Mang Xiao

Summary

Affiliation: Uniformed Services University of the Health Sciences
Country: USA

Publications

  1. ncbi request reprint 5-Androstenediol promotes survival of gamma-irradiated human hematopoietic progenitors through induction of nuclear factor-kappaB activation and granulocyte colony-stimulating factor expression
    Mang Xiao
    Radiation Countermeasures Program, Armed Forces Radiobiology Research Institute, 8901 Wisconsin Ave, Bethesda, MD 20889 5603, USA
    Mol Pharmacol 72:370-9. 2007
  2. doi request reprint Role of NF-kappaB in hematopoietic niche function of osteoblasts after radiation injury
    Mang Xiao
    Radiation Countermeasures Program, Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, Bethesda, MD 20889 5603, USA
    Exp Hematol 37:52-64. 2009
  3. ncbi request reprint Pharmacological countermeasures for the acute radiation syndrome
    Mang Xiao
    Radiation Countermeasures Program, Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, Bethesda, MD 20889, USA
    Curr Mol Pharmacol 2:122-33. 2009
  4. doi request reprint Delta-tocotrienol protects mice from radiation-induced gastrointestinal injury
    Xiang Hong Li
    a Radiation Countermeasures Program, Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, Bethesda, Maryland
    Radiat Res 180:649-57. 2013
  5. pmc Micro-RNA30c negatively regulates REDD1 expression in human hematopoietic and osteoblast cells after gamma-irradiation
    Xiang Hong Li
    Radiation Countermeasures Program, Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States of America
    PLoS ONE 7:e48700. 2012
  6. pmc Delta-Tocotrienol Suppresses Radiation-Induced MicroRNA-30 and Protects Mice and Human CD34+ Cells from Radiation Injury
    Xiang Hong Li
    Radiation Countermeasures Program, Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, Bethesda, MD, United States of America
    PLoS ONE 10:e0122258. 2015
  7. pmc Delta-tocotrienol protects mouse and human hematopoietic progenitors from gamma-irradiation through extracellular signal-regulated kinase/mammalian target of rapamycin signaling
    Xiang Hong Li
    Radiation Countermeasures Program, Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, 8901 Wisconsin Ave, Bethesda, MD 20889 5603, USA
    Haematologica 95:1996-2004. 2010
  8. pmc REDD1 protects osteoblast cells from gamma radiation-induced premature senescence
    Xiang Hong Li
    Radiation Countermeasures Program, Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States of America
    PLoS ONE 7:e36604. 2012
  9. pmc Circulating interleukin-18 as a biomarker of total-body radiation exposure in mice, minipigs, and nonhuman primates (NHP)
    Cam T Ha
    Radiation Countermeasures Program, Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States of America
    PLoS ONE 9:e109249. 2014
  10. doi request reprint Genistein nanoparticles protect mouse hematopoietic system and prevent proinflammatory factors after gamma irradiation
    Cam T Ha
    Radiation Countermeasures Program, Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20889
    Radiat Res 180:316-25. 2013

Collaborators

Detail Information

Publications13

  1. ncbi request reprint 5-Androstenediol promotes survival of gamma-irradiated human hematopoietic progenitors through induction of nuclear factor-kappaB activation and granulocyte colony-stimulating factor expression
    Mang Xiao
    Radiation Countermeasures Program, Armed Forces Radiobiology Research Institute, 8901 Wisconsin Ave, Bethesda, MD 20889 5603, USA
    Mol Pharmacol 72:370-9. 2007
    ..5-AED exerts survival-enhancing effects on irradiated human hematopoietic progenitor cells via induction, stabilization, and activation of NFkappaB, which results in increased secretion of hematopoietic growth factor G-CSF...
  2. doi request reprint Role of NF-kappaB in hematopoietic niche function of osteoblasts after radiation injury
    Mang Xiao
    Radiation Countermeasures Program, Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, Bethesda, MD 20889 5603, USA
    Exp Hematol 37:52-64. 2009
    ..In the present study, we proposed to investigate the mechanisms by which osteoblasts in the hematopoietic niche regulate survival, proliferation, and differentiation of HSPC after radiation injury...
  3. ncbi request reprint Pharmacological countermeasures for the acute radiation syndrome
    Mang Xiao
    Radiation Countermeasures Program, Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, Bethesda, MD 20889, USA
    Curr Mol Pharmacol 2:122-33. 2009
    ..In this review we summarize recent information on intracellular and extracellular signaling pathways relevant to radiation countermeasure research...
  4. doi request reprint Delta-tocotrienol protects mice from radiation-induced gastrointestinal injury
    Xiang Hong Li
    a Radiation Countermeasures Program, Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, Bethesda, Maryland
    Radiat Res 180:649-57. 2013
    ..Our data demonstrate that administration of DT3 protected mice from radiation-induced gastrointestinal system damage. ..
  5. pmc Micro-RNA30c negatively regulates REDD1 expression in human hematopoietic and osteoblast cells after gamma-irradiation
    Xiang Hong Li
    Radiation Countermeasures Program, Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States of America
    PLoS ONE 7:e48700. 2012
    ..Our data suggest that CD34+ and hFOB cells have different miRNA expression patterns after irradiation and miR-30c plays a key role in radiation-induced cell damage which might be through regulation of REDD1 expression...
  6. pmc Delta-Tocotrienol Suppresses Radiation-Induced MicroRNA-30 and Protects Mice and Human CD34+ Cells from Radiation Injury
    Xiang Hong Li
    Radiation Countermeasures Program, Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, Bethesda, MD, United States of America
    PLoS ONE 10:e0122258. 2015
    ..Our data suggest that DT3 protects human and mouse cells from radiation damage may through suppression of IL-1β-induced NFκB/miR-30 signaling. ..
  7. pmc Delta-tocotrienol protects mouse and human hematopoietic progenitors from gamma-irradiation through extracellular signal-regulated kinase/mammalian target of rapamycin signaling
    Xiang Hong Li
    Radiation Countermeasures Program, Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, 8901 Wisconsin Ave, Bethesda, MD 20889 5603, USA
    Haematologica 95:1996-2004. 2010
    ..We explored the effects and mechanisms of δ-tocotrienol on hematopoietic progenitor cell survival after γ-irradiation in both in vivo and in vitro experiments...
  8. pmc REDD1 protects osteoblast cells from gamma radiation-induced premature senescence
    Xiang Hong Li
    Radiation Countermeasures Program, Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States of America
    PLoS ONE 7:e36604. 2012
    ..Our data demonstrated that REDD1 is a protective factor in radiation-induced osteoblast cell premature senescence...
  9. pmc Circulating interleukin-18 as a biomarker of total-body radiation exposure in mice, minipigs, and nonhuman primates (NHP)
    Cam T Ha
    Radiation Countermeasures Program, Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States of America
    PLoS ONE 9:e109249. 2014
    ....
  10. doi request reprint Genistein nanoparticles protect mouse hematopoietic system and prevent proinflammatory factors after gamma irradiation
    Cam T Ha
    Radiation Countermeasures Program, Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20889
    Radiat Res 180:316-25. 2013
    ....
  11. pmc Jun blockade of erythropoiesis: role for repression of GATA-1 by HERP2
    Kamaleldin E Elagib
    University of Virginia School of Medicine, P O Box 800904, Charlottesville, VA 22908, USA
    Mol Cell Biol 24:7779-94. 2004
    ..Furthermore, these results establish a connection between the Notch signaling pathway, of which the HERP factors are a critical component, and the GATA family, which participates in programming of cellular differentiation...
  12. ncbi request reprint Analysis of primitive CD34- and CD34+ hematopoietic cells from adults: gain and loss of CD34 antigen by undifferentiated cells are closely linked to proliferative status in culture
    Douglas C Dooley
    Department of Molecular Microbiology and Immunology, Oregon Health and Sciences University, 3181 SW Sam Jackson Park Road, L220, Portland 97201 3098, USA
    Stem Cells 22:556-69. 2004
    ..In this culture system, expression of CD34 antigen by LIN- cells constitutes an early hallmark of growth. Measurement of CD34 expression by LIN- cells in expansion culture underestimates the total content of hematopoietic cells...
  13. ncbi request reprint Assessment of cell viability and apoptosis in human umbilical cord blood following storage
    Mang Xiao
    Pacific Northwest Regional Blood Services, American Red Cross, Portland, OR 97208, USA
    J Hematother Stem Cell Res 12:115-22. 2003
    ..In conclusion, the data suggest that 7-AAD staining of UCB MNC provides a rapid and simple technique for assessing the viability, recovery, and hematopoietic functionality of stored UCB...