Research Topics
| Mark H WhitnallSummaryAffiliation: Uniformed Services University of the Health Sciences Country: USA Publications
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Detail Information
Publications
Radioprotective efficacy and acute toxicity of 5-androstenediol after subcutaneous or oral administration in miceMark H Whitnall
Radiation Casualty Management Team, Armed Forces Radiobiology Research Institute, Bethesda, MD 20889 5603, USA
Immunopharmacol Immunotoxicol 24:595-626. 2002..Oral administration of AED produced significant survival enhancement at a dose of 1600 mg/kg. We conclude that the radioprotective efficacy of AED is accompanied by low toxicity...- Effects of whole-body gamma irradiation and 5-androstenediol administration on serum G-CSFVijay K Singh
Radiation Casualty Management Team, Armed Forces Radiobiology Research Institute, Bethesda, Maryland 20889 5603, USA
Immunopharmacol Immunotoxicol 27:521-34. 2005.... - Molecular specificity of 5-androstenediol as a systemic radioprotectant in miceMark H Whitnall
Radiation Casualty Management Team, Armed Forces Radiobiology Research Institute, 8901 Wisconsin Ave, Bethesda, MD 20889 5603, USA
Immunopharmacol Immunotoxicol 27:15-32. 2005.... 
Effects of genistein administration on cytokine induction in whole-body gamma irradiated miceVijay K Singh
Department of Radiation Biology, F Edward Hebert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20889 5603, USA
Int Immunopharmacol 9:1401-10. 2009....- Role of NF-kappaB in hematopoietic niche function of osteoblasts after radiation injuryMang Xiao
Radiation Countermeasures Program, Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, Bethesda, MD 20889 5603, USA
Exp Hematol 37:52-64. 2009..In the present study, we proposed to investigate the mechanisms by which osteoblasts in the hematopoietic niche regulate survival, proliferation, and differentiation of HSPC after radiation injury... 
Hematological changes as prognostic indicators of survival: similarities between Gottingen minipigs, humans, and other large animal modelsMaria Moroni
Radiation Countermeasures Program, Scientific Research Department, Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States of America
PLoS ONE 6:e25210. 2011..We have previously shown that the Gottingen minipig manifests hematopoietic ARS phases and symptoms similar to those observed in canines, NHPs, and humans...- Protection against gamma-irradiation with 5-androstenediolMark H Whitnall
Radiation Casualty Management Team, Armed Forces Radiobiology Research Institute, 8901 Wisconsin Avenue, Bethesda, MD 20889-5603, USA
Mil Med 167:64-5. 2002..Clinical chemistry, histopathology, and behavioral assays showed no evidence of toxicity. We conclude that AED and related steroids are attractive candidates to explore as countermeasures to high- and low-level ionizing radiation... - Efficacy of radiation countermeasures depends on radiation qualityLynnette H Cary
Radiation Countermeasures Program, Armed Forces Radiobiology Research Institute AFRRI, Uniformed Services University, Bethesda, Maryland 20889 5603, USA
Radiat Res 177:663-75. 2012..The results indicate that radiation countermeasures should be tested against radiation qualities appropriate for specific scenarios before inclusion in response plans... - Evaluation of EUK-189, a synthetic superoxide dismutase/catalase mimetic as a radiation countermeasureVenkataraman Srinivasan
Radiation Countermeasures Program, Armed Forces Radiobiology Research Institute, Bethesda, Maryland Wisconsin Avenue, Bethesda, MD 20889 5603, USA
Immunopharmacol Immunotoxicol 30:271-90. 2008..EUK-189 did not stimulate production of any cytokine or chemokine tested... - 5-Androstenediol promotes survival of gamma-irradiated human hematopoietic progenitors through induction of nuclear factor-kappaB activation and granulocyte colony-stimulating factor expressionMang Xiao
Radiation Countermeasures Program, Armed Forces Radiobiology Research Institute, 8901 Wisconsin Ave, Bethesda, MD 20889 5603, USA
Mol Pharmacol 72:370-9. 2007..5-AED exerts survival-enhancing effects on irradiated human hematopoietic progenitor cells via induction, stabilization, and activation of NFkappaB, which results in increased secretion of hematopoietic growth factor G-CSF... - Vascular access port implantation and serial blood sampling in a Gottingen minipig (Sus scrofa domestica) model of acute radiation injuryMaria Moroni
Radiation Countermeasures Program, Scientific Research Department, Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA
J Am Assoc Lab Anim Sci 50:65-72. 2011..VAP-related sepsis occurred in 2 minipigs. Blood sampling did not cause detectable stress in nonanesthetized sham-irradiated animals, according to leukograms and clinical signs... - 5-AED enhances survival of irradiated mice in a G-CSF-dependent manner, stimulates innate immune cell function, reduces radiation-induced DNA damage and induces genes that modulate cell cycle progression and apoptosisMarcy B Grace
Radiation Countermeasures Program, Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, 8901 Wisconsin Ave, Bethesda, MD 20889 5603, USA
J Radiat Res 53:840-53. 2012..Our results suggest 5-AED survival enhancement is G-CSF-dependent, and that it stimulates innate immune cell function and reduces radiation-induced DNA damage via induction of genes that modulate cell cycle progression and apoptosis... - Delta-tocotrienol protects mouse and human hematopoietic progenitors from gamma-irradiation through extracellular signal-regulated kinase/mammalian target of rapamycin signalingXiang Hong Li
Radiation Countermeasures Program, Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, 8901 Wisconsin Ave, Bethesda, MD 20889 5603, USA
Haematologica 95:1996-2004. 2010..We explored the effects and mechanisms of δ-tocotrienol on hematopoietic progenitor cell survival after γ-irradiation in both in vivo and in vitro experiments... - A review of radiation countermeasure work ongoing at the Armed Forces Radiobiology Research InstituteVijay K Singh
Radiation Countermeasures Program, Scientific Research Department, Armed Forces Radiobiology Research Institute Department of Radiation Biology, F Edward Hebert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20889, USA
Int J Radiat Biol 88:296-310. 2012..Here we review primarily the in vivo efficacy of selected countermeasures in animal models and clinical studies... - Role of radiation-induced granulocyte colony-stimulating factor in recovery from whole body gamma-irradiationVijay K Singh
Radiation Countermeasures Program, Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, Bethesda, MD, USA
Cytokine 58:406-14. 2012..Neutralizing antibody to G-CSF exacerbates the deleterious effects of radiation, indicating that G-CSF induced in response to irradiation plays an important role in recovery... - Multiple parameter radiation injury assessment using a nonhuman primate radiation model-biodosimetry applicationsWilliam F Blakely
Armed Forces Radiobiology Research Institute, 8901 Wisconsin Avenue, Bethesda, MD 20889 5603 USA
Health Phys 98:153-9. 2010..These results demonstrate the practical use of multiple parameter biomarkers to enhance the discrimination of exposed vs. non-exposed individuals and justify a follow-on rhesus macaque dose-response study... - Hematopoietic radiation syndrome in the Gottingen minipigMaria Moroni
Radiation Countermeasures Program, Scientific Research Department, Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20889 5603, USA
Radiat Res 176:89-101. 2011..The results support further development of the Gottingen minipig as a model for ARS... - Pharmacological countermeasures for the acute radiation syndromeMang Xiao
Radiation Countermeasures Program, Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, Bethesda, MD 20889, USA
Curr Mol Pharmacol 2:122-33. 2009..In this review we summarize recent information on intracellular and extracellular signaling pathways relevant to radiation countermeasure research... - Effects of anesthesia and vehicle injection on circulating blood elements in C3H/HeN male miceKenneth O Jacobsen
Veterinary Medicine Division, U.S. Army Medical Research Institute of Infectious Diseases, 1425 Porter Street, Ft. Detrick, Maryland 21701, USA
Contemp Top Lab Anim Sci 43:8-12. 2004..9%, and mean platelet counts by 11.2% compared with levels in unanesthetized mice. Our results indicate that the effect of anesthesia is an important consideration when circulating blood elements in mice must be measured...