially regulate expression of IL-23 p19 compared with p40 and IFN-beta in Theiler's virus-infected RAW264.7 cellsThomas M Petro
Department of Oral Biology, The Nebraska Center for Virology, University of Nebraska Medical Center, Lincoln, NE 68583, USA
Immunol Lett 97:47-53. 2005..Interestingly, U0126 prolonged TMEV-induced ATF-2 activation to at least 3h. Thus ERK MAPKs regulate expression of TMEV-induced p19 differently than p40 and IFN-beta suggesting the benefits of U0126 in treatment of DD...
- Isolated liver transplantation in infants with end-stage liver disease associated with short bowel syndromeSimon P Horslen
Department of Pediatrics, University of Nebraska, Omaha, Nebraska 68198 3285, USA
Ann Surg 235:435-9. 2002..To evaluate experience with isolated orthotopic liver transplantation in children with liver failure associated with short bowel syndrome (SBS)...
- Feasibility and safety of outpatient Bexxar therapy (tositumomab and iodine I 131 tositumomab) for non-Hodgkin's lymphoma based on radiation doses to family membersF J Rutar
University of Nebraska Medical Center, Omaha 68198 5480, USA
Clin Lymphoma 2:164-72. 2001..In a University of Nebraska Medical Center study, the predicted total radiation doses (based on patient dose rate at 1 meter) ranged from 95-..
- What did we learn about student and faculty "backlash" to the Interdisciplinary Generalist Curriculum Project?D Steele
Year 1 Curriculum Director, College of Medicine, University of Nebraska Medical Center, 983075 Nebraska Medical Center, Omaha, NE 68198 3075, USA
Acad Med 76:S61-7. 2001....
- Mechanisms of immune dysfunction in stem cell transplantationJ E Talmadge
Department of Pathology and Microbiology, University of Nebraska, 987660 Nebraska Medical Center, Omaha, NE 68198 7660, USA
Int J Immunopharmacol 22:1041-56. 2000..Therefore, there is the potential to regulate immune recovery by stem cell product manipulation or post-transplantation cytokine administration...
- Mononuclear phagocytes mediate blood-brain barrier compromise and neuronal injury during HIV-1-associated dementiaY Persidsky
Center for Neurovirology and Neurodegenerative Disorders, The Department of Pathology, University of Nebraska Medical Center, Omaha 68198 5215, USA
J Leukoc Biol 68:413-22. 2000..In toto, these works underscore the diverse roles of chemokines in HIV-1 neuropathogenesis and lay the foundation for future therapeutic interventions...
- IL-8 expression in malignant melanoma: implications in growth and metastasisR K Singh
Department of Pathology and Microbiology, University of Nebraska Medical Center, Nebraska Medical Center, Omaha 68198 5660, USA
Histol Histopathol 15:843-9. 2000..Understanding these events and their significance will allow us to design novel therapeutic approaches for treatment of melanoma...
- Ultrastructure of the blood and lymphatic capillaries of the respiratory tissue during inflammation and endobronchial laser therapyV V Polosukhin
Laboratory of Ultrastructural Research, Russian Academy of Medical Sciences, Novosibirsk, Russia
Ultrastruct Pathol 24:183-9. 2000..Basic principles of pathogenetic therapy were stated. It was shown that low-energy laser irradiation satisfies these requirements as an additional method in the therapy of destructive lung diseases...
- Nitric oxide-dependent ethanol stimulation of ciliary motility is linked to cAMP-dependent protein kinase (PKA) activation in bovine bronchial epitheliumJ H Sisson
Department of Internal Medicine, University of Nebraska Medical Center, Omaha 68198 5300, USA
Alcohol Clin Exp Res 23:1528-33. 1999..Because many agonists stimulate ciliary motility through activation of cyclic nucleotide-dependent protein kinases, we hypothesized that ethanol stimulates ciliary motility by activating protein kinases...
- Acute versus chronic effects of brimonidine on aqueous humor dynamics in ocular hypertensive patientsC B Toris
Department of Ophthalmology, University of Nebraska Medical Center, Omaha 68198 5540, USA
Am J Ophthalmol 128:8-14. 1999..To report the acute vs chronic effects of brimonidine, a selective alpha2-adrenergic receptor agonist, on aqueous humor dynamics in ocular hypertensive patients...
- Association of malondialdehyde-acetaldehyde (MAA) adducted proteins with atherosclerotic-induced vascular inflammatory injuryG E Hill
Department of Internal Medicine, University of Nebraska Medical Center, Omaha 68198 4455, USA
Atherosclerosis 141:107-16. 1998..These data further suggest that previous studies demonstrating MDA modified protein in atherosclerotic plaque may in fact have MAA modified proteins associated with them...
- Transdermal nicotine therapy and primary care. Importance of counseling, demographic, and participant selection factors on 1-year quit rates. The Nebraska Primary Practice Smoking Cessation Trial GroupD Daughton
Department of Internal Medicine, University of Nebraska Medical Center, Omaha, USA
Arch Fam Med 7:425-30. 1998..To evaluate the smoking cessation efficacy of nicotine patch therapy as an adjunct to low-intensity, primary care intervention...
- Human immunodeficiency virus type 1-like DNA sequences and immunoreactive viral particles with unique association with breast cancerE M Rakowicz-Szulczynska
Departments of Obstetrics and Gynecology, University of Nebraska Medical Center, Omaha, Nebraska, USA
Clin Diagn Lab Immunol 5:645-53. 1998..Viral particles detected in breast cancer cell lines were strongly immunogold labeled with the anti-HIV-1 gp120 MAb. The results obtained strongly suggest that the long-postulated breast cancer virus may, in fact, be related to HIV-1...
- International classification for nursing practice (ICNP): most-frequently asked questionsJ J Warren
University of Nebraska, Omaha, USA
J Am Med Inform Assoc 5:335-6. 1998..The authors answer the most-frequently asked questions about the ICNP and encourage nurses in the United States to participate in the revision by sending comments and suggestions to the American Nurses Association...
- Autoimmune enteropathy in a child: response to infliximab therapyJon A Vanderhoof
Department of Pediatrics, University of Nebraska Medical Center, Creighton University, Omaha, Nebraska, USA
J Pediatr Gastroenterol Nutr 34:312-6. 2002
- A unified mechanism in the initiation of cancerErcole L Cavalieri
Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska 68198 6805, USA
Ann N Y Acad Sci 959:341-54. 2002..Thus, a unifying mechanism, namely formation of catechol quinones and reaction with DNA, could initiate not only cancer by oxidation of specific endogenous estrogen metabolites, but also leukemia by oxidation of benzene...
- Diabetic kidney disease: impact of pubertyPascale H Lane
Department of Pediatrics, University of Nebraska Medical Center, Omaha 68198 2169, USA
Am J Physiol Renal Physiol 283:F589-600. 2002..A better understanding of these processes may lead to new treatments to prevent renal failure in diabetes mellitus...
- Ethanol consumption potentiates viral pancreatitis and may inhibit pancreas regeneration: preliminary findingsDahn L Clemens
Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE 68198 8090, USA
Alcohol 33:183-9. 2004..We believe that this model will be a valuable tool to study the biochemical and molecular mechanisms involved in alcoholic pancreatitis...
- Chloride equilibrium potential in salamander conesWallace B Thoreson
Department of Ophthalmology, University of Nebraska Medical Center, Omaha, NE, USA
BMC Neurosci 5:53. 2004..To assess the impact of these and other chloride-dependent mechanisms on release from cones, the chloride equilibrium potential (ECl) was determined in red-sensitive, large single cones from the tiger salamander retinal slice...
- Endoscopic therapy for gastroesophageal reflux disease: can it replace antireflux surgery?D Oleynikov
Department of Surgery, University of Nebraska Medical Center, Omaha, NE 68198 3280, USA
Minerva Chir 59:427-35. 2004..Endoscopic treatment of GERD has future promise, however, more experience and perhaps further refinement in techniques and technology must occur before widespread clinical application can be encouraged...
- Neuroregulatory events follow adaptive immune-mediated elimination of HIV-1-infected macrophages: studies in a murine model of viral encephalitisLarisa Poluektova
Laboratory of Neuroregeneration, Center for Neurovirology and Neurodegenerative Disorders, and Department of Pathology and Microbiology, University of Nebraska Medical Center, 958215 Nebraska Medical Center, Omaha, NE 68198 5215, USA
J Immunol 172:7610-7. 2004..This murine model of HIV-1 encephalitis can be useful in elucidating the role played by innate and adaptive immunity in disease progression and resolution...
- Monoclonal antibody against mouse CAR following genetic immunizationSteven D Carson
Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska 68198 6495, USA
Hybrid Hybridomics 23:19-22. 2004..Since CAR has been shown to form dimers, expression of human CAR in cells that express mouse CAR may have stimulated the host immune system to recognize endogenous CAR in heterodimers...
- Self-monitoring as an intervention to decrease swimmers' stroke countsJodi Polaha
Munroe Meyer Institute, University of Nebraska Medical Center, 68198 5450, USA
Behav Modif 28:261-75. 2004..Limitations of the research, mechanisms of change, and implications for coaches are discussed...
- The work covenant: a management strategy for department chairs and program directorsTimothy M Durham
Department of Dental Practice Management, University of Nebraska Medical Center College of Dentistry, Omaha, NE 69198 9375, USA
J Dent Educ 68:55-63. 2004....
- Contemporary ceramics for dentistryThomas J Salinas
Department of Otolaryngology, University of Nebraska Medical Center, Omaha, Nebraska, USA
Pract Proced Aesthet Dent 15:690. 2003
- Mechanical response of the porcine temporomandibular joint disc to an impact event and repeated tensile loadingMark W Beatty
Department of Adult Restorative Dentistry, College of Dentistry, 40th and Holdrege, PO Box 830740, Lincoln, Nebraska 68583 0750, USA
J Orofac Pain 17:160-6. 2003..To test for orthotropy in the stress-strain behavior of the temporomandibular joint (TMJ) disc under repeated physiologic loading before and after an impact event...
- Medical malpractice and the thyroid glandDaniel D Lydiatt
Department of Otolaryngology, University of Nebraska Medical Center and Methodist Cancer Center, Omaha, Nebraska 68198 1225, USA
Head Neck 25:429-31. 2003..A medical malpractice litigation "crisis" exists in this country. Analyzing litigation trends through verdict summaries may help understand causes...
- Treatment-related myelodysplasia and acute leukemia in non-Hodgkin's lymphoma patientsJames O Armitage
University of Nebraska College of Medicine, Omaha, NE 68198 3332, USA
J Clin Oncol 21:897-906. 2003..However, there is considerable debate over the incidence or risk of tMDS/AML in NHL patients treated with any particular modality and the factors that contribute to malignant transformation...
- Pharmacokinetics and clinical use of drotrecogin alfa (activated) in patients with severe sepsisKeith M Olsen
Department of Pharmacy Practice, College of Pharmacy, University of Nebraska Medical Center, Omaha, Nebraska 68198 6045, USA
Pharmacotherapy 22:196S-205S. 2002..As further data on drotrecogin alfa (activated) therapy become available, dosing and monitoring strategies may be altered to optimize the clinical benefits...
- The study of temporomandibular disorders and orofacial pain from the perspective of the predoctoral dental curriculumRon Attanasio
Department of Dental Practice Management, College of Dentistry, University of Nebraska Medical Center, 40th and Holdrege Streets, Lincoln, NE 68583 0740, USA
J Orofac Pain 16:176-80. 2002..Indeed, an international survey relative to the teaching of TMD and orofacial pain would be of interest and value to dental schools worldwide...
- Gas exchange and lung mechanics during percutaneous transtracheal ventilation in an unparalyzed canine modelT P Tran
Department of Surgery, University of Nebraska Medical Center, Omaha 68198 1150, USA
Acad Emerg Med 5:320-4. 1998..To compare the efficacy of percutaneous transtracheal ventilation (PTV) in the unparalyzed state with that in the paralyzed state using a sedated nonobstructed canine model...
- Pharmacological Treatment of ADHD in Young ChildrenChristopher Kratochvil; Fiscal Year: 2007..Burke, M.D., Professor of Psychiatry at the University of Nebraska Medical Center, will serve as Co-Primary Mentors for the Award...
- Nebraska Blood and Marrow Transplant Research NetworkJulie Vose; Fiscal Year: 2007..End of abstract.) ..
- Fatigue & Breast Cancer-A Behavioral Sleep InterventionAnn Berger; Fiscal Year: 2006..Statistical analyses include RM-ANOVA, generalized estimation equation methodology and multiple regression analysis. Results may inform development of clinical guidelines for fatigue management during adjuvant CT. ..
- Sleep Disturbances in People with Cancer and CaregiversAnn Berger; Fiscal Year: 2004..abstract_text> ..
- NICOTINE INDUCED CEREBROVASCULAR DYSFUNCTIONWILLIAM MAYHAN; Fiscal Year: 2006..In addition, results of these studies may provide insights regarding possible therapeutic approaches for the treatment of nicotine-induced vascular dysfunction. ..
- Cerebral Microcirculation During Alcohol ConsumptionWILLIAM MAYHAN; Fiscal Year: 2007..These studies will provide valuable new insights and will lead to new therapeutic approaches for the treatment of cerebrovascular abnormalities observed in chronic alcoholics. ..
- Cerebrovascular Disease in Type 1 DiabetesWILLIAM MAYHAN; Fiscal Year: 2007..We suggest that our results will provide novel insights regarding therapeutic approaches for the treatment/prevention of cerebrovascular dysfunction in diabetes. ..
- CEREBRAL MICROCIRCULATON DURING ALCOHOL CONSUMPTIONWILLIAM MAYHAN; Fiscal Year: 2002....
- Influence of ExT on Cerebrovacsular Dysfunction in T1DWilliam G Mayhan; Fiscal Year: 2010..Our studies will be the first to examine the potential therapeutic benefits of ExT on brain function during T1D. ..
- RA Comorbidity Bone Health in Men and African AmericansTed Mikuls; Fiscal Year: 2007..Mikuls' continued development as an independent clinical investigator. ..
- Gene-Environment Interactions in RA Autoimmunity and Disease SeverityTed Mikuls; Fiscal Year: 2007..We anticipate that the results of this study will be extended to other RA populations. ..
- Regulation of photoreceptor neurotransmissionWALLACE THORESON; Fiscal Year: 2009..An understanding of normal retinal physiology is also needed for restoring vision to diseased eyes by the use of retinal stem cells, prosthetic devices, or other means. ..
- Regulation of photoreceptor neurotransmissionWALLACE THORESON; Fiscal Year: 2007..g., accompanying ischemia) can have excitotoxic consequences on post-synaptic neurons. ..
- Regulation of photoreceptor neurotransmissionWALLACE BRUCE THORESON; Fiscal Year: 2010..An understanding of normal retinal physiology is also needed for restoring vision to diseased eyes by the use of retinal stem cells, prosthetic devices, or other means. ..
- Regulation of photoreceptor neurotransmission.WALLACE THORESON; Fiscal Year: 2003..Thus, understanding the intrinsic mechanisms in rods and cones that regulate ICa, intracellular Ca2+ levels, and synaptic transmission is important for understanding the physiology of both diseased and normal retina. ..
- Airway Injury Caused by MAA AdductsTodd A Wyatt; Fiscal Year: 2010....
- Airway Injury Caused by MAA AdductsTODD WYATT; Fiscal Year: 2009....
- Interactions of Pluronic block copolymers in drug resistant cancerAlexander Kabanov; Fiscal Year: 2007..As a result, the critical knowledge will be acquired on the activities of a novel chemotherapeutic agent composition that has promise in improving treatment of cancer patents. ..
- Polypeptide modification for enhanced brain deliveryALEXANDER V contact KABANOV; Fiscal Year: 2010..The goal is achieved by modification of polypeptides with Pluronic copolymers (poly(ethylene oxide)- b-poly(propylene oxide)-b-poly(ethylene oxide)). ..
- MOLECULAR ORIGIN OF CANCER--CATECHOL/SEMIQUINOE/QUINONEErcole Cavalieri; Fiscal Year: 2003..In addition, we will identify biomarkers for use in diagnosis and in studies of prevention of breast cancer and other diseases. ..
- MECHANISMS OF CARCINOGENESIS OF DIBENZO(A,1)PYRENEErcole Cavalieri; Fiscal Year: 1993..The data obtained from the chemistry, tumorigenicity, DNA-binding studies and oncogene activation will provide significant clues concerning the mechanism of carcinogenesis of DB[a,l]P...
- Molecular Orgin Cancer--Catechol Estrogen 3 4 QuinonesErcole Cavalieri; Fiscal Year: 2004..The knowledge acquired from these studies will be essential for developing preventive strategies. ..
- Pluronic Block Copolymers in Drug Resistant CancerAlexander Kabanov; Fiscal Year: 2004....
- Polypeptide modification for enhanced brain deliveryAlexander Kabanov; Fiscal Year: 2007..The prospective in the development of a specific drug (leptin) for treatment in a specific disease (obesity) will also be determined. ..