P D Mongan

Summary

Affiliation: Uniformed Services University of the Health Sciences
Country: USA

Publications

  1. ncbi request reprint Intravenous pyruvate prolongs survival during hemorrhagic shock in swine
    P D Mongan
    Department of Anesthesiology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA
    Am J Physiol 277:H2253-63. 1999
  2. ncbi request reprint Pyruvate improves cerebral metabolism during hemorrhagic shock
    P D Mongan
    Department of Anesthesiology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA
    Am J Physiol Heart Circ Physiol 281:H854-64. 2001
  3. ncbi request reprint Pyruvate improves redox status and decreases indicators of hepatic apoptosis during hemorrhagic shock in swine
    Paul D Mongan
    Department of Anesthesiology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA
    Am J Physiol Heart Circ Physiol 283:H1634-44. 2002
  4. ncbi request reprint Pyruvate prevents poly-ADP ribose polymerase (PARP) activation, oxidative damage, and pyruvate dehydrogenase deactivation during hemorrhagic shock in swine
    Paul D Mongan
    Department of Anesthesiology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA
    J Surg Res 112:180-8. 2003
  5. ncbi request reprint Developing meaningful metrics of clinical productivity for military treatment facility anesthesiology departments and operative services
    Paul D Mongan
    Department of Anesthesiology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
    Mil Med 168:880-4. 2003
  6. ncbi request reprint Prolonging viability of swine muscle biopsy specimens in malignant hyperthermia testing
    S Bina
    Department of Anesthesiology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA
    Anesth Analg 93:781-6. 2001
  7. ncbi request reprint Pyruvate modulates hepatic mitochondrial functions and reduces apoptosis indicators during hemorrhagic shock in rats
    Pushpa Sharma
    Department of Anesthesiology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA
    Anesthesiology 103:65-73. 2005
  8. ncbi request reprint A multidisciplinary approach to teach responses to weapons of mass destruction and terrorism using combined simulation modalities
    Richard R Kyle
    Department of Anatomy, Physiology and Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
    J Clin Anesth 16:152-8. 2004
  9. ncbi request reprint Pyruvate ameliorates post ischemic injury of rat astrocytes and protects them against PARP mediated cell death
    Pushpa Sharma
    Department of Anesthesiology, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814, USA
    Brain Res 992:104-13. 2003
  10. doi request reprint Hypertonic sodium pyruvate solution is more effective than Ringer's ethyl pyruvate in the treatment of hemorrhagic shock
    Pushpa Sharma
    Hemorrhagic Shock and Trauma Laboratory, Department of Anesthesiology, The Uniformed Services University, 4301 Jones Bridge Road, Bethesda, MD 20814, USA
    Shock 33:532-40. 2010

Collaborators

Detail Information

Publications15

  1. ncbi request reprint Intravenous pyruvate prolongs survival during hemorrhagic shock in swine
    P D Mongan
    Department of Anesthesiology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA
    Am J Physiol 277:H2253-63. 1999
    ..The findings reveal considerable metabolic and functional enhancement by pyruvate during severe hemorrhagic shock with a 75-min delay in spontaneous cardiovascular decompensation and death...
  2. ncbi request reprint Pyruvate improves cerebral metabolism during hemorrhagic shock
    P D Mongan
    Department of Anesthesiology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA
    Am J Physiol Heart Circ Physiol 281:H854-64. 2001
    ..The findings show that PYR administered after the onset of hemorrhagic shock markedly improves cerebral metabolic and functional status for at least 4 h...
  3. ncbi request reprint Pyruvate improves redox status and decreases indicators of hepatic apoptosis during hemorrhagic shock in swine
    Paul D Mongan
    Department of Anesthesiology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA
    Am J Physiol Heart Circ Physiol 283:H1634-44. 2002
    ....
  4. ncbi request reprint Pyruvate prevents poly-ADP ribose polymerase (PARP) activation, oxidative damage, and pyruvate dehydrogenase deactivation during hemorrhagic shock in swine
    Paul D Mongan
    Department of Anesthesiology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA
    J Surg Res 112:180-8. 2003
    ..We conclude that there are multiple mechanisms by which pyruvate can possibly prevent cell damage caused during HS...
  5. ncbi request reprint Developing meaningful metrics of clinical productivity for military treatment facility anesthesiology departments and operative services
    Paul D Mongan
    Department of Anesthesiology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
    Mil Med 168:880-4. 2003
    ..In addition, these benchmarks are compared with those derived from the use of this system in the civilian sector...
  6. ncbi request reprint Prolonging viability of swine muscle biopsy specimens in malignant hyperthermia testing
    S Bina
    Department of Anesthesiology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA
    Anesth Analg 93:781-6. 2001
    ..This finding was also confirmed in muscle stored under clamped-warm conditions and shipped overnight to another testing center for a parallel CHCT...
  7. ncbi request reprint Pyruvate modulates hepatic mitochondrial functions and reduces apoptosis indicators during hemorrhagic shock in rats
    Pushpa Sharma
    Department of Anesthesiology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA
    Anesthesiology 103:65-73. 2005
    ..This report describes experiments to determine whether modulation of hepatic mitochondrial dysfunctions by pharmacologic agents could prevent liver injury in rats subjected to HS...
  8. ncbi request reprint A multidisciplinary approach to teach responses to weapons of mass destruction and terrorism using combined simulation modalities
    Richard R Kyle
    Department of Anatomy, Physiology and Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
    J Clin Anesth 16:152-8. 2004
    ....
  9. ncbi request reprint Pyruvate ameliorates post ischemic injury of rat astrocytes and protects them against PARP mediated cell death
    Pushpa Sharma
    Department of Anesthesiology, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814, USA
    Brain Res 992:104-13. 2003
    ..Use of pyruvate as an alternate fuel substrate may provide a possibility for the novel therapeutic approach to the treatment of cerebral ischemia...
  10. doi request reprint Hypertonic sodium pyruvate solution is more effective than Ringer's ethyl pyruvate in the treatment of hemorrhagic shock
    Pushpa Sharma
    Hemorrhagic Shock and Trauma Laboratory, Department of Anesthesiology, The Uniformed Services University, 4301 Jones Bridge Road, Bethesda, MD 20814, USA
    Shock 33:532-40. 2010
    ..Resuscitation with small-volume HSP offers significant protection against inflammatory and oxidative stress and in preventing liver injury compared with large-volume Ringer's ethyl pyruvate...
  11. ncbi request reprint Using high-fidelity patient simulation and an advanced distance education network to teach pharmacology to second-year medical students
    Darin K Via
    Department of Anesthesiology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
    J Clin Anesth 16:144-51. 2004
    ....
  12. doi request reprint Regional blood flow after serial normovolemic exchange transfusion with HBOC-201 (Hemopure) in anesthetized swine
    Paul D Mongan
    Hemorrhagic Shock Laboratory, Department of Anesthesiology, The Uniformed Services University, Bethesda, Maryland 20854, USA
    J Trauma 67:51-60. 2009
    ....
  13. ncbi request reprint Porcine-specific hemoglobin saturation measurements
    Richard Serianni
    Department of Anesthesiology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA
    J Appl Physiol 94:561-6. 2003
    ..In contrast, comparison of the porcine-specific oxyhemoglobin saturations with saturations obtained by using human methods highlights the necessity of species-specific measurement methodology...
  14. ncbi request reprint Hemorrhagic shock in swine: nitric oxide and potassium sensitive adenosine triphosphate channel activation
    Jeffrey B Musser
    Anesthesia and Operative Service, Walter Reed Army Medical Center, Washington, D C, USA
    Anesthesiology 101:399-408. 2004
    ..To determine the role of nitric oxide and adenosine triphosphate-sensitive potassium (KATP) vascular channels in vascular decompensation during controlled hemorrhagic shock in swine...
  15. ncbi request reprint Complement activation during hemorrhagic shock and resuscitation in swine
    Janos Szebeni
    Department of Membrane Biochemistry, Walter Reed Army Institute of Research, Washington, DC 20307, USA
    Shock 20:347-55. 2003
    ..The biphasic course of CH50/mL and C5a changes may reflect yet unrecognized physiological responses to hemorrhage-related C activation...