Meera Srivastava

Summary

Affiliation: Uniformed Services University of the Health Sciences
Country: USA

Publications

  1. ncbi request reprint Molecular dissection of nucleolin's role in growth and cell proliferation: new insights
    M Srivastava
    Department of Anatomy, Uniformed Services University of Health Sciences, Bethesda, Maryland 20814, USA
    FASEB J 13:1911-22. 1999
  2. pmc Anx7 is required for nutritional control of gene expression in mouse pancreatic islets of Langerhans
    Meera Srivastava
    Department of Anatomy, Physiology, USU School of Medicine, Bethesda, MD, USA
    Mol Med 8:781-97. 2002
  3. pmc ANX7, a candidate tumor suppressor gene for prostate cancer
    M Srivastava
    Departments of Anatomy, Physiology, and Genetics, and Institute for Molecular Medicine, Uniformed Services University School of Medicine, Bethesda, MD 20814, USA
    Proc Natl Acad Sci U S A 98:4575-80. 2001
  4. ncbi request reprint ANX7 as a bio-marker in prostate and breast cancer progression
    M Srivastava
    Department of Anatomy, Physiology and Genetics, and Institute for Molecular Medicine, Uniformed Services University School of Medicine, Bethesda, MD 20814, USA
    Dis Markers 17:115-20. 2001
  5. pmc Elevated expression levels of ANXA11, integrins β3 and α3, and TNF-α contribute to a candidate proteomic signature in urine for kidney allograft rejection
    Meera Srivastava
    Department of Anatomy, Physiology and Genetics, USU Center for Medical Proteomics, Uniformed Services University School of Medicine, Bethesda, MD, USA
    Proteomics Clin Appl 5:311-21. 2011
  6. ncbi request reprint Influence of the Anx7 (+/-) knockout mutation and fasting stress on the genomics of the mouse adrenal gland
    Meera Srivastava
    Department of Anatomy, Physiology and Genetics, and Institute for Molecular Medicine, Uniformed Services University School of Medicine USUHS, Bethesda, Maryland 20814, USA
    Ann N Y Acad Sci 971:53-60. 2002
  7. ncbi request reprint Low in vivo levels of human anx7 (annexin vii) gene expression are due to endogenous inhibitory promoter sequences
    M Srivastava
    Department of Anatomy and Cell Biology and Institute for Molecular Medicine, USUHS, 4301 Jones Bridge Road, Bethesda, MD 20814, USA
    Cell Biol Int 24:475-81. 2000
  8. ncbi request reprint Prognostic impact of ANX7-GTPase in metastatic and HER2-negative breast cancer patients
    Meera Srivastava
    Department of Anatomy, Physiology and Genetics and Institute for Molecular Medicine, Uniformed Services University School of Medicine, Bethesda, Maryland 20814, USA
    Clin Cancer Res 10:2344-50. 2004
  9. pmc Defects in inositol 1,4,5-trisphosphate receptor expression, Ca(2+) signaling, and insulin secretion in the anx7(+/-) knockout mouse
    M Srivastava
    Department of Anatomy, Institute for Molecular Medicine, Uniformed Services University School of Medicine, Bethesda, MD 20814, USA
    Proc Natl Acad Sci U S A 96:13783-8. 1999
  10. ncbi request reprint ANXA7 expression represents hormone-relevant tumor suppression in different cancers
    Meera Srivastava
    Department of Anatomy, Physiology and Genetics, and Institute for Molecular Medicine, Uniformed Services University School of Medicine USUHS, Bethesda, MD, USA
    Int J Cancer 121:2628-36. 2007

Collaborators

Detail Information

Publications36

  1. ncbi request reprint Molecular dissection of nucleolin's role in growth and cell proliferation: new insights
    M Srivastava
    Department of Anatomy, Uniformed Services University of Health Sciences, Bethesda, Maryland 20814, USA
    FASEB J 13:1911-22. 1999
    ..Exploration of the regulation of this multifaceted protein in a remarkable number of diverse functions is challenging...
  2. pmc Anx7 is required for nutritional control of gene expression in mouse pancreatic islets of Langerhans
    Meera Srivastava
    Department of Anatomy, Physiology, USU School of Medicine, Bethesda, MD, USA
    Mol Med 8:781-97. 2002
    ....
  3. pmc ANX7, a candidate tumor suppressor gene for prostate cancer
    M Srivastava
    Departments of Anatomy, Physiology, and Genetics, and Institute for Molecular Medicine, Uniformed Services University School of Medicine, Bethesda, MD 20814, USA
    Proc Natl Acad Sci U S A 98:4575-80. 2001
    ..We conclude that the ANX7 gene exhibits many biological and genetic properties expected of a TSG and may play a role in prostate cancer progression...
  4. ncbi request reprint ANX7 as a bio-marker in prostate and breast cancer progression
    M Srivastava
    Department of Anatomy, Physiology and Genetics, and Institute for Molecular Medicine, Uniformed Services University School of Medicine, Bethesda, MD 20814, USA
    Dis Markers 17:115-20. 2001
    ..The loss of ANX7 is significant in metastatic and hormone refractory prostate cancer compared to benign prostatic hyperplasia. In addition, ANX7 expression has prognostic value for predicting survival of breast cancer patients...
  5. pmc Elevated expression levels of ANXA11, integrins β3 and α3, and TNF-α contribute to a candidate proteomic signature in urine for kidney allograft rejection
    Meera Srivastava
    Department of Anatomy, Physiology and Genetics, USU Center for Medical Proteomics, Uniformed Services University School of Medicine, Bethesda, MD, USA
    Proteomics Clin Appl 5:311-21. 2011
    ....
  6. ncbi request reprint Influence of the Anx7 (+/-) knockout mutation and fasting stress on the genomics of the mouse adrenal gland
    Meera Srivastava
    Department of Anatomy, Physiology and Genetics, and Institute for Molecular Medicine, Uniformed Services University School of Medicine USUHS, Bethesda, Maryland 20814, USA
    Ann N Y Acad Sci 971:53-60. 2002
    ....
  7. ncbi request reprint Low in vivo levels of human anx7 (annexin vii) gene expression are due to endogenous inhibitory promoter sequences
    M Srivastava
    Department of Anatomy and Cell Biology and Institute for Molecular Medicine, USUHS, 4301 Jones Bridge Road, Bethesda, MD 20814, USA
    Cell Biol Int 24:475-81. 2000
    ....
  8. ncbi request reprint Prognostic impact of ANX7-GTPase in metastatic and HER2-negative breast cancer patients
    Meera Srivastava
    Department of Anatomy, Physiology and Genetics and Institute for Molecular Medicine, Uniformed Services University School of Medicine, Bethesda, Maryland 20814, USA
    Clin Cancer Res 10:2344-50. 2004
    ..ANX7-GTPase located on chromosome 10q21 is significantly altered and associated with hormone-refractory metastatic prostate cancers. Therefore, we investigated whether levels of ANX7 correlate with breast cancer progression and survival..
  9. pmc Defects in inositol 1,4,5-trisphosphate receptor expression, Ca(2+) signaling, and insulin secretion in the anx7(+/-) knockout mouse
    M Srivastava
    Department of Anatomy, Institute for Molecular Medicine, Uniformed Services University School of Medicine, Bethesda, MD 20814, USA
    Proc Natl Acad Sci U S A 96:13783-8. 1999
    ..This is a direct demonstration of a connection between glucose-activated insulin secretion and Ca(2+) signaling through IP(3)-sensitive Ca(2+) stores...
  10. ncbi request reprint ANXA7 expression represents hormone-relevant tumor suppression in different cancers
    Meera Srivastava
    Department of Anatomy, Physiology and Genetics, and Institute for Molecular Medicine, Uniformed Services University School of Medicine USUHS, Bethesda, MD, USA
    Int J Cancer 121:2628-36. 2007
    ..With tumor suppressor pattern validated in different tumors, ANXA7 can be an attractive diagnostic and therapeutic target associated with the hormone and/or neurotransmitter-mediated modulation of tumorigenesis...
  11. pmc Haploinsufficiency of Anx7 tumor suppressor gene and consequent genomic instability promotes tumorigenesis in the Anx7(+/-) mouse
    Meera Srivastava
    Department of Anatomy, Physiology, and Genetics, and Institute for Molecular Medicine, Uniformed Services University School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
    Proc Natl Acad Sci U S A 100:14287-92. 2003
    ....
  12. doi request reprint Annexin-A7 protects normal prostate cells and induces distinct patterns of RB-associated cytotoxicity in androgen-sensitive and -resistant prostate cancer cells
    Yelizaveta Torosyan
    Department of Anatomy, Physiology and Genetics, Institute for Molecular Medicine, Uniformed Services University of Health Sciences School of Medicine, Bethesda, MD 20814, USA
    Int J Cancer 125:2528-39. 2009
    ..Thus, ANXA7 revived the RB-associated cell survival control and overcame androgen resistance and dysfunctional status of major tumor suppressors commonly mutated in prostate cancer. Published 2009 UICC...
  13. pmc Elevated miR-155 promotes inflammation in cystic fibrosis by driving hyperexpression of interleukin-8
    Sharmistha Bhattacharyya
    Department of Health Systems, Risk, and Contingency Management, Graduate School of Nursing, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA
    J Biol Chem 286:11604-15. 2011
    ..These data suggest that miR-155 may play an important role in the activation of IL-8-dependent inflammation in CF...
  14. doi request reprint Differential regulation of inflammation by inflammatory mediators in cystic fibrosis lung epithelial cells
    Motohiro Tsuchiya
    Molecular and Cell Biology Program, School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
    J Interferon Cytokine Res 33:121-9. 2013
    ..We interpret these data to suggest that that CF lung epithelial cells respond to PA or bacterial cell products with a novel miR program that may carry with it serious challenges to survival...
  15. pmc Cardiac glycosides inhibit TNF-alpha/NF-kappaB signaling by blocking recruitment of TNF receptor-associated death domain to the TNF receptor
    QingFeng Yang
    Department of Anatomy, Physiology, and Genetics and Institute for Molecular Medicine, Uniformed Services University School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
    Proc Natl Acad Sci U S A 102:9631-6. 2005
    ..All other antiinflammatory effects of digitoxin on NF-kappaB and c-Jun N-terminal kinase pathways appear to follow from the blockade of this initial upstream signaling event...
  16. ncbi request reprint Distinct effects of annexin A7 and p53 on arachidonate lipoxygenation in prostate cancer cells involve 5-lipoxygenase transcription
    Yelizaveta Torosyan
    Department of Anatomy, Physiology, and Genetics, and Institute for Molecular Medicine, Uniformed Services University of the Health Sciences School of Medicine, Bethesda, MD 20814, USA
    Cancer Res 66:9609-16. 2006
    ..Thus, ANXA7 and p53 can distinctly regulate LOX transcription that is potentially relevant to the AA-mediated cell growth control in tumor suppression...
  17. doi request reprint The Anx7(+/-) knockout mutation alters electrical and secretory responses to Ca(2+)-mobilizing agents in pancreatic β-cells
    David Mears
    Department of Anatomy, Physiology and Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA
    Cell Physiol Biochem 29:697-704. 2012
    ....
  18. pmc Tristetraprolin regulates IL-8 mRNA stability in cystic fibrosis lung epithelial cells
    Nagaraja Sethuraman Balakathiresan
    Departments of Health Systems, Risk, and Contingency Management, Graduate School of Nursing, Uniformed Services Univ of the Health Sciences, Bethesda, MD 20814, USA
    Am J Physiol Lung Cell Mol Physiol 296:L1012-8. 2009
    ..We conclude that enhanced stability of IL-8 mRNA in TTP-deficient CF lung epithelial cells serve to drive the proinflammatory cellular phenotype in the CF lung...
  19. ncbi request reprint Significant allelic loss of ANX7region (10q21) in hormone receptor negative breast carcinomas
    Ximena Leighton
    Department of Anatomy, Physiology and Genetics, and Institute for Molecular Medicine, Uniformed Services University School of Medicine USUHS, 4301 Jones Bridge Road, Bethesda, MD 20814, USA
    Cancer Lett 210:239-44. 2004
    ..06). These results suggest that the ANX7 gene, or other genes of the 10q21 region, could be functionally related to breast cancer, probably influencing the hormone receptor expression associated with poor prognosis during development...
  20. doi request reprint Antibody microarrays: analysis of cystic fibrosis
    Catherine E Jozwik
    Department of Anatomy, Physiology and Genetics, Uniformed Services University School of Medicine, Bethesda, MD, USA
    Methods Mol Biol 823:179-200. 2012
    ..We describe here a workflow that begins with patient-derived bronchial brush biopsies and progresses to analysis of serum and plasma from patients on antibody microarrays...
  21. ncbi request reprint Serum proteomic signature for cystic fibrosis using an antibody microarray platform
    Meera Srivastava
    Department of Anatomy, Physiology and Genetics, Uniformed Services University School of Medicine, USUHS, Bethesda, MD 20814, USA
    Mol Genet Metab 87:303-10. 2006
    ..We conclude that antibody microarray technology is sensitive, quantitative, and robust, and can be useful as a proteomic platform to discriminate between sera from CF and control patients...
  22. ncbi request reprint De novo biosynthetic profiling of high abundance proteins in cystic fibrosis lung epithelial cells
    Harvey B Pollard
    Department of Anatomy, Physiology and Genetics, Uniformed Services University School of Medicine, Bethesda, Maryland 20814, USA
    Mol Cell Proteomics 5:1628-37. 2006
    ..We anticipate that this novel hybrid approach to discovery of the high abundance CF proteome will find general application to other proteomic problems in biology and medicine...
  23. pmc Gender dependence for a subset of the low-abundance signaling proteome in human platelets
    Ofer Eidelman
    Department of Anatomy, Physiology and Genetics, USU Center for Medical Proteomics, Uniformed Services University, School of Medicine, USUHS, 4301 Jones Bridge Road, Bethesda, MD 20814, USA
    Hum Genomics Proteomics 2010:164906. 2010
    ..The difference may suggest a biological mechanism for gender discrimination in cardiovascular disease...
  24. ncbi request reprint Mapping protein expression in mouse pancreatic islets by immunolabeling and electron energy loss spectrum-imaging
    Gertrud Goping
    Department of Anatomy, Physiology and Genetics, and Institute for Molecular Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA
    Microsc Res Tech 61:448-56. 2003
    ..The effects and consequences of reduced ANX7 expression on mitochondria are evident in ultrastructural observations...
  25. pmc Digitoxin mimics gene therapy with CFTR and suppresses hypersecretion of IL-8 from cystic fibrosis lung epithelial cells
    Meera Srivastava
    Department of Anatomy, Physiology, and Genetics and Institute for Molecular Medicine, Uniformed Services University School of Medicine, Bethesda, MD 20814, USA
    Proc Natl Acad Sci U S A 101:7693-8. 2004
    ..We therefore suggest that digitoxin, with its lengthy history of human use, deserves consideration as a candidate drug for suppressing IL-8-dependent lung inflammation in CF...
  26. ncbi request reprint Stability of Nucleolin protein as the basis for the differential expression of Nucleolin mRNA and protein during serum starvation
    Steven K Kim
    Department of Anatomy, Physiology and Genetics, and Institute for Molecular Medicine, Uniformed Services University School of Medicine USUHS, Bethesda, Maryland 20814, USA
    DNA Cell Biol 22:171-8. 2003
    ....
  27. pmc Control of the proinflammatory state in cystic fibrosis lung epithelial cells by genes from the TNF-alphaR/NFkappaB pathway
    O Eidelman
    Department of Anatomy, Institute of Molecular Medicine F. Edward Hebert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA
    Mol Med 7:523-34. 2001
    ....
  28. doi request reprint Protein microarray platforms for clinical proteomics
    Harvey B Pollard
    Department of Anatomy, Physiology and Genetics, Uniformed Services University School of Medicine, USUHS, Bethesda, MD, USA
    Proteomics Clin Appl 1:934-52. 2007
    ..We anticipate that these platforms will eventually evolve to accommodate label-free detection technologies, human genome-scale numbers of analytes, and increases in analytic and bioinformatic speeds...
  29. ncbi request reprint Pharmacogenomics of cystic fibrosis
    H B Pollard
    Department of Anatomy, Physiology, and Genetics, and Institute for Molecular Medicine, USUHS School of Medicine, Bethesda, MD 20814, USA
    Mol Interv 1:54-63. 2001
    ..Pharmacogenomic approaches to CF, and other similar diseases, may eventually give us the opportunity to create drugs that work in a patient- or mutation-specific manner...
  30. ncbi request reprint cDNA microarrays for pharmacogenomic analysis of cystic fibrosis
    Meera Srivastava
    Department of Anatomy, Physiology and Genetics, Institute for Molecular Medicine, Uniformed Services University School of Medicine, USUHS, Bethesda, MD, USA
    Methods Mol Med 70:21-9. 2002
  31. ncbi request reprint Cystic fibrosis and the use of pharmacogenomics to determine surrogate endpoints for drug discovery
    O Eidelman
    Department of Anatomy, Physiology and Genetics, and Institute for Molecular Medicine, Uniformed Services University School of Medicine, USUHS, Bethesda, Maryland 20814, USA
    Am J Pharmacogenomics 1:223-38. 2001
    ..Significantly, the nature of the hypothesis, as well as the algorithm developed for this study, can be easily applied to pharmacogenomic studies with other goals...
  32. pmc Novel isoforms of synexin in Xenopus laevis: multiple tandem PGQM repeats distinguish mRNAs in specific adult tissues and embryonic stages
    M Srivastava
    Laboratory of Cell Biology and Genetics, National Institute of Diabetes, Digestive and Kidney Diseases, NIH, Bethesda, MD 20892, USA
    Biochem J 316:729-35. 1996
    ....
  33. ncbi request reprint Annexin 7 mobilizes calcium from endoplasmic reticulum stores in brain
    W D Watson
    Neurology Department, National Naval Medical Center, Bethesda, MD 20814, USA
    Biochim Biophys Acta 1742:151-60. 2004
    ..We propose that ANX7 mobilizes Ca(2+) from an endoplasmic reticulum-like pool, which can be recruited to enhance IP3-mediated Ca(2+) release...
  34. doi request reprint Role of multi-hnRNP nuclear complex in regulation of tumor suppressor ANXA7 in prostate cancer cells
    Y Torosyan
    Department of Anatomy, Physiology and Genetics, Institute for Molecular Medicine, Uniformed Services University School of Medicine USUHS, Bethesda, MD 20814, USA
    Oncogene 29:2457-66. 2010
    ..Thus, a multi-hnRNP complex can be responsible for aberrant ANXA7 transcription and splicing, thereby affecting ANXA7 expression pattern and tumor suppressor function in prostate cancer...
  35. ncbi request reprint Genomic structure and expression of the human gene encoding cytochrome b561, an integral protein of the chromaffin granule membrane
    M Srivastava
    Laboratory of Cell Biology and Genetics, NIDDK, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 270:22714-20. 1995
    ..Unexpected results on cytochrome b561 expression in cells of lymphocytic origin and its complex regulation in tumor cells provide new insights into cytochrome b561 gene regulation...
  36. pmc H19 and Igf2 monoallelic expression is regulated in two distinct ways by a shared cis acting regulatory region upstream of H19
    M Srivastava
    Laboratory of Mammalian Genes and Development, National Institute of Child Health and Human Development, Bethesda, Maryland 20892, USA
    Genes Dev 14:1186-95. 2000
    ..However, it is likely that other cis-acting elements, positive and negative, have the ability to effect stable changes in the chromatin structure and are not constantly required to give signals to the transcriptional machinery...