Vijay K Singh
Affiliation: Uniformed Services University of the Health Sciences
Singh V, Ducey E, Brown D, Whitnall M. A review of radiation countermeasure work ongoing at the Armed Forces Radiobiology Research Institute. Int J Radiat Biol. 2012;88:296-310 pubmed publisher
..Here we review primarily the in vivo efficacy of selected countermeasures in animal models and clinical studies. ..
Singh V, Shafran R, Jackson W, Seed T, Kumar K. Induction of cytokines by radioprotective tocopherol analogs. Exp Mol Pathol. 2006;81:55-61 pubmed
..These studies may indicate that alpha-tocopherol succinate can be used as an adjunct in cancer chemotherapy, where neutropenia is a serious problem with threatening infectious complications. ..
Singh V, Brown D, Kao T. Tocopherol succinate: a promising radiation countermeasure. Int Immunopharmacol. 2009;9:1423-30 pubmed publisher
..The stimulation of G-CSF by TS supports its effects on myeloid cell compartments. Our studies indicate that TS may be developed as a radioprotectant for humans against the potentially lethal effects of radiation exposure. ..
Singh V, Brown D, Kao T, Seed T. Preclinical development of a bridging therapy for radiation casualties. Exp Hematol. 2010;38:61-70 pubmed publisher
..The transfused cells act secondarily as a bridging therapy for irradiated mice while their own immune system recovers from the radiation-induced damage. ..
Singh P, Wise S, Ducey E, Fatanmi O, Elliott T, Singh V. ?-Tocopherol succinate protects mice against radiation-induced gastrointestinal injury. Radiat Res. 2012;177:133-45 pubmed
..Our data suggest that ?-TS protects mice from radiation-induced gastrointestinal damage by inhibiting apoptosis, promoting regeneration of crypt cells, and inhibiting translocation of gut bacteria. ..
Singh V, Ducey E, Fatanmi O, Singh P, Brown D, Purmal A, et al
. CBLB613: a TLR 2/6 agonist, natural lipopeptide of Mycoplasma arginini , as a novel radiation countermeasure. Radiat Res. 2012;177:628-42 pubmed
..Our immunogenicity study demonstrated that CBLB613 is not immunogenic in mice, indicating that it could be developed as a radioprotector and radiomitigator for humans against the potentially lethal effects of radiation exposure. ..
Singh V, Shafran R, Inal C, Jackson W, Whitnall M. Effects of whole-body gamma irradiation and 5-androstenediol administration on serum G-CSF. Immunopharmacol Immunotoxicol. 2005;27:521-34 pubmed
Singh V, Brown D, Kao T. Alpha-tocopherol succinate protects mice from gamma-radiation by induction of granulocyte-colony stimulating factor. Int J Radiat Biol. 2010;86:12-21 pubmed publisher
..The results indicate that G-CSF-induced by the administration of TS, mobilises hematopoietic stem cells and is responsible for the protection from ionising radiation. ..
Singh V, Grace M, Jacobsen K, Chang C, Parekh V, Inal C, et al
. Administration of 5-androstenediol to mice: pharmacokinetics and cytokine gene expression. Exp Mol Pathol. 2008;84:178-88 pubmed publisher
..The current results suggest that further studies are warranted to directly test the roles of cytokines in the radioprotective effects of 5-AED. ..