Research Topics
| P D MonganSummaryAffiliation: Uniformed Services University of the Health Sciences Country: USA Publications
| Collaborators
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Detail Information
Publications
Intravenous pyruvate prolongs survival during hemorrhagic shock in swineP D Mongan
Department of Anesthesiology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA
Am J Physiol 277:H2253-63. 1999..The findings reveal considerable metabolic and functional enhancement by pyruvate during severe hemorrhagic shock with a 75-min delay in spontaneous cardiovascular decompensation and death...- Pyruvate improves cerebral metabolism during hemorrhagic shockP D Mongan
Department of Anesthesiology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA
Am J Physiol Heart Circ Physiol 281:H854-64. 2001..The findings show that PYR administered after the onset of hemorrhagic shock markedly improves cerebral metabolic and functional status for at least 4 h... - Pyruvate improves redox status and decreases indicators of hepatic apoptosis during hemorrhagic shock in swinePaul D Mongan
Department of Anesthesiology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA
Am J Physiol Heart Circ Physiol 283:H1634-44. 2002.... - Pyruvate prevents poly-ADP ribose polymerase (PARP) activation, oxidative damage, and pyruvate dehydrogenase deactivation during hemorrhagic shock in swinePaul D Mongan
Department of Anesthesiology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA
J Surg Res 112:180-8. 2003..We conclude that there are multiple mechanisms by which pyruvate can possibly prevent cell damage caused during HS... - Developing meaningful metrics of clinical productivity for military treatment facility anesthesiology departments and operative servicesPaul D Mongan
Department of Anesthesiology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
Mil Med 168:880-4. 2003..In addition, these benchmarks are compared with those derived from the use of this system in the civilian sector... - Prolonging viability of swine muscle biopsy specimens in malignant hyperthermia testingS Bina
Department of Anesthesiology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA
Anesth Analg 93:781-6. 2001..This finding was also confirmed in muscle stored under clamped-warm conditions and shipped overnight to another testing center for a parallel CHCT... - Pyruvate modulates hepatic mitochondrial functions and reduces apoptosis indicators during hemorrhagic shock in ratsPushpa Sharma
Department of Anesthesiology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA
Anesthesiology 103:65-73. 2005..This report describes experiments to determine whether modulation of hepatic mitochondrial dysfunctions by pharmacologic agents could prevent liver injury in rats subjected to HS... - A multidisciplinary approach to teach responses to weapons of mass destruction and terrorism using combined simulation modalitiesRichard R Kyle
Department of Anatomy, Physiology and Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
J Clin Anesth 16:152-8. 2004.... - Pyruvate ameliorates post ischemic injury of rat astrocytes and protects them against PARP mediated cell deathPushpa Sharma
Department of Anesthesiology, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814, USA
Brain Res 992:104-13. 2003..Use of pyruvate as an alternate fuel substrate may provide a possibility for the novel therapeutic approach to the treatment of cerebral ischemia... 
Hypertonic sodium pyruvate solution is more effective than Ringer's ethyl pyruvate in the treatment of hemorrhagic shockPushpa Sharma
Hemorrhagic Shock and Trauma Laboratory, Department of Anesthesiology, The Uniformed Services University, 4301 Jones Bridge Road, Bethesda, MD 20814, USA
Shock 33:532-40. 2010..Resuscitation with small-volume HSP offers significant protection against inflammatory and oxidative stress and in preventing liver injury compared with large-volume Ringer's ethyl pyruvate...- Using high-fidelity patient simulation and an advanced distance education network to teach pharmacology to second-year medical studentsDarin K Via
Department of Anesthesiology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
J Clin Anesth 16:144-51. 2004.... - Regional blood flow after serial normovolemic exchange transfusion with HBOC-201 (Hemopure) in anesthetized swinePaul D Mongan
Hemorrhagic Shock Laboratory, Department of Anesthesiology, The Uniformed Services University, Bethesda, Maryland 20854, USA
J Trauma 67:51-60. 2009.... - Porcine-specific hemoglobin saturation measurementsRichard Serianni
Department of Anesthesiology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA
J Appl Physiol 94:561-6. 2003..In contrast, comparison of the porcine-specific oxyhemoglobin saturations with saturations obtained by using human methods highlights the necessity of species-specific measurement methodology... - Hemorrhagic shock in swine: nitric oxide and potassium sensitive adenosine triphosphate channel activationJeffrey B Musser
Anesthesia and Operative Service, Walter Reed Army Medical Center, Washington, D.C, USA
Anesthesiology 101:399-408. 2004.... - Complement activation during hemorrhagic shock and resuscitation in swineJanos Szebeni
Department of Membrane Biochemistry, Walter Reed Army Institute of Research, Washington, DC 20307, USA
Shock 20:347-55. 2003..The biphasic course of CH50/mL and C5a changes may reflect yet unrecognized physiological responses to hemorrhage-related C activation...