University of Colorado Health Sciences Center

..We studied the epidemiology of the scaphoid fracture using a large database in a military population...

..Furthermore, the ultimate goal of some epigenetic modifications might well turn out to be the regulation of histone occupancy on the DNA...

..NH residents tend to be older, suffer from multiple conditions, and take numerous medications, increasing their risk of serious complications. This article examines pharmacotherapy in a rural, tribally owned NH...

..The purpose of this study was to determine if CHRNA7 promoter allelic variants are also associated with abnormal P50 ratios in persons with schizoaffective disorder, bipolar type...

..C. This paper summarizes the content of the working groups charged with providing strategic direction for the future of technology for persons with cognitive disabilities...

..To assess the HIV serostatus of injection drug users (IDU) in Ukraine, as well as associations between serostatus and selected demographic and risk factors...

..Although there may be challenges to achieving the vision of home-based disease management, there are tremendous potential benefits of such an approach for reducing the global burden of cardiovascular disease...

..This is the first reported case of Mycoplasma endocarditis in a child and suggests consideration of this organism as a cause of culture-negative endocarditis...

..In this study we examined the effects of insulin and oxidant stress on Egr-1 expression in vascular smooth muscle cells (VSMC), and identified mechanisms for these effects on Egr-1...

..The trip is a long one and is only about to begin but the train is leaving. Are you on board?..

..We investigated the safety and immunogenicity of 2 doses of hepatitis A virus (HAV) vaccine followed by a booster dose in HIV-infected children receiving stable highly active antiretroviral therapy...

..Of these, calcium oxalate stones are the most predominant. This review will focus only on the pathogenesis and medical management of calcium oxalate stones...

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..Radiologists should consider this diagnosis particularly in young children with hypothalamic tumors that lack the typical cystic appearance seen in PA...

..While short-term or adjuvant use of magnesium carbonate appears safe and effective as a phosphate binder, more studies are needed to evaluate the long-term effects on vascular calcification, bone histology, and mortality...

..In this study we sought to validate urinary biomarkers for diabetes and two common complications, coronary artery disease (CAD) and diabetic nephropathy (DN)...

..Cost-identification analysis with retrospective and calculated cost...

..This is of particular concern in the case of spinal cord injury, where recent studies have shown that transplanted neuroepithelial stem cells can generate pain syndromes...

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..The mechanisms underlying these effects are only partially understood. Hence, the current discussion of the interaction of EtOH and NO is presented...

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..To examine the early adaptation challenges and strengths of young mothers with preterm infants...

..Laboratory testing generally relies on basal hormone levels; however, timing of blood sampling in relation to menses is important to interpretation of the data...

..It is clear, therefore, that just the right amount of the essential nutrients is required to produce optimal outcome; this is as true for the preterm infant as it is for the fetus...

..Two health status measures for adults with diabetes are compared in order to identify gender-based differences between norm-based scores for health status and self-rated health scores...

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..This is the oldest reported case with confirmation of a GFAP mutation. Onset was late in the sixth decade. Genetic analysis of the GFAP gene is recommended in cases of progressive ataxia and palatal tremor...

..Our aim was to assess the effect of treatment of obese subjects with orlistat 120 mg 3 times a day for 6 weeks on fecal lipid and bile acid parameters and colonic mucosal cell proliferation...

..Intensity-modulated radiotherapy has become a mainstay in head and neck cancer treatment, and the authors discuss several popular and emerging approaches. Patient immobilization and imaging are also discussed...

..We assessed cross-sectional validity of EQ-5D after myocardial infarction (MI)...

..Therefore, pharmacokinetic studies are an important component to understanding the therapeutic variability of docetaxel-containing chemotherapeutic regimens...

..It is vital for nurse practitioners to document both the quality and the costs of their care in order to compete with physicians and other health care providers, in order to influence policy and other health-care decision makers...

..Protection from mutational disease in a fashion similar to the use of sanitation for infectious disease appears practical...

..Our results suggest that oxidative lung leak may be altered by the availability of reactive iron and that ferritin may contribute to protection against oxidative lung injury...

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..Because circulating free fatty acids were greatly elevated at all times after the prolonged fast, these may be mediating some of the changes in postprandial metabolism...

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..There was generally no change in the severity of synovial hyperplasia after the procedure. We conclude that MRI evaluation is not routinely indicated prior to radiosynoviorthesis...

..Future directions for research are recommended. Implications of the model for nursing, including an environmental activist role in an interdisciplinary effort to plan and implement noise abatement interventions, are described...

..Recent discoveries show that several of these mutations directly affect components in the pathway of organelle-specific protein trafficking, and provide new insights into the relationships of these pathways in mammals, flies and yeast...

..Results should provide new insights into the mechanisms underlying the progression of breast cancer to hormone resistance, and may suggest strategies for delaying or reversing this process...

..We hypothesized that strategies aimed at inhibiting NFkappaB would abrogate mitogen-induced human VSMC proliferation...

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..At this point in time we consider TDM in the treatment of HIV-infection as experimental with significant promise for the future...

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..There were no significant differences in gender or ethnicity in perceived levels of family communication and parental school support...

..To compare the prevalence, awareness, treatment, and control of hypertension in a population-representative sample of adults with type 1 diabetes and comparable nondiabetic control subjects...

..The elevated CRP levels may provide an additional marker for risk of progression to type 1 diabetes...

..Together these studies provide a molecular and cellular framework for understanding the process of milk lipid formation...

..This report describes a coding scheme developed to analyze how some American Indians changed their drinking behavior and explores the contributions of this approach to our understanding of natural recovery in American-Indian communities...

..The University of Colorado Health Sciences Center School of Medicine has developed a successful interdepartmental research effort in primary ..

..These data indicate that differential expression of the PE/PPE genes has the potential to provide a dynamic antigenic profile during the course of changing microenvironments within the host...

..In conclusion, though treatment with prostanoids is complicated by their generally short half-lives and complicated drug delivery systems, they continue to play an important role in the treatment of PAH...

..The purpose of this study is to develop an improved algorithm for measuring the position of the diaphragm using navigator echoes...

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..In conclusion, gender differences in insulin resistance-associated fat distribution may explain why type 1 diabetes increases coronary calcification in women relatively more than in men...

..Further, judicious application of zinc stable-isotope techniques could make an important contribution to progress toward the eradication of zinc deficiency in infants and young children in the developing world...

..These analyses will define the role of TREG in the inadequate CMV immune reconstitution of HAART recipients. ..

..With completion of the LDLT Cohort Study, the medical community will have a much clearer understanding of the impact of this important procedure on liver transplantation, LDLT recipients and LDLT donors. ..

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..Understanding latency will lead to approaches designed to prevent the cascade of events leading to virus reactivation, a cause of serious neurologic disease in the rapidly increasing elderly and immunocompromised populations. ..

..Upon completion, post-doctorals are qualified to begin junior faculty positions as independent investigators to study neurovirologic or molecular biologic aspects of neurologic diseases. ..

..Understanding latency will lead to approaches designed to prevent the cascade of events leading to virus reactivation, a cause of serious neurologic disease in the rapidly increasing elderly and immunocompromised populations. ..

..These studies will yield information on the molecular basis of viral latency and reactivation which in turn provides the foundation for future studies designed to eradicate neurologic disease in the elderly produced by VZV...

..These studies will yield information on the molecular basis of viral latency and reactivation which in turn provides the foundation for future studies designed to eradicate neurologic disease in the elderly produced by VZV...

..The results of this project will improve a tool that has already been shown to have great potential for helping reduce the high rates of obesity in children. ..

..This program would help abate the national shortage of skilled child psychiatry researchers. ..

..The results of this project will improve a tool that has already been shown to have great potential for helping reduce the high rates of obesity in children. ..

..These procedures will enable us to analyze the effects of the intervention on serious cardiovascular- related factors and complications, and cost-effectiveness of the intervention. ..

..SPEM testing, behavioral and symptom evaluations, and peer adjustment assessments will be repeated 2 years after entry into the study. This will help differentiate these possibilities (aim #4 of this proposal). ..

..Whether and to what extent body fat accumulation will be maintained or increased will ultimately depend on whether or not there are compensatory changes in energy intake and/or energy expenditure. ..

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..The results will help identify the changes required in current dietary and physical activity patterns if we are going to be successful in preventing the development of obesity. ..

..Clarification of this methodology may lead to a novel prenatal intervention strategy designed to decrease risk for adolescent and adult onset of psychosis. ..

..Linkage in both groups will assessed using methods capable of detecting genetic effects on quantitative traits. ..

..In summary, these studies should increase our understanding of the role of amount and composition of dietary fat in producing obesity and the metabolic derangements that often accompany it...