Research Topics
Genomes and Genes | Meera SrivastavaSummaryAffiliation: Uniformed Services University of the Health Sciences Country: USA Publications
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Publications
Molecular dissection of nucleolin's role in growth and cell proliferation: new insightsM Srivastava
Department of Anatomy, Uniformed Services University of Health Sciences, Bethesda, Maryland 20814, USA
FASEB J 13:1911-22. 1999..Exploration of the regulation of this multifaceted protein in a remarkable number of diverse functions is challenging...
Anx7 is required for nutritional control of gene expression in mouse pancreatic islets of LangerhansMeera Srivastava
Department of Anatomy, Physiology, USU School of Medicine, Bethesda, MD, USA
Mol Med 8:781-97. 2002....- Prognostic impact of ANX7-GTPase in metastatic and HER2-negative breast cancer patientsMeera Srivastava
Department of Anatomy, Physiology and Genetics and Institute for Molecular Medicine, Uniformed Services University School of Medicine, Bethesda, Maryland 20814, USA
Clin Cancer Res 10:2344-50. 2004..ANX7-GTPase located on chromosome 10q21 is significantly altered and associated with hormone-refractory metastatic prostate cancers. Therefore, we investigated whether levels of ANX7 correlate with breast cancer progression and survival.. - Influence of the Anx7 (+/-) knockout mutation and fasting stress on the genomics of the mouse adrenal glandMeera Srivastava
Department of Anatomy, Physiology and Genetics, and Institute for Molecular Medicine, Uniformed Services University School of Medicine USUHS, Bethesda, Maryland 20814, USA
Ann N Y Acad Sci 971:53-60. 2002.... - ANXA7 expression represents hormone-relevant tumor suppression in different cancersMeera Srivastava
Department of Anatomy, Physiology and Genetics, and Institute for Molecular Medicine, Uniformed Services University School of Medicine USUHS, Bethesda, MD, USA
Int J Cancer 121:2628-36. 2007..With tumor suppressor pattern validated in different tumors, ANXA7 can be an attractive diagnostic and therapeutic target associated with the hormone and/or neurotransmitter-mediated modulation of tumorigenesis... - ANX7 as a bio-marker in prostate and breast cancer progressionM Srivastava
Department of Anatomy, Physiology and Genetics, and Institute for Molecular Medicine, Uniformed Services University School of Medicine, Bethesda, MD 20814, USA
Dis Markers 17:115-20. 2001..The loss of ANX7 is significant in metastatic and hormone refractory prostate cancer compared to benign prostatic hyperplasia. In addition, ANX7 expression has prognostic value for predicting survival of breast cancer patients... - ANX7, a candidate tumor suppressor gene for prostate cancerM Srivastava
Departments of Anatomy, Physiology, and Genetics, and Institute for Molecular Medicine, Uniformed Services University School of Medicine, Bethesda, MD 20814, USA
Proc Natl Acad Sci U S A 98:4575-80. 2001..We conclude that the ANX7 gene exhibits many biological and genetic properties expected of a TSG and may play a role in prostate cancer progression... - Low in vivo levels of human anx7 (annexin vii) gene expression are due to endogenous inhibitory promoter sequencesM Srivastava
Department of Anatomy and Cell Biology and Institute for Molecular Medicine, USUHS, 4301 Jones Bridge Road, Bethesda, MD 20814, USA
Cell Biol Int 24:475-81. 2000.... - Haploinsufficiency of Anx7 tumor suppressor gene and consequent genomic instability promotes tumorigenesis in the Anx7(+/-) mouseMeera Srivastava
Department of Anatomy, Physiology, and Genetics, and Institute for Molecular Medicine, Uniformed Services University School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
Proc Natl Acad Sci U S A 100:14287-92. 2003.... - Elevated expression levels of ANXA11, integrins β3 and α3, and TNF-α contribute to a candidate proteomic signature in urine for kidney allograft rejectionMeera Srivastava
Department of Anatomy, Physiology and Genetics, USU Center for Medical Proteomics, Uniformed Services University School of Medicine, Bethesda, MD, USA
Proteomics Clin Appl 5:311-21. 2011.... - Defects in inositol 1,4,5-trisphosphate receptor expression, Ca(2+) signaling, and insulin secretion in the anx7(+/-) knockout mouseM Srivastava
Department of Anatomy, Institute for Molecular Medicine, Uniformed Services University School of Medicine, Bethesda, MD 20814, USA
Proc Natl Acad Sci U S A 96:13783-8. 1999..This is a direct demonstration of a connection between glucose-activated insulin secretion and Ca(2+) signaling through IP(3)-sensitive Ca(2+) stores... 
Annexin-A7 protects normal prostate cells and induces distinct patterns of RB-associated cytotoxicity in androgen-sensitive and -resistant prostate cancer cellsYelizaveta Torosyan
Department of Anatomy, Physiology and Genetics, Institute for Molecular Medicine, Uniformed Services University of Health Sciences School of Medicine, Bethesda, MD 20814, USA
Int J Cancer 125:2528-39. 2009..Thus, ANXA7 revived the RB-associated cell survival control and overcame androgen resistance and dysfunctional status of major tumor suppressors commonly mutated in prostate cancer. Published 2009 UICC...- Elevated miR-155 promotes inflammation in cystic fibrosis by driving hyperexpression of interleukin-8Sharmistha Bhattacharyya
Department of Health Systems, Risk, and Contingency Management, Graduate School of Nursing, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA
J Biol Chem 286:11604-15. 2011..These data suggest that miR-155 may play an important role in the activation of IL-8-dependent inflammation in CF... - Distinct effects of annexin A7 and p53 on arachidonate lipoxygenation in prostate cancer cells involve 5-lipoxygenase transcriptionYelizaveta Torosyan
Department of Anatomy, Physiology, and Genetics, and Institute for Molecular Medicine, Uniformed Services University of the Health Sciences School of Medicine, Bethesda, MD 20814, USA
Cancer Res 66:9609-16. 2006..Thus, ANXA7 and p53 can distinctly regulate LOX transcription that is potentially relevant to the AA-mediated cell growth control in tumor suppression... - Cardiac glycosides inhibit TNF-alpha/NF-kappaB signaling by blocking recruitment of TNF receptor-associated death domain to the TNF receptorQingFeng Yang
Department of Anatomy, Physiology, and Genetics and Institute for Molecular Medicine, Uniformed Services University School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
Proc Natl Acad Sci U S A 102:9631-6. 2005..All other antiinflammatory effects of digitoxin on NF-kappaB and c-Jun N-terminal kinase pathways appear to follow from the blockade of this initial upstream signaling event... - The Anx7(+/-) knockout mutation alters electrical and secretory responses to Ca(2+)-mobilizing agents in pancreatic β-cellsDavid Mears
Department of Anatomy, Physiology and Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA
Cell Physiol Biochem 29:697-704. 2012.... - Significant allelic loss of ANX7region (10q21) in hormone receptor negative breast carcinomasXimena Leighton
Department of Anatomy, Physiology and Genetics, and Institute for Molecular Medicine, Uniformed Services University School of Medicine (USUHS, 4301 Jones Bridge Road, Bethesda, MD 20814, USA
Cancer Lett 210:239-44. 2004..06). These results suggest that the ANX7 gene, or other genes of the 10q21 region, could be functionally related to breast cancer, probably influencing the hormone receptor expression associated with poor prognosis during development... - Tristetraprolin regulates IL-8 mRNA stability in cystic fibrosis lung epithelial cellsNagaraja Sethuraman Balakathiresan
Departments of Health Systems, Risk, and Contingency Management, Graduate School of Nursing, Uniformed Services Univ of the Health Sciences, Bethesda, MD 20814, USA
Am J Physiol Lung Cell Mol Physiol 296:L1012-8. 2009..We conclude that enhanced stability of IL-8 mRNA in TTP-deficient CF lung epithelial cells serve to drive the proinflammatory cellular phenotype in the CF lung... - Antibody microarrays: analysis of cystic fibrosisCatherine E Jozwik
Department of Anatomy, Physiology and Genetics, Uniformed Services University School of Medicine, Bethesda, MD, USA
Methods Mol Biol 823:179-200. 2012..We describe here a workflow that begins with patient-derived bronchial brush biopsies and progresses to analysis of serum and plasma from patients on antibody microarrays... - Serum proteomic signature for cystic fibrosis using an antibody microarray platformMeera Srivastava
Department of Anatomy, Physiology and Genetics, Uniformed Services University School of Medicine, USUHS, Bethesda, MD 20814, USA
Mol Genet Metab 87:303-10. 2006..We conclude that antibody microarray technology is sensitive, quantitative, and robust, and can be useful as a proteomic platform to discriminate between sera from CF and control patients... - De novo biosynthetic profiling of high abundance proteins in cystic fibrosis lung epithelial cellsHarvey B Pollard
Department of Anatomy, Physiology and Genetics, Uniformed Services University School of Medicine, Bethesda, Maryland 20814, USA
Mol Cell Proteomics 5:1628-37. 2006..We anticipate that this novel hybrid approach to discovery of the high abundance CF proteome will find general application to other proteomic problems in biology and medicine... - Mapping protein expression in mouse pancreatic islets by immunolabeling and electron energy loss spectrum-imagingGertrud Goping
Department of Anatomy, Physiology and Genetics, and Institute for Molecular Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA
Microsc Res Tech 61:448-56. 2003..The effects and consequences of reduced ANX7 expression on mitochondria are evident in ultrastructural observations... - Gender dependence for a subset of the low-abundance signaling proteome in human plateletsOfer Eidelman
Department of Anatomy, Physiology and Genetics, USU Center for Medical Proteomics, Uniformed Services University, School of Medicine, USUHS, 4301 Jones Bridge Road, Bethesda, MD 20814, USA
Hum Genomics Proteomics 2010:164906. 2010..The difference may suggest a biological mechanism for gender discrimination in cardiovascular disease... - Digitoxin mimics gene therapy with CFTR and suppresses hypersecretion of IL-8 from cystic fibrosis lung epithelial cellsMeera Srivastava
Department of Anatomy, Physiology, and Genetics and Institute for Molecular Medicine, Uniformed Services University School of Medicine, Bethesda, MD 20814, USA
Proc Natl Acad Sci U S A 101:7693-8. 2004..We therefore suggest that digitoxin, with its lengthy history of human use, deserves consideration as a candidate drug for suppressing IL-8-dependent lung inflammation in CF... - Stability of Nucleolin protein as the basis for the differential expression of Nucleolin mRNA and protein during serum starvationSteven K Kim
Department of Anatomy, Physiology and Genetics, and Institute for Molecular Medicine, Uniformed Services University School of Medicine USUHS, Bethesda, Maryland 20814, USA
DNA Cell Biol 22:171-8. 2003.... - Control of the proinflammatory state in cystic fibrosis lung epithelial cells by genes from the TNF-alphaR/NFkappaB pathwayO Eidelman
Department of Anatomy, Institute of Molecular Medicine F. Edward Hebert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA
Mol Med 7:523-34. 2001.... - Protein microarray platforms for clinical proteomicsHarvey B Pollard
Department of Anatomy, Physiology and Genetics, Uniformed Services University School of Medicine, USUHS, Bethesda, MD, USA
Proteomics Clin Appl 1:934-52. 2007..We anticipate that these platforms will eventually evolve to accommodate label-free detection technologies, human genome-scale numbers of analytes, and increases in analytic and bioinformatic speeds... - Pharmacogenomics of cystic fibrosisH B Pollard
Department of Anatomy, Physiology, and Genetics, and Institute for Molecular Medicine, USUHS School of Medicine, Bethesda, MD 20814, USA
Mol Interv 1:54-63. 2001..Pharmacogenomic approaches to CF, and other similar diseases, may eventually give us the opportunity to create drugs that work in a patient- or mutation-specific manner... - cDNA microarrays for pharmacogenomic analysis of cystic fibrosisMeera Srivastava
Department of Anatomy, Physiology and Genetics, Institute for Molecular Medicine, Uniformed Services University School of Medicine, USUHS, Bethesda, MD, USA
Methods Mol Med 70:21-9. 2002 - Cystic fibrosis and the use of pharmacogenomics to determine surrogate endpoints for drug discoveryO Eidelman
Department of Anatomy, Physiology and Genetics, and Institute for Molecular Medicine, Uniformed Services University School of Medicine, USUHS, Bethesda, Maryland 20814, USA
Am J Pharmacogenomics 1:223-38. 2001..Significantly, the nature of the hypothesis, as well as the algorithm developed for this study, can be easily applied to pharmacogenomic studies with other goals... - Novel isoforms of synexin in Xenopus laevis: multiple tandem PGQM repeats distinguish mRNAs in specific adult tissues and embryonic stagesM Srivastava
Laboratory of Cell Biology and Genetics, National Institute of Diabetes, Digestive and Kidney Diseases, NIH, Bethesda, MD 20892, USA
Biochem J 316:729-35. 1996.... - Annexin 7 mobilizes calcium from endoplasmic reticulum stores in brainW D Watson
Neurology Department, National Naval Medical Center, Bethesda, MD 20814, USA
Biochim Biophys Acta 1742:151-60. 2004..We propose that ANX7 mobilizes Ca(2+) from an endoplasmic reticulum-like pool, which can be recruited to enhance IP3-mediated Ca(2+) release... - Role of multi-hnRNP nuclear complex in regulation of tumor suppressor ANXA7 in prostate cancer cellsY Torosyan
Department of Anatomy, Physiology and Genetics, Institute for Molecular Medicine, Uniformed Services University School of Medicine USUHS, Bethesda, MD 20814, USA
Oncogene 29:2457-66. 2010..Thus, a multi-hnRNP complex can be responsible for aberrant ANXA7 transcription and splicing, thereby affecting ANXA7 expression pattern and tumor suppressor function in prostate cancer... - Genomic structure and expression of the human gene encoding cytochrome b561, an integral protein of the chromaffin granule membraneM Srivastava
Laboratory of Cell Biology and Genetics, NIDDK, National Institutes of Health, Bethesda, Maryland 20892, USA
J Biol Chem 270:22714-20. 1995..Unexpected results on cytochrome b561 expression in cells of lymphocytic origin and its complex regulation in tumor cells provide new insights into cytochrome b561 gene regulation... - H19 and Igf2 monoallelic expression is regulated in two distinct ways by a shared cis acting regulatory region upstream of H19M Srivastava
Laboratory of Mammalian Genes and Development, National Institute of Child Health and Human Development, Bethesda, Maryland 20892, USA
Genes Dev 14:1186-95. 2000..However, it is likely that other cis-acting elements, positive and negative, have the ability to effect stable changes in the chromatin structure and are not constantly required to give signals to the transcriptional machinery...