Aryan M A Namboodiri

Summary

Affiliation: Uniformed Services University of the Health Sciences
Country: USA

Publications

  1. ncbi Murine aspartoacylase: cloning, expression and comparison with the human enzyme
    M A Namboodiri
    Section on Neuroendocrinology, Laboratory of Developmental Neurobiology, NICHD, Bethesda, MD 20892, USA
    Brain Res Mol Brain Res 77:285-9. 2000
  2. ncbi Canavan disease and the role of N-acetylaspartate in myelin synthesis
    Aryan M A Namboodiri
    Department of Anatomy, Physiology and Genetics, USUHS, Bethesda, MD 29814, USA
    Mol Cell Endocrinol 252:216-23. 2006
  3. ncbi Role of a pineal cAMP-operated arylalkylamine N-acetyltransferase/14-3-3-binding switch in melatonin synthesis
    S Ganguly
    Section on Neuroendocrinology, Laboratory of Developmental Neurobiology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892 4480, USA
    Proc Natl Acad Sci U S A 98:8083-8. 2001
  4. ncbi Methamphetamine-induced neuronal protein NAT8L is the NAA biosynthetic enzyme: implications for specialized acetyl coenzyme A metabolism in the CNS
    Prasanth S Ariyannur
    Uniformed Services University of Health Sciences, Department of Anatomy, Physiology and Genetics, Molecular and Cell Biology Program, Neuroscience Program, 4301 Jones Bridge Road, Bldg C, Rm 2069, APG, Bethesda, MD 20814, USA
    Brain Res 1335:1-13. 2010
  5. ncbi Metabolic acetate therapy improves phenotype in the tremor rat model of Canavan disease
    Peethambaran Arun
    Department of Anatomy, Physiology and Genetics, Neuroscience Program and Molecular and Cell Biology Program, Uniformed Services University of the Health Sciences, Building C, Bethesda, MD 20814, USA
    J Inherit Metab Dis 33:195-210. 2010
  6. ncbi Defective myelin lipid synthesis as a pathogenic mechanism of Canavan disease
    Aryan M A Namboodiri
    Uniformed Services University of the Health Sciences, 4301 Jones Bridge Rd, Bethesda, MD 20814, USA
    Adv Exp Med Biol 576:145-63; discussion 361-3. 2006
  7. ncbi Nuclear-cytoplasmic localization of acetyl coenzyme a synthetase-1 in the rat brain
    Prasanth S Ariyannur
    Department of Anatomy, Molecular and Cell Biology Program and Neuroscience Program, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA
    J Comp Neurol 518:2952-77. 2010
  8. ncbi cAmp regulation of arylalkylamine N-acetyltransferase (AANAT, EC 2.3.1.87): a new cell line (1E7) provides evidence of intracellular AANAT activation
    S L Coon
    Section on Neuroendocrinology, Laboratory of Developmental Neurobiology, NICHD, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 276:24097-107. 2001
  9. ncbi The structural basis of ordered substrate binding by serotonin N-acetyltransferase: enzyme complex at 1.8 A resolution with a bisubstrate analog
    A B Hickman
    Laboratory of Developmental Neurobiology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 0560, USA
    Cell 97:361-9. 1999
  10. ncbi Natural melatonin 'knockdown' in C57BL/6J mice: rare mechanism truncates serotonin N-acetyltransferase
    P H Roseboom
    Section on Neuroendocrinology, Laboratory of Developmental Neurobiology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Brain Res Mol Brain Res 63:189-97. 1998

Research Grants

  1. Canavan Disease: Pathogenesis and Treatment
    Aryan Namboodiri; Fiscal Year: 2007
  2. CANAVAN DISEASE PATHOGENESIS AND TREATMENT
    Aryan Namboodiri; Fiscal Year: 2002
  3. Biosynthesis of N-acetylaspartate
    Aryan Namboodiri; Fiscal Year: 2005

Collaborators

Detail Information

Publications23

  1. ncbi Murine aspartoacylase: cloning, expression and comparison with the human enzyme
    M A Namboodiri
    Section on Neuroendocrinology, Laboratory of Developmental Neurobiology, NICHD, Bethesda, MD 20892, USA
    Brain Res Mol Brain Res 77:285-9. 2000
    ..Our success in preparing the recombinant ASPA in high purity should permit multiple lines of investigations to understand the pathogenic mechanisms of Canavan disease and the functional roles of NAA...
  2. ncbi Canavan disease and the role of N-acetylaspartate in myelin synthesis
    Aryan M A Namboodiri
    Department of Anatomy, Physiology and Genetics, USUHS, Bethesda, MD 29814, USA
    Mol Cell Endocrinol 252:216-23. 2006
    ..Acetate supplementation therapy is proposed as a simple and inexpensive therapeutic approach to this fatal disease, and progress in our preclinical efforts toward this goal is presented...
  3. ncbi Role of a pineal cAMP-operated arylalkylamine N-acetyltransferase/14-3-3-binding switch in melatonin synthesis
    S Ganguly
    Section on Neuroendocrinology, Laboratory of Developmental Neurobiology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892 4480, USA
    Proc Natl Acad Sci U S A 98:8083-8. 2001
    ..Similar switches could play a role in cAMP signal transduction in other biological systems...
  4. ncbi Methamphetamine-induced neuronal protein NAT8L is the NAA biosynthetic enzyme: implications for specialized acetyl coenzyme A metabolism in the CNS
    Prasanth S Ariyannur
    Uniformed Services University of Health Sciences, Department of Anatomy, Physiology and Genetics, Molecular and Cell Biology Program, Neuroscience Program, 4301 Jones Bridge Road, Bldg C, Rm 2069, APG, Bethesda, MD 20814, USA
    Brain Res 1335:1-13. 2010
    ..We conclude that NAA is a major storage and transport form of acetyl coenzyme A specific to the nervous system, thus linking it to both lipid synthesis and energy metabolism...
  5. ncbi Metabolic acetate therapy improves phenotype in the tremor rat model of Canavan disease
    Peethambaran Arun
    Department of Anatomy, Physiology and Genetics, Neuroscience Program and Molecular and Cell Biology Program, Uniformed Services University of the Health Sciences, Building C, Bethesda, MD 20814, USA
    J Inherit Metab Dis 33:195-210. 2010
    ..These results confirm the critical role played by NAA-derived acetate in brain myelination and development, and demonstrate the potential usefulness of acetate therapy for the treatment of Canavan disease...
  6. ncbi Defective myelin lipid synthesis as a pathogenic mechanism of Canavan disease
    Aryan M A Namboodiri
    Uniformed Services University of the Health Sciences, 4301 Jones Bridge Rd, Bethesda, MD 20814, USA
    Adv Exp Med Biol 576:145-63; discussion 361-3. 2006
  7. ncbi Nuclear-cytoplasmic localization of acetyl coenzyme a synthetase-1 in the rat brain
    Prasanth S Ariyannur
    Department of Anatomy, Molecular and Cell Biology Program and Neuroscience Program, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA
    J Comp Neurol 518:2952-77. 2010
    ..Neuronal and axonal localization implicates AceCS1 in cytoplasmic acetylation reactions in some neurons...
  8. ncbi cAmp regulation of arylalkylamine N-acetyltransferase (AANAT, EC 2.3.1.87): a new cell line (1E7) provides evidence of intracellular AANAT activation
    S L Coon
    Section on Neuroendocrinology, Laboratory of Developmental Neurobiology, NICHD, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 276:24097-107. 2001
    ..This previously unrecognized switching mechanism could function physiologically to control melatonin production without changing AANAT protein levels...
  9. ncbi The structural basis of ordered substrate binding by serotonin N-acetyltransferase: enzyme complex at 1.8 A resolution with a bisubstrate analog
    A B Hickman
    Laboratory of Developmental Neurobiology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 0560, USA
    Cell 97:361-9. 1999
    ..A water-filled channel leading from the active site to the surface provides a pathway for proton removal following amine deprotonation. Furthermore, structural and mutagenesis results indicate an important role for Tyr-168 in catalysis...
  10. ncbi Natural melatonin 'knockdown' in C57BL/6J mice: rare mechanism truncates serotonin N-acetyltransferase
    P H Roseboom
    Section on Neuroendocrinology, Laboratory of Developmental Neurobiology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Brain Res Mol Brain Res 63:189-97. 1998
    ..The decrease in melatonin signaling may have been a selective factor in the development of laboratory strains of mice because melatonin can inhibit reproduction and modify circadian rhythmicity...
  11. ncbi Cloning and characterization of the epsilon and zeta isoforms of the 14-3-3 proteins
    P H Roseboom
    Section on Neuroendocrinology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892
    DNA Cell Biol 13:629-40. 1994
    ..This investigation also revealed the epsilon isoform was present at high levels in the rat pineal gland early in development and decreased steadily thereafter and that 30-kD isoforms exhibited the inverse developmental pattern...
  12. ncbi Metabolic acetate therapy for the treatment of traumatic brain injury
    Peethambaran Arun
    Department of Anatomy, Physiology and Genetics, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA
    J Neurotrauma 27:293-8. 2010
    ..We found that GTA administration significantly increased the levels of both NAA and ATP in the injured hemisphere 4 and 6 days after injury, and also resulted in significantly improved motor performance in rats 3 days after injury...
  13. ncbi Riluzole decreases synthesis of N-acetylaspartate and N-acetylaspartylglutamate in SH-SY5Y human neuroblastoma cells
    Peethambaran Arun
    Department of Anatomy, Physiology and Genetics and Neuroscience Program, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Rd, Bethesda, MD 20814, USA
    Brain Res 1334:25-30. 2010
    ..These results suggest that the synthesis of NAA and NAAG may be coupled to glutamatergic neurotransmission, and further investigations along these lines are warranted...
  14. ncbi N-Acetylaspartate in the CNS: from neurodiagnostics to neurobiology
    John R Moffett
    Department of Anatomy, Physiology and Genetics, Uniformed Services University of the Health Sciences, Building C, 4301 Jones Bridge Rd, Bethesda, MD 20814, USA
    Prog Neurobiol 81:89-131. 2007
    ..Further research will be required to more fully understand the biochemical functions served by NAA in CNS development and activity, and additional functions are likely to be discovered...
  15. ncbi Extensive aspartoacylase expression in the rat central nervous system
    John R Moffett
    Department of Anatomy, Physiology and Genetics, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA
    Glia 59:1414-34. 2011
    ..Expression of ASPA in microglia may indicate a role in lipid synthesis in these cells, whereas expression in axons suggests that some neurons can both synthesize and catabolize NAA...
  16. ncbi Antipsychotic drugs increase N-acetylaspartate and N-acetylaspartylglutamate in SH-SY5Y human neuroblastoma cells
    Peethambaran Arun
    Department of Anatomy, Physiology and Genetics, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA
    J Neurochem 106:1669-80. 2008
    ....
  17. ncbi Evidence for mitochondrial and cytoplasmic N-acetylaspartate synthesis in SH-SY5Y neuroblastoma cells
    Peethambaran Arun
    Dept of Anatomy, Physiology and Genetics, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Rd, Bethesda, MD 20814, United States
    Neurochem Int 55:219-25. 2009
    ..We conclude that NAA biosynthesis occurs in both the cytoplasm and mitochondria of SH-SY5Y cells, and that the contribution from the mitochondrial compartment is quantitatively larger than that in the extramitochondrial compartment...
  18. ncbi N-acetylaspartate synthesis in the brain: mitochondria vs. microsomes
    Prasanth S Ariyannur
    Rm C 2069, Department of Anatomy, Physiology and Genetics, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814, USA
    Brain Res 1227:34-41. 2008
    ..670 kD) on size-exclusion HPLC...
  19. ncbi NAA synthesis and functional roles
    Chikkathur N Madhavarao
    Department of Anatomy, Physiology and Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
    Adv Exp Med Biol 576:49-66; discussion 361-3. 2006
  20. ncbi Expression of N-acetylaspartate and N-acetylaspartylglutamate in the nervous system
    John R Moffett
    Uniformed Services University of the Health Sciences, 4301 Jones Bridge Rd, Bethesda MD, 20814, USA
    Adv Exp Med Biol 576:7-26; discussion 361-3. 2006
  21. ncbi Preface: a brief review of N-acetylaspartate
    John R Moffett
    Uniformed Services University of the Health Sciences, 4301 Jones Bridge Rd, Bethesda, MD 20814, USA
    Adv Exp Med Biol 576:vii-xiii. 2006
  22. ncbi Selective metabolism of kynurenine in the spleen in the absence of indoleamine 2,3-dioxygenase induction
    M G Espey
    Radiation Biology Branch, National Cancer Institute, NIH, Bethesda, MD 20892, USA
    Immunol Lett 71:67-72. 2000
    ..In vivo manipulation of Quin synthesis in the absence of IDO induction may serve as a model for studying regulation and function of the kynurenine pathway activation in the immune system...
  23. ncbi Pineal serotonin N-acetyltransferase: expression cloning and molecular analysis
    S L Coon
    Section on Neuroendocrinology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Science 270:1681-3. 1995
    ..The night-to-day ratio of ovine pineal AA-NAT mRNA is less than 2. In contrast, the ratio exceeds 150 in rats. AA-NAT represents a family within a large superfamily of acetyltransferases...

Research Grants6

  1. Canavan Disease: Pathogenesis and Treatment
    Aryan Namboodiri; Fiscal Year: 2007
    ..These studies are likely to lead to a simple and inexpensive method for the treatment of CD and also advance our knowledge on the functional roles of NAA and the relationship of increased NAA to CD pathology. ..
  2. CANAVAN DISEASE PATHOGENESIS AND TREATMENT
    Aryan Namboodiri; Fiscal Year: 2002
    ....
  3. Biosynthesis of N-acetylaspartate
    Aryan Namboodiri; Fiscal Year: 2005
    ..Based on the above information, biochemical approaches aimed at replenishing the NAA could be developed as a novel therapeutic strategy. ..