Research Topics
Genomes and Genes | John R MoffettSummaryAffiliation: Uniformed Services University of the Health Sciences Country: USA Publications
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Publications
Preface: a brief review of N-acetylaspartateJohn R Moffett
Uniformed Services University of the Health Sciences, 4301 Jones Bridge Rd, Bethesda, MD 20814, USA
Adv Exp Med Biol 576:vii-xiii. 2006- Reductions in N-acetylaspartylglutamate and the 67 kDa form of glutamic acid decarboxylase immunoreactivities in the visual system of albino and pigmented rats after optic nerve transectionsJohn R Moffett
Department of Biology, Georgetown University, Washington, DC 20057 1229, USA
J Comp Neurol 458:221-39. 2003..This is consistent with NAAG acting as a neurotransmitter release modulator that is coreleased with a variety of classical transmitters in specific neural pathways... 
Extensive aspartoacylase expression in the rat central nervous systemJohn R Moffett
Department of Anatomy, Physiology and Genetics, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA
Glia 59:1414-34. 2011..Expression of ASPA in microglia may indicate a role in lipid synthesis in these cells, whereas expression in axons suggests that some neurons can both synthesize and catabolize NAA...
Miasmas, germs, homeopathy and hormesis: commentary on the relationship between homeopathy and hormesisJohn R Moffett
Department of Anatomy, Physiology and Genetics, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA
Hum Exp Toxicol 29:539-43. 2010..Without supporting scientific evidence for the efficacy or purported mechanisms of homeopathy, the term hormesis should not be linked with it in any way...- N-Acetylaspartate in the CNS: from neurodiagnostics to neurobiologyJohn R Moffett
Department of Anatomy, Physiology and Genetics, Uniformed Services University of the Health Sciences, Building C, 4301 Jones Bridge Rd, Bethesda, MD 20814, USA
Prog Neurobiol 81:89-131. 2007..Further research will be required to more fully understand the biochemical functions served by NAA in CNS development and activity, and additional functions are likely to be discovered... - Laboratory research in homeopathy: conJohn R Moffett
Uniformed Services, University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD, USA
Integr Cancer Ther 5:333-42. 2006..2006;5:320-332) are composed of a thesis section, a response section in reaction to the companion thesis, and a rebuttal section to address issues raised in the companion response... - Expression of N-acetylaspartate and N-acetylaspartylglutamate in the nervous systemJohn R Moffett
Uniformed Services University of the Health Sciences, 4301 Jones Bridge Rd, Bethesda MD, 20814, USA
Adv Exp Med Biol 576:7-26; discussion 361-3. 2006 - Tryptophan and the immune responseJohn R Moffett
Department of Anatomy, Uniformed Services University of the Health Sciences, Building C, Room 2109, 4301 Jones Bridge Road, Bethesda, MD 20814, USA
Immunol Cell Biol 81:247-65. 2003..In addition to the immunomodulatory actions of tryptophan catabolites, we discuss the possible involvement of quinolinate as a means of replenishing NAD + in leucocytes, which is depleted by oxidative stress during an immune response... - Nuclear-cytoplasmic localization of acetyl coenzyme a synthetase-1 in the rat brainPrasanth S Ariyannur
Department of Anatomy, Molecular and Cell Biology Program and Neuroscience Program, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA
J Comp Neurol 518:2952-77. 2010..Neuronal and axonal localization implicates AceCS1 in cytoplasmic acetylation reactions in some neurons... - Metabolic acetate therapy improves phenotype in the tremor rat model of Canavan diseasePeethambaran Arun
Department of Anatomy, Physiology and Genetics, Neuroscience Program and Molecular and Cell Biology Program, Uniformed Services University of the Health Sciences, Building C, Bethesda, MD 20814, USA
J Inherit Metab Dis 33:195-210. 2010..These results confirm the critical role played by NAA-derived acetate in brain myelination and development, and demonstrate the potential usefulness of acetate therapy for the treatment of Canavan disease... - Defective myelin lipid synthesis as a pathogenic mechanism of Canavan diseaseAryan M A Namboodiri
Uniformed Services University of the Health Sciences, 4301 Jones Bridge Rd, Bethesda, MD 20814, USA
Adv Exp Med Biol 576:145-63; discussion 361-3. 2006 - Methamphetamine-induced neuronal protein NAT8L is the NAA biosynthetic enzyme: implications for specialized acetyl coenzyme A metabolism in the CNSPrasanth S Ariyannur
Uniformed Services University of Health Sciences, Department of Anatomy, Physiology and Genetics, Molecular and Cell Biology Program, Neuroscience Program, 4301 Jones Bridge Road, Bldg C, Rm 2069, APG, Bethesda, MD 20814, USA
Brain Res 1335:1-13. 2010..We conclude that NAA is a major storage and transport form of acetyl coenzyme A specific to the nervous system, thus linking it to both lipid synthesis and energy metabolism... - Metabolic acetate therapy for the treatment of traumatic brain injuryPeethambaran Arun
Department of Anatomy, Physiology and Genetics, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA
J Neurotrauma 27:293-8. 2010..We found that GTA administration significantly increased the levels of both NAA and ATP in the injured hemisphere 4 and 6 days after injury, and also resulted in significantly improved motor performance in rats 3 days after injury... - Antipsychotic drugs increase N-acetylaspartate and N-acetylaspartylglutamate in SH-SY5Y human neuroblastoma cellsPeethambaran Arun
Department of Anatomy, Physiology and Genetics, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA
J Neurochem 106:1669-80. 2008.... - Canavan disease and the role of N-acetylaspartate in myelin synthesisAryan M A Namboodiri
Department of Anatomy, Physiology and Genetics, USUHS, Bethesda, MD 29814, USA
Mol Cell Endocrinol 252:216-23. 2006..Acetate supplementation therapy is proposed as a simple and inexpensive therapeutic approach to this fatal disease, and progress in our preclinical efforts toward this goal is presented... - Regulation of N-acetylaspartate and N-acetylaspartylglutamate biosynthesis by protein kinase activatorsPeethambaran Arun
Department of Anatomy, Physiology and Genetics, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA
J Neurochem 98:2034-42. 2006..These results suggest that, while the neuronal production of NAA and NAAG are biochemically related, significant differences exist in the regulatory mechanisms controlling their biosynthesis... - Evidence for mitochondrial and cytoplasmic N-acetylaspartate synthesis in SH-SY5Y neuroblastoma cellsPeethambaran Arun
Dept of Anatomy, Physiology and Genetics, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Rd, Bethesda, MD 20814, United States
Neurochem Int 55:219-25. 2009..We conclude that NAA biosynthesis occurs in both the cytoplasm and mitochondria of SH-SY5Y cells, and that the contribution from the mitochondrial compartment is quantitatively larger than that in the extramitochondrial compartment... - Riluzole decreases synthesis of N-acetylaspartate and N-acetylaspartylglutamate in SH-SY5Y human neuroblastoma cellsPeethambaran Arun
Department of Anatomy, Physiology and Genetics and Neuroscience Program, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Rd, Bethesda, MD 20814, USA
Brain Res 1334:25-30. 2010..These results suggest that the synthesis of NAA and NAAG may be coupled to glutamatergic neurotransmission, and further investigations along these lines are warranted... - Defective N-acetylaspartate catabolism reduces brain acetate levels and myelin lipid synthesis in Canavan's diseaseChikkathur N Madhavarao
Department of Anatomy, Physiology, and Genetics, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814, USA
Proc Natl Acad Sci U S A 102:5221-6. 2005.... - Aspartoacylase is a regulated nuclear-cytoplasmic enzymeJeremy R Hershfield
Dept of Anatomy, Physiology, and Genetics, USUHS, 4301 Jones Bridge Rd, Bethesda, MD 20814, USA
FASEB J 20:2139-41. 2006..GFP-hASPA was enzymatically active and showed mixed nuclear-cytoplasmic distribution. We conclude that ASPA is a regulated nuclear-cytoplasmic protein that may have distinct functional roles in the two cellular compartments... - Immunohistochemical localization of aspartoacylase in the rat central nervous systemChikkathur N Madhavarao
Department of Anatomy, Physiology and Genetics, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA
J Comp Neurol 472:318-29. 2004..The predominant immunoreactivity in oligodendrocytes is consistent with the proposed role of ASPA in myelination, supporting the case for acetate supplementation as an immediate and inexpensive therapy for infants diagnosed with CD... - Progress toward acetate supplementation therapy for Canavan disease: glyceryl triacetate administration increases acetate, but not N-acetylaspartate, levels in brainRaji Mathew
Department of Anatomy, Physiology, and Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
J Pharmacol Exp Ther 315:297-303. 2005..Based on these results and the current Food and Drug Administration-approved use of GTA as a food additive, we propose that it is a potential candidate for use in acetate supplementation therapy for CD... - NAAG peptidase inhibition in the periaqueductal gray and rostral ventromedial medulla reduces flinching in the formalin model of inflammationToshihiko Yamada
Department of Biology, Georgetown University, Washington, DC, USA
Mol Pain 8:67. 2012..The goal of this study was to begin defining locations within the central pain pathway at which NAAG activation of its receptor mediates this effect... - SH-SY5Y neuroblastoma cells: a model system for studying biosynthesis of NAAGPeethambaran Arun
Department of Anatomy, Physiology and Genetics, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Rd, Bethesda, MD 20814, USA
Neuroreport 15:1167-70. 2004..Differentiation of SH-SY5Y cells with retinoic acid resulted in decreased radiolabel incorporation into NAAG, whereas differentiation with nerve growth factor did not affect radiolabel incorporation... - Rapid sodium cyanide depletion in cell culture media: outgassing of hydrogen cyanide at physiological pHPeethambaran Arun
Department of Anatomy, Physiology, and Genetics, Uniformed Services University of the Health Sciences, Building C, 4301 Jones Bridge Road, Bethesda, MD 20814, USA
Anal Biochem 339:282-9. 2005.... - Effects of N-acetylaspartylglutamate (NAAG) peptidase inhibition on release of glutamate and dopamine in prefrontal cortex and nucleus accumbens in phencyclidine model of schizophreniaDaiying Zuo
Department of Biology, Georgetown University, Washington, DC 20057, USA
J Biol Chem 287:21773-82. 2012.... - Selective vulnerability of hippocampal NAAGergic neurons in experimental temporal lobe epilepsyLuis F Pacheco Otalora
Department of Biological Sciences at the University of Texas at Brownsville Texas Southmost College, 80 Fort Brown, Brownsville, TX 78520, USA
Brain Res 1144:219-30. 2007..Our findings indicate a selective vulnerability of NAAGergic neurons in temporal lobe epilepsy... - Down regulation of sodium channel Na(v)1.1 expression by veratridine and its reversal by a novel sodium channel blocker, RS100642, in primary neuronal culturesJitendra R Dave
Department of Neuropharmacology and Molecular Biology, Division of Neurosciences, Walter Reed Army Institute of Research, 503 Robert Grant Ave, Silver Spring, MD 20910 7500, USA
Neurotox Res 5:213-20. 2003..1 sodium channel gene may play a key role in the neuronal injury/recovery process... - Studies on neuronal apoptosis in primary forebrain cultures: neuroprotective/anti-apoptotic action of NR2B NMDA antagonistsJitendra R Dave
Department of Neuropharmacology and Molecular Biology, Division of Neurosciences, Walter Reed Army Institute of Research, Silver Spring, MD 20910 7500, USA
Neurotox Res 5:255-64. 2003..These studies demonstrate that NR2B NMDA receptor antagonists are anti-apoptotic and may mediate their action via mechanism(s) that are dependent or independent of caspase-3 activation... - IDO expands human CD4+CD25high regulatory T cells by promoting maturation of LPS-treated dendritic cellsMarcelo Hill
INSERM, U 643, Nantes, Cedex 1, France
Eur J Immunol 37:3054-62. 2007..In conclusion, we show that IDO constitutes an intermediate pathway in DC maturation leading to expansion of CD4(+)CD25(high) regulatory T cells...