Xiaoming Zhou

Summary

Affiliation: Uniformed Services University of the Health Sciences
Country: USA

Publications

  1. ncbi request reprint Gliotoxin-induced cytotoxicity proceeds via apoptosis and is mediated by caspases and reactive oxygen species in LLC-PK1 cells
    X Zhou
    Department of Medicine, Uniformed Services University, Bethesda, Maryland 20814, USA
    Toxicol Sci 54:194-202. 2000
  2. pmc Contribution of SHP-1 protein tyrosine phosphatase to osmotic regulation of the transcription factor TonEBP/OREBP
    Xiaoming Zhou
    Division of Nephrology, Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
    Proc Natl Acad Sci U S A 107:7072-7. 2010
  3. ncbi request reprint Mitochondrial reactive oxygen species contribute to high NaCl-induced activation of the transcription factor TonEBP/OREBP
    Xiaoming Zhou
    Div of Nephrology, Uniformed Services Univ of the Health Sciences, Bethesda, MD 20814, USA
    Am J Physiol Renal Physiol 290:F1169-76. 2006
  4. ncbi request reprint Hydrogen peroxide mediates FK506-induced cytotoxicity in renal cells
    Xiaoming Zhou
    Division of Nephrology, Department of Medicine, Uniformed Services University, Bethesda, Maryland 20814, USA
    Kidney Int 65:139-47. 2004
  5. ncbi request reprint Stimulation of Na,K-ATPase by low potassium requires reactive oxygen species
    Xiaoming Zhou
    Department of Medicine, Uniformed Services University, 4301 Jones Bridge Rd, Bethesda, MD 20814, USA
    Am J Physiol Cell Physiol 285:C319-26. 2003
  6. ncbi request reprint Inhibition of Na,K-ATPase activates PI3 kinase and inhibits apoptosis in LLC-PK1 cells
    X Zhou
    Division of Nephrology, Uniformed Services University, Bethesda, Maryland 20814, USA
    Biochem Biophys Res Commun 285:46-51. 2001
  7. pmc Rac1/osmosensing scaffold for MEKK3 contributes via phospholipase C-gamma1 to activation of the osmoprotective transcription factor NFAT5
    Xiaoming Zhou
    Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
    Proc Natl Acad Sci U S A 108:12155-60. 2011
  8. ncbi request reprint Increased reactive oxygen species contribute to high NaCl-induced activation of the osmoregulatory transcription factor TonEBP/OREBP
    Xiaoming Zhou
    Division of Nephrology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
    Am J Physiol Renal Physiol 289:F377-85. 2005
  9. pmc High NaCl- and urea-induced posttranslational modifications that increase glycerophosphocholine by inhibiting GDPD5 phosphodiesterase
    Supachai Topanurak
    Systems Biology Center, National Heart, Lung, and Blood Institute, and Department of Medicine, Uniformed Services University, Bethesda, MD 20892 1603
    Proc Natl Acad Sci U S A 110:7482-7. 2013
  10. pmc Water restriction increases renal inner medullary manganese superoxide dismutase (MnSOD)
    Xiaoming Zhou
    Department of Medicine, Uniformed Services University, 4301 Jones Bridge Rd, Bethesda, MD 20814, USA
    Am J Physiol Renal Physiol 303:F674-80. 2012

Detail Information

Publications14

  1. ncbi request reprint Gliotoxin-induced cytotoxicity proceeds via apoptosis and is mediated by caspases and reactive oxygen species in LLC-PK1 cells
    X Zhou
    Department of Medicine, Uniformed Services University, Bethesda, Maryland 20814, USA
    Toxicol Sci 54:194-202. 2000
    ....
  2. pmc Contribution of SHP-1 protein tyrosine phosphatase to osmotic regulation of the transcription factor TonEBP/OREBP
    Xiaoming Zhou
    Division of Nephrology, Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
    Proc Natl Acad Sci U S A 107:7072-7. 2010
    ..Thus, TonEBP/OREBP is extensively regulated by phosphatases, including SHP-1, whose inhibition by high NaCl increases phosphorylation of TonEBP/OREBP at Y143, contributing to the nuclear localization and activation of TonEBP/OREBP...
  3. ncbi request reprint Mitochondrial reactive oxygen species contribute to high NaCl-induced activation of the transcription factor TonEBP/OREBP
    Xiaoming Zhou
    Div of Nephrology, Uniformed Services Univ of the Health Sciences, Bethesda, MD 20814, USA
    Am J Physiol Renal Physiol 290:F1169-76. 2006
    ..We conclude that high NaCl increases mitochondrial ROS production, which contributes to the activation of TonEBP/OREBP by increasing its transactivating activity...
  4. ncbi request reprint Hydrogen peroxide mediates FK506-induced cytotoxicity in renal cells
    Xiaoming Zhou
    Division of Nephrology, Department of Medicine, Uniformed Services University, Bethesda, Maryland 20814, USA
    Kidney Int 65:139-47. 2004
    ..The present study was undertaken to determine the role of hydrogen peroxide in FK506-mediated cytotoxicity in a porcine renal proximal tubular cell line, LLC-PK1 cells, and human embryonic kidney (HEK293) cells...
  5. ncbi request reprint Stimulation of Na,K-ATPase by low potassium requires reactive oxygen species
    Xiaoming Zhou
    Department of Medicine, Uniformed Services University, 4301 Jones Bridge Rd, Bethesda, MD 20814, USA
    Am J Physiol Cell Physiol 285:C319-26. 2003
    ....
  6. ncbi request reprint Inhibition of Na,K-ATPase activates PI3 kinase and inhibits apoptosis in LLC-PK1 cells
    X Zhou
    Division of Nephrology, Uniformed Services University, Bethesda, Maryland 20814, USA
    Biochem Biophys Res Commun 285:46-51. 2001
    ..These data together indicate that inhibition of Na,K-ATPase activates PI3 kinase in LLC-PK1 cells which could then exert the cytoprotective effect...
  7. pmc Rac1/osmosensing scaffold for MEKK3 contributes via phospholipase C-gamma1 to activation of the osmoprotective transcription factor NFAT5
    Xiaoming Zhou
    Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
    Proc Natl Acad Sci U S A 108:12155-60. 2011
    ..Similarly, dominant-negative Rac1 also does not inhibit TonEBP/OREBP in PLC-γ1-null cells unless PLC-γ1 is reconstituted. We conclude that Rac1/OSM supports TonEBP/OREBP activity and that this activity is mediated via PLC-γ1, not p38...
  8. ncbi request reprint Increased reactive oxygen species contribute to high NaCl-induced activation of the osmoregulatory transcription factor TonEBP/OREBP
    Xiaoming Zhou
    Division of Nephrology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
    Am J Physiol Renal Physiol 289:F377-85. 2005
    ..We conclude that the high NaCl-induced increase in ROS, including superoxide, contributes to activation of TonEBP/OREBP by increasing its transactivation...
  9. pmc High NaCl- and urea-induced posttranslational modifications that increase glycerophosphocholine by inhibiting GDPD5 phosphodiesterase
    Supachai Topanurak
    Systems Biology Center, National Heart, Lung, and Blood Institute, and Department of Medicine, Uniformed Services University, Bethesda, MD 20892 1603
    Proc Natl Acad Sci U S A 110:7482-7. 2013
    ..iii) Alteration at an unknown site mediated by CDK1. Inhibition of CDK1 protein kinase reduces GDE-PDE activity of GDPD5 without altering phosphorylation at T587, and CDK1/5 inhibitor reduces activity of GDPD5- C25S/C571S-T587A...
  10. pmc Water restriction increases renal inner medullary manganese superoxide dismutase (MnSOD)
    Xiaoming Zhou
    Department of Medicine, Uniformed Services University, 4301 Jones Bridge Rd, Bethesda, MD 20814, USA
    Am J Physiol Renal Physiol 303:F674-80. 2012
    ..We conclude that ROS, induced by high NaCl and urea, increase MnSOD activity in the renal inner medulla, which moderates oxidative stress...
  11. pmc MKP-1 inhibits high NaCl-induced activation of p38 but does not inhibit the activation of TonEBP/OREBP: opposite roles of p38alpha and p38delta
    Xiaoming Zhou
    Division of Nephrology, Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
    Proc Natl Acad Sci U S A 105:5620-5. 2008
    ....
  12. pmc Inhibitory phosphorylation of GSK-3β by AKT, PKA, and PI3K contributes to high NaCl-induced activation of the transcription factor NFAT5 (TonEBP/OREBP)
    Xiaoming Zhou
    Department of Medicine, Uniformed Services University, 4301 Jones Bridge Rd, Bethesda, MD 20814, USA
    Am J Physiol Renal Physiol 304:F908-17. 2013
    ..When activated by high NaCl, PKA, PI3K, and AKT1, but not p38α, increase phosphorylation of GSK-3β-S9, which reduces the inhibitory effect of GSK-3β on NFAT5, and thus contributes to activation of NFAT5...
  13. pmc High NaCl-induced inhibition of PTG contributes to activation of NFAT5 through attenuation of the negative effect of SHP-1
    Xiaoming Zhou
    Dept of Medicine, Uniformed Services Univ of the Health Sciences, 4301 Jones Bridge Rd, Bethesda, MD 20814
    Am J Physiol Renal Physiol 305:F362-9. 2013
    ..Our findings add to the known functions of PTG, which was previously recognized only for its glycogenic activity. ..
  14. pmc Fibronectin fibrillogenesis regulates three-dimensional neovessel formation
    Xiaoming Zhou
    The Division of Molecular Medicine and Genetics, Department of Internal Medicine, The Life Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109, USA
    Genes Dev 22:1231-43. 2008
    ..These results advance a new model wherein Fn polymerization serves as a structural scaffolding that displays adhesive ligands on a mechanically ideal substratum for promoting neovessel development...