Vijay K Singh

Summary

Affiliation: Uniformed Services University of the Health Sciences
Country: USA

Publications

  1. ncbi request reprint Role of cytokines in experimental and clinical uveitis
    V K Singh
    Department of Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
    Indian J Ophthalmol 49:81-90. 2001
  2. doi request reprint A review of radiation countermeasure work ongoing at the Armed Forces Radiobiology Research Institute
    Vijay K Singh
    Radiation Countermeasures Program, Scientific Research Department, Armed Forces Radiobiology Research Institute Department of Radiation Biology, F Edward Hebert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20889, USA
    Int J Radiat Biol 88:296-310. 2012
  3. doi request reprint Role of radiation-induced granulocyte colony-stimulating factor in recovery from whole body gamma-irradiation
    Vijay K Singh
    Radiation Countermeasures Program, Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, Bethesda, MD, USA
    Cytokine 58:406-14. 2012
  4. ncbi request reprint CBLB613: a TLR 2/6 agonist, natural lipopeptide of Mycoplasma arginini , as a novel radiation countermeasure
    Vijay K Singh
    Radiation Countermeasures Program, Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20889 5603, USA
    Radiat Res 177:628-42. 2012
  5. doi request reprint α-Tocopherol succinate- and AMD3100-mobilized progenitors mitigate radiation-induced gastrointestinal injury in mice
    Vijay K Singh
    Radiation Countermeasures Program, Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, Bethesda, MD 20889 5603, USA
    Exp Hematol 40:407-17. 2012
  6. ncbi request reprint α-Tocopherol succinate protects mice against radiation-induced gastrointestinal injury
    Pankaj K Singh
    Radiation Countermeasures Program, Armed Forces Radiobiology Research Institute, 8901 Wisconsin Ave, Bethesda, MD 20889 5603, USA
    Radiat Res 177:133-45. 2012
  7. ncbi request reprint Role of cytokines and growth factors in radioprotection
    Vijay K Singh
    Department of Immunology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow 226 014, India
    Exp Mol Pathol 78:156-69. 2005
  8. doi request reprint Alpha-tocopherol succinate protects mice from gamma-radiation by induction of granulocyte-colony stimulating factor
    Vijay K Singh
    Radiation Countermeasures Program, Armed Forces Radiobiology Research Institute, Bethesda, Maryland 20889 5603, USA
    Int J Radiat Biol 86:12-21. 2010
  9. doi request reprint Tocopherol succinate: modulation of antioxidant enzymes and oncogene expression, and hematopoietic recovery
    Vijay K Singh
    Radiation Countermeasures Program, Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, Bethesda, MD 20889, USA
    Int J Radiat Oncol Biol Phys 79:571-8. 2011
  10. ncbi request reprint Induction of cytokines by radioprotective tocopherol analogs
    Vijay K Singh
    Armed Forces Radiobiology Research Institute, Bethesda, MD 20889 5603, USA
    Exp Mol Pathol 81:55-61. 2006

Detail Information

Publications47

  1. ncbi request reprint Role of cytokines in experimental and clinical uveitis
    V K Singh
    Department of Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
    Indian J Ophthalmol 49:81-90. 2001
    ..This article discusses in detail the uveitopathogenic and therapeutic potential of Th1 and Th2 cytokines in experimental and clinical uveitis...
  2. doi request reprint A review of radiation countermeasure work ongoing at the Armed Forces Radiobiology Research Institute
    Vijay K Singh
    Radiation Countermeasures Program, Scientific Research Department, Armed Forces Radiobiology Research Institute Department of Radiation Biology, F Edward Hebert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20889, USA
    Int J Radiat Biol 88:296-310. 2012
    ..In this communication we discuss selected promising radiation countermeasures at advanced stages of development...
  3. doi request reprint Role of radiation-induced granulocyte colony-stimulating factor in recovery from whole body gamma-irradiation
    Vijay K Singh
    Radiation Countermeasures Program, Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, Bethesda, MD, USA
    Cytokine 58:406-14. 2012
    ..Neutralizing antibody to G-CSF exacerbates the deleterious effects of radiation, indicating that G-CSF induced in response to irradiation plays an important role in recovery...
  4. ncbi request reprint CBLB613: a TLR 2/6 agonist, natural lipopeptide of Mycoplasma arginini , as a novel radiation countermeasure
    Vijay K Singh
    Radiation Countermeasures Program, Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20889 5603, USA
    Radiat Res 177:628-42. 2012
    ..Our immunogenicity study demonstrated that CBLB613 is not immunogenic in mice, indicating that it could be developed as a radioprotector and radiomitigator for humans against the potentially lethal effects of radiation exposure...
  5. doi request reprint α-Tocopherol succinate- and AMD3100-mobilized progenitors mitigate radiation-induced gastrointestinal injury in mice
    Vijay K Singh
    Radiation Countermeasures Program, Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, Bethesda, MD 20889 5603, USA
    Exp Hematol 40:407-17. 2012
    ....
  6. ncbi request reprint α-Tocopherol succinate protects mice against radiation-induced gastrointestinal injury
    Pankaj K Singh
    Radiation Countermeasures Program, Armed Forces Radiobiology Research Institute, 8901 Wisconsin Ave, Bethesda, MD 20889 5603, USA
    Radiat Res 177:133-45. 2012
    ..Our data suggest that α-TS protects mice from radiation-induced gastrointestinal damage by inhibiting apoptosis, promoting regeneration of crypt cells, and inhibiting translocation of gut bacteria...
  7. ncbi request reprint Role of cytokines and growth factors in radioprotection
    Vijay K Singh
    Department of Immunology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow 226 014, India
    Exp Mol Pathol 78:156-69. 2005
    ..The information and insight gained about therapeutic potential of cytokine manipulation will allow for more rational design of treatment protocols...
  8. doi request reprint Alpha-tocopherol succinate protects mice from gamma-radiation by induction of granulocyte-colony stimulating factor
    Vijay K Singh
    Radiation Countermeasures Program, Armed Forces Radiobiology Research Institute, Bethesda, Maryland 20889 5603, USA
    Int J Radiat Biol 86:12-21. 2010
    ..The purpose of this study was to further elucidate the role of granulocyte-colony stimulating factor (G-CSF)-induced in response to alpha-tocopherol succinate (TS) administration in protecting mice from total body irradiation (TBI)...
  9. doi request reprint Tocopherol succinate: modulation of antioxidant enzymes and oncogene expression, and hematopoietic recovery
    Vijay K Singh
    Radiation Countermeasures Program, Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, Bethesda, MD 20889, USA
    Int J Radiat Oncol Biol Phys 79:571-8. 2011
    ..We recently demonstrated that α-tocopherol succinate (TS) is a potential radiation prophylactic agent. Our objective in this study was to further investigate the mechanism of action of TS in mice exposed to (60)Co γ-radiation...
  10. ncbi request reprint Induction of cytokines by radioprotective tocopherol analogs
    Vijay K Singh
    Armed Forces Radiobiology Research Institute, Bethesda, MD 20889 5603, USA
    Exp Mol Pathol 81:55-61. 2006
    ..These studies may indicate that alpha-tocopherol succinate can be used as an adjunct in cancer chemotherapy, where neutropenia is a serious problem with threatening infectious complications...
  11. doi request reprint Effects of genistein administration on cytokine induction in whole-body gamma irradiated mice
    Vijay K Singh
    Department of Radiation Biology, F Edward Hebert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20889 5603, USA
    Int Immunopharmacol 9:1401-10. 2009
    ....
  12. ncbi request reprint Effects of whole-body gamma irradiation and 5-androstenediol administration on serum G-CSF
    Vijay K Singh
    Radiation Casualty Management Team, Armed Forces Radiobiology Research Institute, Bethesda, Maryland 20889 5603, USA
    Immunopharmacol Immunotoxicol 27:521-34. 2005
    ....
  13. doi request reprint Administration of 5-androstenediol to mice: pharmacokinetics and cytokine gene expression
    V K Singh
    Radiation Countermeasures Program, Armed Forces Radiobiology Research Institute, Bethesda, MD 20889 5603, USA
    Exp Mol Pathol 84:178-88. 2008
    ..The current results suggest that further studies are warranted to directly test the roles of cytokines in the radioprotective effects of 5-AED...
  14. doi request reprint Preclinical development of a bridging therapy for radiation casualties
    Vijay K Singh
    Radiation Countermeasures Program, Armed Forces Radiobiology Research Institute, F Edward Hebert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20889 5603, USA
    Exp Hematol 38:61-70. 2010
    ..We report here preclinical development of a new bridging therapy that will allow the victim's immune system to recover from damage caused by ionizing radiation...
  15. doi request reprint Tocopherol succinate: a promising radiation countermeasure
    Vijay K Singh
    Department of Radiation Biology, F Edward Hebert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20889 5603, USA
    Int Immunopharmacol 9:1423-30. 2009
    ..The stimulation of G-CSF by TS supports its effects on myeloid cell compartments. Our studies indicate that TS may be developed as a radioprotectant for humans against the potentially lethal effects of radiation exposure...
  16. ncbi request reprint Radioprotection by N-palmitoylated nonapeptide of human interleukin-1beta
    Vijay K Singh
    Radiation Casualty Management Team, Radiation Medicine Department, Armed Forces Radiobiology Research Institute, 8901 Wisconsin Avenue, Bethesda, MD 20889 5603, USA
    Peptides 26:413-8. 2005
    ..These results suggest the importance of the derivatization of small peptides of radioprotective, but toxic cytokines in order to enhance radioprotective activity while reducing unwanted toxic side effects...
  17. ncbi request reprint N-palmitoylation of the radioprotective domain of interleukin-1 affords inhibition of LPS-induced nitric oxide generation
    V K Singh
    Radiation Casualty Management Team, Radiation Medicine Department, Armed Forces Radiobiology Research Institute, Bethesda, Maryland 20889 5603, USA
    Immunopharmacol Immunotoxicol 26:193-202. 2004
    ..These results indicate that N-palmitoylation of SRD may effectively ameliorate potentially fatal symptoms of LPS-induced endotoxemic hypotensive shock associated with IL-1 without inflammatory and pyrogenic toxic side effects...
  18. doi request reprint Mobilized progenitor cells as a bridging therapy for radiation casualties: a brief review of tocopherol succinate-based approaches
    Vijay K Singh
    Radiation Countermeasures Program, Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, 8901 Wisconsin Ave, Bethesda, MD 20889 5603, USA
    Int Immunopharmacol 11:842-47. 2011
    ....
  19. ncbi request reprint Immunomodulation by lead
    Vijay K Singh
    Department of Immunology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India
    Immunol Res 28:151-66. 2003
    ....
  20. ncbi request reprint Gene therapy in ocular diseases
    Vijay K Singh
    Department of Immunology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India
    Indian J Ophthalmol 50:173-81. 2002
    ..Gene transfer into ocular tissues has been demonstrated with growing functional success and may develop into a new therapeutic tool for clinical ophthalmology in future...
  21. doi request reprint Alpha-tocopherol succinate-mobilized progenitors improve intestinal integrity after whole body irradiation
    Vijay K Singh
    Armed Forces Radiobiology Research Institute, Bethesda, MD 20889 5603, USA
    Int J Radiat Biol 89:334-45. 2013
    ..The objective of this study was to elucidate the action of α-tocopherol succinate (TS)- and AMD3100-mobilized progenitors in mitigating radiation-induced injuries...
  22. ncbi request reprint Immunomodulation by peptide analogs of retroviral envelope protein
    Shikhar Mehrotra
    Department of Immunology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow 226014, India
    Peptides 24:979-85. 2003
    ..7. Our observations suggests immunomodulatory potential of two retroviral peptide analogs...
  23. pmc 5-AED enhances survival of irradiated mice in a G-CSF-dependent manner, stimulates innate immune cell function, reduces radiation-induced DNA damage and induces genes that modulate cell cycle progression and apoptosis
    Marcy B Grace
    Radiation Countermeasures Program, Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, 8901 Wisconsin Ave, Bethesda, MD 20889 5603, USA
    J Radiat Res 53:840-53. 2012
    ..Our results suggest 5-AED survival enhancement is G-CSF-dependent, and that it stimulates innate immune cell function and reduces radiation-induced DNA damage via induction of genes that modulate cell cycle progression and apoptosis...
  24. ncbi request reprint Myeloid progenitors: a radiation countermeasure that is effective when initiated days after irradiation
    Vijay K Singh
    Radiation Countermeasures Program, Armed Forces Radiobiology Research Institute, Bethesda, Maryland 20889 5603, USA
    Radiat Res 177:781-91. 2012
    ..With respect to efficacy, timing, and practicality of administration, mMPC appear to be a very promising radiation countermeasure for acute radiation syndrome among all candidate therapeutics currently under development...
  25. ncbi request reprint Preclinical development of a bridging therapy for radiation casualties: appropriate for high risk personnel
    Vijay K Singh
    Armed Forces Radiobiology Research Institute, Bethesda, MD Department of Radiation Biology, F Edward Hebert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD Tech Micro Services, 4417 Maple Avenue, Bethesda, MD
    Health Phys 106:689-98. 2014
    ..Therefore, it is proposed that tocopherol succinate be considered for further translational development and ultimately for use in humans. ..
  26. pmc Alpha-tocopherol succinate- and AMD3100-mobilized progenitors mitigate radiation combined injury in mice
    Vijay K Singh
    Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, 8901 Wisconsin Ave, Bethesda, MD 20889 5603, USA
    J Radiat Res 55:41-53. 2014
    ..We suggest that this novel bridging therapeutic approach involving the infusion of TS-mobilized hematopoietic progenitors following acute radiation exposure or combined injury might be applicable to humans. ..
  27. doi request reprint Radioprotective efficacy of tocopherol succinate is mediated through granulocyte-colony stimulating factor
    Pankaj K Singh
    Radiation Countermeasures Program, Armed Forces Radiobiology Research Institute, Bethesda, MD 20889 5603, USA
    Cytokine 56:411-21. 2011
    ..In conclusion, our current study suggests that induction of G-CSF resulting from TS administration is responsible for protection from 60Co γ-radiation injury...
  28. ncbi request reprint Evaluation of EUK-189, a synthetic superoxide dismutase/catalase mimetic as a radiation countermeasure
    Venkataraman Srinivasan
    Radiation Countermeasures Program, Armed Forces Radiobiology Research Institute, Bethesda, Maryland Wisconsin Avenue, Bethesda, MD 20889 5603, USA
    Immunopharmacol Immunotoxicol 30:271-90. 2008
    ..EUK-189 did not stimulate production of any cytokine or chemokine tested...
  29. ncbi request reprint Inhibition of LPS-induced nitric oxide production in RAW cells by radioprotective thiols
    K Sree Kumar
    Radiation Casualty Management Team, Armed Forces Radiobiology Research Institute, 8901 Wisconsin Avenue, Bethesda, Maryland 20889 5603, USA
    Exp Mol Pathol 74:68-73. 2003
    ....
  30. ncbi request reprint Human S-antigen: peptide determinant recognition in uveitis patients
    Parul Tripathi
    Department of Immunology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow 226014, India
    Exp Mol Pathol 76:122-8. 2004
    ..In brief, our study suggests that a particular region of S-antigen plays an important role in idiopathic uveitis...
  31. doi request reprint Radioprotective efficacy of delta-tocotrienol, a vitamin E isoform, is mediated through granulocyte colony-stimulating factor
    Vijay K Singh
    Armed Forces Radiobiology Research Institute, Bethesda, MD, USA Department of Radiation Biology, F Edward Hebert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD, USA Electronic address
    Life Sci 98:113-22. 2014
    ....
  32. pmc Vitamin E: tocopherols and tocotrienols as potential radiation countermeasures
    Vijay K Singh
    Radiation Countermeasures Program, Scientific Research Department, Armed Forces Radiobiology Research Institute, 8901 Wisconsin Ave, Bethesda, MD 20889 5603, USA
    J Radiat Res 54:973-88. 2013
    ..In this brief review we identify and discuss selected tocols and their derivatives currently under development as radiation countermeasures, and attempt to describe in some detail their in vivo efficacy. ..
  33. pmc Radioprotective properties of tocopherol succinate against ionizing radiation in mice
    Vijay K Singh
    Radiation Countermeasures Program, Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, 8901 Wisconsin Ave, Bethesda, MD 20889 5603, USA
    J Radiat Res 54:210-20. 2013
    ..Results of this study further support our contention that TS protects mice against lethal doses of ionizing radiation by inhibiting radiation-induced apoptosis and DNA damage while enhancing cell proliferation...
  34. doi request reprint Interleukin-1 and tumor necrosis factor-alpha: novel targets for immunotherapy in Eales disease
    Sandeep Saxena
    Department of Ophthalmology, King George s Medical University, Lucknow, India
    Ocul Immunol Inflamm 17:201-6. 2009
    ..The authors evaluated interleukin 1 beta (IL-1beta), interleukin-6 (IL-6), Interleukin-10 (IL-10), and tumor necrosis factor-alpha (TNF-alpha) in the serum of patients with Eales disease stages for the first time...
  35. doi request reprint Granulocyte colony-stimulating factor antibody abrogates radioprotective efficacy of gamma-tocotrienol, a promising radiation countermeasure
    Shilpa Kulkarni
    Radiation Countermeasures Program, Armed Forces Radiobiology Research Institute, Uniformed Services University of Health Sciences, Bethesda, MD 20889 5603, USA
    Cytokine 62:278-85. 2013
    ..Our results suggest that induction of high levels of G-CSF by GT3 administration is responsible for its protective efficacy against radiation injury...
  36. ncbi request reprint Radioprotection of hematopoietic progenitors by low dose amifostine prophylaxis
    Thomas M Seed
    Tech Micro Services, Bethesda, MD, USA
    Int J Radiat Biol 90:594-604. 2014
    ..Mature, lineage-restricted progenitors appear to be more responsive to the protective effects of low doses of amifostine than the more primitive, multipotential progenitors. ..
  37. ncbi request reprint Immunomodulatory effects of curcumin
    V S Yadav
    Department of Immunology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India
    Immunopharmacol Immunotoxicol 27:485-97. 2005
    ..Our results suggest that curcumin most likely inhibits cell proliferation and cytokine production by inhibiting NF-kappaB target genes involved in the induction of these immune parameters...
  38. ncbi request reprint Modulation of autoimmune diseases by nitric oxide
    V K Singh
    Department of Immunology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India
    Immunol Res 22:1-19. 2000
    ..This review will discuss the role of NO and nitric oxide synthase (NOS) in pathophysiologic and therapeutic implications in various autoimmune diseases with particular reference to T helper-1 (Th1) and T helper-2 (Th2) cytokines...
  39. ncbi request reprint Immunomodulation by opioid peptidomimetic compound
    P Narayan
    Department of Immunology, Sanjay Gandhi Post-Graduate Institute of Medical Sciences, Lucknow, India
    Neuroimmunomodulation 9:134-40. 2001
    ..7, respectively. CONCLUSION: These observations suggest that compound 3 inhibits MLR through mu-opioid receptor present on cells...
  40. ncbi request reprint Inhibition of anti-CD3 and interleukin-2 stimulated T lymphocyte proliferation by peptidomimetic opioid compound
    P Narayan
    Department of Immunology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India
    Immunopharmacol Immunotoxicol 25:225-33. 2003
    ..However, this peptidomimetic compound did not show any effect on LPS induced MAPK activation. These observations suggest that above peptidomimetic compound has potential to inhibit immune responses mediated by lymphocytes...
  41. ncbi request reprint Immunomodulation by biphalin, dimeric synthetic opioid peptide, and its analog
    S Mehrotra
    Department of Immunology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India
    Immunopharmacol Immunotoxicol 24:83-96. 2002
    ..7. Our observations suggest immunomodulatory property of biphalin and its analog...
  42. ncbi request reprint The paradigm of Th1 and Th2 cytokines: its relevance to autoimmunity and allergy
    V K Singh
    Department of Immunology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India
    Immunol Res 20:147-61. 1999
    ..In this review, we have discussed the paradigm of Th1 and Th2 cytokines in relation to autoimmunity and allergy...
  43. ncbi request reprint Thymopentin and splenopentin as immunomodulators. Current status
    V K Singh
    Department of Immunology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India
    Immunol Res 17:345-68. 1998
    ..The immunomodulatory properties of TP, SP, TP-5, SP-5 and some of their synthetic analogs reported in the literature have been briefly reviewed...
  44. ncbi request reprint Cytokines in posterior uveitis: an update
    V K Singh
    Department of Immunology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India
    Immunol Res 23:59-74. 2001
    ..This review evaluates various studies in which uveitopathogenic and therapeutic potentials of various Th1 and Th2 cytokines have been investigated...
  45. ncbi request reprint Anticellular and immunosuppressive properties of ethanolic extract of Acorus calamus rhizome
    S Mehrotra
    Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow 226 014, India
    Int Immunopharmacol 3:53-61. 2003
    ..calamus extract but CD25 expression was down regulated. Our study demonstrates the antiproliferative and immunosuppressive potential of ethanolic extract of A. calamus rhizome in vitro...
  46. ncbi request reprint Inhibition of antigen specific lymphocyte proliferation and cytokine stimulation by peptidomimetic opioid compound
    P Narayan
    Department of Immunology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India
    Int Immunopharmacol 2:751-7. 2002
    ..Its immunosuppressive effect was further demonstrated by inhibition of interleukin-9 (IL-9), IL-10 but failed to influence IL-2, IL-15 and interferon-y (IFN-gamma) in PPD stimulated human PBMCs...
  47. ncbi request reprint Immunomodulation by ethanolic extract of Boerhaavia diffusa roots
    S Mehrotra
    Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India
    Int Immunopharmacol 2:987-96. 2002
    ..Intracytoplasmic IFN-gamma and cell surface markers such as CD16, CD25, and HLA-DR did not get affected on treatment with B. diffusa extract. Our study demonstrates immunosuppressive potential of ethanolic extract of B. diffusa...