Mark H Whitnall

Summary

Affiliation: Uniformed Services University of the Health Sciences
Country: USA

Publications

  1. ncbi request reprint Radioprotective efficacy and acute toxicity of 5-androstenediol after subcutaneous or oral administration in mice
    Mark H Whitnall
    Radiation Casualty Management Team, Armed Forces Radiobiology Research Institute, Bethesda, MD 20889 5603, USA
    Immunopharmacol Immunotoxicol 24:595-626. 2002
  2. ncbi request reprint Effects of whole-body gamma irradiation and 5-androstenediol administration on serum G-CSF
    Vijay K Singh
    Radiation Casualty Management Team, Armed Forces Radiobiology Research Institute, Bethesda, Maryland 20889 5603, USA
    Immunopharmacol Immunotoxicol 27:521-34. 2005
  3. ncbi request reprint Molecular specificity of 5-androstenediol as a systemic radioprotectant in mice
    Mark H Whitnall
    Radiation Casualty Management Team, Armed Forces Radiobiology Research Institute, 8901 Wisconsin Ave, Bethesda, MD 20889 5603, USA
    Immunopharmacol Immunotoxicol 27:15-32. 2005
  4. ncbi request reprint Accelerated hematopoietic syndrome after radiation doses bridging hematopoietic (H-ARS) and gastrointestinal (GI-ARS) acute radiation syndrome: early hematological changes and systemic inflammatory response syndrome in minipig
    Maria Moroni
    Radiation Countermeasures Program, Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, Bethesda
    Int J Radiat Biol 90:363-72. 2014
  5. doi request reprint Delta-tocotrienol protects mice from radiation-induced gastrointestinal injury
    Xiang Hong Li
    a Radiation Countermeasures Program, Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, Bethesda, Maryland
    Radiat Res 180:649-57. 2013
  6. doi request reprint Effects of genistein administration on cytokine induction in whole-body gamma irradiated mice
    Vijay K Singh
    Department of Radiation Biology, F Edward Hebert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20889 5603, USA
    Int Immunopharmacol 9:1401-10. 2009
  7. doi request reprint Role of NF-kappaB in hematopoietic niche function of osteoblasts after radiation injury
    Mang Xiao
    Radiation Countermeasures Program, Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, Bethesda, MD 20889 5603, USA
    Exp Hematol 37:52-64. 2009
  8. pmc Evaluation of the gamma-H2AX assay for radiation biodosimetry in a swine model
    Maria Moroni
    Armed Forces Radiobiology Research Institute, Uniformed Services University, Bethesda, MD 20889 5603, USA
    Int J Mol Sci 14:14119-35. 2013
  9. pmc Delta-tocotrienol protects mouse and human hematopoietic progenitors from gamma-irradiation through extracellular signal-regulated kinase/mammalian target of rapamycin signaling
    Xiang Hong Li
    Radiation Countermeasures Program, Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, 8901 Wisconsin Ave, Bethesda, MD 20889 5603, USA
    Haematologica 95:1996-2004. 2010
  10. pmc Hematological changes as prognostic indicators of survival: similarities between Gottingen minipigs, humans, and other large animal models
    Maria Moroni
    Radiation Countermeasures Program, Scientific Research Department, Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States of America
    PLoS ONE 6:e25210. 2011

Collaborators

Detail Information

Publications23

  1. ncbi request reprint Radioprotective efficacy and acute toxicity of 5-androstenediol after subcutaneous or oral administration in mice
    Mark H Whitnall
    Radiation Casualty Management Team, Armed Forces Radiobiology Research Institute, Bethesda, MD 20889 5603, USA
    Immunopharmacol Immunotoxicol 24:595-626. 2002
    ..Oral administration of AED produced significant survival enhancement at a dose of 1600 mg/kg. We conclude that the radioprotective efficacy of AED is accompanied by low toxicity...
  2. ncbi request reprint Effects of whole-body gamma irradiation and 5-androstenediol administration on serum G-CSF
    Vijay K Singh
    Radiation Casualty Management Team, Armed Forces Radiobiology Research Institute, Bethesda, Maryland 20889 5603, USA
    Immunopharmacol Immunotoxicol 27:521-34. 2005
    ....
  3. ncbi request reprint Molecular specificity of 5-androstenediol as a systemic radioprotectant in mice
    Mark H Whitnall
    Radiation Casualty Management Team, Armed Forces Radiobiology Research Institute, 8901 Wisconsin Ave, Bethesda, MD 20889 5603, USA
    Immunopharmacol Immunotoxicol 27:15-32. 2005
    ....
  4. ncbi request reprint Accelerated hematopoietic syndrome after radiation doses bridging hematopoietic (H-ARS) and gastrointestinal (GI-ARS) acute radiation syndrome: early hematological changes and systemic inflammatory response syndrome in minipig
    Maria Moroni
    Radiation Countermeasures Program, Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, Bethesda
    Int J Radiat Biol 90:363-72. 2014
    ..To characterize acute radiation syndrome (ARS) sequelae at doses intermediate between the bone marrow (H-ARS) and full gastrointestinal (GI-ARS) syndrome...
  5. doi request reprint Delta-tocotrienol protects mice from radiation-induced gastrointestinal injury
    Xiang Hong Li
    a Radiation Countermeasures Program, Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, Bethesda, Maryland
    Radiat Res 180:649-57. 2013
    ..Our data demonstrate that administration of DT3 protected mice from radiation-induced gastrointestinal system damage. ..
  6. doi request reprint Effects of genistein administration on cytokine induction in whole-body gamma irradiated mice
    Vijay K Singh
    Department of Radiation Biology, F Edward Hebert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20889 5603, USA
    Int Immunopharmacol 9:1401-10. 2009
    ....
  7. doi request reprint Role of NF-kappaB in hematopoietic niche function of osteoblasts after radiation injury
    Mang Xiao
    Radiation Countermeasures Program, Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, Bethesda, MD 20889 5603, USA
    Exp Hematol 37:52-64. 2009
    ..In the present study, we proposed to investigate the mechanisms by which osteoblasts in the hematopoietic niche regulate survival, proliferation, and differentiation of HSPC after radiation injury...
  8. pmc Evaluation of the gamma-H2AX assay for radiation biodosimetry in a swine model
    Maria Moroni
    Armed Forces Radiobiology Research Institute, Uniformed Services University, Bethesda, MD 20889 5603, USA
    Int J Mol Sci 14:14119-35. 2013
    ..8 and 5 Gy with residual γ-H2AX foci proportional to the initial radiation doses. These findings show that the Gottingen minipig provides a useful in vivo model for validation of γ-H2AX biodosimetry for dose assessment in humans...
  9. pmc Delta-tocotrienol protects mouse and human hematopoietic progenitors from gamma-irradiation through extracellular signal-regulated kinase/mammalian target of rapamycin signaling
    Xiang Hong Li
    Radiation Countermeasures Program, Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, 8901 Wisconsin Ave, Bethesda, MD 20889 5603, USA
    Haematologica 95:1996-2004. 2010
    ..We explored the effects and mechanisms of δ-tocotrienol on hematopoietic progenitor cell survival after γ-irradiation in both in vivo and in vitro experiments...
  10. pmc Hematological changes as prognostic indicators of survival: similarities between Gottingen minipigs, humans, and other large animal models
    Maria Moroni
    Radiation Countermeasures Program, Scientific Research Department, Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States of America
    PLoS ONE 6:e25210. 2011
    ..We have previously shown that the Gottingen minipig manifests hematopoietic ARS phases and symptoms similar to those observed in canines, NHPs, and humans...
  11. pmc The Gottingen minipig is a model of the hematopoietic acute radiation syndrome: G-colony stimulating factor stimulates hematopoiesis and enhances survival from lethal total-body γ-irradiation
    Maria Moroni
    Radiation Countermeasures Program, Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA
    Int J Radiat Oncol Biol Phys 86:986-92. 2013
    ....
  12. pmc 5-AED enhances survival of irradiated mice in a G-CSF-dependent manner, stimulates innate immune cell function, reduces radiation-induced DNA damage and induces genes that modulate cell cycle progression and apoptosis
    Marcy B Grace
    Radiation Countermeasures Program, Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, 8901 Wisconsin Ave, Bethesda, MD 20889 5603, USA
    J Radiat Res 53:840-53. 2012
    ..Our results suggest 5-AED survival enhancement is G-CSF-dependent, and that it stimulates innate immune cell function and reduces radiation-induced DNA damage via induction of genes that modulate cell cycle progression and apoptosis...
  13. ncbi request reprint Protection against gamma-irradiation with 5-androstenediol
    Mark H Whitnall
    Radiation Casualty Management Team, Armed Forces Radiobiology Research Institute, 8901 Wisconsin Avenue, Bethesda, MD 20889 5603, USA
    Mil Med 167:64-5. 2002
    ..Clinical chemistry, histopathology, and behavioral assays showed no evidence of toxicity. We conclude that AED and related steroids are attractive candidates to explore as countermeasures to high- and low-level ionizing radiation...
  14. ncbi request reprint Efficacy of radiation countermeasures depends on radiation quality
    Lynnette H Cary
    Radiation Countermeasures Program, Armed Forces Radiobiology Research Institute AFRRI, Uniformed Services University, Bethesda, Maryland 20889 5603, USA
    Radiat Res 177:663-75. 2012
    ..The results indicate that radiation countermeasures should be tested against radiation qualities appropriate for specific scenarios before inclusion in response plans...
  15. ncbi request reprint Evaluation of EUK-189, a synthetic superoxide dismutase/catalase mimetic as a radiation countermeasure
    Venkataraman Srinivasan
    Radiation Countermeasures Program, Armed Forces Radiobiology Research Institute, Bethesda, Maryland Wisconsin Avenue, Bethesda, MD 20889 5603, USA
    Immunopharmacol Immunotoxicol 30:271-90. 2008
    ..EUK-189 did not stimulate production of any cytokine or chemokine tested...
  16. ncbi request reprint 5-Androstenediol promotes survival of gamma-irradiated human hematopoietic progenitors through induction of nuclear factor-kappaB activation and granulocyte colony-stimulating factor expression
    Mang Xiao
    Radiation Countermeasures Program, Armed Forces Radiobiology Research Institute, 8901 Wisconsin Ave, Bethesda, MD 20889 5603, USA
    Mol Pharmacol 72:370-9. 2007
    ..5-AED exerts survival-enhancing effects on irradiated human hematopoietic progenitor cells via induction, stabilization, and activation of NFkappaB, which results in increased secretion of hematopoietic growth factor G-CSF...
  17. pmc Vascular access port implantation and serial blood sampling in a Gottingen minipig (Sus scrofa domestica) model of acute radiation injury
    Maria Moroni
    Radiation Countermeasures Program, Scientific Research Department, Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA
    J Am Assoc Lab Anim Sci 50:65-72. 2011
    ..VAP-related sepsis occurred in 2 minipigs. Blood sampling did not cause detectable stress in nonanesthetized sham-irradiated animals, according to leukograms and clinical signs...
  18. ncbi request reprint Hematopoietic radiation syndrome in the Gottingen minipig
    Maria Moroni
    Radiation Countermeasures Program, Scientific Research Department, Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20889 5603, USA
    Radiat Res 176:89-101. 2011
    ..The results support further development of the Gottingen minipig as a model for ARS...
  19. doi request reprint A review of radiation countermeasure work ongoing at the Armed Forces Radiobiology Research Institute
    Vijay K Singh
    Radiation Countermeasures Program, Scientific Research Department, Armed Forces Radiobiology Research Institute Department of Radiation Biology, F Edward Hebert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20889, USA
    Int J Radiat Biol 88:296-310. 2012
    ..In this communication we discuss selected promising radiation countermeasures at advanced stages of development...
  20. doi request reprint Role of radiation-induced granulocyte colony-stimulating factor in recovery from whole body gamma-irradiation
    Vijay K Singh
    Radiation Countermeasures Program, Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, Bethesda, MD, USA
    Cytokine 58:406-14. 2012
    ..Neutralizing antibody to G-CSF exacerbates the deleterious effects of radiation, indicating that G-CSF induced in response to irradiation plays an important role in recovery...
  21. doi request reprint Multiple parameter radiation injury assessment using a nonhuman primate radiation model-biodosimetry applications
    William F Blakely
    Armed Forces Radiobiology Research Institute, 8901 Wisconsin Avenue, Bethesda, MD 20889 5603 USA
    Health Phys 98:153-9. 2010
    ..These results demonstrate the practical use of multiple parameter biomarkers to enhance the discrimination of exposed vs. non-exposed individuals and justify a follow-on rhesus macaque dose-response study...
  22. ncbi request reprint Pharmacological countermeasures for the acute radiation syndrome
    Mang Xiao
    Radiation Countermeasures Program, Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, Bethesda, MD 20889, USA
    Curr Mol Pharmacol 2:122-33. 2009
    ..In this review we summarize recent information on intracellular and extracellular signaling pathways relevant to radiation countermeasure research...
  23. ncbi request reprint Effects of anesthesia and vehicle injection on circulating blood elements in C3H/HeN male mice
    Kenneth O Jacobsen
    Veterinary Medicine Division, U S Army Medical Research Institute of Infectious Diseases, 1425 Porter Street, Ft Detrick, Maryland 21701, USA
    Contemp Top Lab Anim Sci 43:8-12. 2004
    ..9%, and mean platelet counts by 11.2% compared with levels in unanesthetized mice. Our results indicate that the effect of anesthesia is an important consideration when circulating blood elements in mice must be measured...